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公开(公告)号：WO0061608A3
公开(公告)日：2001-01-11
申请号：PCT/EP0002710
申请日：2000-03-28
Applicant: BASF AG
Inventor： HILLEN HEINZ , SCHMIDT MARTIN , MACK HELMUT , SEITZ WERNER , HAUPT ANDREAS , ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS
IPC: C12N9/99 , A61K38/00 , A61P1/04 , A61P1/18 , A61P5/14 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/02 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P37/02 , C07B43/00 , C07D401/12 , C07K5/06 , C07K5/065 , C07K5/062 , A61K38/05 , C07D409/12 , C07K5/068 , C07K5/072 , C07K5/078
CPC classification number: C07D401/12 , A61K38/00 , C07B43/00 , C07K5/06078
Abstract: The invention relates to peptidic substances, to the production of said substances and to their use as complement inhibitors. In particular, the invention relates to substances with a guanidine or amidine radical as the terminal group, especially inhibitors of the complement proteases C1s and C1r.
Abstract translation: 本发明涉及肽的物质，它们的制备和它们作为补体抑制剂的用途。 具体而言，存在与一个胍或脒基作为末端基团的物质。 特别地，本发明涉及的C1s和C1R Komplementproteasen的抑制剂。
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公开(公告)号：ZA200107978B
公开(公告)日：2003-03-26
申请号：ZA200107978
申请日：2001-09-28
Applicant: BASF AG
Inventor： HILLEN HEINZ , SCHMIDT MARTIN , MACK HELMUT , SEITZ WERNER , HAUPT ANDREAS , ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS
IPC: A61K38/00 , A61K38/55 , A61P1/04 , A61P1/18 , C12N9/99 , A61P5/14 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/02 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P37/02 , C07B43/00 , C07D401/12 , C07D409/12 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/078 , C07K , C07D , A61K , A61P
Abstract: Peptide substances, their preparation and their use as complement inhibitors are described. These are in particular substances having a guanidine or amidine radical as a terminal group. In particular, inhibitors of the complement proteases C1s and C1r are described.
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公开(公告)号：HU0203167A2
公开(公告)日：2003-02-28
申请号：HU0203167
申请日：2000-03-28
Applicant: BASF AG
Inventor： HAUPT ANDREAS , HILLEN HEINZ , KLING ANDREAS , MACK HELMUT , SCHMIDT MARTIN , SEITZ WERNER , ZECHEL JOHANN-CHRISTIAN
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61P1/04 , A61P1/18 , A61P5/14 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/02 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P37/02 , C07B43/00 , C07D401/12 , C07D409/12 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/078
Abstract: Peptide substances, their preparation and their use as complement inhibitors are described. These are in particular substances having a guanidine or amidine radical as a terminal group. In particular, inhibitors of the complement proteases C1s and C1r are described.
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公开(公告)号：CZ20013577A3
公开(公告)日：2002-07-17
申请号：CZ20013577
申请日：2000-03-28
Applicant: BASF AG
Inventor： HILLEN HEINZ , SCHMIDT MARTIN , MACK HELMUT , SEITZ WERNER , HAUPT ANDREAS , ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61P1/04 , A61P1/18 , A61P5/14 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/02 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P37/02 , C07B43/00 , C07D401/12 , C07D409/12 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/078
Abstract: Peptide substances, their preparation and their use as complement inhibitors are described. These are in particular substances having a guanidine or amidine radical as a terminal group. In particular, inhibitors of the complement proteases C1s and C1r are described.
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公开(公告)号：SK14232001A3
公开(公告)日：2002-06-04
申请号：SK14232001
申请日：2000-03-28
Applicant: BASF AG
Inventor： HILLEN HEINZ , SCHMIDT MARTIN , MACK HELMUT , SEITZ WERNER , HAUPT ANDREAS , ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS
IPC: A61K38/00 , A61K38/55 , A61P1/04 , A61P1/18 , A61P5/14 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , C12N9/99 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/02 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P37/02 , C07B43/00 , C07D401/12 , C07D409/12 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/078
Abstract: Peptide substances, their preparation and their use as complement inhibitors are described. These are in particular substances having a guanidine or amidine radical as a terminal group. In particular, inhibitors of the complement proteases C1s and C1r are described.
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Patent Agency Ranking
公开(公告)号：HU9900574A2
公开(公告)日：1999-06-28
申请号：HU9900574
申请日：1997-02-11
Applicant: BASF AG
Inventor： BOLLSCHWEILER CLAUS , FRIEDRICH THOMAS , HOEFFKEN HANS WOLFGANG , RADITSCH MARTIN , RUEBSAMEN KLAUS , SCHMIDT MARTIN , SCHWEDEN JUERGEN
IPC: C12N15/09 , A61K31/00 , A61K38/00 , A61K38/46 , A61P7/00 , A61P7/04 , C07K14/47 , C12N9/74 , C12N15/00 , C12N15/57 , C12R1/91 , A61K38/48
Abstract: PCT No. PCT/EP97/00612 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/29198 PCT Pub. Date Aug. 14, 1997The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.
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公开(公告)号：NO983677A
公开(公告)日：1998-08-11
申请号：NO983677
申请日：1998-08-11
Applicant: BASF AG
Inventor： RADITSCH MARTIN , FRIEDRICH THOMAS , BOLLSCHWEILER CLAUS , SCHMIDT MARTIN , H FFKEN HANS WOLFGANG , SCHWEDEN J RGEN , R BSAMEN KLAUS
IPC: C12N15/09 , A61K31/00 , A61K38/00 , A61K38/46 , A61P7/00 , A61P7/04 , C07K14/47 , C12N9/74 , C12N15/00 , C12N15/57 , C12R1/91 , A61K38/48
CPC classification number: C12N9/6429 , A61K38/00 , C12Y304/21005
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公开(公告)号：NO962023D0
公开(公告)日：1996-05-15
申请号：NO962023
申请日：1996-05-15
Applicant: BASF AG
Inventor： KROGER BURKHARD , SEULBERGER HARALD , MEYER THOMAS , SCHMIDT MARTIN , JACOB ELARD , OTTER RAINER , SUBKOWSKI THOMAS , HILLEN HEINZ
IPC: G01N33/573 , A01K67/027 , A61K31/70 , A61K35/12 , A61K38/00 , A61K38/43 , A61K38/48 , A61K39/395 , A61K48/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/04 , A61P25/28 , A61P29/00 , A61P31/04 , C07H21/04 , C07K14/47 , C07K16/40 , C12N5/00 , C12N5/10 , C12N9/64 , C12N15/09 , C12N15/113 , C12N15/57 , C12R1/91 , C12N
Abstract: PCT No. PCT/EP94/03706 Sec. 371 Date May 16, 1996 Sec. 102(e) Date May 16, 1996 PCT Filed Nov. 10, 1994 PCT Pub. No. WO95/14095 PCT Pub. Date May 26, 1995The invention relates to endothelin-converting enzymes containing the polypeptide sequence described in SEQ. ID. NO. 30 or SEQ. ID. NO. 36 or functional fragments thereof, genes which code for such enzymes, and processes for producing the said enzymes and the use thereof.
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公开(公告)号：FI962047A0
公开(公告)日：1996-05-14
申请号：FI962047
申请日：1996-05-14
Applicant: BASF AG
Inventor： KROEGER BURKHARD , SEULBERGER HARALD , MEYER THOMAS , SCHMIDT MARTIN , JACOB ELARD , OTTER RAINER , SUBKOWSKI THOMAS , HILLEN HEINZ
IPC: G01N33/573 , A01K67/027 , A61K31/70 , A61K35/12 , A61K38/00 , A61K38/43 , A61K38/48 , A61K39/395 , A61K48/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/04 , A61P25/28 , A61P29/00 , A61P31/04 , C07H21/04 , C07K14/47 , C07K16/40 , C12N5/00 , C12N5/10 , C12N9/64 , C12N15/09 , C12N15/113 , C12N15/57 , C12R1/91 , C12N
Abstract: PCT No. PCT/EP94/03706 Sec. 371 Date May 16, 1996 Sec. 102(e) Date May 16, 1996 PCT Filed Nov. 10, 1994 PCT Pub. No. WO95/14095 PCT Pub. Date May 26, 1995The invention relates to endothelin-converting enzymes containing the polypeptide sequence described in SEQ. ID. NO. 30 or SEQ. ID. NO. 36 or functional fragments thereof, genes which code for such enzymes, and processes for producing the said enzymes and the use thereof.
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公开(公告)号：PL351441A1
公开(公告)日：2003-04-22
申请号：PL35144100
申请日：2000-03-28
Applicant: BASF AG
Inventor： HILLEN HEINZ , SCHMIDT MARTIN , MACK HELMUT , SEITZ WERNER , HAUPT ANDREAS , ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS
IPC: A61K38/00 , A61K38/55 , A61P1/04 , A61P1/18 , A61P5/14 , A61P7/02 , A61P9/00 , A61P9/10 , C12N9/99 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/02 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P37/02 , C07B43/00 , C07D401/12 , C07D409/12 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/078 , A61K38/05
Abstract: Peptide substances, their preparation and their use as complement inhibitors are described. These are in particular substances having a guanidine or amidine radical as a terminal group. In particular, inhibitors of the complement proteases C1s and C1r are described.
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