公开(公告)号：DE19940889A1

公开(公告)日：2001-03-01

申请号：DE19940889

申请日：1999-08-27

Applicant: BASF AG

Inventor： WUENSCH THOMAS ,  WESTENFELDER HORST

IPC: A61K8/27 ,  A61K8/49 ,  A61Q17/04 ,  A61K7/40

Abstract: A cosmetic or pharmaceutical composition comprises at least one 1,3,5-triazine derivatives (I) (0.1-10 wt. %) and zinc oxide (0.1-15 wt. %). A cosmetic or pharmaceutical composition comprises at least one 1,3,5-triazine derivatives of formula (I) (0.1-10 wt. %) and zinc oxide (0.1-15 wt. %). R -R = 1-20C alkyl, aryl or heteroaryl (all optionally substituted); X = O or NR ; and R = 1-20C alkyl, aryl, heteroaryl (all optionally substituted) or H.

公开(公告)号：DE59606192D1

公开(公告)日：2001-01-11

申请号：DE59606192

申请日：1996-08-08

Applicant: BASF AG

Inventor： JACHOW HARALD ,  SCHWAB EKKEHARD ,  KORMANN CLAUDIUS ,  DAUSCH WILMA ,  SPERLING KARIN ,  WESTENFELDER HORST

IPC: A61K8/19 ,  A61K8/00 ,  A61K8/04 ,  A61K8/26 ,  A61K8/29 ,  A61Q17/04 ,  A61Q19/00 ,  C01G23/053 ,  C09C1/36 ,  A61K7/00

Abstract: PCT No. PCT/EP96/03504 Sec. 371 Date Feb. 12, 1998 Sec. 102(e) Date Feb. 12, 1998 PCT Filed Aug. 8, 1996 PCT Pub. No. WO97/07058 PCT Pub. Date Feb. 27, 1997Titanium dioxide pigments are obtainable by complete hydrolysis of a hydrolyzable titanium compound at from 0 to 100 DEG C. with intensive stirring and with setting of a pH in the range from 3 to 8 and maintenance of this pH within a range of 0.3 units. The titanium dioxide pigments can be employed for the production of cosmetic preparations and medicaments.

公开(公告)号：DE19926779A1

公开(公告)日：2000-12-14

申请号：DE19926779

申请日：1999-06-11

Applicant: BASF AG

Inventor： PRECHTL FRANZ ,  HABECK THORSTEN ,  WESTENFELDER HORST ,  WUENSCH THOMAS

IPC: A61K8/00 ,  C07D311/58 ,  A61K8/30 ,  A61K8/35 ,  A61K8/368 ,  A61K8/37 ,  A61K8/40 ,  A61K8/49 ,  A61K47/08 ,  A61K47/14 ,  A61K47/16 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07C255/34 ,  C07C261/02 ,  C07D311/04 ,  C07D495/04 ,  C08K5/07 ,  C08K5/1545 ,  C08K5/20 ,  C08K5/315 ,  C08K5/3435 ,  C08K5/42 ,  C08L101/00 ,  C09K3/00 ,  C09K15/06 ,  C09K15/16 ,  C09K15/20 ,  C09K15/30 ,  A61K7/40

Abstract: 6-Vinyl-3,4-dihydro-2H-1-benzopyran, 6-vinyl-1,2,3,4-tetrahydronaphthalene or 6-vinyl-1,2,3,4-tetrahydroquinoline derivatives (I) are used as photostable ultraviolet (UV) filters in cosmetic and pharmaceutical compositions for protecting human skin and hair against solar radiation. Compounds of formula (I) are used as photostable UV filters in cosmetic and pharmaceutical compositions for protecting human skin and hair against solar radiation: X = O, CO, optionally substituted imino or CR9R10; Y = CO or CR9R10; R1, R2 = CN, alkanoyl, aroyl, alkoxycarbonyl, aryloxycarbonyl, optionally substituted carbamoyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl or optionally substituted sulfamoyl; R3 = H, CN, OH, COOH, CONH2, Q, OQ, CONHQ or COOQ; Q = 1-20C alkyl or 5-20C aryl; R4 = H, OH, NH2, Q or OQ; R5-R10 = H or 1-20C alkyl, or R7+R8 can be oxo. Independent claims are also included for the following: (1) use of (I) as photoprotective agents for stabilizing plastics; (2) cosmetic compositions for protecting human epidermis and hair against UV light of wavelength 280-400 nm, comprising (I) in a carrier; and (3) new compounds of formula (II): R3' = lower alkyl; R4' = H, lower alkyl or lower alkoxy; X' = O or CRR; R = H or lower alkyl.

公开(公告)号：DE19917906A1

公开(公告)日：2000-10-26

申请号：DE19917906

申请日：1999-04-20

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  PRECHTL FRANK ,  WUENSCH THOMAS ,  WESTENFELDER HORST ,  HAREMZA SYLKE ,  BACH THORSTEN ,  SPIEGEL ANJA

IPC: C07D295/14 ,  A61K8/00 ,  A61K8/41 ,  A61K8/44 ,  A61K8/49 ,  A61K31/136 ,  A61K31/196 ,  A61K31/24 ,  A61K31/40 ,  A61P17/16 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07C225/00 ,  C07C225/22 ,  C07C229/52 ,  C07D295/10 ,  C07D295/112 ,  C09K3/00 ,  A61K7/42

Abstract: Amino-substituted hydroxybenzophenones (I) are used as photostable UV filters in cosmetic and pharmaceutical compositions for protecting human skin or hair against solar radiation, optionally in combination with other UV absorbers. Amino-substituted hydroxybenzophenones of formula (I) are used as photostable UV filters in cosmetic and pharmaceutical compositions for protecting human skin or hair against solar radiation, optionally in combination with other UV absorbers. [Image] R1>, R2>H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl or 3-10C cycloalkenyl, or NR1>R2> is a 5- or 6-membered ring; R3>, R4>1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl, nitrile, carboxylate, sulfonate or ammonium; X : H, COOR5> or CONR6>R7>; R5>-R7>H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, (YO)oZ or aryl; Y : (CH2)x or CH(Me)CH2; x : 2-4; Z : Et, n-Pr, n-Bu or i-Pr; m : 0-3; n : 0-4; o : 1-20. Independent claims are also included for: (1) use of (I) as UV stabilizers in cosmetic and pharmaceutical compositions; (2) cosmetic and pharmaceutical compositions for protecting human skin or hair against UV light of wavelength 280-400 nm, comprising compounds (I) in a carrier, optionally in combination with other UV absorbers.

公开(公告)号：AU2886900A

公开(公告)日：2000-10-26

申请号：AU2886900

申请日：2000-04-18

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  PRECHTL FRANK ,  WUENSCH THOMAS ,  WESTENFELDER HORST ,  HAREMZA SYLKE ,  BACH THORSTEN ,  SPIEGEL ANJA

IPC: C07D295/14 ,  A61K8/00 ,  A61K8/41 ,  A61K8/44 ,  A61K8/49 ,  A61K31/136 ,  A61K31/196 ,  A61K31/24 ,  A61K31/40 ,  A61P17/16 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07C225/00 ,  C07C225/22 ,  C07C229/52 ,  C07D295/10 ,  C07D295/112 ,  C09K3/00 ,  A61K7/44 ,  A61P43/00

Abstract: Amino-substituted hydroxybenzophenones (I) are used as photostable UV filters in cosmetic and pharmaceutical compositions for protecting human skin or hair against solar radiation, optionally in combination with other UV absorbers. Amino-substituted hydroxybenzophenones of formula (I) are used as photostable UV filters in cosmetic and pharmaceutical compositions for protecting human skin or hair against solar radiation, optionally in combination with other UV absorbers. [Image] R1>, R2>H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl or 3-10C cycloalkenyl, or NR1>R2> is a 5- or 6-membered ring; R3>, R4>1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl, nitrile, carboxylate, sulfonate or ammonium; X : H, COOR5> or CONR6>R7>; R5>-R7>H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, (YO)oZ or aryl; Y : (CH2)x or CH(Me)CH2; x : 2-4; Z : Et, n-Pr, n-Bu or i-Pr; m : 0-3; n : 0-4; o : 1-20. Independent claims are also included for: (1) use of (I) as UV stabilizers in cosmetic and pharmaceutical compositions; (2) cosmetic and pharmaceutical compositions for protecting human skin or hair against UV light of wavelength 280-400 nm, comprising compounds (I) in a carrier, optionally in combination with other UV absorbers.

公开(公告)号：DE19857127A1

公开(公告)日：2000-06-15

申请号：DE19857127

申请日：1998-12-11

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  WUENSCH THOMAS ,  WESTENFELDER HORST

IPC: A61K8/00 ,  A61K8/40 ,  A61Q17/00 ,  A61Q17/04 ,  C07C67/343 ,  C07C69/618 ,  C07C253/30 ,  C07C255/41 ,  C09K3/00 ,  C07C255/23 ,  C07F9/38 ,  C07C233/09 ,  C07C235/76 ,  A61K7/40

Abstract: New oligomeric 4,4-diarylbutadiene carboxylic acid ester or amide sunscreen compounds. Oligomeric 4,4-diarylbutadiene carboxylic acid esters or amides of formula (I) are new. R1, R2 = H; aliphatic-, cycloaliphatic-, aromatic- or araliphatic- group; or carboxylate, sulfonate or ammonium; R3 = aliphatic, cycloaliphatic, aromatic, araliphatic or heterocyclic group; carbonyl, sulfonyl, phosphonyl, carboxylic acid ester or CN; Y = O or N(R4); R4 = H or aliphatic-, cycloaliphatic-, aromatic-,araliphatic or heterocyclic group; m = 2-10; n = 1-3 X = the residue of a polyol with 2-10 OH groups (corresponding to m). Am Independent claim is included for preparation of (I).

公开(公告)号：DE19756778A1

公开(公告)日：1999-06-24

申请号：DE19756778

申请日：1997-12-19

Applicant: BASF AG

Inventor： HABECK THORSTEN DR ,  HAREMZA SYLKE DR ,  TRAUTH HUBERT ,  SCHEHLMANN VOLKER DR ,  WESTENFELDER HORST

IPC: A61K8/49 ,  A61K8/00 ,  A61K31/4035 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07D209/46 ,  C08K5/3417 ,  C08L101/00 ,  C09D7/12 ,  C09K3/00 ,  C09K15/30 ,  A61K31/405

Abstract: Use of isoindolinone derivatives of formula (I) as stabilizers for organic materials is new, where: R = H, COOR , COR , CONR R , CN, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, aryl or heteroaryl (optionally substituted); R = COOR , COR , CONR R or CN; or R +R = 7-10C bicycloalkyl or 7-10C bicycloalkenyl; R = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl (optionally substituted) or a water-solubilizing carboxylate, sulfonate or alkylammonium group; R and R = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, aryl or heteroaryl (optionally substituted). An Independent claim is included for compounds (I) as medicaments.

公开(公告)号：DE19755649A1

公开(公告)日：1999-06-17

申请号：DE19755649

申请日：1997-12-15

Applicant: BASF AG

Inventor： HABECK THORSTEN DR ,  HAREMZA SYLKE DR ,  SCHEHLMANN VOLKER DR ,  WESTENFELDER HORST ,  WUENSCH THOMAS DR ,  DROEGEMUELLER MICHAEL DR ,  BOMM VOLKER DR

IPC: A61K8/35 ,  A61K8/37 ,  A61K8/42 ,  A61Q17/04 ,  C07C69/602 ,  C07C69/618 ,  C07C69/738 ,  C07C233/11 ,  C07C235/32 ,  C07C235/34 ,  A61K7/42 ,  A61K7/48 ,  C07C255/23

Abstract: Use of 4,4-diarylbutadienes (I) as photostable UV filters in cosmetics for protecting the skin and hair from the sun's rays. The use of 4,4-diarylbutadiene derivatives of formula (I) as a cosmetic preparation is new: Where the diene system is Z,Z; Z,E; E,Z or E,E; R1, R2 = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl (optionally substituted by carboxylate, sulfonate or ammonium residues); R3 = H, COOR5, COR5, CONR5,R6, CN, O=S(R5)=O, O=S(OR5)=O, R7OP(OR8)=O, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); R4 = COOR6, COR6, CONR5,R6, CN, O=S(R6)=O, O=S(OR6)=O, R7OP(OR8)=O, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); R5-R8 = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); and n = 1-3; where R3-R8 may in each case together with the C atoms to which they are bonded, form a 5- or 6-membered ring which may be further fused.

公开(公告)号：ITMI960497U3

公开(公告)日：1998-01-12

申请号：ITMI960497

申请日：1996-07-12

Applicant: BASF AG

Inventor： KANDZIA CHRISTOF ,  WESTENFELDER HORST

IPC: C09K3/00 ,  A61K8/37 ,  A61K8/67 ,  A61Q17/04 ,  C09K15/08

公开(公告)号：DE4325158A1

公开(公告)日：1995-02-02

申请号：DE4325158

申请日：1993-07-28

Applicant: BASF AG

Inventor： SCHADE CHRISTIAN DR ,  WESTENFELDER HORST ,  SPERLING-VIETMEIER KARIN DR ,  SANNER AXEL DR ,  WEKEL HANS-ULRICH DR

IPC: A61K47/30 ,  A61K8/06 ,  A61K8/72 ,  A61K8/81 ,  A61K9/113 ,  A61K47/32 ,  C08F2/08 ,  C08F20/04 ,  C08F20/06 ,  C08F220/00 ,  C08F220/06 ,  C08F220/08 ,  C08F222/00 ,  C08K3/20 ,  C09K23/00 ,  C09K23/52 ,  B01F17/52 ,  A61K7/00

Abstract: The use of crosslinked copolymers obtainable by precipitation polymerization of monomer mixtures comprising(a) monoethylenically unsaturated C3-C8-carboxylic acids, their anhydrides or mixtures of said carboxylic acids and anhydrides,(b) compounds with at least 2 non-conjugated ethylenic double bonds in the molecule as crosslinkers and, where appropriate,(c) other monoethylenically unsaturated monomers which are copolymerizable with monomers (a) and (b),in the presence of free-radical polymerization initiators and from 0.1 to 20% by weight, based on the monomers used, of saturated, nonionic surface-active compounds, as stabilizer in oil-in-water emulsions in amounts of from 0.01 to 5% of the weight of the emulsions, and cosmetic and pharmaceutical formulations based on oil-in-water emulsions which contain said precipitation polymers.