中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

109 records (took 0.029 seconds)

    디오스민을 포함하는 동맥경화증 및 고지혈증의 예방 및치료용 조성물
    61.
    发明公开
    디오스민을 포함하는 동맥경화증 및 고지혈증의 예방 및치료용 조성물 失效
    含有二氢DI UL UL UL UL UL A A A A A A A A A A A A A A A A A A A A A A A A

    公开(公告)号：KR1020010007625A

    公开(公告)日：2001-01-26

    申请号：KR1020000058789

    申请日：2000-10-06

    Applicant: 한국과학기술연구원

    Inventor： 복성해 ,  정태숙 ,  배기환 ,  박용복 ,  최명숙 ,  문석식 ,  권용국 ,  이은숙 ,  현병화 ,  최양규 ,  이철호 ,  안병태 ,  이새봄

    IPC: A61K31/70

    Abstract: PURPOSE: A composition containing diosmin is provided for preventing and treating ateriosclerosis and hyperlipemia, thereby adhesion of macrophage-lipid complex on inner layer of artery is strongly inhibited, the amounts of cholesterol and fat in serum is decreased, and the activity of ACAT and HMG-CoA reductase is inhibited. CONSTITUTION: The amount of cholesterol in serum can be decreased by inhibiting the activities of acyl CoA:cholesterol-o-acyltransferase(ACAT) in liver, cholesterol ester transfer protein(CETP) transferring cholesterol between lipid proteins, 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) relating to biosynthesis of cholesterol in liver. Diosmin(C28H32O15, M.W. 608.55) may be obtained from vegetables and oranges or be synthesized. The composition containing an effective amount of diosmin, that is, 0.1 to 500 mg/kg, preferably 1 to 100 mg/kg a day, is orally or topically administrated into a patient and the dose thereof may be variable by patient's age, weight, sex, health, diet, severity of disease, and so on. The composition containing diosmin may be added into foods and drinks in an amount of 0.01 to 10 wt.%, preferably 0.1 to 5 wt.% of diosmin.

    Abstract translation: 目的：提供含有diosmin的组合物，用于预防和治疗动脉硬化和高脂血症，从而强烈抑制巨噬细胞 - 脂质复合物对动脉内层的粘附，血清中胆固醇和脂肪的含量降低，ACAT和HMG的活性 -CoA还原酶被抑制。 构成：通过抑制肝脏中酰基CoA：胆固醇 - 邻 - 酰基转移酶（ACAT），胆固醇酯转移蛋白（CETP）在脂质蛋白，3-羟基-3-甲基戊二醛之间转运胆固醇的活性，可以降低血清中的胆固醇含量 辅酶A（HMG-CoA）涉及胆固醇在肝脏中的生物合成。 Diosmin（C28H32O15，M.W. 608.55）可以从蔬菜和橙子中获得或被合成。 将包含有效量的二糖苷的组合物，即每天0.1至500mg / kg，优选1至100mg / kg，口服或局部施用于患者，其剂量可以根据患者的年龄，体重， 性别，健康，饮食，疾病严重程度等。 含有diosmin的组合物可以以diosmin的0.01〜10重量％，优选0.1〜5重量％的量添加到食品和饮料中。

    헤마테인을 함유하는 고지혈증 및 동맥경화증 예방 및 치료용 조성물
    62.
    发明公开
    헤마테인을 함유하는 고지혈증 및 동맥경화증 예방 및 치료용 조성물 失效
    用于保护或治疗含有高脂血症的药物组合物和含有HAEMATIN的阿片样物质

    公开(公告)号：KR1020000073945A

    公开(公告)日：2000-12-05

    申请号：KR1019990017558

    申请日：1999-05-17

    Applicant: 한국과학기술연구원

    Inventor： 정태숙 ,  이새봄 ,  이은숙 ,  복성해 ,  오구택 ,  이병재 ,  최재훈 ,  이형규 ,  오세량

    IPC: A61K31/335

    Abstract: PURPOSE: A haematin substance has characteristically an LDL(low density lipoprotein)-antioxidation, reduces the concentration of cholesterol in blood, and inhibits the activity of liver microsome ACAT(acyl-CoA: cholesterol acyl-transferase). Thereby, the pharmaceutical composition containing the haematin has an excellent effect for treating or protecting specific diseases such as hyperlipidemia or arteriosclerosis. CONSTITUTION: The haematin used is conventionally derivable from Heartwood of Caesalpinia sappan, or is available industrially. The pharmaceutical composition is used to treat or protect hyperlipidemia or arteriosclerosis by using usual haematin in drug, beverage or food.

    Abstract translation: 目的：血红素物质具有LDL（低密度脂蛋白） - 抗氧化作用，降低血液中胆固醇的浓度，并抑制肝微粒体ACAT（酰基辅酶A：胆固醇酰基转移酶）的活性。 因此，含有血红素的药物组合物对治疗或保护特异性疾病如高脂血症或动脉硬化具有优异的效果。 构成：所使用的血红素通常衍生自凯撒山茱萸的心材，或在工业上可用。 药物组合物用于通过在药物，饮料或食物中使用普通血红素来治疗或保护高脂血症或动脉硬化。

    헤스페리딘 또는 헤스페레틴을 포함하는 혈소판 응집억제용 조성물
    63.
    发明公开
    헤스페리딘 또는 헤스페레틴을 포함하는 혈소판 응집억제용 조성물 失效
    用于抑制含有赫赛霉素或HESPERETIN的片剂的组合物

    公开(公告)号：KR1020000058219A

    公开(公告)日：2000-09-25

    申请号：KR1020000028977

    申请日：2000-05-29

    Applicant: 한국과학기술연구원

    Inventor： 복성해 ,  정태숙 ,  조한익 ,  이동순

    IPC: A61K31/35

    Abstract: PURPOSE: A composition containing hesperidin or hesperetin for inhibition of the platelet coagulation is provided, which prevents coagulation of platelets caused by exposed collagen when blood vessel endothelial cells is damaged; so which can prevents and cures formation of atheroma, or thrombosis; and which can be used in a medicine and food. CONSTITUTION: A hesperidin or hesperetin is extracted from oranges(a grapefruit, a citron, a lemon, a orange, etc) or manufactured from well-known synthetic process. A pharmaceutical composition as an inhibitor to platelet coagulation comprises of naringin or naringenin as an effective ingredient and pharmaceutically acceptable carriers, which can also contains diluents, disintegrators, sweeteners, lubricants, perfume; and which can be made in the form of tablets, capsules, powders, suspensions, emulsions, syrup, solution or parenteral preparations. A dosage of the composition for inhibition of the platelet coagulation containing naringin or naringenin is 0.5-100mg/kg, desirably 2-10mg/kg. The hesperidin or hesperetin can be added in food or beverages with same purposes.

    Abstract translation: 目的：提供含有用于抑制血小板凝血的橙皮苷或橙皮素的组合物，其防止血管内皮细胞损伤时由胶原蛋白引起的血小板凝结; 因此可以预防和治愈动脉粥样化的形成或血栓形成; 并可用于医药和食品。 构成：橙子（葡萄柚，香橼，柠檬，橙子等）中提取橙皮苷或橙皮素，或由熟知的合成方法制成。 作为血小板凝血抑制剂的药物组合物包含柚皮苷或柚皮苷作为有效成分和药学上可接受的载体，其还可以含有稀释剂，崩解剂，甜味剂，润滑剂，香料; 并且其可以以片剂，胶囊，粉末，悬浮液，乳剂，糖浆，溶液或肠胃外制剂的形式制成。 用于抑制含有柚皮苷或柚皮苷的血小板凝血的组合物的剂量为0.5-100mg / kg，优选为2-10mg / kg。 橙皮苷或橙皮素可以添加到具有相同目的的食品或饮料中。

    바이오플라보노이드계화합물을포함하는혈청고밀도지단백질증가용조성물
    64.
    发明公开
    바이오플라보노이드계화합물을포함하는혈청고밀도지단백질증가용조성물 失效
    用于增加含有生物素的血清高密度脂蛋白的组合物

    公开(公告)号：KR1020000026393A

    公开(公告)日：2000-05-15

    申请号：KR1019980043909

    申请日：1998-10-20

    Applicant: 한국과학기술연구원

    Inventor： 복성해 ,  현병화 ,  이철호 ,  최양규 ,  정태숙 ,  최명숙 ,  문석식 ,  권용국 ,  이은숙 ,  김성규 ,  문옥성 ,  이새봄 ,  안병태 ,  박용복

    IPC: A61K31/35

    CPC classification number: A61K31/352 ,  A61K31/7034 ,  A61K31/704

    Abstract: PURPOSE: A composition for increasing serum high density lipoprotein containing bioflavonoids is provided which is useful for preventing and treating diseases of cardiac circulatory organs. CONSTITUTION: The medical composition for increasing high density lipoprotein consists of(i) an effective amount of bioflavonoids of the following general formula(I) or a plant extract containing thereof, where each R¬1-R¬9 is independently hydrogen, hydroxy, alkoxy having 1-9 carbon atoms(optionally, which is able to include hydroxy, alkoxy having 1-5 carbon atoms, aryloxy or phenyl group which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido), cycloalkyloxy having 5-9 carbon atoms which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido, cycloalkylcarbonyloxy having 5-9 carbon atoms which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido, acyloxy having 2-10 or 16-18 carbon atoms(optionally, which is able to include hydroxy, alkoxy having 1-5 carbon atoms, aryloxy or phenyl group which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido), or rutinosyl, and X is either a single bond or a double bond; and (ii) a medically acceptable carrier.

    Abstract translation: 目的：提供一种用于增加血清高密度脂蛋白含有生物类黄酮的组合物，可用于预防和治疗心脏循环系统疾病。 构成：用于增加高密度脂蛋白的医药组合物包括（i）有效量的以下通式（I）的生物类黄酮或含有它们的植物提取物，其中每个R 1 -R 9独立地是氢，羟基， 具有1-9个碳原子的烷氧基（任选地，其可以包括羟基，具有1-5个碳原子的烷氧基，芳氧基或被一至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代的苯基） ），具有5-9个碳原子的环烷氧基，其被一至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代，具有5-9个碳原子的环烷基羰基氧基，被一至三个选自羟基， 烷氧基，芳氧基，卤素，硝基和酰氨基，具有2-10或16-18个碳原子的酰氧基（任选地，其可以包括羟基，具有1-5个碳原子的烷氧基，芳氧基或被一个 至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基）或芸香糖基，X为单键或双键; 和（ii）医学上可接受的载体。

Patent Agency Ranking