公开(公告)号：FI841766A

公开(公告)日：1984-11-08

申请号：FI841766

申请日：1984-05-03

Applicant: HOECHST AG

Inventor： SCHWAB WILFRIED ,  DUERCKHEIMER WALTER ,  KIRRSTETTER REINER ,  LATTRELL RUDOLF

IPC: C07D501/18 ,  C12P35/02 ,  C07D

Abstract: Process for the preparation of 7-aminocephalosporanic acid derivatives of the general formula

公开(公告)号：FI843933A0

公开(公告)日：1984-10-05

申请号：FI843933

申请日：1984-10-05

Applicant: HOECHST AG

Inventor： FLEISCHMANN KLAUS ,  DUERCKHEIMER WALTER ,  LATTRELL RUDOLF ,  SCHWAB WILFRIED ,  SEEGER KARL

IPC: C07D501/46 ,  A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/56 ,  C07D501/57 ,  C07D

Abstract: Cephalosporin derivatives of the formula pharmaceutical preparations active against bacterial infections and which contain cephem derivatives of this type, process for the preparation of the cephem derivatives and the pharmaceutical preparations and use of the cephem derivatives for combating bacterial infections.

公开(公告)号：DK480384D0

公开(公告)日：1984-10-05

申请号：DK480384

申请日：1984-10-05

Applicant: HOECHST AG

Inventor： LATTRELL RUDOLF ,  BLUMBACH JUERGEN ,  DUERCKHEIMER WALTER ,  SCHWAB WILFRIED ,  SEEGER KARL

IPC: A61K31/545 ,  C07D20060101 ,  C07D501/46 ,  C07D

公开(公告)号：DK479984D0

公开(公告)日：1984-10-05

申请号：DK479984

申请日：1984-10-05

Applicant: HOECHST AG

Inventor： LATTRELL RUDOLF ,  BLUMBACH JUERGEN ,  DUERCKHEIMER WALTER ,  SCHWAB WILFRIED ,  SEIBERT GERHARD

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/38 ,  C07D501/46 ,  C07D501/56 ,  C07D501/57 ,  C07D

公开(公告)号：MTP925A

公开(公告)日：1984-02-13

申请号：MTP925

申请日：1983-03-02

Applicant: HOECHST AG

Inventor： LATTZELL RUDOLF ,  KURSTETTER REINER ,  SCHWAB WILFRIED ,  DUESCHHEIMER WALTER ,  SEIBERT GERHARD

IPC: C07D501/36 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/20 ,  C07D501/34 ,  C07D501/46

CPC classification number: C07D277/587

公开(公告)号：FI830704L

公开(公告)日：1983-09-05

申请号：FI830704

申请日：1983-03-02

Applicant: HOECHST AG

Inventor： LATTRELL RUDOLF ,  KIRRSTETTER REINER ,  SCHWAB WILFRIED ,  DYRCKHEIMER WALTER ,  SEIBERT GERHARD

IPC: C07D501/36 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/20 ,  C07D501/34 ,  C07D501/46 ,  C07D

Abstract: The invention relates to cephem derivatives of the general formula I and their physiologically acceptable acid addition salts, to pharmaceutical formulations active against bacterial infections, to processes for preparing the compounds and formulations, and to the use of the compounds for combating bacterial infections.

公开(公告)号：FI830704A0

公开(公告)日：1983-03-02

申请号：FI830704

申请日：1983-03-02

Applicant: HOECHST AG

Inventor： LATTRELL RUDOLF ,  KIRRSTETTER REINER ,  SCHWAB WILFRIED ,  DYRCKHEIMER WALTER ,  SEIBERT GERHARD

IPC: C07D501/36 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/20 ,  C07D501/34 ,  C07D501/46 ,  C07D

Abstract: The invention relates to cephem derivatives of the general formula I and their physiologically acceptable acid addition salts, to pharmaceutical formulations active against bacterial infections, to processes for preparing the compounds and formulations, and to the use of the compounds for combating bacterial infections.

公开(公告)号：CA2188228C

公开(公告)日：2008-08-12

申请号：CA2188228

申请日：1996-10-18

Applicant: HOECHST AG

Inventor： SCHWAB WILFRIED ,  CZECH JORG ,  BOSLETT KLAUS

IPC: C07D213/06 ,  C07D213/75 ,  A61K31/198 ,  A61K31/275 ,  A61K31/42 ,  A61K31/422 ,  A61K31/44 ,  A61K31/4418 ,  A61P35/00 ,  A61P35/02 ,  C07C255/22 ,  C07D261/18 ,  C07D413/12

Abstract: The compound of the formula I or II (see Formula II) is suitable for the production of a pharmaceutical for the treatment of carcinomatous disorders, where R1 is (C3-C5)-cycloalkyl, (C2-C6)-alkenyl or (C2-C6)-alkynyl, R2 is CF3 , OCF3, SCF3 , OH, NO2 , halogen, benzyl, phenyl, CN or O-phenyl, R3 is (C1-C4)-alkyl, halogen or a hydrogen atom and X is a -CH group or a nitrogen atom.

公开(公告)号：CZ297550B6

公开(公告)日：2007-02-07

申请号：CZ145398

申请日：1996-11-04

Applicant: HOECHST AG

Inventor： THORWART WERNER ,  SCHWAB WILFRIED ,  SCHUDOK MANFRED ,  HAASE BURKHARD ,  BARTNIK ECKART ,  WEITHMANN KLAUS-ULRICH

IPC: C07D217/26 ,  A61K31/00 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/4725 ,  A61P19/00 ,  A61P35/00 ,  A61P43/00 ,  C07D209/42 ,  C07D221/16 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/056

Abstract: Vynález se týká cyklické a heterocyklické N-substituované alfa-iminohydroxamové a karboxylové kyseliny obecného vzorce I, která je vhodná pro lécení onemocnení, na jejichz prubehu se podílí zvýsená aktivita metaloproteináz odbourávajících základní telesnou tkán.

公开(公告)号：HU225499B1

公开(公告)日：2007-01-29

申请号：HU9602458

申请日：1995-03-03

Applicant: HOECHST AG

Inventor： SCHLEYERBACH RUDOLF ,  ANAGNOSTOPULOS HIRISTO ,  SCHWAB WILFRIED ,  BARTLETT ROBERT RYDER ,  WEITHMANN KLAUS ULRICH

IPC: A61K31/41 ,  A61K31/42 ,  A61K31/423 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5377 ,  A61P11/00 ,  A61P29/00 ,  A61P37/00 ,  C07C205/51 ,  C07D261/04 ,  C07D261/08 ,  C07D261/18 ,  C07D261/20 ,  C07D263/30 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07F9/653

Abstract: PCT No. PCT/EP95/00784 Sec. 371 Date Nov. 19, 1996 Sec. 102(e) Date Nov. 19, 1996 PCT Filed Mar. 3, 1995 PCT Pub. No. WO95/24397 PCT Pub. Date Sep. 14, 1995A compound having the formula (I), a physiologically tolerable salt of the compound having the formula (I) and/or a steroisomeric form of the compound having the formula (I), in which one residue R1 or R2 stands for the formula (II), are suitable for preparing medicaments for the therapy of inflammations, asthma, rheumatoid diseases and auto-immune diseases.