-
71.发明授权公开(公告)号：US09956248B2
公开(公告)日：2018-05-01
申请号：US14070040
申请日：2013-11-01
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin Qiang Kuang , Jennifer Michelle Marconi
CPC classification number: A61K35/28 , A01N1/0221 , A61K35/50 , A61K38/1825 , A61K38/1841 , A61K38/39 , A61K38/57 , C12N5/0605 , C12N2500/02 , C12N2501/115 , C12N2502/025
Abstract: This invention provides a fluid therapeutic placental product comprising placental cells and a placental dispersion comprising placental factors. The placental cells and the placental dispersion are derived from placental tissue. A placental tissue can optionally be an amnion, chorion, or a trophoblast-depleted chorion. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
-
72.发明申请公开(公告)号：US20180104282A1
公开(公告)日：2018-04-19
申请号：US15632142
申请日：2017-06-23
Applicant: Osiris Therapeutics, Inc.
Inventor： Steven Michael Sinclair , Alla Danilkovitch , Malathi Sathyamoorthy , Jin-Qiang Kuang , Sandeep Dhall , Anthony John Melchiorri
CPC classification number: A61K35/50 , A01N1/0221 , A01N1/0284 , A61F13/00 , A61K9/1682 , A61K9/19 , A61K35/32 , A61K35/36 , A61L27/3604 , A61L27/3608 , A61L27/362 , A61L27/3691
Abstract: Disclosed are methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are lyophilized tissues prepared using the disclosed methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are methods of treating a wound or tissue defect comprising administering a reconstituted lyophilized tissue to the wound or tissue defect.
-
公开(公告)号：US20140127317A1
公开(公告)日：2014-05-08
申请号：US14070035
申请日：2013-11-01
Applicant: Osiris Therapeutics, Inc.
Inventor： Timothy Jansen , Samson Tom , Alla Danilkovitch , Dana Yoo , Jaime Zerhusen
IPC: A61K35/50
CPC classification number: A61K35/28 , A01N1/0221 , A61K35/50 , A61K38/1825 , A61K38/1841 , A61K38/39 , A61K38/57 , C12N5/0605 , C12N2500/02 , C12N2501/115 , C12N2502/025
Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
Abstract translation: 本文提供了包含免疫兼容的羊膜的胎盘产品。 这样的胎盘产物可以冷冻保存并且解冻后含有可行的治疗细胞。 本发明的胎盘产品可用于通过将胎盘产品应用于损伤来治疗患有组织损伤（例如伤口或烧伤）的患者。 类似的应用可用于韧带和腱修复以及植入手术如骨移植。
-
公开(公告)号：US20030031695A1
公开(公告)日：2003-02-13
申请号：US09840284
申请日：2002-06-26
Applicant: Osiris Therapeutics, Inc.
Inventor： Sudhakar Kadiyala , Scott P. Bruder
IPC: A61K045/00 , A61F002/00
CPC classification number: A61L27/3847 , A61F2310/00293 , A61K38/1875 , A61K2035/124 , A61L27/12 , A61L27/3808 , A61L27/3821 , A61L27/3895 , A61L27/58 , A61L2430/02 , C12N5/0654 , C12N5/0663 , C12N2500/38 , C12N2500/42 , C12N2501/155 , C12N2501/39 , C12N2533/18 , C12N2533/52 , C12N2533/54 , A61L27/24 , A61L27/222 , A61L27/20 , C08L1/02 , A61K2300/00
Abstract: Disclosed are compositions and methods for augmenting bone formation by administering isolated human mesenchymal stem cells (hMSCs) with a ceramic material or matrix or by administering hMSCs; fresh, whole marrow; or combinations thereof in a resorbable biopolymer which supports their differentiation into the osteogenic lineage. Contemplated is the delivery of (i) isolated, culture-expanded, human mesenchymal stem cells; (ii) freshly aspirated bone marrow; or (iii) their combination in a carrier material or matrix.
-
公开(公告)号：US20250161370A1
公开(公告)日：2025-05-22
申请号：US19027897
申请日：2025-01-17
Applicant: Osiris Therapeutics, Inc.
Inventor： Steven Michael SINCLAIR , Alla DANILKOVITCH , Malathi SATHYAMOORTHY , Jin-Qiang KUANG , Sandeep DHALL , Yishan LIU , Anthony John MELCHIORRI , Matthew Robert MOORMAN , Mena Schiano LO MORIELLO , Anne Allgood LERCH
IPC: A61K35/50 , A61K9/00 , A61K9/06 , A61K9/19 , A61K35/33 , A61K35/51 , A61L26/00 , A61L27/36 , A61L27/38 , A61P17/02 , A61P19/00 , A61P19/02 , A61P19/04 , A61P19/10 , A61P29/00
Abstract: Disclosed are compositions comprising a non-homogenized chorionic matrix, a homogenized amniotic matrix and a homogenized UC (UC) matrix, wherein the non-homogenized chorionic matrix comprises viable cells. Disclosed are methods of making the compositions disclosed herein comprising preparing a non-homogenized chorionic matrix, preparing a homogenized amniotic matrix, preparing a homogenized UC matrix, and combining the non-homogenized chorionic matrix, the non-homogenized chorionic matrix, and the homogenized UC matrix. Disclosed are methods of treating a tissue injury or chronic pain comprising administering any of the disclosed compositions to an area of a subject comprising a tissue injury.
-
Patent Agency Ranking
公开(公告)号：US12268797B2
公开(公告)日：2025-04-08
申请号：US17681064
申请日：2022-02-25
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
Abstract: This invention provides porated cartilage products and methods of producing porated cartilage products. Optionally, the cartilage products are sized, porated, and digested to provide a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
-
77.发明公开公开(公告)号：US20240050482A1
公开(公告)日：2024-02-15
申请号：US18101727
申请日：2023-01-26
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
CPC classification number: A61K35/28 , A01N1/0221 , A61K35/50 , A61K38/1825 , A61K38/1841 , A61K38/39 , A61K38/57 , C12N5/0605 , C12N2500/02 , C12N2502/025 , C12N2501/115
Abstract: This invention provides a fluid therapeutic placental product comprising placental cells and a placental dispersion comprising placental factors. The placental cells and the placental dispersion are derived from placental tissue. A placental tissue can optionally be an amnion, chorion, or a trophoblast-depleted chorion. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
-
公开(公告)号：US11590172B2
公开(公告)日：2023-02-28
申请号：US16296463
申请日：2019-03-08
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana YOo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
-
公开(公告)号：US11406735B2
公开(公告)日：2022-08-09
申请号：US14485210
申请日：2014-09-12
Applicant: Osiris Therapeutics, Inc.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
Abstract: This invention provides porated cartilage products and methods of producing porated cartilage products. Optionally, the cartilage products are sized, porated, and digested to provide a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
-
公开(公告)号：US10828395B2
公开(公告)日：2020-11-10
申请号：US15298142
申请日：2016-10-19
Applicant: Osiris Therapeutics, Inc.
Inventor： Thomas E. Uveges , Jin-Qiang Kuang , Alla Danilkovitch , S. Michael Sinclair , Sandra D. Geraghty
Abstract: Provided herein is a bone repair composition that is composed of periosteum containing an angiogenic growth factor(s), cancellous bone chips containing viable osteogenic cells, and, optionally, demineralized bone matrix (DBM) chips. Also provided herein are articles of manufacture and methods of use thereof to treat bone defects.
-
-
-
-
-
-
-
-
-
Search Results
571
records
(took 0.035 seconds)
