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公开(公告)号：IT1229766B
公开(公告)日：1991-09-10
申请号：IT2055489
申请日：1989-05-19
Applicant: SCLAVO SPA
Inventor： MAGISTRIS MARIA TERESA DE , BARTOLONI ANTONELLA , RAPPUOLI RINO , TAGLIABUE ALDO
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公开(公告)号：IT1223529B
公开(公告)日：1990-09-19
申请号：IT2308587
申请日：1987-12-18
Applicant: SCLAVO SPA
Inventor： BARTOLONI ANTONELLA , PIZZA MARIAGRAZIA , RAPPUOLI RINO
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公开(公告)号：IT1223334B
公开(公告)日：1990-09-19
申请号：IT2248187
申请日：1987-11-02
Applicant: SCLAVO SPA
Inventor： PIZZA MARIAGRAZIA , BARTOLONI ANTONELLA , RAPPUOLI RINO
IPC: A61K39/00 , A61K39/10 , A61P31/04 , C07H21/04 , C07K14/00 , C07K14/195 , C07K14/235 , C07K14/41 , C12N1/20 , C12N1/21 , C12N15/09 , C12P21/00 , C12P21/02 , C12R1/19 , A61K
Abstract: Immunologically active polypeptides with no or reduced toxicity useful for the preparation of an antipertussis vaccine. Method for the preparation of said polypeptides which comprises, cultivating a microorganismtransformed with a hybrid plasmid including the gene/s which codes for at least one of said polypeptides in a suitable medium and recovering the desired polypeptide from the cells or from the culture medium.
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公开(公告)号：IT8722481D0
公开(公告)日：1987-11-02
申请号：IT2248187
申请日：1987-11-02
Applicant: SCLAVO SPA
Inventor： PIZZA MARIAGRAZIA , BARTOLONI ANTONELLA , RAPPUOLI RINO
IPC: A61K39/00 , A61K39/10 , A61P31/04 , C07H21/04 , C07K14/00 , C07K14/195 , C07K14/235 , C07K14/41 , C12N1/20 , C12N1/21 , C12N15/09 , C12P21/00 , C12P21/02 , C12R1/19
Abstract: Immunologically active polypeptides with no or reduced toxicity useful for the preparation of an antipertussis vaccine. Method for the preparation of said polypeptides which comprises, cultivating a microorganismtransformed with a hybrid plasmid including the gene/s which codes for at least one of said polypeptides in a suitable medium and recovering the desired polypeptide from the cells or from the culture medium.
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公开(公告)号：IT8920554D0
公开(公告)日：1989-05-19
申请号：IT2055489
申请日：1989-05-19
Applicant: SCLAVO SPA
Inventor： MAGISTRIS MARIA TERESA DE , BARTOLONI ANTONELLA , RAPPUOLI RINO , TAGLIABUE ALDO
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Patent Agency Ranking
公开(公告)号：CA1341582C
公开(公告)日：2008-10-07
申请号：CA581889
申请日：1988-11-01
Applicant: SCLAVO SPA
Inventor： PIZZA MARIAGRAZIA , RAPPUOLI RINO , BARTOLONI ANTONELLA
IPC: C12N15/32 , A61K39/00 , A61K39/10 , A61P31/04 , C07H21/04 , C07K14/00 , C07K14/195 , C07K14/235 , C07K14/41 , C12N1/20 , C12N1/21 , C12N9/10 , C12N15/09 , C12N15/54 , C12P21/00 , C12P21/02 , C12R1/19
Abstract: Immunologically active polypeptides with no or reduced toxicity useful for the preparation of an antipertussis vaccine. Method for the preparation of said polypeptides which comprises, cultivating a microorganismtransformed with a hybrid plasmid including the gene/s which codes for at least one of said polypeptides in a suitable medium and recovering the desired polypeptide from the cells or from the culture medium.
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公开(公告)号：DE3853876T2
公开(公告)日：1995-10-05
申请号：DE3853876
申请日：1988-10-25
Applicant: SCLAVO SPA
Inventor： PIZZA MARIAGRAZIA , RAPPUOLI RINO , BARTOLONI ANTONELLA
IPC: A61K39/00 , A61K39/10 , A61P31/04 , C07H21/04 , C07K14/00 , C07K14/195 , C07K14/235 , C07K14/41 , C12N1/20 , C12N1/21 , C12N15/09 , C12P21/00 , C12P21/02 , C12R1/19 , C12N15/31
Abstract: Immunologically active polypeptides with no or reduced toxicity useful for the preparation of an antipertussis vaccine. Method for the preparation of said polypeptides which comprises, cultivating a microorganismtransformed with a hybrid plasmid including the gene/s which codes for at least one of said polypeptides in a suitable medium and recovering the desired polypeptide from the cells or from the culture medium.
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公开(公告)号：ES2072857T3
公开(公告)日：1995-08-01
申请号：ES88117742
申请日：1988-10-25
Applicant: SCLAVO SPA
Inventor： PIZZA MARIAGRAZIA , RAPPUOLI RINO , BARTOLONI ANTONELLA
IPC: A61K39/00 , A61K39/10 , A61P31/04 , C07H21/04 , C07K14/00 , C07K14/195 , C07K14/235 , C07K14/41 , C12N1/20 , C12N1/21 , C12N15/09 , C12P21/00 , C12P21/02 , C12R1/19 , C12N15/31
Abstract: Immunologically active polypeptides with no or reduced toxicity useful for the preparation of an antipertussis vaccine. Method for the preparation of said polypeptides which comprises, cultivating a microorganismtransformed with a hybrid plasmid including the gene/s which codes for at least one of said polypeptides in a suitable medium and recovering the desired polypeptide from the cells or from the culture medium.
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公开(公告)号：CA2017180A1
公开(公告)日：1990-11-19
申请号：CA2017180
申请日：1990-05-18
Applicant: SCLAVO SPA
Inventor： DE MAGISTRIS MARIA T , BARTOLONI ANTONELLA , RAPPUOLI RINO , TAGLIABUE ALDO
Abstract: SYNTHETIC PEPTIDES CAPABLE OF STIMULATING A T-CELLULAR IMMUNITY The S1 subunit regions of pertussis toxin from Bordetella pertussis comprising the antigenic sites recognized by the human T helper clones anti-S1 are described and said sites are characterized. Synthetic peptides having an amino acid sequence corresponding to the sequence of said regions or of the T-epitopes comprised therein are novel. Said peptides, alone or in combination with the immunodominant Bepitope of the pertussis toxin S1 subunit from Bordetella pertussis, are particularly useful as immunogens for manufacturing acellular anti-pertussis vaccines.
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公开(公告)号：HK192995A
公开(公告)日：1995-12-29
申请号：HK192995
申请日：1995-12-21
Applicant: SCLAVO SPA
Inventor： PIZZA MARIAGRAZIA , RAPPUOLI RINO , BARTOLONI ANTONELLA
IPC: A61K39/00 , A61K39/10 , A61P31/04 , C07H21/04 , C07K14/00 , C07K14/195 , C07K14/235 , C07K14/41 , C12N1/20 , C12N1/21 , C12N15/09 , C12P21/00 , C12P21/02 , C12R1/19 , C12N15/31
Abstract: Immunologically active polypeptides with no or reduced toxicity useful for the preparation of an antipertussis vaccine. Method for the preparation of said polypeptides which comprises, cultivating a microorganismtransformed with a hybrid plasmid including the gene/s which codes for at least one of said polypeptides in a suitable medium and recovering the desired polypeptide from the cells or from the culture medium.
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