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公开(公告)号：AU714717B2
公开(公告)日：2000-01-06
申请号：AU2294097
申请日：1997-04-04
Applicant: BASF AG
Inventor： RIECHERS HARTMUT , KLINGE DAGMAR , AMBERG WILHELM , KLING ANDREAS , HILLEN HEINZ , UNGER LILIANE , ELGER BERND
IPC: C07D251/30 , A61K31/00 , A61K31/505 , A61K31/517 , A61K31/529 , A61K31/53 , A61P7/00 , A61P9/00 , A61P9/02 , A61P9/12 , A61P13/00 , A61P13/08 , A61P13/12 , C07D239/34 , C07D239/46 , C07D239/52 , C07D239/60 , C07D239/70 , C07D251/48 , C07D403/12 , C07D491/044
Abstract: The invention relates to carboxylic acid derivatives of the formulawhere the radicals have the meanings defined in the description, to the preparation of these compounds and to their use as drugs.
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公开(公告)号：NO996268L
公开(公告)日：1999-12-17
申请号：NO996268
申请日：1999-12-17
Applicant: BASF AG
Inventor： AMBERG WILHELM , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , HERGENROEDER STEFAN , RASCHACK MANFRED , UNGER LILIANE
IPC: C07D251/16 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/53 , A61P7/02 , A61P9/02 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/08 , A61P13/12 , A61P25/06 , A61P35/00 , A61P35/04 , A61P43/00 , C07C247/12 , C07D213/68 , C07D237/14 , C07D237/16 , C07D239/34 , C07D239/52 , C07D239/56 , C07D239/60 , C07D239/70 , C07D239/80 , C07D239/95 , C07D241/18 , C07D251/22 , C07D251/34 , C07D251/52 , C07D253/06 , C07D403/12 , C07D491/048
Abstract: The invention relates to carboxylic acid derivatives of formula (I) wherein the constituents have the meaning given in the description. The invention also relates to the production of said derivatives, and to their use as endothelin receptor antagonists.
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公开(公告)号：BG102868A
公开(公告)日：1999-11-30
申请号：BG10286898
申请日：1998-10-26
Applicant: BASF AG
Inventor： KLINGE DAGMAR , AMBERG WILHELM , BAUMANN ERNST , KLING ANDREAS , RIECHERS HARTMUT , UNGER LILIANE , RASCHACK MANFRED , HERGENRODER STEFAN , SCHULT SABINE
IPC: A61K31/00 , A61K31/505 , A61K31/517 , A61P5/42 , A61P9/10 , A61P13/00 , A61P13/12 , C07D217/22 , C07D239/34 , C07D239/48 , C07D239/52 , C07D239/56 , C07D239/60 , C07D239/70 , C07D239/80 , C07D239/96 , C07D251/20 , C07D251/22 , C07D251/30 , C07D251/38 , C07D251/52 , C07D403/12 , C07D405/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/044
Abstract: The invention relates to derivatives of caboxylic acids withthe formulawhere the radicals have the meanings listed in the description, tothe preparation of these compounds and to their application asmedicamentous forms11 claims
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公开(公告)号：BG102814A
公开(公告)日：1999-11-30
申请号：BG10281498
申请日：1998-10-05
Applicant: BASF AG
Inventor： RIECHERS HARTMUT , KLINGE DAGMAR , AMBERG WILHELM , KLING ANDREAS , HILLEN HEINZ , UNGER LILIANE , ELGER BERND
IPC: C07D251/30 , A61K31/00 , A61K31/505 , A61K31/517 , A61K31/529 , A61K31/53 , A61P7/00 , A61P9/00 , A61P9/02 , A61P9/12 , A61P13/00 , A61P13/08 , A61P13/12 , C07D239/34 , C07D239/46 , C07D239/52 , C07D239/60 , C07D239/70 , C07D251/48 , C07D403/12 , C07D491/044
Abstract: The invention relates to derivatives of carboxylic acids withthe formulawhere the radicals have the meanings listed in the description, aswell to the preparation of these compounds and their applicationas medicamentous forms.9 claims
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公开(公告)号：DE59603295D1
公开(公告)日：1999-11-11
申请号：DE59603295
申请日：1996-07-12
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANSSEN BERND , ULRICH KARL , KLING ANDREAS , MUELLER STEFAN , RITTER KURT , ZIERKE THOMAS
IPC: C07K1/02 , C07K1/12 , C07K5/06 , C07K5/078 , C07K5/08 , C07K5/083 , C07K5/10 , C07K5/103 , C07K7/06
Abstract: PCT No. PCT/EP96/03073 Sec. 371 Date Jan. 13, 1998 Sec. 102(e) Date Jan. 13, 1998 PCT Filed Jul. 12, 1996 PCT Pub. No. WO97/05162 PCT Pub. Date Feb. 13, 1997A process for preparing pentapeptides of the formula I where A and R1-R3 have the stated meanings, comprises assembling the pentapeptide stepwise starting from a prolinamide of the formula II where R1 and R2 have the abovementioned meanings, and eliminating the group -NR1R2 by hydrolysis where appropriate the peptide obtained in this way.
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Patent Agency Ranking
公开(公告)号：AU3408799A
公开(公告)日：1999-09-20
申请号：AU3408799
申请日：1999-02-25
Applicant: BASF AG
Inventor： AMBERG WILHELM , JANSEN ROLF , KLINGE DAGMAR
IPC: C07D239/38 , A61K31/19 , A61K31/215 , A61K31/357 , A61K31/36 , A61K31/505 , A61P43/00 , C07C319/14 , C07C323/56 , C07D239/56 , C07D239/60 , C07D317/62 , C07C323/00
Abstract: A process for preparing endothelin receptor antagonists of the sulfanyl type of the general formula Iby nucleophilic reaction of a carboxylic acid derivative of the formula II with a sulfide of the formula IIIto give endothelin receptor antagonists of the formula I.
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公开(公告)号：AU2624799A
公开(公告)日：1999-09-20
申请号：AU2624799
申请日：1999-02-25
Applicant: BASF AG
Inventor： AMBERG WILHELM , JANSEN ROLF , KLINGE DAGMAR , RIECHERS HARTMUT , HERGENRODER STEFAN , RASCHACK MANFRED , UNGER LILIANE
IPC: C07D251/22 , A61K31/192 , A61K31/216 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/53 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/08 , A61P13/12 , A61P35/00 , A61P43/00 , C07C59/66 , C07C59/68 , C07C69/734 , C07D213/63 , C07D239/34 , C07D239/52 , C07D239/60 , C07D405/12 , C07D491/048 , C07D403/12 , C07D213/64
Abstract: The invention relates to carboxylic acid derivatives of formula (I), wherein R -R , Q, W, X, Y and Z have the meanings given in the description. The novel compounds are suitable for combating diseases.
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公开(公告)号：CA2322226A1
公开(公告)日：1999-09-10
申请号：CA2322226
申请日：1999-02-25
Applicant: BASF AG
Inventor： AMBERG WILHELM , JANSEN ROLF , KLINGE DAGMAR
IPC: C07D239/38 , A61K31/19 , A61K31/215 , A61K31/357 , A61K31/36 , A61K31/505 , A61P43/00 , C07C319/14 , C07C323/56 , C07D239/56 , C07D239/60 , C07D317/62 , C07C323/22 , C07D317/56
Abstract: The invention relates to a method for preparing sulfanyl-type endothelin receptor antagonists of general formula (I) wherein R1 represents hydroxy, alkoxy, sulfonamidyl, amino; R2 represents alkyl, aryl or heteroaryl, optionally substituted, and R3, R4, R5 can be the same or different and are alkyl or aryl, optionally substituted, by means of nucleophilic reaction of a carboxylic acid derivative of formula (II) with a sulfide of formula (III), X being SR6 or SO2R6 and R6 being alkyl or aryl, optionally substituted.
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公开(公告)号：DE19809635A1
公开(公告)日：1999-09-09
申请号：DE19809635
申请日：1998-03-06
Applicant: BASF AG
Inventor： AMBERG WILHELM , JANSEN ROLF , KLINGE DAGMAR
IPC: C07D239/38 , A61K31/19 , A61K31/215 , A61K31/357 , A61K31/36 , A61K31/505 , A61P43/00 , C07C319/14 , C07C323/56 , C07D239/56 , C07D239/60 , C07D317/62 , C07B45/06 , C07D239/46 , C07D319/06 , C07C323/50
Abstract: The invention relates to a method for preparing sulfanyl-type endothelin receptor antagonists of general formula (I) wherein R represents hydroxy, alkoxy, sulfonamidyl, amino; R represents alkyl, aryl or heteroaryl, optionally substituted, and R , R , R can be the same or different and are alkyl or aryl, optionally substituted, by means of nucleophilic reaction of a carboxylic acid derivative of formula (II) with a sulfide of formula (III), X being SR or SO2R and R being alkyl or aryl, optionally substituted.
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公开(公告)号：BG102362A
公开(公告)日：1999-08-31
申请号：BG10236298
申请日：1998-04-01
Applicant: BASF AG
Inventor： KLINGE DAGMAR , AMBERG WILHELM , KLING ANDREAS , RIECHERS HARTMUT , UNGER LILIANE , RASCHACK MANFRED
IPC: A61K31/00 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/505 , A61K31/53 , A61P5/24 , A61P5/36 , A61P5/42 , A61P9/12 , C07D213/74 , C07D239/10 , C07D239/42 , C07D239/46 , C07D239/48 , C07D239/50 , C07D239/52 , C07D239/58 , C07D251/46 , C07D401/04 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , C07D491/052 , C07D491/056 , C07D239/70 , C07D487/02 , C07D251/42
Abstract: The invention relates to derivatives of aminoacids with theformulawhere the radicals have the meanings listed in the description, aswell as to their use as medicamentous forms.4 claims
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