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    COLOR FORMING COMPOSITION
    62.
    发明专利
    COLOR FORMING COMPOSITION 失效

    公开(公告)号：JPS6320382A

    公开(公告)日：1988-01-28

    申请号：JP16608386

    申请日：1986-07-15

    Applicant: KAO CORP

    Inventor： SATO NAOKI ,  YAHAGI KAZUYUKI ,  TSUJII KAORU

    IPC: A61K8/30 ,  A61K8/18 ,  A61K8/34 ,  A61K8/36 ,  A61K8/362 ,  A61K8/44 ,  A61Q1/02 ,  A61Q5/00 ,  C09K3/00

    Abstract: PURPOSE:To obtain a color forming composition which contains neither a coloring matter nor a pigment, has excellent stability and safety, and forms a continuously changing color, by dissolving a specified amount of an alkenylsuccinic acid (derivative) in an aqueous alcohol. CONSTITUTION:An alkenylsuccinic anhydride obtained from a 16C or higher olefin and maleic anhydride is hydrolyzed or reacted with an amino compound (e.g., an amino acid) to give an alkenylsuccinic acid (derivative) (A) of the formula (wherein R1 is an 8-36C straight-chain or branched alkenyl; R2 is OH or an amidated amino acid residue). 0.1-10wt% component A is dissolved in a liquid (B) comprising water and, if necessary, 50wt% or less alcohol, thus giving a color forming composition comprising an aqueous alcohol solution of component A. This composition can be utilized for cosmetics such as a shampoo or a rinse, decorative goods such as an ornament for the alcove, an an optical element such as a diffraction grating.

    AQUEOUS DISPERSION LIQUID
    63.
    发明专利
    AQUEOUS DISPERSION LIQUID 失效

    公开(公告)号：JPS61204034A

    公开(公告)日：1986-09-10

    申请号：JP4585185

    申请日：1985-03-08

    Applicant: KAO CORP

    Inventor： ENDO SHINICHI ,  TSUJII KAORU

    IPC: B01F17/18 ,  B01F17/22 ,  B01F17/42 ,  B01F17/52 ,  B01J13/00 ,  C08L33/00 ,  C08L33/02 ,  C08L33/04 ,  C08L33/24 ,  D21H17/03 ,  D21H17/17 ,  D21H17/30 ,  D21H17/34 ,  D21H17/37 ,  D21H17/45

    Abstract: PURPOSE:To make the dispersion stability and the rise of the sizing performance excellent by incorporating a specified cationic surface-active agent, a water soluble copolymer of a cationic monomer and a nonionic monomer and a water nonsoluble substance. CONSTITUTION:A water soluble copolymer is prepared by using a cationic surface-active agent A having 4-28C hydrocarbon group and a functional group capable of polymerization, a cationic monomer B capable of copolymerization and a nonionic monomer C capable of copolymerization. An aqueous dispersion liquid is prepared by incorporating a water insoluble substance to this water soluble copolymer. As the ratio of each component of the above-mentioned water soluble copolymer, about 1-15 mol% A, about 10-70 mol% B and about 10-70 mol% C are preferable. Also as the water insoluble substance, ketone dimer is preferable and

    External drug composition
    64.
    发明专利
    External drug composition 失效
    外用药物组合物

    公开(公告)号：JPS6191137A

    公开(公告)日：1986-05-09

    申请号：JP21315284

    申请日：1984-10-11

    Applicant: Kao Corp

    Inventor： HARA KENJI ,  TAKAHASHI HIROMICHI ,  KAMIYA TETSURO ,  TSUJII KAORU

    IPC: A61K31/66 ,  A61K47/24 ,  C07F9/09

    CPC classification number: A61K9/0014 ,  A61K31/66 ,  A61K47/24 ,  C07F9/091

    Abstract: PURPOSE: To provide an external drug composition having improved transcutaneous absorptivity of the drug component and high safety, by adding a specific dialkyl phosphate to a drug component.
    CONSTITUTION: A drug component is mixed with a dialkyl phosphate of formula (R
    1 and R
    2 are 6W24C hydrocarbon group; R
    3 and R
    4 are 2W6C hydrocarbon group; m and n are 0W20; X is H, alkali metal, ammonium, etc.). The amount of the dialkyl phosphate in the composition is 0.5W30wt%, preferably 1W20%, and the weight ratio of dialkyl phosphate/drug component is preferably 20/1W1/10. Since the absorptivity of the drug component is remarkably improved in the present composition, a sufficient pharmacological effect can be attained at a low concentration of the drug component compared with conventional drug, and accordingly, the side effects of the drug component can be decreased.
    COPYRIGHT: (C)1986,JPO&Japio

    Abstract translation: 目的：通过向药物成分中加入特定的二烷基磷酸酯，提供具有改善药物成分的经皮吸收性和高安全性的外用药物组合物。 构成：将药物成分与式（R1和R2为6-24C烃基）的二烷基磷酸酯混合，R3和R4为2-6C烃基; m和n为0-20; X为H，碱金属，铵 等）。 组合物中磷酸二烷基酯的量为0.5-30重量％，优选1-20重量％，磷酸二烷基酯/药物组分的重量比优选为20 / 1-1 / 10。 由于药物成分的吸收性在本发明的组合物中显着提高，所以与常规药物相比，药物成分浓度低时，能够得到充分的药理作用，能够降低药物成分的副作用。

    COMPOSITION FOR VESICLE
    65.
    发明专利
    COMPOSITION FOR VESICLE 失效

    公开(公告)号：JPS6075434A

    公开(公告)日：1985-04-27

    申请号：JP18378183

    申请日：1983-09-30

    Applicant: KAO CORP

    Inventor： TAKAHASHI HIROMICHI ,  TSUJII KAORU

    IPC: A61K47/06 ,  A61K9/127

    Abstract: PURPOSE:The titled composition, consisting of a system obtained by incorporating a glyceryl ether having the ability to form vesicles with a certain surfactant and water, and capable of existing stably for a long term. CONSTITUTION:A composition for vesicles obtained by incorporating (A) a glyceryl ether derivative of formula I (R1 and R2 are 6-24C hydrocarbon group; A is 2-4C alkylene; Z is H or neutralized anionic hydrophilic group; n is an integer 1-20 when Z is H, and 0 or an integer 1-20 when Z is not H) with (B) one or two or more surfactants selected from a compound of the formula R3COOM (R3 is 6-36C hydrocarbon group; M is alkali metal, etc.), a compound of the formula R3OSO3M or formula II, etc. at (100:1)-(100:100) weight ratio between the components (A) and (B), dissolving the resultant mixture in a solvent capable of dissolving both, stirring the solution to make it uniform, and removing the solvent. The resultant composition for the vesicles may be suspended in water and irradiated with ultrasonic waves to give the aimed vesicles.

    COMPOSITION FOR VESICLE
    66.
    发明专利
    COMPOSITION FOR VESICLE 失效

    公开(公告)号：JPS6072831A

    公开(公告)日：1985-04-24

    申请号：JP18162983

    申请日：1983-09-29

    Applicant: KAO CORP

    Inventor： TAKAHASHI HIROMICHI ,  TSUJII KAORU

    IPC: A61K47/16 ,  A61K9/127 ,  A61K47/06 ,  B01F17/18 ,  B01J13/02

    Abstract: PURPOSE:The titled composition, consisting of a system obtained by incorporating a specific quaternary ammonium salt having a vesicle-forming ability with a certain surfactant and water, and capable of existing stably for a long term. CONSTITUTION:A composition for vesicles obtained by incorporating (A) a double stranded quaternary ammonium salt of formula I (R1 and R2 are 10-24C hydrocarbon group; R3 and R4 are 1-4C hydrocarbon group, benzyl, etc.; X is anion to be a counter ion of the quaternary ammonium ions) with (B) one or two or more surfactants selected from a compound of formula II (R5 is 1-4C hydrocarbon group, etc.; R6 is 8-36C hydrocarbon group), a compound of the formula R6O(AO)nH (A is 2-4C alkylene; n is 0 or an integer 1-150), a compound of formula III, etc. at (100:1)-(100:100) weight ratio between the components (A) and (B), dissolving the resultant mixture in a solvent capable of dissolving both to give 1-50wt% concentration, removing the solvent, stirring the solution to make it uniform, and removing the solvent therefrom.

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