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    IMPEDANCE BASED DEVICES AND METHODS FOR USE IN ASSAYS
    61.
    发明专利
    IMPEDANCE BASED DEVICES AND METHODS FOR USE IN ASSAYS 未知

    公开(公告)号：CA2493108A1

    公开(公告)日：2004-01-29

    申请号：CA2493108

    申请日：2003-07-18

    Applicant: ACEA BIOSCIENCES INC

    Inventor： WANG XIAOBO ,  XU XIAO

    IPC: G01N27/02 ,  C12M1/00 ,  C12M1/34 ,  C12M1/42 ,  C12N1/00 ,  C12N13/00 ,  C12Q1/00 ,  C12Q1/02 ,  G01N20060101 ,  G01N1/00 ,  G01N27/06 ,  G01N27/12 ,  G01N27/30 ,  G01N27/327 ,  G01N27/416 ,  G01N33/50 ,  G01N33/543 ,  G01N37/00

    Abstract: A device for detecting cells and/or molecules on an electrode surface is disclosed. The device detects cells and/or molecules through measurement of impedance changes resulting from the cells and/or molecules. A disclosed embodiment of the device includes a substrate having two opposing ends along a longitudinal axis. A plurality of electrode arrays (100) are positioned on t he substrate. Each electrode array includes at least two electrodes (110, 120), and each electrode is separated from at least one adjacent electrode in the electrode array by an expanse of non-conductive material. The electrode has a width at its widest point of more than about 1.5 and less than about 10 time s the width of the expanse of non-conductive material. The device also include s electrically conductive traces (125, 130) extending substantially longitudinally to one of the two opposing ends of the substrate without intersecting another trace. Each trace is in electrical communication with a t least one of the electrode arrays.

    PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF PROTEIN KINASES
    65.
    发明专利
    PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF PROTEIN KINASES 未知

    公开(公告)号：CA2881275C

    公开(公告)日：2020-10-20

    申请号：CA2881275

    申请日：2013-07-11

    Applicant: ACEA BIOSCIENCES INC

    Inventor： XU XIAO ,  WANG XIAOBO ,  MAO LONG ,  ZHAO LI ,  XI BIAO

    IPC: C07D487/04 ,  A61K31/52 ,  A61P35/00

    Abstract: The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3(D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK) and/or the respective pathways. One example of a compound according to the present disclosure is a compound according to Formula (VIII).

    Pyrimidine derivatives as kinase inhibitors
    66.
    发明专利
    Pyrimidine derivatives as kinase inhibitors 未知

    公开(公告)号：NZ715687A

    公开(公告)日：2019-04-26

    申请号：NZ71568714

    申请日：2014-07-11

    Applicant: ACEA BIOSCIENCES INC

    Inventor： XU XIAO ,  WANG XIAOBO ,  MAO LONG ,  ZHAO LI ,  XI BIAO

    IPC: A61P35/00 ,  A61K31/506 ,  C07D239/46 ,  C07D403/12 ,  C07D473/18 ,  C07D487/04 ,  C07D519/00

    Abstract: The present invention relates to pharmaceutical compounds, compositions and methods comprising compounds of Formula (Ia) as further described herein, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder, a cancer, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye or an immunologically related disease, and in some embodiments diseases or disorders related to the dysregulation of kinase such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, FLT3(D835Y), ITK, TEC, TXK, BTK, or JAK, and the respective pathways.

    OPTICAL DETECTION SYSTEM FOR FLOW CYTOMETER, FLOW CYTOMETER SYSTEM AND METHODS OF USE
    67.
    发明专利
    OPTICAL DETECTION SYSTEM FOR FLOW CYTOMETER, FLOW CYTOMETER SYSTEM AND METHODS OF USE 未知

    公开(公告)号：CA3030966A1

    公开(公告)日：2018-01-18

    申请号：CA3030966

    申请日：2017-07-15

    Applicant: ACEA BIOSCIENCES INC

    Inventor： LI NAN ,  KONG LINGBO ,  WU JIAN ,  CHENG TINGTING ,  QING YANGDE ,  WANG XIAOBO

    IPC: G01N15/14 ,  G01N21/64

    Abstract: An optical engine its use in a bench top flow cytometer, the optical engine having a set of lasers, each focused horizontally along an x-axis to a same horizontal position and vertically along a y-axis to a different vertical position along a same excitation plane of a flow cell, a set of optics that separate fluorescence of a same wavelength range into different locations in a focal plane of collection optics according to the different lasers by which the fluorescent light is excited; and a detector that selectively detects light from the different locations thereby distinguishing between fluorescence emitted within the same wavelength range as excited by the different lasers.

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