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公开(公告)号:DK1046391T3
公开(公告)日:2004-10-18
申请号:DK00105806
申请日:2000-03-18
Applicant: BASF AG
Inventor: HABECK THORSTEN , PRECHTL FRANK , WESTENFELDER HORST , WUENSCH THOMAS , HAREMZA SYLKE , BACH THORSTEN , SPIEGEL ANJA
IPC: C07D295/14 , A61K8/00 , A61K8/41 , A61K8/44 , A61K8/49 , A61K31/136 , A61K31/196 , A61K31/24 , A61K31/40 , A61P17/16 , A61Q1/00 , A61Q1/04 , A61Q17/04 , C07C225/00 , C07C225/22 , C07C229/52 , C07D295/10 , C07D295/112 , C09K3/00 , A61K7/42
Abstract: Amino-substituted hydroxybenzophenones (I) are used as photostable UV filters in cosmetic and pharmaceutical compositions for protecting human skin or hair against solar radiation, optionally in combination with other UV absorbers. Amino-substituted hydroxybenzophenones of formula (I) are used as photostable UV filters in cosmetic and pharmaceutical compositions for protecting human skin or hair against solar radiation, optionally in combination with other UV absorbers. [Image] R1>, R2>H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl or 3-10C cycloalkenyl, or NR1>R2> is a 5- or 6-membered ring; R3>, R4>1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl, nitrile, carboxylate, sulfonate or ammonium; X : H, COOR5> or CONR6>R7>; R5>-R7>H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, (YO)oZ or aryl; Y : (CH2)x or CH(Me)CH2; x : 2-4; Z : Et, n-Pr, n-Bu or i-Pr; m : 0-3; n : 0-4; o : 1-20. Independent claims are also included for: (1) use of (I) as UV stabilizers in cosmetic and pharmaceutical compositions; (2) cosmetic and pharmaceutical compositions for protecting human skin or hair against UV light of wavelength 280-400 nm, comprising compounds (I) in a carrier, optionally in combination with other UV absorbers.
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公开(公告)号:AT275929T
公开(公告)日:2004-10-15
申请号:AT00105806
申请日:2000-03-18
Applicant: BASF AG
Inventor: HABECK THORSTEN , PRECHTL FRANK , WUENSCH THOMAS , WESTENFELDER HORST , HAREMZA SYLKE , BACH THORSTEN , SPIEGEL ANJA
IPC: C07D295/14 , A61K8/00 , A61K8/41 , A61K8/44 , A61K8/49 , A61K31/136 , A61K31/196 , A61K31/24 , A61K31/40 , A61P17/16 , A61Q1/00 , A61Q1/04 , A61Q17/04 , C07C225/00 , C07C225/22 , C07C229/52 , C07D295/10 , C07D295/112 , C09K3/00 , A61K7/42
Abstract: Amino-substituted hydroxybenzophenones (I) are used as photostable UV filters in cosmetic and pharmaceutical compositions for protecting human skin or hair against solar radiation, optionally in combination with other UV absorbers. Amino-substituted hydroxybenzophenones of formula (I) are used as photostable UV filters in cosmetic and pharmaceutical compositions for protecting human skin or hair against solar radiation, optionally in combination with other UV absorbers. [Image] R1>, R2>H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl or 3-10C cycloalkenyl, or NR1>R2> is a 5- or 6-membered ring; R3>, R4>1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl, nitrile, carboxylate, sulfonate or ammonium; X : H, COOR5> or CONR6>R7>; R5>-R7>H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, (YO)oZ or aryl; Y : (CH2)x or CH(Me)CH2; x : 2-4; Z : Et, n-Pr, n-Bu or i-Pr; m : 0-3; n : 0-4; o : 1-20. Independent claims are also included for: (1) use of (I) as UV stabilizers in cosmetic and pharmaceutical compositions; (2) cosmetic and pharmaceutical compositions for protecting human skin or hair against UV light of wavelength 280-400 nm, comprising compounds (I) in a carrier, optionally in combination with other UV absorbers.
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公开(公告)号:AU773111B2
公开(公告)日:2004-05-20
申请号:AU2886900
申请日:2000-04-18
Applicant: BASF AG
Inventor: HABECK THORSTEN , PRECHTL FRANK , WUENSCH THOMAS , WESTENFELDER HORST , HAREMZA SYLKE , BACH THORSTEN , SPIEGEL ANJA
IPC: C07D295/14 , A61K8/00 , A61K8/41 , A61K8/44 , A61K8/49 , A61K31/136 , A61K31/196 , A61K31/24 , A61K31/40 , A61P17/16 , A61Q1/00 , A61Q1/04 , A61Q17/04 , C07C225/00 , C07C225/22 , C07C229/52 , C07D295/10 , C07D295/112 , C09K3/00 , A61K7/44 , A61P43/00
Abstract: Amino-substituted hydroxybenzophenones (I) are used as photostable UV filters in cosmetic and pharmaceutical compositions for protecting human skin or hair against solar radiation, optionally in combination with other UV absorbers. Amino-substituted hydroxybenzophenones of formula (I) are used as photostable UV filters in cosmetic and pharmaceutical compositions for protecting human skin or hair against solar radiation, optionally in combination with other UV absorbers. [Image] R1>, R2>H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl or 3-10C cycloalkenyl, or NR1>R2> is a 5- or 6-membered ring; R3>, R4>1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl, nitrile, carboxylate, sulfonate or ammonium; X : H, COOR5> or CONR6>R7>; R5>-R7>H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, (YO)oZ or aryl; Y : (CH2)x or CH(Me)CH2; x : 2-4; Z : Et, n-Pr, n-Bu or i-Pr; m : 0-3; n : 0-4; o : 1-20. Independent claims are also included for: (1) use of (I) as UV stabilizers in cosmetic and pharmaceutical compositions; (2) cosmetic and pharmaceutical compositions for protecting human skin or hair against UV light of wavelength 280-400 nm, comprising compounds (I) in a carrier, optionally in combination with other UV absorbers.
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公开(公告)号:BR0200839A
公开(公告)日:2003-03-25
申请号:BR0200839
申请日:2002-03-14
Applicant: BASF AG
Inventor: HEIDENFELDER THOMAS , TIEFENSEE KRISTIN , WUENSCH THOMAS
IPC: A61K8/00 , A61K8/02 , A61K8/06 , A61K8/33 , A61K8/37 , A61K8/41 , A61K8/49 , A61K8/58 , A61K8/89 , A61K8/891 , A61K31/12 , A61K31/216 , A61K31/225 , A61K31/24 , A61K31/4184 , A61K31/4192 , A61K31/53 , A61K31/695 , A61K31/80 , A61P17/00 , A61Q1/00 , A61Q1/04 , A61Q17/04 , C08L83/08 , A61K7/40
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公开(公告)号:DE10113058A1
公开(公告)日:2002-09-19
申请号:DE10113058
申请日:2001-03-15
Applicant: BASF AG
Inventor: HEIDENFELDER THOMAS , TIEFENSEE KRISTIN , WUENSCH THOMAS
IPC: A61K8/00 , A61K8/02 , A61K8/06 , A61K8/33 , A61K8/37 , A61K8/41 , A61K8/49 , A61K8/58 , A61K8/89 , A61K8/891 , A61K31/12 , A61K31/216 , A61K31/225 , A61K31/24 , A61K31/4184 , A61K31/4192 , A61K31/53 , A61K31/695 , A61K31/80 , A61P17/00 , A61Q1/00 , A61Q1/04 , A61Q17/04 , C08L83/08 , A61K7/40
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公开(公告)号:AU742274B2
公开(公告)日:2001-12-20
申请号:AU3519397
申请日:1997-08-21
Applicant: BASF AG
Inventor: HABECK THORSTEN , AUMUELLER ALEXANDER , SCHEHLMANN VOLKER , WESTENFELDER HORST , WUENSCH THOMAS
IPC: A61K8/00 , A61K8/30 , A61K8/40 , A61K8/49 , A61K8/92 , A61Q1/00 , A61Q1/04 , A61Q17/04 , C07C255/40 , C07D307/52 , C07D317/54 , C07D333/24 , A61K7/42 , C07D333/22
Abstract: The use of compounds of formula (I) as UV-A filters in cosmetic products (optionally in combination with standard UV absorbers) to protect the human skin against sunlight is claimed. R1-R3 = H or (cyclo)aliphatic group containing up to 18 C, or two of these groups can combine to form a 5 or 6-membered ring ; R4 = optionally substituted (hetero)aryl containing 5-12 ring atoms ; and R5 = R4 or H. Also claimed are (i) cosmetic products containing (I) for protecting the epidermis layer against UV radiation with a wavelength of 280-400 nm and (ii) compounds of formula (II) : R7-R9 = lower alkyl ; R6 = 2-thienyl (optionally substituted with lower alkyl), 4-(3,5-di-t-butyl)-1-hydroxyphenyl or 4-(3,5-di-t-butyl)-1-alkoxyphenyl.
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公开(公告)号:DE10012408A1
公开(公告)日:2001-09-20
申请号:DE10012408
申请日:2000-03-15
Applicant: BASF AG
Inventor: HEIDENFELDER THOMAS , HABECK THORSTEN , WUENSCH THOMAS
IPC: A61K47/02 , A61K8/00 , A61K8/29 , A61K8/33 , A61K8/35 , A61K8/37 , A61K8/41 , A61K8/44 , A61K8/49 , A61K8/58 , A61K8/893 , A61K8/896 , A61K8/898 , A61K47/08 , A61K47/14 , A61K47/18 , A61K47/22 , A61K47/24 , A61Q1/00 , A61Q1/04 , A61Q1/06 , A61Q5/00 , A61Q17/04 , C08L83/06 , A61K7/40 , A61K7/42
Abstract: A photostable ultraviolet (UV) filter for protecting human skin or hair against sunlight contains as UV-A absorbing components a combination of a hydroxybenzophenone (I), optionally together with a 4,4-diaryl-butadiene (II); and other UV protectant(s) i.e. dibenzoylmethane, triazine, benzotriazole, benzimidazole, tetrahydroxybenzophenone and/or organosiloxane-benzal malonate derivatives. Use of a light-protectant combination of a UV-A absorber and further UV-A and/or UV-B absorbers is claimed as a photostable UV-filter in cosmetic or pharmaceutical preparations for protecting human skin or hair against sunlight, optionally used together with other conventional light protectants. First UV light absorber is a hydroxybenzophenone of formula (I), optionally together with a 4,4-diaryl-butadiene of formula (II); and other UV protectants including 4-(R6)-4'-(R7)-dibenzoylmethane, 1,3,5-triazine derivatives of formula (III), 2,4,6-triphenyl-1,3,5-triazines, in which the phenyl rings are bonded with at least one o-hydroxy group and at least one p-(1-20C) alkoxy group, 2,2'-dihydroxy-3,3'-bis-(1,2,3-benzotriazol-2-yl)-5,5'-bis-(1,1,3,3-te tramethylbutyl)-diphenylmethane, 1,4-bis-(5,6-disulfo-benzimidazol-2-yl)-benzene or its salts, 2-(2-hydroxy-3-(2-methyl-4,4-bis-(trimethylsilyloxy)-4-silapentyl)-5-m ethyl)-1,2,3-benzotriazole, 2,2',4,4'-tetrahydroxybenzophenone and/or siloxanes of formula (IV). R1, R2 = H, 1-20C alkyl, 3-10C cycloalkyl or 3-10C cycloalkenyl; or NR1R2 = 5-6 membered ring; R3 = 1-20C alkyl; R4, R5 = H, 1-20C alkyl, 3-10C cycloalkyl or 3-10C cycloalkenyl; R6 = 1-12C alkyl; R7 = H, 1-12C alkyl or 1-12C alkoxy; R8-R10 = optionally substituted 1-20C alkyl, 5-10C aryl, 5-10C heteroaryl or -Sp-Sil; Sp = spacer; Sil = silane, oligosilane or polysiloxane residue; X = O or NR11; R11 = H or optionally substituted 1-20C alkyl, 5-10C aryl, 5-10C heteroaryl; V = 3-(4-(2,2-bis-(ethoxycarbonyl)-vinyl)-phenoxy)-prop-1-en-1-yl or 3-(4-(2,2-bis-(ethoxycarbonyl)-vinyl)-phenoxy)-prop-1-en-2-yl; V' = V or Me; t = up to 100; u = up to 20; provided that u = 0 if V' = V or u = 1-20 if V' = Me. An Independent claim is also included for cosmetic or pharmaceutical preparations for protecting human epidermis or hair against UV light in the 280-400 nm range, comprising the UV absorbing combination, a carrier and optionally other conventional light protectants.
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公开(公告)号:DE10007486A1
公开(公告)日:2001-08-23
申请号:DE10007486
申请日:2000-02-18
Applicant: BASF AG
Inventor: HOESSEL PETER , WUENSCH THOMAS , DIEING REINHOLD
Abstract: An inorganic UV filter material is mixed with a radically-initiated solution copolymer containing quaternized or protonated groups. A mixture comprises: (A) an inorganic UV filter material; and (B) a radically-initiated solution copolymer obtained from the following monomer mixture (by wt.), with the copolymer obtained being at least partly quaternized or protonated when monomer (i) is not (or only partly) quaternized: (i) an N-vinylimidazole or diallylamine, optionally partly or completely quaternized (0.01-99.99%); (ii) a neutral or basic monomer other than (i) (0.01-99.99%); (iii) an unsaturated acid or anhydride (0-50%); (iv) a radically-polymerizable monomer other than (i) - (iii) (0-50%); and (v) a crosslinking monomer with \-2 ethylenically-unsaturated non-conjugated double bonds.
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公开(公告)号:DE10007116A1
公开(公告)日:2001-08-23
申请号:DE10007116
申请日:2000-02-17
Applicant: BASF AG
Inventor: HEGER ROBERT , AUWETER HELMUT , DAUSCH WILMA , ZWISSLER GEORG KONRAD , WUENSCH THOMAS
Abstract: Aqueous dispersions of difficultly water-soluble or water-insoluble organic UV filter substances (I) contain at least one such substance as a colloidally-dispersed phase in amorphous or partly amorphous form. Also included are Independent claims for: (1) the production of the dispersions by: (a) treating a molecularly-disperse organic solvent solution of (I) with an aqueous solution of a protective colloid so as to convert the hydrophobic phase of the substance into a colloid disperse phase and then removing the organic solvent; or (b) treating a molecularly-disperse organic solvent solution containing (I) and also a water-insoluble polymer with water or with an aqueous solution of a protective colloid so as to convert the hydrophobic phase of (I) and the polymer into a colloid disperse phase and then removing the organic solvent; and (2) production of dry powders by removal of the water and drying optionally in the presence of a coating material, these powders then being optionally converted into double dispersions by emulsifying in an oil.
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公开(公告)号:DE59607052D1
公开(公告)日:2001-07-12
申请号:DE59607052
申请日:1996-10-25
Applicant: BASF AG
Inventor: HOLDERBAUM MARTIN , AUMUELLER ALEXANDER , SPERLING KARIN , WESTENFELDER HORST , WUENSCH THOMAS
Abstract: PCT No. PCT/EP96/04637 Sec. 371 Date Apr. 29, 1998 Sec. 102(e) Date Apr. 29, 1998 PCT Filed Oct. 25, 1996 PCT Pub. No. WO97/17054 PCT Pub. Date May 15, 1997A sunscreen-containing cosmetic formulation to protect the human epidermis from UV light in the range from 280 to 400 nm, which formulation includes a cosmetically suitable carrier, together with compounds which absorb in the UV-B region and as photostable UV-A filters effective amounts of compounds of the formula I as defined in the specification.
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