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公开(公告)号：CL2017001422A1
公开(公告)日：2018-01-05
申请号：CL2017001422
申请日：2017-06-05
Applicant: CELGENE CORP , ARRAY BIOPHARMA INC
Inventor： BURGUESS LAURENCE E , LAIRD ELLEN , HINKLIN RONALD JAY , ALLEN SHELLEY , HICKEN ERIK JAMES , BOYS MARK LAURENCIE , CHICARELLI MARK J , FELL JAY BRADFORD , FISCHER JOHN P , GAUDINO JOHN , KRASER CHRISTOPHER F , ROBINSON JOHN E , TANG TONY P , RIEGER ROBERT ANDREW , PHENEGER JED , SATOH YOSHITAKA , LEFHERIS KATERINA , RAHEJA RAJ K , BENNETT BRYDON L
IPC: A61K31/4985 , A61P29/00 , A61P37/00 , C07D487/04
Abstract: COMPUESTOS DE FORMULA I, Y ESTEREOISÓMEROS Y SALES SOLVATOS FARMACÉUTICAMENTE ACEPTABLES DE ESTOS EN LOS QUE R1 , R2 , R3 Y R4 TIENEN LOS SIGNIFICADOS DADOS EN LA MEMORIA DESCRIPTIVA, SON INHIBIDORES DE UNA O MÁS JAK CINASAS Y SON ÚTILES EN EL TRATAMIENTO DE ENFERMEDADES Y TRASTORNOS RELACIONADOS CON LA JAK CINASA, TALES COMO ENFERMEDADES AUTOINMUNITARIAS, RECHAZO DEL TRASPLANTE DE ÓRGANOS, TEJIDOS Y CÉLULAS, ASÍ COMO TAMBIÉN NEOPLASIAS Y TRASTORNOS HEMATOLÓGICOS Y SUS COMORBILIDADES.
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公开(公告)号：CY1112770T1
公开(公告)日：2016-02-10
申请号：CY121100291
申请日：2012-03-19
Applicant: ARRAY BIOPHARMA INC
Inventor： GRONEBERG ROBERT , BURGESS LAURENCE E , HARVEY DARREN , LAIRD ELLEN , MUNSON MARK , RIZZI JAMES , RODRIGUEZ MARTHA , EARY CHARLES TODD , WATSON DANIEL
IPC: C07D231/40 , A61K31/416 , A61P29/00 , C07D231/56
Abstract: Ηένωσητουτύπου (Ι) καιταφαρμακευτικώςαποδεκτάάλατακαιπροφάρμακάτηςείναιχρήσιμαστηθεραπείακαιπρόληψηδιαφόρωνπαθήσεωνπουδιαμεσολαβούνταιαπόκινάσες.
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公开(公告)号：CA2584866C
公开(公告)日：2014-09-23
申请号：CA2584866
申请日：2005-10-18
Applicant: ARRAY BIOPHARMA INC
Inventor： HANS JEREMY , WALLACE ELI M , ZHAO QIAN , LYSSIKATOS JOSEPH P , AICHER TOM , LAIRD ELLEN , ROBINSON JOHN , ALLEN SHELLEY
IPC: C07D285/12 , A61K31/4245 , A61K31/433 , A61K31/4439 , C07D271/10 , C07D401/12 , C07D417/06
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders (see above formula)
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公开(公告)号：AU2011213738B2
公开(公告)日：2013-05-09
申请号：AU2011213738
申请日：2011-08-18
Applicant: ARRAY BIOPHARMA INC
Inventor： WALLACE ELI , ZHAO QIAN , LYSSIKATOS JOSEPH , HANS JEREMY , AICHER TOM , LAIRD ELLEN , ROBINSON JOHN , ALLEN SHELLLY
IPC: C07D413/04 , A61K31/4245 , A61K31/433 , A61K31/4439 , A61K31/496 , A61K31/675 , A61K38/04 , C07D417/04
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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公开(公告)号：CO6630187A2
公开(公告)日：2013-03-01
申请号：CO12203751
申请日：2012-11-13
Applicant: ARRAY BIOPHARMA INC
Inventor： BOYS MARK L , BURGESS LAURENCE E , GRONEBERG ROBERT , HARVEY DARREN , HUANG LILY , KERCHER TIMOTHY , KRASER CHRSITOPHER F , LAIRD ELLEN , TARLTON EUGENE , ZHAO QIAN
IPC: C07D487/04
Abstract: Los compuestos de la Fórmula I:y estereoisómeros y sales y solvatos de los mismos farmacéuticamente aceptables en los cuales R, R, R, R4, R, R, R, Xy Xtienen los significados dados en la especificación, son inhibidores de una o más cinasas JAK y son útiles en el tratamiento de enfermedades autoinmunitarias, enfermedades inflamatorias, rechazo de órganos, tejidos y células transplantados, así como también trastornos hematolágicos y malignidades y sus comorbilidades.
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Patent Agency Ranking
公开(公告)号：AU2011240808A1
公开(公告)日：2012-11-29
申请号：AU2011240808
申请日：2011-04-11
Applicant: ARRAY BIOPHARMA INC
Inventor： BOYS MARK LAURENCE , BURGESS LAURENCE E , GRONEBERG ROBERT D , HARVEY DARREN M , HUANG LILY , KERCHER TIMOTHY , KRASER CHRISTOPHER F , LAIRD ELLEN , TARLTON EUGENE , ZHAO QIAN
IPC: C07D487/04 , A61K31/519 , A61P29/00 , A61P37/00
Abstract: Compounds of Formula I: (Formula should be inserted here) and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R, R, R, R, R, R, R, X and X have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
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公开(公告)号：PL1981851T3
公开(公告)日：2012-07-31
申请号：PL07762713
申请日：2007-01-26
Applicant: ARRAY BIOPHARMA INC
Inventor： GRONEBERG ROBERT , BURGESS LAURENCE E , HARVEY DARREN , LAIRD ELLEN , MUNSON MARK , RIZZI JAMES , RODRIGUEZ MARTHA , EARY CHARLES TODD , WATSON DANIEL
IPC: C07D231/40 , A61K31/416 , A61P29/00 , C07D231/56
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公开(公告)号：RS52037B
公开(公告)日：2012-04-30
申请号：RSP20110460
申请日：2005-10-18
Applicant: ARRAY BIOPHARMA INC
Inventor： WALLACE ELI M , ZHAO QIAN , LYSSIKATOS JOSEPH P , LAIRD ELLEN , ROBINSON JOHN , ALLEN SHELLEY , HANS JEREMY , AICHER TOM
IPC: A61K31/4245 , C07D413/00 , C07D417/00
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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公开(公告)号：SI1809280T1
公开(公告)日：2011-11-30
申请号：SI200531391
申请日：2005-10-18
Applicant: ARRAY BIOPHARMA INC
Inventor： HANS JEREMY , WALLACE ELI M , ZHAO QIAN , LYSSIKATOS JOSEPH P , AICHER TOM , LAIRD ELLEN , ROBINSON JOHN , ALLEN SHELLEY
IPC: A61K31/4245 , C07D413/00 , C07D417/00
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公开(公告)号：DK1809280T3
公开(公告)日：2011-10-31
申请号：DK05819172
申请日：2005-10-18
Applicant: ARRAY BIOPHARMA INC
Inventor： HANS JEREMY , ALLEN SHELLEY , WALLACE ELI M , ZHAO QIAN , LYSSIKATOS JOSEPH P , AICHER TOM , LAIRD ELLEN , ROBINSON JOHN
IPC: A61K31/4245 , C07D413/00 , C07D417/00
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