公开(公告)号：JPS5136436A

公开(公告)日：1976-03-27

申请号：JP10762174

申请日：1974-09-20

Applicant: TORAY INDUSTRIES

Inventor： IMAMURA SHINZO ,  KAWAMOTO ICHIRO ,  NATSUME KOJI ,  SAKAI SHINNOSUKE

IPC: C07C251/44

公开(公告)号：JPS5136435A

公开(公告)日：1976-03-27

申请号：JP10761474

申请日：1974-09-20

Applicant: TORAY INDUSTRIES

Inventor： KAWAMOTO ICHIRO ,  SARUYAMA MASAO ,  SEKOYA TAKESHI ,  IMAMURA SHINZO ,  MATSUKUMA YOSHIHISA

IPC: C07C251/44

公开(公告)号：JPH11217349A

公开(公告)日：1999-08-10

申请号：JP3067198

申请日：1998-01-28

Applicant: SODA AROMATIC ,  TORAY INDUSTRIES

Inventor： TAKAOKA HIDEAKI ,  ITO NOBUHIKO ,  HASEBE AKIO ,  MURAOKA HIDEO ,  IMAMURA SHINZO

IPC: C07D307/33 ,  C07C29/145 ,  C07C31/20 ,  C07C45/65 ,  C07C49/17

Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound useful as a synthetic intermediate for producing an α,ω-alkanediol by a simple and industrially excellent method, by condensing a specific dicarboxylic acid ester with γ-butyrolactone. SOLUTION: A dicarboxylic acid ester of the formula ROOC(CH2 )n COOR ((n) is 7-13; R is an alkyl or an alkenyl) is condensed with γ-butyrolactone in the presence of a condensation agent composed of preferably a base generally at temperatures of 0-200 deg.C, preferably 50-150 deg.C to produce an α,ω- bis-(tetrahydro-2-oxo-3-furany1)-α,ω-alkanedione of formula I. The alkanedione is hydrolyzed and decarboxylated to give an α,ω-dihydroxy-(ω-3)-alkanedione of formula IT, which is further reduced to give an α,ω-alkanediol of formula III.

公开(公告)号：JPH1129587A

公开(公告)日：1999-02-02

申请号：JP18820497

申请日：1997-07-14

Applicant: TORAY INDUSTRIES

Inventor： TSURUOKA HISASHI ,  IMAMURA SHINZO

IPC: C07D213/74 ,  C07F9/10

Abstract: PROBLEM TO BE SOLVED: To obtain the subject substance easy to handle and usable for synthesis of highly pure phosphatidic acid, by making glycerol-3-hosphate which is highly hygroscopic and hard to handle, carry on a solid. SOLUTION: This substance is obtained by making glycerol-3-phosphate (hereafter, G3P) carry on a solid (preferably, silica gel, almina, Super Flow Cel, Celite or a resin), wherein, the solid is added to G3P solution (preferably, methanol, ethanol, propanol, butanol, etc., is preferably used as a solvent), then, the solvent is distilled for drying. The temperature for dying G3P is preferably 30-150 deg.C. By reacting the solid-carried G3P with an activated fatty acid (preferably, a chlorinated or bromated fatty acid anhydride), highly pure phosphatidic acid can be obtained in high yield.

公开(公告)号：JPH1121283A

公开(公告)日：1999-01-26

申请号：JP18902197

申请日：1997-06-30

Applicant: SODA AROMATIC ,  TORAY INDUSTRIES

Inventor： TAKAOKA HIDEAKI ,  WADA SHIGERU ,  ITO NOBUHIKO ,  HASEBE AKIO ,  IMAMURA SHINZO

IPC: C07D307/33

Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound in high selectivity and yield in an industrially advantageous way using readily available and inexpensive raw materials by condensation reaction of a specific compound with γ-butyrolactone and an alkali metal alcoholate. SOLUTION: (A) A dicarboxylic ester of the formula ROOC(CH2 )n COOR ((n) is 7-13; R is an alkyl) (e.g. 1,12-dodecanediacid dimethyl ester) is agitated under heating followed by adding (B) γ-butyrolactone and (B) an alkali metal alcoholate (e.g. sodium methylate) to the component A to carry out a condensation reaction to obtain the objective compound. The reaction is pref. carried out under reduced pressures (pref. at 50-760 mmHg) while distilling the alcohol formed off the system; alternatively, for example, it is also preferable that, in the 1st step, a pressure is reduced under conditions enough to evaporate the alcohol formed, and in the 2nd step, the pressure is further reduced; namely, the pressure reduction is conducted in two or more steps.

公开(公告)号：JPH1121270A

公开(公告)日：1999-01-26

申请号：JP18902297

申请日：1997-06-30

Applicant: SODA AROMATIC ,  TORAY INDUSTRIES

Inventor： TAKAOKA HIDEAKI ,  ITO NOBUHIKO ,  HASEBE AKIO ,  IMAMURA SHINZO

IPC: C07C67/32 ,  C07C69/716

Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound useful as an intermediate ester for a hydroxy fatty acid, which is an important intermediate for large cyclolactone- based perfumes. SOLUTION: This compound is shown by formula I [(n) is 10 or 11; and R is a 1-6C alkyl]. The compound shown by formula I is obtained by heating the γ-butylolactone section of an alkali metal salt of 2-(ω-alkoxycarbonyl alkanoyl)-4-butanolide shown by formula II [(n) is 10 or 11; R is an alkyl; and M is an alkali metal] [e.g. 2-(11-methoxycarbonyl undecanoyl)-γ-butylolactone, and 2-(12-methoxycarbonyl dodecanoyl)-γ-butylolactone] at 80 to 1-10 deg.C for 1 to 20 h, preferably in the presence of 0.5 to 1 equivalent of a weak acid (e.g. phosphoric, pyrophosphoric or carbonic acid), for selective hydrolysis and decarboxylation.

公开(公告)号：JPH1087560A

公开(公告)日：1998-04-07

申请号：JP23949196

申请日：1996-09-10

Applicant: TORAY INDUSTRIES

Inventor： ENDO ITARU ,  IMAMURA SHINZO

IPC: B01J31/22 ,  C07B61/00 ,  C07C51/15 ,  C07C65/03 ,  C07F1/04 ,  C07F1/06

Abstract: PROBLEM TO BE SOLVED: To obtain a complex useful as synthetic intermediate of p-hydroxy benzoic as a raw material of medicine, agrochemical material and liquid crystalline polymer, by mixing phenol with an alkali metal hydroxide in an aprotic polar solvent, and removing water therefrom. SOLUTION: This complex consisting of an alkali metal salt of phenol and an aprotic polar solvent and having 1:2 molar ratio of the alkali metal salt of phenol to the aprotic polar solvent, is obtained by mixing phenol and an alkali metal hydroxide such as sodium hydroxide and potassium hydroxide in the aprotic polar solvent such as dimethylsulfoxide, dimethylformamide and dimethylacetamide, and removing water therefrom.

公开(公告)号：JPH1087559A

公开(公告)日：1998-04-07

申请号：JP23949396

申请日：1996-09-10

Applicant: TORAY INDUSTRIES

Inventor： ENDO ITARU ,  IMAMURA SHINZO

IPC: B01J31/22 ,  C07B61/00 ,  C07C51/15 ,  C07C65/03 ,  C07F1/04 ,  C07F1/06

Abstract: PROBLEM TO BE SOLVED: To improve the yield of p-hydroxy benzoic acid to be >=33%, while maintaining the selectivity of the acid in a reaction of an alkali metal salt of phenol with carbon dioxide in DMSO high in selectivity of the acid among various aprotic polar solvents. SOLUTION: This method for producing p-hydroxybenzoic acid by mixing dimethylsulfoxide, phenol and 0.9-1.1 molar fold sodium hydroxide relative to the phenol, or their aqueous solutions, then removing water by a distillation to generate a complex consisting of 1mol alkali metal salt of phenol and 2mols DMSO and reacting carbon dioxide with the complex at

公开(公告)号：JPH1081647A

公开(公告)日：1998-03-31

申请号：JP20731397

申请日：1997-07-16

Applicant: TORAY INDUSTRIES ,  SODA AROMATIC

Inventor： NIWA ATSUSHI ,  IMAMURA SHINZO ,  ITO NOBUHIKO ,  HASEBE AKIO

IPC: B01J31/08 ,  C07B61/00 ,  C07C67/08 ,  C07C69/34

Abstract: PROBLEM TO BE SOLVED: To obtain the subject high-purity compound in high yield by reacting a carboxylic acid with an alcohol under a specific condition. SOLUTION: A carboxylic acid, especially an alkanedioic acid is esterified with an alcohol in the presence of a solid acid catalyst. In the operation, a dehydrating process is provided in the middle of the reaction to remove water formed in the reaction system. Then the esterification reaction is newly restarted and completed to give the objective compound. The dehydrating process is provided in a state not to bring the reaction solution into contact with an acid catalyst and the times of the dehydrating processes is one to three times. Preferably, the dehydration is carried out until the water content of the reaction mixture at the point of the starting time of the restarted esterification reaction reaches

公开(公告)号：JP2530662B2

公开(公告)日：1996-09-04

申请号：JP20995087

申请日：1987-08-24

Applicant: TORAY INDUSTRIES

Inventor： SATO HARUYO ,  ITO NORIKO ,  IMAMURA SHINZO

IPC: C12P41/00 ,  C12R1/01 ,  C12R1/05 ,  C12R1/185 ,  C12R1/20 ,  C12R1/22 ,  C12R1/38 ,  C12R1/40 ,  C12R1/425 ,  C12R1/645 ,  C12R1/72 ,  C12R1/84 ,  C12R1/88