公开(公告)号：FR2646603B1

公开(公告)日：1991-07-12

申请号：FR8905909

申请日：1989-05-03

Applicant: OREAL

Inventor： LAUGIER JEAN-PIERRE ,  FANCHON CHANTAL ,  JOMARD ANDRE ,  SHROOT BRAHAM ,  RINGENBACH FRANCOIS

IPC: A61K8/00 ,  A61K8/36 ,  A61K8/37 ,  A61K8/39 ,  A61K8/41 ,  A61K8/44 ,  A61K8/46 ,  A61K8/64 ,  A61K9/00 ,  A61K31/135 ,  A61K47/20 ,  A61P17/00 ,  A61Q5/02 ,  A61Q19/10 ,  C11D3/48 ,  A61K7/48

公开(公告)号：NO166937B

公开(公告)日：1991-06-10

申请号：NO872158

申请日：1987-05-22

Applicant: OREAL

Inventor： MAIGNA JEAN ,  LANG GERARD ,  MALLE GERARD ,  RESTLE SERGE ,  SHROOT BRAHAM

IPC: A61K8/00 ,  A61K8/30 ,  A61K8/34 ,  A61K8/35 ,  A61K8/36 ,  A61K8/368 ,  C07C41/00 ,  A61K8/37 ,  A61K8/41 ,  A61K8/42 ,  A61K8/49 ,  A61K31/045 ,  A61K31/085 ,  A61K31/12 ,  A61K31/16 ,  A61K31/165 ,  A61K31/19 ,  A61K31/215 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  C07C29/143 ,  C07C33/18 ,  C07C33/26 ,  C07C33/28 ,  C07C33/32 ,  C07C33/46 ,  C07C41/18 ,  C07C43/14 ,  C07C43/164 ,  C07C43/20 ,  C07C43/23 ,  C07C45/30 ,  C07C45/46 ,  C07C47/546 ,  C07C49/215 ,  C07C49/76 ,  C07C49/86 ,  C07C51/347 ,  C07C57/44 ,  C07C59/48 ,  C07C59/64 ,  C07C59/84 ,  C07C59/90 ,  C07C63/36 ,  C07C65/24 ,  C07C65/34 ,  C07C65/40 ,  C07C67/00 ,  C07C69/618 ,  C07C69/738 ,  C07C69/76 ,  C07C231/00 ,  C07C231/02 ,  C07C233/11 ,  C07C233/65 ,  C07C235/34 ,  C07C235/66 ,  C07C235/84 ,  C07C239/00 ,  C07C65/36 ,  C07C65/17 ,  C07C229/38 ,  C07C239/18

Abstract: An aromatic naphthyl compound of the formula (I) wherein n is 0 or 1, R' is hydrogen, OH, acyloxy, alkoxy or NH2, R'' is hydrogen or lower alkoxy, or R' and R'' taken together form an oxo, methano or hydroxy-imino radical, R is -CH2OH or -COR8, R8 is hydrogen, -OR9 or R9 is hydrogen, alkyl having 1-20 carbon atoms, mono or polyhydroxyalkyl, aryl, aralkyl, the residue of a sugar or is 1, 2 or 3, r' and r'' each independently represent hydrogen, alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl, benzyl, the residue of amino acid or the residue of aminated sugar, or r' and r'' together form a heterocycle, R1, R2, R3 and R4 represent hydrogen, lower alkyl, alkoxy having 1-4 carbon atoms, fluoroalkoxy, CF3, cycloalkyl, lower acyl, halogen, OH, amino, acylamino or alkoxy carbonyl, R5, R6 and R7 represent hydrogen or methyl or when n=1, R5 and R7 taken together can form with the benzene ring a naphthalene ring, and the salts of the compound of formula I or their geometric or optical isomers. These compounds are useful in human and veterinary medicine and in cosmetic compositions.

公开(公告)号：ZA903334B

公开(公告)日：1991-02-27

申请号：ZA903334

申请日：1990-05-02

Applicant: OREAL

Inventor： LAUGIER JEAN-PIERRE ,  JEAN-PIERRE LAUGIER ,  FANCHON CHANTAL ,  CHANTAL FANCHON ,  JOMARD ANDRE ,  ANDRE JOMARD ,  SHROOT BRAHAM ,  BRAHAM SHROOT ,  RINGENBACH FRANCOIS ,  FRANCOIS RINGENBACH

IPC: A61K8/00 ,  A61K8/36 ,  A61K8/37 ,  A61K8/39 ,  A61K8/41 ,  A61K8/44 ,  A61K8/46 ,  A61K8/64 ,  A61K9/00 ,  A61K31/135 ,  A61K47/20 ,  A61P17/00 ,  A61Q5/02 ,  A61Q19/10 ,  C11D3/48 ,  A61K

公开(公告)号：GB2228734B

公开(公告)日：1990-11-28

申请号：GB9007490

申请日：1990-04-03

Applicant: OREAL

Inventor： MAIGNAN JEAN ,  LANG GERARD ,  MALLE GERARD ,  RESTLE SERGE ,  SHROOT BRAHAM

IPC: C07C33/26 ,  C07C65/105 ,  C07C65/11 ,  C07C65/26 ,  C07C65/34 ,  C07C65/36 ,  C07C65/38 ,  C07C65/40 ,  C07C69/76 ,  A61K31/045 ,  A61K31/12 ,  A61K31/185 ,  A61K31/215 ,  C07C49/86 ,  C07C65/00

公开(公告)号：GB2187455B

公开(公告)日：1990-05-09

申请号：GB8705344

申请日：1987-03-06

Applicant: OREAL

Inventor： FORESTIER SERGE ,  LAGRANGE ALAIN ,  LANG GERARD ,  SHROOT BRAHAM

IPC: C07D307/93 ,  A61K8/04 ,  A61K8/25 ,  A61K8/31 ,  A61K8/36 ,  A61K8/49 ,  A61K8/65 ,  A61K8/73 ,  A61K8/86 ,  A61K31/34 ,  A61K31/343 ,  A61P17/00 ,  A61P27/02 ,  A61P27/14 ,  A61P29/00 ,  A61P37/08 ,  A61Q5/00 ,  A61Q5/02 ,  C07D307/94

Abstract: A benzofuran derivative which is a compound of formula (I): (I) wherein a to d each are 0 to 1, with a+b+c+d>/=2; R1 to R6 are each H or C1-C6 alkyl; R7 is -CH2OR8 (R8=H, C1-C6 alkyl, C2-C6 mono- or polyhydroxyalkyl), -COR9 (R9=H, C1-C6 alkyl, which is an amino acid or amino sugar residue or where R' and R'' are H, C1-C6 alkyl, C2-C6 mono- or polyhydroxyalkyl, C3-C6 alkenyl or form a heterocycle) or OR10 (where R10 is H, C1-C20 alkyl, C2-C6 mono- or polyhydroxyalkyl or -OR10 is derived from a sugar) has retinoid type action and can be used in cosmetics (body and hair hygiene) and in medicine (treatment of dermatological conditions; atopy; degenerative diseases of connective tissue; or corneopathies).

公开(公告)号：GB2189482B

公开(公告)日：1990-03-28

申请号：GB8705765

申请日：1987-03-11

Applicant: OREAL

Inventor： MAIGNAN JEAN ,  LANG GERARD ,  MALLE GERARD ,  RESTLE SERGE ,  SHROOT BRAHAM

IPC: A61K8/00 ,  A61K8/36 ,  A61K8/41 ,  A61K8/49 ,  A61K31/35 ,  A61K31/352 ,  A61K31/38 ,  A61K31/382 ,  A61P11/00 ,  A61P17/00 ,  A61P27/02 ,  A61P31/00 ,  A61P35/02 ,  A61P37/00 ,  A61Q5/00 ,  C07D311/04 ,  C07D311/58 ,  C07D335/06

Abstract: An aromatic benzopyranyl or benzothiopyranyl compound of the formula (I) wherein n is 0 or 1, X represents R' represents H, OH, acyloxy or NH2, R'' represents H or alkoxy or R' and R'' taken together form an oxo, methano or hydroxyimino radical, R8 represents H, R9 represents H, alkyl, mono or polyhydroxyalkyl, aryl, aralkyl, a residue of a sugar or p equals 1, 2 or 3, r' and r'' represent H, alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl, benzyl, the residue of an amino acid or an aminated sugar, or together form a heterocycle, R1, R2, R3 and R4 represents H or lower alkyl, R5, R6 and R7 represent H or methyl or when n=1, R5 and R7 taken together form with the benzene ring a naphthalene ring (R5-R7=-CH=CH-), and the salts of said compounds as well as their geometric and optical isomers. These compounds are useful in pharmaceutical and cosmetic compositions.

公开(公告)号：CA1267153A

公开(公告)日：1990-03-27

申请号：CA490040

申请日：1985-09-05

Applicant: OREAL

Inventor： LANG GERARD ,  MAIGNAN JEAN ,  RESTLE SERGE ,  SHROOT BRAHAM

IPC: A61K31/10 ,  A61K8/00 ,  A61K31/045 ,  A61K31/075 ,  A61K31/11 ,  A61K31/12 ,  A61K31/16 ,  A61K31/165 ,  A61K31/19 ,  A61K31/21 ,  A61K31/215 ,  A61K31/22 ,  A61K31/235 ,  A61K31/255 ,  A61K31/70 ,  A61K31/7024 ,  A61P17/00 ,  A61P27/02 ,  A61P27/14 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  A61Q5/00 ,  A61Q7/00 ,  A61Q19/00 ,  C07C1/00 ,  C07C13/605 ,  C07C17/00 ,  C07C25/22 ,  C07C27/00 ,  C07C29/143 ,  C07C33/34 ,  C07C33/50 ,  C07C43/14 ,  C07C43/20 ,  C07C45/00 ,  C07C47/238 ,  C07C47/546 ,  C07C49/225 ,  C07C49/237 ,  C07C49/252 ,  C07C49/255 ,  C07C49/76 ,  C07C49/792 ,  C07C49/813 ,  C07C49/84 ,  C07C57/50 ,  C07C57/62 ,  C07C59/54 ,  C07C59/72 ,  C07C63/66 ,  C07C63/74 ,  C07C65/19 ,  C07C65/28 ,  C07C67/00 ,  C07C69/017 ,  C07C69/618 ,  C07C69/76 ,  C07C233/05 ,  C07C233/11 ,  C07C233/65 ,  C07C313/00 ,  C07C315/04 ,  C07C317/14 ,  C07C317/22 ,  C07C321/28 ,  C07C323/09 ,  C07C323/18 ,  C07H13/04 ,  C11D9/50 ,  A61K7/00 ,  C07C103/76

Abstract: L'invention concerne un composé de formule (I): (I) des isomères et ses sels, où R1, R3 et R4 représentent, indépendamment l'un de l'autre, un atome d'hydrogène, un radical alkyle C1-C8, un radical alkoxy C1-C8, un atome d'halogène, un radical acyloxy C1-C8 ou un radical hydroxyle; R1 représente un atome d'hydrogène ou un radical alkyle C1-C6; R" représente un groupement insaturé, qui est, soit une chaîne polyéique, soit un noyau benzénique. L'invention concerne également deux variantes de procédés de préparation des composés de formule (Il ainsi que les compositions cosmétiques les contenant.

公开(公告)号：FR2596050B1

公开(公告)日：1989-06-23

申请号：FR8701830

申请日：1987-02-13

Applicant: OREAL

Inventor： FORESTIER SERGE ,  LAGRANGE ALAIN ,  LANG GERARD ,  SHROOT BRAHAM

IPC: C07D307/93 ,  A61K8/04 ,  A61K8/25 ,  A61K8/31 ,  A61K8/36 ,  A61K8/49 ,  A61K8/65 ,  A61K8/73 ,  A61K8/86 ,  A61K31/34 ,  A61K31/343 ,  A61P17/00 ,  A61P27/02 ,  A61P27/14 ,  A61P29/00 ,  A61P37/08 ,  A61Q5/00 ,  A61Q5/02 ,  C07D307/94 ,  C07D307/79

Abstract: A benzofuran derivative which is a compound of formula (I): (I) wherein a to d each are 0 to 1, with a+b+c+d>/=2; R1 to R6 are each H or C1-C6 alkyl; R7 is -CH2OR8 (R8=H, C1-C6 alkyl, C2-C6 mono- or polyhydroxyalkyl), -COR9 (R9=H, C1-C6 alkyl, which is an amino acid or amino sugar residue or where R' and R'' are H, C1-C6 alkyl, C2-C6 mono- or polyhydroxyalkyl, C3-C6 alkenyl or form a heterocycle) or OR10 (where R10 is H, C1-C20 alkyl, C2-C6 mono- or polyhydroxyalkyl or -OR10 is derived from a sugar) has retinoid type action and can be used in cosmetics (body and hair hygiene) and in medicine (treatment of dermatological conditions; atopy; degenerative diseases of connective tissue; or corneopathies).

公开(公告)号：IT1208048B

公开(公告)日：1989-06-01

申请号：IT2064987

申请日：1987-05-22

Applicant: OREAL

Inventor： MAIGNAN JEAN ,  LANG GERARD ,  MALLE GERARD ,  RESTLE SERGE ,  SHROOT BRAHAM

IPC: C07C41/00 ,  A61K8/00 ,  A61K8/30 ,  A61K8/34 ,  A61K8/35 ,  A61K8/36 ,  A61K8/368 ,  A61K8/37 ,  A61K8/41 ,  A61K8/42 ,  A61K8/49 ,  A61K31/045 ,  A61K31/085 ,  A61K31/12 ,  A61K31/16 ,  A61K31/165 ,  A61K31/19 ,  A61K31/215 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  C07C29/143 ,  C07C33/18 ,  C07C33/26 ,  C07C33/28 ,  C07C33/32 ,  C07C33/46 ,  C07C41/18 ,  C07C43/14 ,  C07C43/164 ,  C07C43/20 ,  C07C43/23 ,  C07C45/30 ,  C07C45/46 ,  C07C47/546 ,  C07C49/215 ,  C07C49/76 ,  C07C49/86 ,  C07C51/347 ,  C07C57/44 ,  C07C59/48 ,  C07C59/64 ,  C07C59/84 ,  C07C59/90 ,  C07C63/36 ,  C07C65/24 ,  C07C65/34 ,  C07C65/40 ,  C07C67/00 ,  C07C69/618 ,  C07C69/738 ,  C07C69/76 ,  C07C231/00 ,  C07C231/02 ,  C07C233/11 ,  C07C233/65 ,  C07C235/34 ,  C07C235/66 ,  C07C235/84 ,  C07C239/00 ,  C07C

Abstract: An aromatic naphthyl compound of the formula (I) wherein n is 0 or 1, R' is hydrogen, OH, acyloxy, alkoxy or NH2, R'' is hydrogen or lower alkoxy, or R' and R'' taken together form an oxo, methano or hydroxy-imino radical, R is -CH2OH or -COR8, R8 is hydrogen, -OR9 or R9 is hydrogen, alkyl having 1-20 carbon atoms, mono or polyhydroxyalkyl, aryl, aralkyl, the residue of a sugar or is 1, 2 or 3, r' and r'' each independently represent hydrogen, alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl, benzyl, the residue of amino acid or the residue of aminated sugar, or r' and r'' together form a heterocycle, R1, R2, R3 and R4 represent hydrogen, lower alkyl, alkoxy having 1-4 carbon atoms, fluoroalkoxy, CF3, cycloalkyl, lower acyl, halogen, OH, amino, acylamino or alkoxy carbonyl, R5, R6 and R7 represent hydrogen or methyl or when n=1, R5 and R7 taken together can form with the benzene ring a naphthalene ring, and the salts of the compound of formula I or their geometric or optical isomers. These compounds are useful in human and veterinary medicine and in cosmetic compositions.

公开(公告)号：BE1000427A4

公开(公告)日：1988-12-06

申请号：BE8700214

申请日：1987-03-05

Applicant: OREAL

Inventor： FORESTIER SERGE ,  LAGRANGE ALAIN ,  LANG GERARD ,  SHROOT BRAHAM

IPC: C07D307/93 ,  A61K8/04 ,  A61K8/25 ,  A61K8/31 ,  A61K8/36 ,  A61K8/49 ,  A61K8/65 ,  A61K8/73 ,  A61K8/86 ,  A61K31/34 ,  A61K31/343 ,  A61P17/00 ,  A61P27/02 ,  A61P27/14 ,  A61P29/00 ,  A61P37/08 ,  A61Q5/00 ,  A61Q5/02 ,  C07D307/94

Abstract: Ces composés, à action de type rétinoide, sont représentés par la formule a à d valent chacun 0 ou 1,avec a + b + c + d > ou égale à 2 ; R1 à R6 sont chacun H, alkyle en C1-C6;R7 = -CH2OR8(R8=H, alkyle en C1-C6, mono- ou polyhydroxyalkyle en C2-C6; ou -COR9 (R9=H, alkyle en C1-C6, -N-R'R'', R' et R'' ayant diverses significations; ou OR10, avec R10=H, alkyle C1-C20, mono ou polyhydroxyalkyle C2-C6, -OR10 pouvant aussi etre dérivé d'un sucre); ils sont utilisés en cosmétique (hygiène corporelle et capillaire) et en médicine (traitement des affections dermatologiques; de l'atopie; des maladies de dégéné rescence du tissu conjonctif;ou des cornéopathies)