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公开(公告)号：AU2013354278B2
公开(公告)日：2017-10-12
申请号：AU2013354278
申请日：2013-12-02
Applicant: HOFFMANN LA ROCHE
Inventor： FREI BEAT , GOBBI LUCA , GRETHER UWE , KIMBARA ATSUSHI , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , ROGERS-EVANS MARK , SCHULZ-GASCH TANJA
IPC: C07D401/14 , A61K31/44 , A61K31/4427 , A61P3/10 , A61P9/00 , A61P27/02 , A61P29/00 , C07D213/81 , C07D401/04 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The invention relates to a compound of formula (I) wherein R
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公开(公告)号：HRP20171099T1
公开(公告)日：2017-10-06
申请号：HRP20171099
申请日：2017-07-18
Applicant: F HOFFMANN - LA ROCHE AG
Inventor： GRETHER UWE , KIMBARA ATSUSHI , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , ROGERS-EVANS MARK , SCHULZ-GASCH TANJA
IPC: C07D487/04 , A61K31/519 , A61P1/00 , A61P3/00 , A61P9/00 , A61P25/00 , A61P29/00 , C07D519/00
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公开(公告)号：MA38555A1
公开(公告)日：2017-09-29
申请号：MA38555
申请日：2014-04-29
Applicant: HOFFMANN LA ROCHE
Inventor： GRETHER UWE , KIMBARA ATSUSHI , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , ROGERS-EVANS MARK , SCHULZ-GASCH TANJA
IPC: A61K31/519 , A61P1/00 , A61P3/00 , A61P9/00 , A61P25/00 , A61P29/00 , C07D487/04 , C07D519/00
Abstract: L'invention concerne un composé représenté par la formule (i) dans laquelle a et r1 à r3 sont tels que définis dans la description et dans les revendications. Le composé représenté par la formule (i) peut être utilisé en tant que médicament
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公开(公告)号：EA027497B1
公开(公告)日：2017-07-31
申请号：EA201591976
申请日：2014-04-28
Applicant: HOFFMANN LA ROCHE
Inventor： BENDELS STEFANIE , GRETHER UWE , KIMBARA ATSUSHI , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , ROGERS-EVANS MARK , SCHULZ-GASCH TANJA
IPC: C07D473/16 , A61K31/52 , A61P1/00 , A61P3/00 , A61P9/00 , A61P25/00 , A61P29/00 , C07D473/18 , C07D473/34 , C07D519/00
Abstract: Изобретениеотноситсяк соединениюформулы (I)гдеА и R-Rопределеныв описаниии вформулеизобретения. Соединениеформулы (I) можетбытьпримененов качествелекарственногопрепарата.
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公开(公告)号：UA114656C2
公开(公告)日：2017-07-10
申请号：UAA201506688
申请日：2013-12-02
Applicant: HOFFMANN LA ROCHE
Inventor： FREI BEAT , GOBBI LUCA , GRETHER UWE , KIMBARA ATSUSHI , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , ROGERS-EVANS MARK , SCHULZ-GASCH TANJA
IPC: C07D401/14 , A61K31/44 , A61K31/4427 , A61P3/10 , A61P9/00 , A61P27/02 , A61P29/00 , C07D213/81 , C07D401/04 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: Винахідстосуєтьсясполукиформули (І), де R1-R3 визначенів описітау формулівинаходу. Сполукуформули (І) можнавикористовуватияклікарськийзасіб. EMBED ISISServer (I)
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Patent Agency Ranking
公开(公告)号：DK2964646T3
公开(公告)日：2017-07-10
申请号：DK14709590
申请日：2014-03-04
Applicant: HOFFMANN LA ROCHE
Inventor： GRETHER UWE , NETTEKOVEN MATTHIAS , RICKLIN FABIENNE , ROEVER STEPHAN , ROGERS-EVANS MARK , SCHULZ-GASCH TANJA , KIMBARA ATSUSHI
IPC: C07D471/04 , C07D473/04 , C07D487/04
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公开(公告)号：NZ715284A
公开(公告)日：2017-06-30
申请号：NZ71528412
申请日：2012-06-07
Applicant: HOFFMANN LA ROCHE
Inventor： ROGERS-EVANS MARK , BISSANTZ CATERINA , GRETHER UWE , HEBEISEN PAUL , KIMBARA ATSUSHI , LIU QINGPING , NETTEKOVEN MATTHIAS , PRUNOTTO MARCO , ROEVER STEPHAN , SCHULZ-GASCH TANJA , ULLMER CHRISTOPH , WANG ZHIWEI , YANG WULUN
IPC: C07D213/81 , A61K31/44 , A61P29/00 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D491/107
Abstract: Provided are compounds of the general formula (I) wherein the variables are as defined in the specification. Examples of the compounds include Methyl 2-(6-(3-chlorophenyl)picolinamido)-2-methylpropanoate, 6-(3-Chloro-phenyl)-pyridine-2-carboxylic acid piperidin-1-ylamide, 5-Chloro-6-(3-chloro-phenyl)-pyridine-2-carboxylic acid (1-methyl-1-oxazol-2-yl-ethyl)-amide and (S)-N-(3,3-Dimethyl-1-(methylamino)-1-oxobutan-2-yl)-6-phenylpicolinamide. The compounds are agonists of Cannabinoid Receptor 2 (CB2). The compounds may be useful in the treatment of pain, atherosclerosis, regulation of bone mass, inflammation, ischemia, reperfusion injury, systemic fibrosis, liver fibrosis, lung fibrosis, kidney fibrosis, chronic allograft nephropathy, congestive heart failure, myocardial infarction, systemic sclerosis, glomerulonephropathy, thermal injury, burning, hypertrophic scars, keloids, gingivitis pyrexia, liver cirrhosis or tumors.
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公开(公告)号：CA2999216A1
公开(公告)日：2017-06-15
申请号：CA2999216
申请日：2016-12-06
Applicant: HOFFMANN LA ROCHE
Inventor： GAVELLE OLIVIER , GRETHER UWE , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , ROGERS-EVANS MARK , ROMBACH DIDIER
IPC: C07D231/12 , A61K31/4245 , A61P29/00 , C07C13/04 , C07D205/04 , C07D207/14 , C07D209/54 , C07D213/61 , C07D271/06 , C07D277/30 , C07D305/06 , C07D331/04 , C07D401/10 , C07D403/10 , C07D413/06 , C07D413/10 , C07D413/12
Abstract: The invention relates to a compound of formula (I) wherein R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
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公开(公告)号：PL2771327T3
公开(公告)日：2017-05-31
申请号：PL12778342
申请日：2012-10-25
Applicant: HOFFMANN LA ROCHE
Inventor： BISSANTZ CATERINA , DHURWASULU BALEDI , GRETHER UWE , HAZRA ANINDYA , HEBEISEN PAUL , ROEVER STEPHAN , ROGERS-EVANS MARK
IPC: C07D241/12 , A61K31/497 , A61P9/00 , C07D241/18 , C07D401/12 , C07D403/04 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14
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公开(公告)号：EA026669B1
公开(公告)日：2017-05-31
申请号：EA201591064
申请日：2013-12-02
Applicant: HOFFMANN LA ROCHE
Inventor： FREI BEAT , GOBBI LUCA , GRETHER UWE , KIMBARA ATSUSHI , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , ROGERS-EVANS MARK , SCHULZ-GASCH TANJA
IPC: C07D401/14 , A61K31/44 , A61K31/4427 , A61P3/10 , A61P9/00 , A61P27/02 , A61P29/00 , C07D213/81 , C07D401/04 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: Изобретениеотноситсяк соединениюформулы (I), где R-Rопределены, какв описаниии вформулеизобретения. Соединениеформулы (I) можноиспользоватьв качествелекарственногосредства.
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