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公开(公告)号:DE69736974D1
公开(公告)日:2007-01-04
申请号:DE69736974
申请日:1997-09-22
Applicant: BAXTER INT
Inventor: PRINCE R , PEKKARINEN O , BELLAMY DAVID , STERNBERG SHMUEL
IPC: B01D65/02 , A61M1/26 , A61M1/34 , B01D39/16 , B01D61/14 , B01D61/22 , B01D63/16 , B01D65/08 , B01D69/00 , B01D69/02
Abstract: A method and apparatus for filtering suspensions of medical and biological fluids, one aspect of which is separating a suspension comprising at least two types of particles which are differently sized or shaped and in which the first type of particle may be deformable at a relatively lower force and/or faster rate than the second type of particle. A filter member is provided having substantially precisely dimensioned pore sizes, with the pores being dimensioned to allow passage of the first type of suspended particle without distortion or only minimal distortion and passage of the second type of particle only with substantial distortion. Because the filter membrane has precisely dimensioned pores, with spacing between the pores being maintained despite the smaller interval between the pores, the porosity of the membrane may be much greater than nominal pore size membranes, allowing faster filtration rates and/or smaller membranes for a given filtration rate, while reducing the exposure time of the cells within the shear environment, and consequently reducing particle damage. Various methods for preventing clogging of the membrane are also disclosed.
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公开(公告)号:AU758405B2
公开(公告)日:2003-03-20
申请号:AU4834299
申请日:1999-06-25
Applicant: BAXTER INT
Inventor: BOGGS DANIEL R , STERNBERG SHMUEL , PAULEY ROBIN G , MCLARTY DONNA L
IPC: B01D69/12 , A61M1/36 , B01D69/14 , B01D71/20 , B01D71/30 , B01D71/38 , B01D71/54 , B01J20/28 , B01D24/00 , B01D29/00 , B05D5/00
Abstract: Membranes and methods for making membranes are disclosed. The membranes include a polymeric matrix and a particulate material immobilized within the matrix. The membranes may find particular application in methods and apparatus for removing organic compounds from a biological fluid as part of a pathogen inactivation treatment.
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63.
公开(公告)号:AU4142801A
公开(公告)日:2001-08-07
申请号:AU4142801
申请日:2001-01-26
Applicant: BAXTER INT
Inventor: WOO LECON , BOGGS DANIEL R , STERNBERG SHMUEL , SANDFORD CRAIG , KHARE ATUL , BREILLATT JULIAN
Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a "carrying" mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows through the belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).
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公开(公告)号:AU4834299A
公开(公告)日:2000-02-01
申请号:AU4834299
申请日:1999-06-25
Applicant: BAXTER INT
Inventor: BOGGS DANIEL R , STERNBERG SHMUEL , PAULEY ROBIN G , MCLARTY DONNA L
IPC: B01D69/12 , A61M1/36 , B01D69/14 , B01D71/20 , B01D71/30 , B01D71/38 , B01D71/54 , B01J20/28 , B01D24/00 , B01D29/00 , B05D5/00
Abstract: Membranes and methods for making membranes are disclosed. The membranes include a polymeric matrix and a particulate material immobilized within the matrix. The membranes may find particular application in methods and apparatus for removing organic compounds from a biological fluid as part of a pathogen inactivation treatment.
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公开(公告)号:CA2336788A1
公开(公告)日:2000-01-20
申请号:CA2336788
申请日:1999-06-25
Applicant: BAXTER INT
Inventor: PAULEY ROBIN G , MCLARTY DONNA L , BOGGS DANIEL R , STERNBERG SHMUEL
IPC: B01D69/12 , A61M1/36 , B01D69/14 , B01D71/20 , B01D71/30 , B01D71/38 , B01D71/54 , B01J20/28 , B01D24/00 , B01D29/00 , B05D5/00
Abstract: Membranes and methods for making membranes are disclosed. The membranes (10) include a polymeric matrix (16) and a particulate material immobilized withi n the matrix. The membrane may further include a skin layer (19) having random ly spaced surface pores (21). The membranes may find particular application in methods and apparatus for removing organic compounds from a biological fluid as part of a pathogen inactivation treatment.
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公开(公告)号:AU686723B2
公开(公告)日:1998-02-12
申请号:AU1443795
申请日:1994-12-20
Applicant: BAXTER INT
Inventor: STERNBERG SHMUEL
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公开(公告)号:AU1443795A
公开(公告)日:1995-07-10
申请号:AU1443795
申请日:1994-12-20
Applicant: BAXTER INT
Inventor: STERNBERG SHMUEL
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