公开(公告)号：SI2651939T1

公开(公告)日：2015-07-31

申请号：SI201130508

申请日：2011-12-13

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  DELISLE ROBERT KIRK ,  HICKEN ERIK JAMES ,  KENNEDY APRIL L ,  MARESKA DAVID A ,  MARMSATER FREDRIK P ,  MUNSON MARK C ,  NEWHOUSE BRAD ,  RAST BRYSON ,  RIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN

IPC: C07D471/00 ,  A61K31/00 ,  A61P35/00

公开(公告)号：DK2651939T3

公开(公告)日：2015-06-01

申请号：DK11808427

申请日：2011-12-13

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  DELISLE ROBERT KIRK ,  HICKEN ERIK JAMES ,  KENNEDY APRIL L ,  MARESKA DAVID A ,  MARMSATER FREDRIK P ,  MUNSON MARK C ,  NEWHOUSE BRAD ,  RAST BRYSON ,  RIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

公开(公告)号：AU2010333752B2

公开(公告)日：2014-12-04

申请号：AU2010333752

申请日：2010-12-20

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  BRADLEY MICHAEL F ,  DELISLE ROBERT KIRK ,  HENNINGS D DAVID ,  KENNEDY APRIL L ,  MARMSATER FREDRIK P ,  MEDINA MATTHEW DAVID ,  MUNSON MARK C ,  RAST BRYSON ,  RIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN

IPC: C07D471/04 ,  A61K31/437 ,  A61K31/4985 ,  A61P9/00 ,  A61P19/08 ,  A61P29/00 ,  A61P35/00 ,  C07D519/00

Abstract: Compounds of Formula (I): and pharmaceutically acceptable salts thereof in which R

公开(公告)号：SMT201400142B

公开(公告)日：2014-11-10

申请号：SM201400142

申请日：2014-09-30

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  BRADLEY MICHAEL F ,  DELISLE ROBERT KIRK ,  HENNINGS DAVID D ,  KENNEDY APRIL L ,  MARMSATER FREDRIK P ,  MEDINA MATTHEW DAVID ,  MUNSON MARK C ,  RAST BRYSON ,  PIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN

Abstract: Compounds of Formula (I): and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4 and R5 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases and pain.

公开(公告)号：HRP20140770T1

公开(公告)日：2014-11-07

申请号：HRP20140770

申请日：2014-08-18

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  BRADLEY MICHAEL F ,  DELISLE ROBERT KIRK ,  HENNINGS D DAVID ,  KENNEDY APRIL L ,  MARMSATER FREDRIK P ,  MEDINA MATTHEW DAVID ,  MUNSON MARK C ,  RAST BRYSON ,  RIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN

IPC: C07D471/04 ,  A61K31/437 ,  A61K31/4985 ,  A61P9/00 ,  A61P19/08 ,  A61P29/00 ,  A61P35/00 ,  C07D519/00

公开(公告)号：UY33801A

公开(公告)日：2013-06-28

申请号：UY33801

申请日：2011-12-13

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK KAURENCE ,  DELISLE ROBERT KIRK ,  HICKEN ERIK JAMES ,  KENNEDY APRIL L ,  MARESKA DAVID A ,  MARMSATER FREDRIK P ,  MUNSON MARK C ,  BRAD NEWHOUSE ,  BRYSON RAST ,  RIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  QUTAN ZHAO

IPC: A61P17/02 ,  A61K31/416 ,  A61K31/4188 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07D231/56 ,  C07D487/04

Abstract: Compuestos de Fórmula I y sales farmacéuticamente aceptables del mismo donde R', R2, R3, R4, R5 y R6 tienen los significados dados en la memoria descriptiva, son inhibidores de cFMS y son útiles en el tratamiento de fibrosis, enfermedades relacionadas con los huesos, cáncer, trastornos autoinmunes, enfermedades inflamatorias, enfermedades cardiovasculares, dolor y quemaduras en un mamífero.

公开(公告)号：CR20120389A

公开(公告)日：2012-08-16

申请号：CR20120389

申请日：2012-07-20

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  BRADLEY MICHAEL F ,  DELISLE ROBERT KIRK ,  HENNINGS D DAVID ,  KENNEDY APRIL L ,  MARMSATER FREDRIK P ,  MEDINA MATTHEW DAVID ,  MUNSON MARK C ,  RAST BRYSON ,  RIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN

IPC: A61K31/437 ,  A61K31/4985 ,  A61P9/00 ,  A61P19/08 ,  A61P29/00 ,  A61P35/00 ,  C07D471/04 ,  C07D519/00

Abstract: Compuestos de la formula I y sus sales farmacéuticamente aceptables, en donde R1, R2, R3, R4 y R5 tienen los significados dados en la memoria descriptiva, son inhibidores de cFMS y son de utilidad en el tratamiento de enfermedades relacionadas con los huesos, cáncer, trastornos autoinmunes, enfermedades inflamatorias, enfermedades cardiovasculares y dolor.

公开(公告)号：AU2010333752A1

公开(公告)日：2012-08-09

申请号：AU2010333752

申请日：2010-12-20

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  BRADLEY MICHAEL F ,  DELISLE ROBERT KIRK ,  HENNINGS D DAVID ,  KENNEDY APRIL L ,  MARMSATER FREDRIK P ,  MEDINA MATTHEW DAVID ,  MUNSON MARK C ,  RAST BRYSON ,  RIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN

IPC: C07D471/04 ,  A61K31/437 ,  A61K31/4985 ,  A61P9/00 ,  A61P19/08 ,  A61P29/00 ,  A61P35/00 ,  C07D519/00

Abstract: Compounds of Formula (I): and pharmaceutically acceptable salts thereof in which R, R, R, R and R have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases and pain.

公开(公告)号：CA2821712A1

公开(公告)日：2012-06-21

申请号：CA2821712

申请日：2011-12-13

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  DELISLE ROBERT KIRK ,  HICKEN ERIK JAMES ,  KENNEDY APRIL L ,  MARESKA DAVID A ,  MARMSATER FREDRIK P ,  MUNSON MARK C ,  NEWHOUSE BRAD ,  RAST BRYSON ,  RIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.

公开(公告)号：CA3116561C

公开(公告)日：2023-09-12

申请号：CA3116561

申请日：2019-10-17

Applicant: ARRAY BIOPHARMA INC

Inventor： BLAKE JAMES F ,  BOYS MARK LAURENCE ,  CHICARELLI MARK JOSEPH ,  COOK ADAM ,  ELSAYED MOHAMED S A ,  FELL JAY B ,  FISCHER JOHN P ,  HINKLIN RONALD JAY ,  MCNULTY OREN T ,  MEJIA MACEDONIO J ,  RODRIGUEZ MARTHA E ,  WONG CHRISTINA E

IPC: C07D401/04 ,  A61K31/498 ,  A61K31/4985 ,  A61P35/00 ,  C07D471/04 ,  C07D519/00

Abstract: Compounds of Formula la or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases in the view of their ability to inhibit SHP2. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.