公开(公告)号：CA2214146A1

公开(公告)日：1997-08-28

申请号：CA2214146

申请日：1997-02-10

Applicant: BAXTER INT

Inventor： BISCHOF DANIEL F

IPC: A61K35/14 ,  A61M1/36 ,  A61K35/16 ,  B01D21/00 ,  C12M1/10 ,  C12S3/22 ,  C12Q1/24

Abstract: Blood processing systems and methods establish on-line communication between a container and a source of blood containing leukocytes and platelets, such as a human donor. The systems and methods create a centrifugal field (14) between the source of blood and the container that separates from the blood an unfinished suspension of platelets having a first physiologic characteristic different than the desired physiologic characteristic. The systems and methods pump the unfinished platelet suspension outside the centrifugal field through a finishing device (24). The finishing device (24) changes the first physiologic characteristic to the desired physiological characteristic, thereby creating the finished platelet suspension. The system and methods convey the finished platelet suspension from the finishing device directly into the container. The systems and methods function without interrupting the on-line communication between the container and the source of blood.

公开(公告)号：AU9179991A

公开(公告)日：1992-07-22

申请号：AU9179991

申请日：1991-12-20

Applicant: BAXTER INT

Inventor： BISCHOF DANIEL F

IPC: A61K35/14 ,  A61L2/00 ,  A61M1/02 ,  A61M1/36 ,  B01J19/12 ,  A61M37/00

Abstract: Systems and methods remove a contaminant from a fluid like blood, regardless of whether the contaminant is carried free within the fluid or entrained within cellular matter carried within the fluid. The systems and methods rely upon photodynamic processes to remove free contaminants from the fluid. The systems and methods rely upon separation processes to remove the cellular matter and, with it, the contaminants it entrains from the fluid.

公开(公告)号：AU9165191A

公开(公告)日：1992-07-22

申请号：AU9165191

申请日：1991-12-20

Applicant: BAXTER INT

Inventor： BISCHOF DANIEL F ,  WOLF LUDWIG JR ,  FOLEY JOHN T ,  BRATTEN WILLIAM R

IPC: A61M1/36 ,  A61L2/00 ,  A61L2/08 ,  A61M1/34 ,  B01J19/12 ,  A61M37/00

Abstract: A system and method for treating a fluid carrying a biological contaminant to which a photoactive material has been bound include a treatment device that defines a flow passage with a gap. The system and method operate to establish a flow of fluid from the inlet end of the gap to the outlet end of the gap. The system and method expose the fluid, as it transits the gap, to a source of radiation that activates the photoactive material bound to the contaminant. The system and method also mix the fluid as it flows within the gap.

公开(公告)号：CA2582301C

公开(公告)日：2016-03-15

申请号：CA2582301

申请日：2005-09-27

Applicant: BAXTER INT

Inventor： MATHIAS JEAN-MARIE ,  BLICKHAN BRYAN J ,  HALDIMAN STEPHANIE ,  SERVI LAWRENCE J JR ,  BERNES JEAN-CLAUDE ,  BISCHOF DANIEL F

IPC: A61B5/15 ,  A61J1/14 ,  A61M1/02

Abstract: Methods and apparatus for collecting blood samples in vacuum sample tubes are disclosed. The samples, including the initial blood sample, are substantially free of excess air. Disclosed is also a biological fluid sampling system (18) comprising: a plastic container (42) including an interior chamber (54); a sample access site (68) external to and spaced from said container by y preselected distance; an internal flow path (43) communicating with said access site and extending substantially into said interior chamber, said internal flow path providing the only path for blood flow into and from said chamber.

公开(公告)号：CA2239070C

公开(公告)日：2005-06-21

申请号：CA2239070

申请日：1997-10-03

Applicant: BAXTER INT

Inventor： MATHIAS JEAN M ,  MAYAUDON VERONIQUE ,  DE GHELDERE SERGE ,  CHAPMAN JOHN ,  BISCHOF DANIEL F ,  HERMAN ROBERT E ,  CHONG-SON SUN

IPC: C12N5/06 ,  A61J3/00 ,  A61K35/16 ,  A61L2/00 ,  A61M1/36 ,  C12N7/00 ,  A61L2/08 ,  C12N7/04 ,  A61L2/16 ,  A61M1/34

Abstract: Systems and methods treat plasma carrying contaminants and cellular matter that are capable of entraining contaminants. The systems and methods separate cellular matter from the plasma by filtration, thereby removing contaminants entrained within the cellular matter. The system and methods add to the plasma a photoactive material. The systems and methods emit radiation at a selected wavelength into the plasma to activate the photoactive material and thereby eradicate the contaminant that is free of entrainment by cellular matter.

公开(公告)号：NO316989B1

公开(公告)日：2004-07-19

申请号：NO973790

申请日：1997-08-18

Applicant: BAXTER INT

Inventor： SUN CHONG-SON ,  CHAPMAN JOHN ,  BISCHOF DANIEL F

IPC: A61K35/14 ,  A61K35/16 ,  A61L2/00 ,  A61M1/02 ,  A61M1/36 ,  B01J19/12 ,  A61M1/34 ,  A01N1/02

公开(公告)号：CA2500738A1

公开(公告)日：2004-04-22

申请号：CA2500738

申请日：2003-09-24

Applicant: BAXTER INT ,  CERUS CORP

Inventor： MOORE JOSEPH S ,  MAYAUDON VERONIQUE ,  HEI DEREK J ,  BRIERE YVON ,  LAIRD JAMES ,  MOHIUDDIN MAHMOOD ,  CIMINO GEORGE D ,  HERMAN ROBERT E ,  DING YUANPANG SAMUEL ,  METZEL PEYTON S ,  BISCHOF DANIEL F ,  LECOUR DANIEL ,  SOUDANT GREGORY

IPC: A61J1/00 ,  A61J1/05 ,  A61L2/00 ,  A61M1/02 ,  A61M1/36 ,  B01D15/00 ,  A61B19/00

Abstract: Apparatus, systems and methods are disclosed for treating a biological fluid with light. A disposable fluid processing set (200) including integrally connected containers (202, 206, 210, 214) and tubing (203, 205, 208, 211, 21 9) and a holder (260) or organizer (500) for receiving at least some of the containers and tubing are disclosed.

公开(公告)号：AU2002366632A1

公开(公告)日：2003-06-23

申请号：AU2002366632

申请日：2002-11-22

Applicant: BAXTER INT

Inventor： LO YING-CHENG ,  LYNN DANIEL ,  BLICKHAN BRYAN J ,  BISCHOF DANIEL F

IPC: A61J1/05 ,  A01N1/02 ,  A61K35/14 ,  A61M1/02 ,  A61M1/36 ,  A61P7/04

Abstract: Systems and methods manually process blood and blood components in sterile, closed environments, which further condition the blood components for subsequent pathogen inactivation processes. The systems and methods mate the manual collection of random donor platelet units with the creation of larger therapeutic doses of platelets targeted to undergo pathogen inactivation prior to long term storage and/or transfusion.

公开(公告)号：CA2469364A1

公开(公告)日：2003-06-19

申请号：CA2469364

申请日：2002-11-22

Applicant: BAXTER INT

Inventor： LO YING-CHENG ,  BISCHOF DANIEL F

IPC: A61J3/00 ,  A61M1/02 ,  A61M1/36 ,  A61L2/00 ,  A01N1/02 ,  A61J1/05 ,  A61K35/14 ,  A61K35/16

Abstract: Methods and systems for preparing blood products that are ready for treatmen t in established pathogen inactivation procedures are disclosed. The methoids include providing a source of a blood component and combining the blood component with a synthetic medium in a selected ratio of the blood component to the synthetic media, whereby the resulting blood product is treatment-rea dy.

公开(公告)号：CA2434317A1

公开(公告)日：2003-06-19

申请号：CA2434317

申请日：2002-11-22

Applicant: BAXTER INT

Inventor： BISCHOF DANIEL F ,  BLICKHAN BRYAN J ,  LYNN DANIEL ,  LO YING-CHENG

IPC: A61J1/05 ,  A01N1/02 ,  A61K35/14 ,  A61M1/02 ,  A61M1/36 ,  A61P7/04 ,  A61M1/34

Abstract: Systems and methods for manually process blood and blood components in sterile, closed environments, which further condition the blood components f or subsequent pathogen inactivation processes. The systems and methods mate the manual collection of random donor platelet units with the creation of larger therapeutic doses of platelets targeted to undergo pathogen inactivation pri or to long term storage and/or transfusion.