公开(公告)号：KR1020060014989A

公开(公告)日：2006-02-16

申请号：KR1020040063776

申请日：2004-08-13

Applicant: 대구한의대학교산학협력단

Inventor： 서정철 ,  임강현 ,  정주호 ,  신동훈 ,  최강덕 ,  양재하 ,  김상찬 ,  정승기 ,  한상원

IPC: C12Q1/68

CPC classification number: C12Q1/6827 ,  C12Q1/6809 ,  C12Q1/6844 ,  C12Q1/6869

Abstract: 본 발명은 파이로시퀀싱(Pyrosequencing)법에 의한 인삼의 종간 유전자를 감별하는 감별 키트에 관한 것으로써, 상세하게는 고려삼과 서양삼을 파이로시퀀싱법에 의하여 유전자형을 분석하고, 인삼의 종간 특이성 시퀀싱 프라이머를 고안하여 파낙스 종(Panax species)의 종간 연관성과 유전적 변이를 평가하기 위한 감별 키트에 관한 것이다. 본 발명의 감별 키트를 통하여 인삼의 종을 판별함으로써 정확한 인삼 원료를 공급할 수 있으며, 인삼의 품질관리 방법으로 활용 할 수 있다.
고려삼, 서양삼, 파이로시퀀싱(Pyrosequencing)법, 감별 키트

公开(公告)号：KR101880442B1

公开(公告)日：2018-07-23

申请号：KR1020170014800

申请日：2017-02-02

Applicant: 대구한의대학교산학협력단

Inventor： 김희영 ,  양재하

IPC: A61K9/70 ,  A61K31/165 ,  A61K36/31

CPC classification number: A61K9/7023 ,  A61K31/165 ,  A61K36/31

Abstract: 본발명은혈압강하용패치조성물에관한것으로, 구체적으로 TRPV1(transient receptor potential cation channel subfamily V member 1)의효현제(agonist) 및 TRPA1(transient receptor potential cation channel subfamily A member 1)의효현제로이루어진군 중에서선택된효현제를유효성분으로함유하는혈압강하용패치조성물, 이패치조성물이도포된패치, 그리고이 패치를사용하는방법에관한것이다. 본발명의패치조성물은 TRPV1의효현제및 TRPA1의효현제로이루어진군 중에서선택된효현제를함유하고있어팔목내측정중신경의 C 섬유신경(C-fiber)을자극하여고혈압상태의혈압을효과적으로낮출수 있다. 패치조성물을피부에접촉하는방법으로상기와같은효과를나타낼수 있기때문에, 본발명의패치조성물또는패치를이용하면기존의경구투여약물에비해매우간편하고안전하게혈압강하가가능하다는장점이있다. 또한상기효현제로고가의화합물이아닌캡사이신이나머스타드오일을사용할수 있어매우저렴한비용으로제공할수 있다는장점도있다.

公开(公告)号：KR101503834B1

公开(公告)日：2015-03-24

申请号：KR1020120103744

申请日：2012-09-19

Applicant: 대구한의대학교산학협력단

Inventor： 김미려 ,  양재하 ,  신인순

IPC: A61K36/68 ,  A61P3/06 ,  A61P3/04

Abstract: 본 발명은 차전초 조추출물 또는 분획물을 유효성분을 함유하는 고지혈증 및 비만증 예방 또는 치료를 위한 약학조성물에 대한 것이다. 본 발명의 생약 추출물은 마우스 유래 지방세포인 3T3-L1 세포의 지방분화를 억제 시켜주는 효과와 고지방 식이를 이용해 비만을 유도한 흰쥐에서 체중감소 및 체지방 감소, 혈중지질농도 감소효과 및 조직병리학적 영향에 효과가 있으므로 고지혈증 및 비만증의 예방 또는 치료용 약제 또는 건강기능식품에 유용하게 이용될 수 있다.

公开(公告)号：KR101421347B1

公开(公告)日：2014-07-18

申请号：KR1020120110030

申请日：2012-10-04

Applicant: 대구한의대학교산학협력단

Inventor： 김미려 ,  양재하 ,  김성옥 ,  신인순 ,  박지영

IPC: A61K36/232 ,  A61P3/04 ,  A61P3/00

Abstract: 본 발명은 당귀(
Angelica gigas Nakai)로부터 지방간 억제 및 항비만 활성을 나타내는 정유(essential oil) 분획물을 제조하는 제조방법 및 이 분획물을 포함하는 지방간, 비만 예방 및 치료효과를 갖는 조성물에 관한 것으로, 본 발명의 조성물은 고지방 식이를 이용한 비만 유도 동물에서 체중 및 체지방 감소, 혈중 중성지방의 감소 및 식이섭취량의 감소를 가져왔으며, 조직에서 고지방식이 공급으로 유발되는 지방 간병증, 지방세포 비대, 췌장섬 증식, 인슐린(insulin), 글루카곤(glucagon) 생산세포의 증가를 억제함을 확인함으로써, 지방간 및 비만증 예방 및 치료용 약제 및 건강기능식품에 유용하게 이용될 수 있다.

公开(公告)号：KR1020140062958A

公开(公告)日：2014-05-27

申请号：KR1020120129306

申请日：2012-11-15

Applicant: 대구한의대학교산학협력단

Inventor： 양재하 ,  정지욱 ,  박현정 ,  이은숙 ,  임언주 ,  오사랑 ,  여미진 ,  안은미 ,  심인섭

IPC: A61K8/97 ,  A61K8/92 ,  A61K36/26 ,  A61P25/24

CPC classification number: A61K8/97 ,  A61K8/922 ,  A61Q13/00 ,  A61Q19/00 ,  C11B9/00

Abstract: The present invention relates to an aroma oil composition and a cosmetic composition comprising an essential oil fraction from asaroum for preventing and reducing a body fact and cellulite, and a cosmetic composition for preventing and treating depression and, more specifically, the asaroum of the present invention is proved to have an antidepressant effect by a fored swimming test and a tail suspension test on a mouse, and thus more strongly inhibits the depression than an existing antidepressant, to be used for an aroma oil composition and a cosmetic composition for preventing and reducing depression.

Abstract translation: 本发明涉及一种芳香油组合物和一种化妆品组合物，其包含来自用于预防和减少身体事实和脂肪团的洋葱的精油馏分，以及用于预防和治疗抑郁症的化妆品组合物，更具体地说，本发明的砂浆 通过前驱游泳试验和尾巴悬浮试验证实具有抗抑郁作用，因此比现有的抗抑郁药更强烈地抑制抑制作用，用于芳香油组合物和用于预防和减少抑郁症的化妆品组合物 。

公开(公告)号：KR1020140050297A

公开(公告)日：2014-04-29

申请号：KR1020120116533

申请日：2012-10-19

Applicant: 대구한의대학교산학협력단

Inventor： 양재하 ,  안은미 ,  신인석 ,  장은영 ,  김향숙

IPC: A61K35/644 ,  A61K31/353 ,  A23L1/30

CPC classification number: A61K35/644 ,  A23L33/10 ,  A61K31/353

Abstract: The present invention relates to a composition that contains an extract of propolis or chrysin isolated therefrom as an active ingredient. Specifically, the extract of propolis or chrysin isolated therefrom of the present invention dose dependently decreases a self intake amount of cocaine in a self-administration experiment, which is a behavioral experiment technique suitable for researching reinforcing effects of psychomotor stimulants. By checking the fact that the above characteristic exerts no influence on a food reinforcing effect through a food test, the composition can be used as a pharmaceutical composition and a health supplement for preventing and treating cocaine intoxication and withdrawal symptoms.

Abstract translation: 本发明涉及一种组合物，其含有作为活性成分从其中分离出的蜂胶或木质素提取物。 具体地说，本发明中分离出的蜂胶或巧克力提取物剂量依赖性地降低了自身给药实验中可卡因的自身摄取量，这是适用于研究精神运动兴奋剂的增强作用的行为实验技术。 通过检查上述特征通过食品试验对食品增强效果没有影响的事实，该组合物可以用作药物组合物和用于预防和治疗可卡因中毒和戒断症状的健康补充剂。

公开(公告)号：KR1020130065185A

公开(公告)日：2013-06-19

申请号：KR1020110131931

申请日：2011-12-09

Applicant: 대구한의대학교산학협력단

Inventor： 박성민 ,  유영은 ,  김옥아 ,  강정숙 ,  양재하 ,  김상찬

IPC: A23L3/3472

CPC classification number: A23L3/3472 ,  A23L19/00 ,  A23V2002/00 ,  A23V2250/21

Abstract: PURPOSE: A manufacturing method of a natural food additive containing a Rosa rugosa extract is provided to have an antibacterial property with respect to microorganisms separated from a polluted food. CONSTITUTION: A natural food additive contains a Rosa rugosa extract as an active ingredient. The natural food additive is a natural food preservative, a food antiseptic agent, or a food sterilizing agent. The additive shows a strong anti-biotic activity against Bacillus germ and Paenibacillus genus germ. The additive shows a strong antibiotic activity against a strain selected from the group consisting of CBB6 Bacillus circulans, CBB15 B. benzoevorans, CBB16 B. circulans, CBB3 Paenibacillus sp., and CBB5 Paenibacillus sp. The Rosa rugosa extract is obtained by extracting an extract using a solvent having 1 to 25(v/v) times the amount of a weight of dried Rosa rugosa for about 10 to 96 hours and filtering and concentrating the extract. The solvent is a lower alcohol solvent having C1 to C4 or a mixed solvent of the same and water. The extraction includes enfleurage extraction, reflux cooling extraction, ultrasonic wave extraction, or room temperature extraction.

Abstract translation: 目的：提供含有罗莎蔷薇提取物的天然食品添加剂的制造方法，以对与污染食物分离的微生物具有抗菌性。 构成：天然食品添加剂含有罗莎玫瑰提取物作为活性成分。 天然食品添加剂是天然食品防腐剂，食品防腐剂或食品消毒剂。 添加剂对芽孢杆菌和芽孢杆菌属细菌具有强烈的抗生物活性。 该添加剂显示出对选自CBB6环状芽孢杆菌，CBB15B。苯草甘蓝，CBB16B.环孢素，CBB3 Paenibacillus sp。和CBB5 Paenibacillus sp。的菌株的强抗生素活性。 通过使用具有1〜25（v / v）倍干燥的罗莎酱的重量的溶剂提取提取物约10〜96小时，并过滤并浓缩提取物来获得罗莎蔷薇提取物。 溶剂是具有C1至C4的低级醇溶剂或其混合溶剂和水。 提取包括提取提取，回流冷却提取，超声波提取或室温萃取。

公开(公告)号：KR1020130048302A

公开(公告)日：2013-05-10

申请号：KR1020110113070

申请日：2011-11-02

Applicant: 대구한의대학교산학협력단

Inventor： 박성민 ,  유영은 ,  김옥아 ,  강정숙 ,  양재하 ,  김상찬

IPC: A23L3/3472

CPC classification number: A23L3/3472 ,  A23L19/09

Abstract: PURPOSE: A method of manufacturing a plant-derived antibacterial substance that has a strong antibacterial activity against food poisoning bacteria, safe for the human body, and can be taken as food without repulsion is provided. CONSTITUTION: A natural food additive contains a pomegranate skin extract as an active ingredient. The natural food additive is a natural food preservative, a food decomposition preventing agent, or a food sterilizing agent. The additive has a strong antibacterial activity against bacillus and paenibacillus genus. The additive has a strong antibacterial activity to the strain selected from the group consisting of CBB4 Bacillus sp., CBB5 Bacillus circulans, CBB6 Bacillus sp. CBB11 Bacillus sp., CBB15B. benzoevorans, CBB16 B. circulans, CBB3 Paenibacillus sp. CBB14, and Paenibacillus sp.. The pomegranate skin extract is an extract that is extracted from the skins of fruit, stem, branch, or root of Punica granatum. The pomegranate skin extract is prepared by the following two steps: extracting the extract using a C1-C4 lower alcohol solvent or a mixed solvent of water and the same to an amount of about 1-25 times(v/v) the amount of dried pomegranate skin at room temperature for about 10-96 hours to obtain residue of the extract; and filtering and concentrating the extract.

Abstract translation: 目的：提供一种对食物中毒细菌具有强抗菌活性的植物来源的抗菌物质的制造方法，对人体安全，可作为不排斥食品的食品。 构成：天然食品添加剂含有石榴皮提取物作为活性成分。 天然食品添加剂是天然食品防腐剂，食品分解防止剂或食品消毒剂。 该添加剂对芽孢杆菌属和paenibacillus属具有很强的抗菌活性。 添加剂对选自CBB4芽孢杆菌，CBB5环状芽孢杆菌，CBB6芽孢杆菌属的菌株具有很强的抗菌活性。 CBB11芽孢杆菌，CBB15B。 苯乙草胺，CBB16 B.环孢菌素，CBB3 Paenibacillus sp。 CBB14和Paenibacillus sp ..石榴皮提取物是从Punica granatum的水果，茎，枝或根的皮肤中提取的提取物。 通过以下两个步骤制备石榴皮提取物：使用C1-C4低级醇溶剂或水的混合溶剂萃取提取物，其量为约1-25倍（v / v）的量， 石榴皮肤在室温下进行约10-96小时，以获得提取物的残留物; 并对提取物进行过滤和浓缩。

公开(公告)号：KR1020120078245A

公开(公告)日：2012-07-10

申请号：KR1020100140476

申请日：2010-12-31

Applicant: 대구한의대학교산학협력단

Inventor： 박찬익 ,  양재하 ,  김보애 ,  이은주 ,  강정수

IPC: A61K8/97 ,  A61Q19/00

CPC classification number: A61K8/97 ,  A61K36/536 ,  A61K2236/37 ,  A61Q19/00 ,  A61Q19/10 ,  Y10S514/844

Abstract: PURPOSE: A composition containing Prunella vulgaris PSE extract is provided to ensure antioxidative and antibacterial effects. CONSTITUTION: A method for preparing Prunella vulgaris PSE(pressed solvent extract) extract with antioxidative and antibacterial effects comprises: a step of pulverizing Prunella vulgaris; a step of injecting Prunella vulgaris using low carbon number alcohol, acetone, chloroform, methylene chloride, hexane, 1,3-butylene glycol, polyethylene glycol, glycerol, propylene glycol, or mixture solvent thereof; a step of extracting at 10-100°C using a PSE extractor for 30 minutes to 5 hours; and a step of filtering the extract solution at 10-100°C. A cosmetic composition with antioxidative and antibacterial effects contains the Prunella vulgaris PSE extract as an active ingredient. The composition is manufactured in a form of a lotion, skin, nutrition lotion, nutrition cream, essence, pack, cleansing agent, soap, and treatment.

Abstract translation: 目的：提供含有普通寻常精选PSE提取物的组合物，以确保抗氧化和抗菌作用。 构成：具有抗氧化和抗菌作用的普通普洱精浆提取物的制备方法包括：将普Pr of粉碎的步骤; 使用低碳数醇，丙酮，氯仿，二氯甲烷，己烷，1,3-丁二醇，聚乙二醇，甘油，丙二醇或其混合溶剂注入普通小檗碱的步骤; 使用PSE提取器在10-100℃下提取30分钟至5小时的步骤; 以及在10-100℃下过滤提取液的步骤。 具有抗氧化和抗菌作用的化妆品组合物含有普通寻常精选PSE提取物作为活性成分。 该组合物以洗剂，皮肤，营养洗剂，营养霜，精华，包装，清洁剂，肥皂和治疗的形式制造。

公开(公告)号：KR1020120073389A

公开(公告)日：2012-07-05

申请号：KR1020100135136

申请日：2010-12-27

Applicant: 대구한의대학교산학협력단

Inventor： 양재하 ,  정지욱 ,  박성민 ,  유영은 ,  김옥아 ,  강정숙

IPC: A23L3/3472 ,  A23L19/00

CPC classification number: A23L3/3472 ,  A23L33/105 ,  A23V2200/10

Abstract: PURPOSE: A natural food preservative containing a salvia miltiorrhiza extract, a producing method thereof, and a composition containing thereof are provided to offer strong antibacterial activity to food poisoning bacteria to users. CONSTITUTION: A producing method of a natural food preservative contains a salvia miltiorrhiza extract obtained by the following steps: extracting dried salvia miltiorrhiza using a C1-4 low class alcohol solvent or its water solution for 10-96 hours at room temperature; filtering and concentrating the extract to obtain the salvia miltiorrhiza extract. The extraction of the salvia miltiorrhiza is performed by using a method selected from cold extraction, reflux extraction, or ultrasonic wave extraction.

Abstract translation: 目的：提供含有丹参提取物，其制备方法和含有它们的组合物的天然食品防腐剂，以向使用者提供对食物中毒细菌的强抗菌活性。 构成：天然食品防腐剂的制备方法含有通过以下步骤获得的丹参提取物：使用C1-4低级醇溶剂或其水溶液在室温下提取干燥的丹参，10-96小时; 过滤并浓缩提取物以获得丹参提取物。 通过使用选自冷提取，回流提取或超声波提取的方法进行丹参的提取。