公开(公告)号：CA2946195A1

公开(公告)日：2010-01-21

申请号：CA2946195

申请日：2009-07-16

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR DOUGLAS ,  NEET JOHN

IPC: A61L29/08 ,  A61K9/00 ,  A61L29/16 ,  A61L31/08 ,  A61L31/16

Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.

公开(公告)号：CA2730995A1

公开(公告)日：2010-01-21

申请号：CA2730995

申请日：2009-07-16

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR DOUGLAS ,  NEET JOHN

IPC: A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16

Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.

公开(公告)号：AU2009270849A1

公开(公告)日：2010-01-21

申请号：AU2009270849

申请日：2009-07-16

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR DOUGLAS ,  NEET JOHN

IPC: A61L33/00

Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.

公开(公告)号：CA2667228A1

公开(公告)日：2008-05-02

申请号：CA2667228

申请日：2007-10-23

Applicant: MICELL TECHNOLOGIES INC

Inventor： WORM STEVE ,  MCCLAIN JAMES B ,  TAYLOR DOUG ,  DICKINSON ED

IPC: B05D1/06

Abstract: A stent holder for mounting and electrically charging a stent during coat ing of the stent using dry particles, the particles comprising inert polymer s, pharmaceutical or biological agents, is provided. An assembly for support ing and electrically charging a stent during the coating of the stent using dry particles, the particles comprising inert polymers, pharmaceutical or bi ological agents, is provided. A chamber for creating an electrical field aro und a stent and for supporting, electrically charging, and exposing the sten t to dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. A method for creating an electrical field around a stent and for supporting, electrically charging, and exposing the stent to dry particles comprising inert polymers, pharmaceutical or biologic al agents is provided.

公开(公告)号：CA2922492A1

公开(公告)日：2007-01-04

申请号：CA2922492

申请日：2006-06-21

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  DEYOUNG JAMES P

IPC: A61K9/00 ,  A61K47/34

公开(公告)号：CA2613280A1

公开(公告)日：2007-01-04

申请号：CA2613280

申请日：2006-06-21

Applicant: MICELL TECHNOLOGIES INC

Inventor： DEYOUNG JAMES P ,  MCCLAIN JAMES B

IPC: A61K9/00 ,  A61F13/00 ,  A61K9/20 ,  A61K9/48

Abstract: A method of forming a drug/polymer composite material is carried out by combining a drug material with a polymer material under pressure in the presence of a densified gas solvent (e.g., carbon dioxide) to form the drug/polymer composite material. Drug/polymer composite materials and shaped articles (e.g., subcutaneous drug depots) which may be produced by a process are also described, along with methods of use thereof.

公开(公告)号：AU2003299658A1

公开(公告)日：2004-08-30

申请号：AU2003299658

申请日：2003-12-08

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  DEYOUNG JAMES P ,  GROSS STEPHEN M ,  WAGNER MARK I

IPC: B05D1/18 ,  B08B7/00 ,  B81B3/00 ,  B81C1/00 ,  H01L21/00 ,  H01L21/306

Abstract: A method of displacing a supercritical fluid from a pressure vessel (e.g., in a microelectronic manufacturing process), with the steps of: providing an enclosed pressure vessel containing a first supercritical fluid (said supercritical fluid preferably comprising carbon dioxide); adding a second fluid (typically also a supercritical fluid) to said vessel, with said second fluid being added at a pressure greater than the pressure of the first supercritical fluid, and with said second fluid having a density less than that of the first supercritical fluid; forming an interface between the first supercritical fluid and the second fluid; and displacing at least a portion of the first supercritical fluid from the vessel with the pressure of the second, preferably fluid while maintaining the interface therebetween.

公开(公告)号：AU2003294557A1

公开(公告)日：2004-08-30

申请号：AU2003294557

申请日：2003-12-02

Applicant: MICELL TECHNOLOGIES INC

Inventor： TAYLOR DOUG ,  WAGNER MARK I ,  BRAINARD DAVID E ,  DEYOUNG JAMES P ,  MCCLAIN JAMES B ,  GROSS STEPHEN M

IPC: B05D1/18 ,  H01L21/00 ,  H01L21/02 ,  H01L21/285 ,  H01L21/288

Abstract: A method of coating a substrate comprises the steps of: (a) providing a substrate in an enclosed vessel, the substrate having a surface portion; (b) at least partially filling the enclosed vessel with a first supercritical fluid so that said first supercritical fluid contacts the surface portion, with the first supercritical fluid carrying or containing a coating component; then (c) adding a separate compressed gas atmosphere to the reaction vessel so that a boundary is formed between the first supercritical fluid and the separate compressed gas atmosphere, said separate compressed gas atmosphere having a density less than said first supercritical fluid; and then (d) displacing said first supercritical fluid from said vessel by continuing adding said separate compressed gas atmosphere to said vessel so that said boundary moves across said surface portion and a thin film of coating component is deposited on said microelectronic substrate.

公开(公告)号：AU2003279725A8

公开(公告)日：2004-05-04

申请号：AU2003279725

申请日：2003-09-30

Applicant: MICELL TECHNOLOGIES INC

Inventor： WAGNER MARK I ,  GROSS STEPHEN M ,  DEYOUNG JAMES P ,  MCCLAIN JAMES B

IPC: C23F1/10 ,  H01L21/306 ,  H01L21/311 ,  H01L21/3205 ,  H01L21/3213 ,  C23G1/02

Abstract: Compositions useful for cleaning metal from a substrate or coating metal onto a substrate are described: Such compositions comprise (a) a densified carbon dioxide continuous phase; (b) a polar discrete phase in said carbon dioxide continuous phase; (c) a metal in said discrete phase (i.e., a metal removed from the substrate, or to be coated onto the substrate); (d) at least one ligand in said continuous phase, said discrete phase, or both said continuous and said discrete phase.

公开(公告)号：AU2003222080A1

公开(公告)日：2003-10-20

申请号：AU2003222080

申请日：2003-03-26

Applicant: MICELL TECHNOLOGIES INC

Inventor： CARBONELL RUBEN ,  DESIMONE JOSEPH M ,  MCCLAIN JAMES B ,  DEYOUNG JAMES P

IPC: B05D1/40 ,  B05D3/04 ,  G03F7/16 ,  G03F7/26 ,  G03F7/38 ,  H01L21/027 ,  H01L21/3105 ,  B05D3/12

Abstract: A method of reducing undesired topographic features, increasing film density, and/or increasing adhesion to an underlying substrate in a polymer film formed on a microelectronic substrate, comprises: (a) providing a microelectronic substrate, the substrate having a polymer film deposited thereon; (b) contacting the substrate to carbon dioxide (optionally containing additional ingredients such as cosolvents or chemical intermediates); and (c) elevating the pressure of the carbon dioxide to plasticize the polymer film and reduce undesired topographic features, increase film density, and/or increase adhesion of the film to the underlying substrate.