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    COATED STENTS
    52.
    发明专利
    COATED STENTS 未知

    公开(公告)号：CA2757276C

    公开(公告)日：2017-06-06

    申请号：CA2757276

    申请日：2010-03-31

    Applicant: MICELL TECHNOLOGIES INC

    Inventor： TAYLOR DOUGLAS ,  MCCLAIN JAMES B

    IPC: A61L31/10 ,  A61F2/82 ,  A61K31/436 ,  A61L31/02 ,  A61L31/14 ,  A61L31/16 ,  A61M31/00

    Abstract: Provided herein is a coated stent comprising a stent comprising a plurality of stent struts each having an abluminal surface, a luminal surface, and two sidewall surfaces, and a coating comprising an active agent and a bioabsorbable polymer wherein a ratio of an abluminal coating thickness on the abluminal surface to a luminal coating thickness on the luminal surface is at most 90:10. Also provided herein are methods of preparing said coated stents.

    Polymer films for medical device coating
    54.
    发明专利
    Polymer films for medical device coating 未知

    公开(公告)号：AU2012203203B2

    公开(公告)日：2014-10-30

    申请号：AU2012203203

    申请日：2012-05-30

    Applicant: MICELL TECHNOLOGIES INC

    Inventor： TAYLOR DOUGLAS ,  MCCLAIN JAMES B

    IPC: A61L27/04 ,  B05D1/04

    Abstract: Abstract A method for depositing a coating comprising a polymer and impermeable dispersed solid on a substrate, comprising the following steps: discharging at least one 5 impermeable dispersed solid in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or impermeable dispersed solid particles onto said substrate, wherein an electrical potential is maintained between the substrate and the impermeable dispersed solid and/or polymer particles, thereby forming said coating; and sintering said coating under 10 conditions that do not disrupt the activity and/or function of the substrate. A similar method is provided for depositing a coating comprising a hydrophobic polymer and a water-vapor-trapping material on a substrate.

    STENTS HAVING BIOABSORBABLE LAYERS
    55.
    发明专利
    STENTS HAVING BIOABSORBABLE LAYERS 未知

    公开(公告)号：NZ600814A

    公开(公告)日：2013-11-29

    申请号：NZ60081412

    申请日：2012-06-22

    Applicant: MICELL TECHNOLOGIES INC

    Inventor： MCCLAIN JAMES B

    IPC: A61F2/82 ,  A61F13/00

    Abstract: Disclosed is a method of preparing a device comprising a stent and a plurality of layers that form a laminate coating on said stent; said method comprising: (a) providing a stent; (b) discharging at least one pharmaceutical agent and/or at least one active biological agent in dry powder form through a first orifice; (c) forming a supercritical or near supercritical fluid solution comprising at least one supercritical fluid solvent and at least one polymer and discharging said supercritical or near supercritical fluid solution through a second orifice under conditions sufficient to form solid particles of the polymer; (d) depositing the polymer and pharmaceutical agent and/or active biological agent particles onto said substrate, wherein an electrical potential is maintained between the substrate and the polymer and pharmaceutical agent and/or active biological agent particles, thereby forming said coating; and (e) sintering said coating under conditions that do not substantially modify a morphology of said pharmaceutical agent and/or activity of said biological agent.

    NANOPARTICLE AND SURFACE-MODIFIED PARTICULATE COATINGS, COATED BALLOONS, AND METHODS THEREFORE
    56.
    发明专利
    NANOPARTICLE AND SURFACE-MODIFIED PARTICULATE COATINGS, COATED BALLOONS, AND METHODS THEREFORE 未知

    公开(公告)号：CA2823355A1

    公开(公告)日：2012-07-05

    申请号：CA2823355

    申请日：2011-12-29

    Applicant: MICELL TECHNOLOGIES INC

    Inventor： MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  ZANI BRETT G ,  KIORPES TIMOTHY CHARLES

    IPC: A61K9/00 ,  A61K31/436 ,  B05D7/00 ,  B82Y5/00

    Abstract: Devices, coatings, and methods therefore comprise a medical device for delivering nanoparticles of an active agent to a treatment site. A coating on the medical device comprises active agent nanoparticles, which delivers coating to the treatment site and releases active agent nanoparticles into the treatment site over at least one day. A coating may comprise a polymer, a surfactant, and the nanoparticles. The coating may be prepared by forming a nanoemulsion. A coating may comprise encapsulated active agent nanoparticles which comprise active agent nanoparticles encapsulated in a polymer. The coating may have a positive surface charge. The coating may deliver active agent nanoparticles into the treatment site over at least about one day. The coating may be formed of a surfactant and nanoparticles mixture. The active agent nanoparticles may be deposited on the medical device using electrostatic capture.

    DRUG DELIVERY MEDICAL DEVICE
    58.
    发明专利
    DRUG DELIVERY MEDICAL DEVICE 未知

    公开(公告)号：CA2805631A1

    公开(公告)日：2012-01-19

    申请号：CA2805631

    申请日：2011-07-15

    Applicant: MICELL TECHNOLOGIES INC

    Inventor： MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  ZANI BRETT G ,  NEET JOHN ,  KIORPES TIMOTHY CHARLES

    IPC: A61L29/08 ,  A61K9/00 ,  A61K31/436 ,  A61L29/16 ,  A61M31/00

    Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.

    STENTS AND OTHER DEVICES HAVING EXTRACELLULAR MATRIX COATING
    59.
    发明专利
    STENTS AND OTHER DEVICES HAVING EXTRACELLULAR MATRIX COATING 未知

    公开(公告)号：CA2797110A1

    公开(公告)日：2011-10-27

    申请号：CA2797110

    申请日：2011-04-20

    Applicant: MICELL TECHNOLOGIES INC

    Inventor： MCCLAIN JAMES B ,  BENVENUTO ARTHUR J

    IPC: A61F2/02

    Abstract: Provided herein are devices comprising a stent; and a coating on said stent comprising a polymer and an active agent, wherein the active agent comprises at least one of: extracellular matrix and an extracellular matrix component. Provided herein are methods of preparing a device comprising a stent and a coating on said stent; said method comprising: providing a stent; and forming a plurality of layers on said stent; wherein the coating comprises a polymer and at least one of said layers comprises one or more active agents; wherein at least a portion of the active agent comprises at least one of extracellular matrix and an extracellular matrix component.

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