公开(公告)号：IT8621031D0

公开(公告)日：1986-07-04

申请号：IT2103186

申请日：1986-07-04

Applicant: SCLAVO SPA

Inventor： RAPPUOLI RINO ,  PERUGINI MARIA ,  RATTI GIULIO

IPC: C12N15/09 ,  C07K14/34 ,  C12N1/20 ,  C12N15/00 ,  C12Q1/68 ,  C12Q1/689 ,  C12R1/15 ,  C12R1/19 ,  C12P

公开(公告)号：CA1341582C

公开(公告)日：2008-10-07

申请号：CA581889

申请日：1988-11-01

Applicant: SCLAVO SPA

Inventor： PIZZA MARIAGRAZIA ,  RAPPUOLI RINO ,  BARTOLONI ANTONELLA

IPC: C12N15/32 ,  A61K39/00 ,  A61K39/10 ,  A61P31/04 ,  C07H21/04 ,  C07K14/00 ,  C07K14/195 ,  C07K14/235 ,  C07K14/41 ,  C12N1/20 ,  C12N1/21 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12P21/00 ,  C12P21/02 ,  C12R1/19

Abstract: Immunologically active polypeptides with no or reduced toxicity useful for the preparation of an antipertussis vaccine. Method for the preparation of said polypeptides which comprises, cultivating a microorganismtransformed with a hybrid plasmid including the gene/s which codes for at least one of said polypeptides in a suitable medium and recovering the desired polypeptide from the cells or from the culture medium.

公开(公告)号：DE68928933T2

公开(公告)日：1999-08-26

申请号：DE68928933

申请日：1989-10-20

Applicant: UNIV LELAND STANFORD JUNIOR ,  SCLAVO SPA

Inventor： RELMAN DAVID ,  DOMENIGHINI MARIO ,  RAPPUOLI RINO ,  FALKOW STANLEY

IPC: C12N15/09 ,  A61K31/70 ,  A61K38/00 ,  A61K39/00 ,  A61K39/10 ,  A61K39/395 ,  A61P37/04 ,  C07K14/235 ,  C12N1/21 ,  C12N5/10 ,  C12N9/12 ,  C12P21/02 ,  C12R1/01 ,  C12R1/19

公开(公告)号：DE68928933D1

公开(公告)日：1999-04-01

申请号：DE68928933

申请日：1989-10-20

Applicant: UNIV LELAND STANFORD JUNIOR ,  SCLAVO SPA

Inventor： RELMAN DAVID ,  DOMENIGHINI MARIO ,  RAPPUOLI RINO ,  FALKOW STANLEY

IPC: C12N15/09 ,  A61K31/70 ,  A61K38/00 ,  A61K39/00 ,  A61K39/10 ,  A61K39/395 ,  A61P37/04 ,  C07K14/235 ,  C12N1/21 ,  C12N5/10 ,  C12N9/12 ,  C12P21/02 ,  C12R1/01 ,  C12R1/19

公开(公告)号：HK192795A

公开(公告)日：1995-12-29

申请号：HK192795

申请日：1995-12-21

Applicant: SCLAVO SPA

Inventor： GROSS ROY ,  RAPPUOLI RINO

IPC: C12N15/09 ,  C12N1/21 ,  C12N15/74 ,  C12P21/00 ,  C12R1/01 ,  C12R1/19

公开(公告)号：ES2078258T3

公开(公告)日：1995-12-16

申请号：ES90107892

申请日：1990-04-25

Applicant: SCLAVO SPA

Inventor： PIZZA MARIAGRAZIA ,  COVACCI ANTONELLO ,  RAPPUOLI RINO ,  NENCIONI LUCIANO

IPC: C12N1/20 ,  A61K39/00 ,  A61K39/10 ,  C07K14/235 ,  C12N15/00 ,  C12N15/01 ,  C12N15/09 ,  C12N15/31 ,  C12R1/01

公开(公告)号：DE69022106D1

公开(公告)日：1995-10-12

申请号：DE69022106

申请日：1990-04-25

Applicant: SCLAVO SPA

Inventor： PIZZA MARIAGRAZIA ,  COVACCI ANTONELLO ,  RAPPUOLI RINO ,  NENCIONI LUCIANO

IPC: C12N1/20 ,  A61K39/00 ,  A61K39/10 ,  C07K14/235 ,  C12N15/00 ,  C12N15/01 ,  C12N15/09 ,  C12N15/31 ,  C12R1/01

公开(公告)号：DE3853876T2

公开(公告)日：1995-10-05

申请号：DE3853876

申请日：1988-10-25

Applicant: SCLAVO SPA

Inventor： PIZZA MARIAGRAZIA ,  RAPPUOLI RINO ,  BARTOLONI ANTONELLA

IPC: A61K39/00 ,  A61K39/10 ,  A61P31/04 ,  C07H21/04 ,  C07K14/00 ,  C07K14/195 ,  C07K14/235 ,  C07K14/41 ,  C12N1/20 ,  C12N1/21 ,  C12N15/09 ,  C12P21/00 ,  C12P21/02 ,  C12R1/19 ,  C12N15/31

Abstract: Immunologically active polypeptides with no or reduced toxicity useful for the preparation of an antipertussis vaccine. Method for the preparation of said polypeptides which comprises, cultivating a microorganismtransformed with a hybrid plasmid including the gene/s which codes for at least one of said polypeptides in a suitable medium and recovering the desired polypeptide from the cells or from the culture medium.

公开(公告)号：ES2072857T3

公开(公告)日：1995-08-01

申请号：ES88117742

申请日：1988-10-25

Applicant: SCLAVO SPA

Inventor： PIZZA MARIAGRAZIA ,  RAPPUOLI RINO ,  BARTOLONI ANTONELLA

IPC: A61K39/00 ,  A61K39/10 ,  A61P31/04 ,  C07H21/04 ,  C07K14/00 ,  C07K14/195 ,  C07K14/235 ,  C07K14/41 ,  C12N1/20 ,  C12N1/21 ,  C12N15/09 ,  C12P21/00 ,  C12P21/02 ,  C12R1/19 ,  C12N15/31

Abstract: Immunologically active polypeptides with no or reduced toxicity useful for the preparation of an antipertussis vaccine. Method for the preparation of said polypeptides which comprises, cultivating a microorganismtransformed with a hybrid plasmid including the gene/s which codes for at least one of said polypeptides in a suitable medium and recovering the desired polypeptide from the cells or from the culture medium.

公开(公告)号：DE68916087D1

公开(公告)日：1994-07-21

申请号：DE68916087

申请日：1989-04-06

Applicant: SCLAVO SPA

Inventor： GROSS ROY ,  RAPPUOLI RINO

IPC: C12N15/09 ,  C12N1/21 ,  C12N15/74 ,  C12P21/00 ,  C12R1/01 ,  C12R1/19