公开(公告)号：DE102005011988A1

公开(公告)日：2006-11-16

申请号：DE102005011988

申请日：2005-03-14

Applicant: BASF AG

Inventor： BARG HEIKO ,  SUBKOWSKI THOMAS ,  LEMAIRE HANS-GEORG ,  BOLLSCHWEILER CLAUS ,  PTOCK ARNE

IPC: A61K8/64 ,  A61K47/42 ,  A61Q5/00 ,  A61Q5/12

公开(公告)号：DE102004047409A1

公开(公告)日：2006-03-30

申请号：DE102004047409

申请日：2004-09-28

Applicant: BASF AG

Inventor： KAROS MARVIN ,  SUBKOWSKI THOMAS ,  LEMAIRE HANS-GEORG ,  BOLLSCHWEILER CLAUS ,  NUESLEIN BERNHARD ,  FISCHER REINHARD

IPC: C12Q1/68

公开(公告)号：AU2005247092A1

公开(公告)日：2005-12-08

申请号：AU2005247092

申请日：2005-05-24

Applicant: BASF AG

Inventor： BARG HEIKO ,  PTOCK ARNE ,  BOLLSCHWEILER CLAUS ,  LEMAIRE HANS-GEORG ,  SUBKOWSKI THOMAS

IPC: A61K8/64 ,  A61Q1/02 ,  A61Q3/00 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/04 ,  A61Q19/10 ,  C07K14/47

Abstract: The invention relates to novel keratin-binding protein active substances, and also to the production and use thereof. Particularly suitable keratin-binding polypeptides are sequences which are contained in human desmoplakin or are derived therefrom by altering the human desmoplakin polypeptide sequences such as amino acid insertions, substitutions or deletions. The polypeptide sequences of the human desmoplakin is represented in SEQ ID NO: 1. A suitable keratin-binding domain (domain B) is the polypeptide sequence SEQ ID NO: 1, position 2193 2481, in addition to functional equivalents thereof. An additional keratin-binding domain (domain C) is the polypeptide sequence SEQ ID NO: 1, position 2606 2871 and the functional equivalents thereof.

公开(公告)号：CZ20013678A3

公开(公告)日：2002-07-17

申请号：CZ20013678

申请日：2000-03-29

Applicant: BASF AG

Inventor： ZECHEL JOHANN-CHRISTIAN ,  KLING ANDREAS ,  GENESTE HERVE ,  LANGE UDO ,  LAUTERBACH AMULF ,  GRAEF CLAUDIA ISABELLA ,  SUBKOWSKI THOMAS ,  SADOWSKI JENS ,  HORNBERGER WILFRIED

IPC: C07D239/36 ,  A61K31/505 ,  A61K45/00 ,  A61K45/06 ,  A61P3/14 ,  A61P7/02 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P17/02 ,  A61P17/06 ,  A61P19/08 ,  A61P19/10 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  C07D239/34 ,  C07D239/60 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D239/32 ,  C07D239/70 ,  C07D239/46 ,  A61K31/506 ,  A61K31/541 ,  A61K31/517 ,  A61P9/00 ,  A61P7/00 ,  A61P19/00 ,  A61P31/00

Abstract: The invention relates to novel compounds which bind to integrin receptors, to their preparation, to their use as integrin receptor ligands and for treating diseases, to pharmaceutical preparations comprising these compounds, and to pharmaceutical preparations comprising at least one other active compound.

公开(公告)号：BG106040A

公开(公告)日：2002-05-31

申请号：BG10604001

申请日：2001-10-23

Applicant: BASF AG

Inventor： KLING ANDREAS ,  LANGE UDO ,  LAUTERBACH ARNULF ,  GENESTE HERVE ,  SUBKOWSKI THOMAS ,  ZECHEL JOHANN-CHRISTIA ,  GRAEF CLAUDIA I ,  HORNBERGER WILFRIED

IPC: C12N9/99 ,  A61K31/27 ,  A61K31/381 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4406 ,  A61K31/443 ,  A61K31/4439 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61P3/10 ,  A61P3/14 ,  A61P7/02 ,  A61P9/00 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P13/12 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P43/00 ,  C07C275/42 ,  C07D207/34 ,  C07D213/56 ,  C07D249/14 ,  C07D263/34 ,  C07D263/48 ,  C07D277/20 ,  C07D277/48 ,  C07D277/56 ,  C07D307/68 ,  C07D333/38 ,  C07D333/40 ,  C07D401/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07K5/02 ,  C07K5/023 ,  A61K38/04 ,  A61K31/33

Abstract: The invention relates to new compounds which bind to integrin receptors, as well as to their production, their use as integrin receptor antagonists and for the treatment of diseases, pharmaceutical preparations containing said compounds and pharmaceutical preparations containing at least one other active compound. 28 claims

公开(公告)号：DE10028575A1

公开(公告)日：2002-03-14

申请号：DE10028575

申请日：2000-06-14

Applicant: BASF AG

Inventor： GENESTE HERVE ,  KLING ANDREAS ,  LANGE UDO ,  LAUTERBACH ARNULF ,  SEITZ WERNER ,  GRAEF CLAUDIA ISABELLA ,  SUBKOWSKI THOMAS ,  HORNBERGER WILFRIED

IPC: A61K45/06 ,  A61P9/00 ,  C07D403/04 ,  C07D401/04 ,  C07D409/04 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  A61K31/55

Abstract: The invention relates to novel compounds which bind to integrin receptors, their use as ligands of integrin receptors, in particular as ligands of the αv&bgr;3 integrin receptor, and pharmaceutical preparations comprising these compounds.

公开(公告)号：AU9175601A

公开(公告)日：2002-02-25

申请号：AU9175601

申请日：2001-08-09

Applicant: BASF AG

Inventor： GENESTE HERVE ,  KLING ANDREAS ,  LAUTERBACH ARNULF ,  GRAEF CLAUDIA ISABELLA ,  SUBKOWSKI THOMAS ,  HORNBERGER WILFRIED

IPC: C07D401/12 ,  A61K31/55 ,  A61K45/00 ,  A61K45/06 ,  A61P3/10 ,  A61P3/14 ,  A61P5/18 ,  A61P7/02 ,  A61P7/10 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P9/14 ,  A61P13/12 ,  A61P17/02 ,  A61P17/06 ,  A61P19/00 ,  A61P19/02 ,  A61P19/10 ,  A61P29/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P35/04 ,  A61P41/00 ,  A61P43/00 ,  C07D277/28 ,  C07D403/12 ,  C07D471/04 ,  C07D487/04

公开(公告)号：CA2379977A1

公开(公告)日：2001-02-15

申请号：CA2379977

申请日：2000-08-01

Applicant: BASF AG

Inventor： HORNBERGER WILFRIED ,  LANGE UDO ,  GENESTE HERVE ,  KLING ANDREAS ,  SUBKOWSKI THOMAS ,  HOLZENKAMP UTA ,  MACK HELMUT ,  GRAEF CLAUDIA ISABELLA ,  LAUTERBACH ARNULF ,  LAUX VOLKER ,  SADOWSKI JENS

IPC: A61K31/4402 ,  A61K31/55 ,  A61K31/5513 ,  A61P3/14 ,  A61P5/18 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P9/14 ,  A61P13/12 ,  A61P17/02 ,  A61P17/06 ,  A61P19/00 ,  A61P19/08 ,  A61P19/10 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D213/74 ,  C07D223/20 ,  C07D243/38 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D409/12 ,  C07D409/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D495/14 ,  C07D221/00 ,  C07D223/00 ,  C07D233/00 ,  C07D333/00 ,  C07D491/04 ,  C07D213/73

Abstract: The invention relates to novel compounds of formula (I) which bind to integr in receptors, wherein G and L have the following meaning: L is a structural element of formula IL, wherein T represents a COOH group or a radical that c an be hydrolyzed to obtain COOH and U- represents (XL)a-(CRL1RL2)b-, -CRL1=CRL2 -, ethylene or =CRL1-, wherein a is 0 or 1; b is 0, 1 or 2; XL represents CRL3RL4, NRL5, oxygen or sulfur and G is a structural element of formula IG, wherein the insertion of structural element G can occur in both orientations and XO represents nitrogen or CRG1. The invention also relates to the production of said compounds and to their use as medicaments.

公开(公告)号：CA2371604A1

公开(公告)日：2000-11-09

申请号：CA2371604

申请日：2000-04-17

Applicant: BASF AG

Inventor： GENESTE HERVE ,  LANGE UDO ,  KLING ANDREAS ,  LAUTERBACH ARNULF ,  GRAEF CLAUDIA ISABELLA ,  HORNBERGER WILFRIED ,  ZECHEL JOHANN-CHRISTIAN ,  SUBKOWSKI THOMAS

IPC: C12N9/99 ,  A61K31/27 ,  A61K31/381 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4406 ,  A61K31/443 ,  A61K31/4439 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61P3/10 ,  A61P3/14 ,  A61P7/02 ,  A61P9/00 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P13/12 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P43/00 ,  C07C275/42 ,  C07D207/34 ,  C07D213/56 ,  C07D249/14 ,  C07D263/34 ,  C07D263/48 ,  C07D277/20 ,  C07D277/48 ,  C07D277/56 ,  C07D307/68 ,  C07D333/38 ,  C07D333/40 ,  C07D401/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07K5/02 ,  C07K5/023 ,  A61K38/04 ,  A61K31/33

Abstract: The invention relates to new compounds which bind to integrin receptors, as well as to their production, their use as integrin receptor antagonists and for the treatment of diseases, pharmaceutical preparations containing said compounds and pharmaceutical preparations containing at least one other acti ve compound.

公开(公告)号：CZ200057A3

公开(公告)日：2000-05-17

申请号：CZ200057

申请日：1998-06-23

Applicant: BASF AG

Inventor： SUBKOWSKI THOMAS ,  HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61K39/395 ,  A61P7/02 ,  A61P7/04 ,  A61P39/02 ,  C07K16/00 ,  C07K16/40 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  G01N33/573

Abstract: Ancrod-specific monoclonal antibodies, antibody fragments, mixtures or derivatives thereof are used in pharmaceutical preparations and in diagnosis. Cells which express these antibodies, antibody fragments, mixtures or derivatives thereof are also disclosed.