公开(公告)号：EE05498B1

公开(公告)日：2011-12-15

申请号：EEP200300086

申请日：2001-08-30

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  FRIEDRICH THOMAS ,  NUEBLING CHRISTOPH ,  STUERMER RAINER ,  LADNER WOLFGANG

IPC: C12N1/20 ,  C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/16 ,  C12N9/18 ,  C12N15/55 ,  C12N15/63 ,  C12P7/00 ,  C12P7/62 ,  C12P41/00 ,  C12R1/38

Abstract: The invention relates to novel proteins from Pseudomonas glumae, having esterase activity, in particular butynol I esterase activity, to nucleic acid sequences coding therefore, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis or transesterification of organic esters.

公开(公告)号：DE102005063191A1

公开(公告)日：2007-07-05

申请号：DE102005063191

申请日：2005-12-30

Applicant: BASF AG

Inventor： SCHAEDLER ANDREAS ,  FRIEDRICH THOMAS ,  STUERMER RAINER ,  RINCK-JAHNKE SABINE

IPC: C12P7/24 ,  C12N9/02 ,  C12P7/04

Abstract: Preparation of an optically active saturated aldehyde or alcohol (II) comprises reduction of alpha , beta unsaturated aldehyde (I) with a polypeptide sequence (SEQ ID NO: 1 or 2), or a polypeptide sequence exhibiting at least 80% sequence identity of (SEQ ID NO: 1 or 2), in the presence of an enoate reductase. Preparation of an optically active saturated aldehyde or alcohol of formula (II) comprises reduction of alpha , beta unsaturated aldehyde (I) of formula (R 3>-C(R 2>)=C(R 1>)-CH(=O)) with a polypeptide sequence (SEQ ID NO: 1 or 2) (not defined), or a polypeptide sequence exhibiting at least 80% sequence identity of (SEQ ID NO: 1 or 2), in the presence of a enoate reductase. R 1>, R 2>H or 1-4C-alkyl; and R 3>H or 1-6C alkyl or alkenyl. [Image].

公开(公告)号：DE102005062383A1

公开(公告)日：2007-06-28

申请号：DE102005062383

申请日：2005-12-23

Applicant: BASF AG

Inventor： STUERMER RAINER

IPC: C07C213/04 ,  C07C215/30 ,  C12P7/22

Abstract: Preparation of optically active aromatic substituted aminoethanol compound (II) comprises converting corresponding chloroethanol compound (I) with ammonia. Preparation of optically active aromatic substituted aminoethanol compound (II) of formula (IIa) and/or (IIb) comprises converting corresponding chloroethanol compound (I) of formula (Ia) and/or (Ib), with ammonia. X : F, Cl, Br, I, NH2, NH(alkyl), N(alkyl)2, OH, O-alkyl or alkyl; and n : 0-3. [Image].

公开(公告)号：DE50305771D1

公开(公告)日：2007-01-04

申请号：DE50305771

申请日：2003-07-31

Applicant: BASF AG

Inventor： STUERMER RAINER

IPC: C07D333/20 ,  C07B57/00

Abstract: The present invention relates to a process for the preparation of enantiomerically pure (S)-3-methyl-amino-1-(thien-2-yl)propan-1-ol of the formula II-S by obtainment of (S)-3-hydroxy-3-thien-2-ylpropionitrile from its enantiomer mixture with the R isomer and the subsequent reaction of (S)-3-hydroxy-3-thien-2-ylpropionitrile with hydrogen and methylamine in the presence of a catalyst to give II-S.

公开(公告)号：DE102005000867A1

公开(公告)日：2006-07-13

申请号：DE102005000867

申请日：2005-01-05

Applicant: BASF AG

Inventor： STUERMER RAINER ,  DAEUWEL JUERGEN ,  KESELER MARIA ,  ACHATZ BRIGITTE ,  BREUER MICHAEL

IPC: C07D333/20

Abstract: The present invention relates to a method for purifying (1S)-3-METHYLAMINO-1-(2-THIENYL)-1-PROPANOL by distilling a reaction mixture which comprises between 25 and 99% by weight of (IS)-3-METHYLAMINO-1-(2-THIENYL)-1-PROPANOL.

公开(公告)号：CA2590660A1

公开(公告)日：2006-07-13

申请号：CA2590660

申请日：2005-12-31

Applicant: BASF AG

Inventor： STUERMER RAINER ,  BREUER MICHAEL ,  DAEUWEL JUERGEN ,  KESSELER MARIA ,  ACHATZ BRIGITTE

IPC: C07D333/20 ,  B01D3/12

Abstract: The present invention relates to a method for purifying (1S)-3-METHYLAMINO-1-(2-THIENYL)-1-PROPANOL by distilling a reaction mixture which comprises between 25 and 99% by weight of (IS)-3-METHYLAMINO-1-(2-THIENYL)-1-PROPANOL.

公开(公告)号：DE102004022686A1

公开(公告)日：2005-11-24

申请号：DE102004022686

申请日：2004-05-05

Applicant: BASF AG

Inventor： STUERMER RAINER ,  KESELER MARIA ,  HAUER BERNHARD ,  FRIEDRICH THOMAS ,  BREUER MICHAEL ,  SCHROEDER HARTWIG

IPC: C07D333/16 ,  C12N9/04 ,  C12P20060101 ,  C12P7/02 ,  C12P13/00 ,  C12P17/00

Abstract: The invention relates to a method for producing the optically active alkanols of formula (I), wherein n is an integer of from 0 to 5; Cyc represents an optionally substituted, mononuclear or polynuclear, saturated or unsaturated, carbocylic or heterocyclic ring, and R1 represents halogen, SH, OH, NO2, NR2R3 or NR2R3R4+X−, wherein R2, R3 and R4 independently represent H or a lower alkyl or lower alkoxy group and X− represents a counterion. According to the invention, an enzyme (E) selected from the groups of dehydrogenases, aldehyde reductases and carbonyl reductases is incubated in a medium containing the alkanone of formula (II), wherein n, Cyc and R1 are defined as above, in the presence of reduction equivalents. The compound of formula (II) is enzymatically reduced to the compound of formula (I) and the reduction equivalents consumed during reaction are regenerated by reacting a sacrificial alcohol to the corresponding sacrificial ketone using enzyme (E) and at least partially removing the sacrificial ketone from the reaction medium, and then isolating the product (I) so produced.

公开(公告)号：CA2513542A1

公开(公告)日：2004-08-05

申请号：CA2513542

申请日：2004-01-15

Applicant: BASF AG

Inventor： STUERMER RAINER

IPC: C07D333/16 ,  C07D333/22

Abstract: The invention relates to the production of 3-methylamino-1-(2-thienyl)-1- propanone and the use thereof for producing the pharmaceutical (+)-(S)-N- methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate (trade name Duloxetine.RTM.).

公开(公告)号：AT263160T

公开(公告)日：2004-04-15

申请号：AT01969391

申请日：2001-07-13

Applicant: BASF AG

Inventor： BALDENIUS KAI-UWE ,  SCHROEDER HARTWIG ,  KRAEMER KLAUS ,  SCHEIN KARIN ,  STUERMER RAINER

IPC: A23L33/105 ,  A61K31/34 ,  A61K31/343 ,  A61P3/00 ,  A61P3/06 ,  A61P3/10 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  C07C46/06 ,  C07C50/28 ,  C07D307/04 ,  C07D307/94

Abstract: A description is given of the use of at least one compound of the formula I where R 1 , R 2 , R 3 and R 4 independently of one another are H or C 1 -C 6 -alkyl; and the use of a compound of the formula I for medical use.

公开(公告)号：AT260984T

公开(公告)日：2004-03-15

申请号：AT98109999

申请日：1998-06-02

Applicant: BASF AG

Inventor： STUERMER RAINER ,  DITRICH KLAUS ,  SIEGEL WOLFGANG

IPC: C12P13/00 ,  C07C229/48 ,  C07C233/63 ,  C07C235/12 ,  C07C235/14 ,  C07C321/06 ,  C12P13/04 ,  C12P41/00

Abstract: Production of acylated amino acid esters comprises acylating an amino acid ester with a carboxylic acid ester, which carries a halo, N, O or S atom in the neighbourhood of the carbonyl group of the acid component, in the presence of an amidase, protease, esterase or lipase as catalyst. Also claimed are (1) the production of optically active amino acid esters by: (a) enantioselectively acylating a racemic amino acid ester with a carboxylic acid ester, which carries a halo, N, O or S atom in the neighbourhood of the carbonyl group of the acid component, in the presence of an amidase, protease, esterase or lipase as catalyst; (b) separating the mixture obtained into optically active amino acid ester and optically active N-acyl-amino acid ester; and optionally (c) converting the optically active N-acyl-amino acid ester into the opposite amino acid ester enantiomer by amide cleavage; and (2) optically active amino acid esters of formula (I) and optically active N-acyl-amino acid esters of formula (II ) in which the NH2 and COOCH3 (or amino and COOR groups) are cis or trans to one another: R = 1-10C alkyl; 1-4C alkoxy; OH; NH2; halo; or Ar; R = H or 1-10C alkyl; X = halo; OR ; SR ; or NR R ; R and R = H; 1-10C alkyl; or Ar; R = 1-10C alkyl or Ar; Ar = aryl optionally substituted by NH2, OH, 1-4C alkyl, 1-4C alkoxy or halo; i = 0-4; m = 0-2; n = 1-3.