公开(公告)号：RS54783B1

公开(公告)日：2016-10-31

申请号：RSP20160342

申请日：2011-04-07

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  KRAWIEC MARIUSZ

IPC: A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  C07D213/75 ,  C07D405/12 ,  C07D405/14

Abstract: Čvrsti oblik 3-(6-(1-(2,2-Difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metil piridin-2-il)benzoeva kiselina (Jedinjenje 1), karakterisano kao Jedinjenje 1, Solvatni Oblik A.Prijava sadrži još 22 patentna zahteva.

公开(公告)号：AU2011237494C1

公开(公告)日：2016-05-26

申请号：AU2011237494

申请日：2011-04-07

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  KRAWIEC MARIUSZ

IPC: C07D405/12

Abstract: The present invention relates to a substantially a solid form of 3-(6-(l-(2,2- difluorobenzo[d][l,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1, Solvate Form A and Compound 1, HCl Salt Form A), processes for making such forms, pharmaceutical compositions thereof, and methods of treatment therewith.

公开(公告)号：NZ702159A

公开(公告)日：2016-03-31

申请号：NZ70215908

申请日：2008-12-04

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  KRAWIEC MARIUSZ

IPC: C07D405/12 ,  A61K31/443 ,  A61P11/00

Abstract: The present invention relates to a pharmaceutical composition comprising 3-(6-(1-(2,2-Difluorobenzo[d][1,3] dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid characterized as Form I, an additional therapeutic agent, and a pharmaceutically acceptable carrier, wherein the Form I is characterized by one or more peaks at 15.2 to 15.6 degrees, 16.1 to 16.5 degrees, and 14.3 to 14.7 degrees in an X-ray powder diffraction obtained using Cu K alpha radiation.

公开(公告)号：NZ612918A

公开(公告)日：2015-10-30

申请号：NZ61291812

申请日：2012-01-13

Applicant: VERTEX PHARMA

Inventor： KRAWIEC MARIUSZ ,  SHANNON DEAN ,  LUISI BRIAN ,  KULDIPKUMAR ANUJ K

IPC: C07D413/14 ,  A61K31/4184 ,  A61P31/00

Abstract: The disclosure relates to crystalline forms of 8(R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl) pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea represented by formula (I) and hydrochloride and mesylate salts thereof, which inhibit bacterial enzymes gyrase and/or topoisomerase IV. Also disclosed are pharmaceutical compositions comprising said compound of formula (I) or its salts and their use for treating bacterial infection caused by Mycobacterium tuberculosis, Streptococcus pneumoniae, Staphylococcus epidermidis, Enterococcus faecalis, Staphylococcus aureus, Clostridium difficile, Moraxella catarrhalis, Neisseria gonorrhoeae, Neisseria meningitidis, Mycobacterium avium complex, Mycobacterium abscessus, Mycobacterium kansasii, Mycobacterium ulcerans, Chlamydophila pneumoniae, Chlamydia trachomatis, Haemophilus injluenzae, Streptococcus pyogenes or &bgr;-haemolytic streptococci.

公开(公告)号：AU2015221470A1

公开(公告)日：2015-09-24

申请号：AU2015221470

申请日：2015-09-02

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  KRAWIEC MARIUSZ

IPC: C07D405/12

Abstract: SOLID FORMS OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL) CYCLOPROPANECARBOXAMIDO)-3-METHYLPYRIDIN-2-YL)BENZOIC Abstract The present invention relates to a substantially a solid form of 3-(6-1-(2,2 difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1, Solvate Form A and Compound 1, HCl Salt Form A), processes for making such forms, pharmaceutical compositions thereof, and methods of treatment therewith.

公开(公告)号：AU2008333845C1

公开(公告)日：2014-01-16

申请号：AU2008333845

申请日：2008-12-04

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  KRAWIEC MARIUSZ ,  ZHANG BEILI

IPC: C07D405/12 ,  A61K31/443 ,  A61P11/00

Abstract: The present invention relates to a substantially crystalline and free solid state form of 3-(6-(l-(2,2-difluorobenzo[d][l,3]dioxol-5-yl) cyclopropanecarboxamido)-3- methylPyridin-2-yl)benzoic acid (Form I) of following formula: (I), pharmaceutical compositions thereof, and methods of treatment therewith.

公开(公告)号：CL2013002026A1

公开(公告)日：2013-12-27

申请号：CL2013002026

申请日：2013-07-12

Applicant: VERTEX PHARMA

Inventor： LIAO YUSHENG ,  SHANNON DEAN ,  LUISI BRAIN ,  KRAWIEC MARIUSZ

IPC: C07D407/04 ,  A61K31/506

公开(公告)号：SI2358680T1

公开(公告)日：2013-08-30

申请号：SI200930620

申请日：2009-10-23

Applicant: VERTEX PHARMA

Inventor： ZHANG BEILI ,  KRAWIEC MARIUSZ ,  BOTFIELD MARTYN ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK

IPC: C07D215/00 ,  A61K31/00 ,  A61P1/00 ,  A61P11/00

公开(公告)号：SG191924A1

公开(公告)日：2013-08-30

申请号：SG2013053152

申请日：2012-01-13

Applicant: VERTEX PHARMA

Inventor： SHANNON DEAN ,  LUISI BRIAN ,  LIAO YUSHENG ,  KRAWIEC MARIUSZ

Abstract: The present application is directed to solid forms of compounds of formula (I): and pharmaceutically acceptable salts thereof, that inhibit bacterial gyrase and/or Topo IV and pharmaceutical compositions comprising said compounds and salts. These compounds and salts are useful in treating bacterial infection.

公开(公告)号：DK2358680T3

公开(公告)日：2013-06-24

申请号：DK09744286

申请日：2009-10-23

Applicant: VERTEX PHARMA

Inventor： ZHANG BEILI ,  KRAWIEC MARIUSZ ,  BOTFIELD MARTYN ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK

IPC: C07D215/56 ,  A61K31/4704 ,  A61P1/00 ,  A61P11/00