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公开(公告)号：KR101263780B1
公开(公告)日：2013-05-13
申请号：KR1020110083646
申请日：2011-08-22
Applicant: 강원대학교산학협력단
IPC: A61K31/37 , A61K31/195 , A61K31/185 , A61K47/48
Abstract: 본발명은쿠마린유도체와프로테노이드가화학적으로결합된쿠마린-프로테노이드결합체를수상에분산시킴으로써제조되고, 광조사및 pH 변화에의해목적물질의방출을제어할수 있는것을특징으로하는광 및 pH 응답성자가결집체및 그제조방법을개시한다.
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公开(公告)号：KR1020120132145A
公开(公告)日：2012-12-05
申请号：KR1020110050791
申请日：2011-05-27
Applicant: 강원대학교산학협력단
IPC: C08J3/075 , C08J3/24 , C08L101/02 , A61K47/30
Abstract: PURPOSE: A photoresponsive hydrogel is provided to control the emission of light under 260 nm by reducing the cross-linking density of hydrogel by irradiating with a light in 260 nm or less, or increasing the cross-linked density by irradiating with a light in 310 nm or more. CONSTITUTION: A photoresponsive hydrogel is formed by photocrosslinking an aqueous polymer combined with photocrosslinking the water-aqueous polymer combined with a coumarin derivative, and can control the emission of water-soluble target material by photo-irradiation. A manufacturing method of the photosensitive hydrogel comprises: a step of binding a coumarin derivative to an aqueous polymer; a step of manufacturing hydrogel by photo-crosslinking an aqueous polymer solution combined with a coumarin derivative, and a step of mounting a hydrophilic target material to the hydrogel.
Abstract translation: 目的：提供光响应性水凝胶，通过用260nm或更小的光照射降低水凝胶的交联密度，或通过在310中照射光来增加交联密度来控制260nm以下的光的发射 nm以上。 构成：光反应性水凝胶是通过将与水凝胶与香豆素衍生物结合的水性聚合物结合的水性聚合物进行光交联而形成的，并且可以通过光照照射来控制水溶性目标物质的发射。 感光性水凝胶的制造方法包括：将香豆素衍生物与水性聚合物结合的工序; 通过光聚合与香豆素衍生物组合的聚合物水溶液进行光交联制造水凝胶的步骤，以及将亲水性靶材料安装在水凝胶上的步骤。
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公开(公告)号：KR101077635B1
公开(公告)日：2011-10-27
申请号：KR1020090060241
申请日：2009-07-02
Applicant: 강원대학교산학협력단
Abstract: 본발명은목적물질을포집하고있는수화겔에있어서, 산성기를가지고있는산성고분자와염기성기를가지고있는염기성고분자사이에형성되는염다리의내부에목적물질이포집되어형성되는것을특징으로하는수화겔 및그의제조방법에관한것으로, 산성고분자와염기성고분자로구성된수화겔로서 pH에따라포집된목적물질을선택적으로방출하는특징이있는바, 내부에포집된항암제, 항생제, 항진균제, 항박테리아제, 항산화제, 미백제, 소염제등의다양한소수성, 친수성생리활성성분을필요한상황에따라선택적으로외부에방출시킬수 있는효과를발휘한다.
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公开(公告)号：KR1020110002659A
公开(公告)日：2011-01-10
申请号：KR1020090060241
申请日：2009-07-02
Applicant: 강원대학교산학협력단
Abstract: PURPOSE: A hydrogel is provided to selectively discharge target materials according to pH and to be prepared without a chemical cross-linker. CONSTITUTION: A method for preparing hydrogel comprises the steps of: dissolving an acidic polymer with an acidic group and pH value lower than pH of water to prepare an acidic polymer solution; dissolving a basic polymer with a base group and pK value higher than pH of water; and mixing acidic polymer water solution, basic polymer solution and a capture material.
Abstract translation: 目的：提供水凝胶以根据pH选择性地排放靶材料，并且在没有化学交联剂的情况下制备。 构成：制备水凝胶的方法包括以下步骤：将具有酸性基团的酸性聚合物溶解并且pH值低于水的pH以制备酸性聚合物溶液; 溶解碱性聚合物，pK值高于pH值; 并混合酸性聚合物水溶液，碱性聚合物溶液和捕获材料。
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公开(公告)号：KR100891548B1
公开(公告)日：2009-04-03
申请号：KR1020070140201
申请日：2007-12-28
Applicant: 강원대학교산학협력단
IPC: C08F220/52 , C08F220/00 , C08K3/00
CPC classification number: C08F218/02 , C08F2/44 , C08F8/32 , C08F220/56 , C08J3/091 , C08J3/12
Abstract: An alginate particle containing poly(N-isopropylacrylamide) is provided to emit a relatively small amount of capture target materials below Tg of poly(N-isopropylacrylamide) and emit a relatively large amount of the capture target materials above the Tg of poly(N-isopropylacrylamide). A method for preparing an alginate particle having capture target materials comprises the following steps of: melting or dispersing capture target materials in a liquid or colloidal suspension containing a copolymer of poly(N-isopropylacrylamide) and alginate; and dropping or spraying the liquid or colloidal suspension in a solution with Ca^(2+), Mg^(2+), Al^(3+), Cr^(3+). The copolymer of poly(N-isopropylacrylamide) and alginate is prepared by reacting a NH2 group to poly(N-isopropylacrylamide) and then condensation-reacting the poly(N-isopropylacrylamide) to a carboxyl group of the alginate.
Abstract translation: 提供含有聚（N-异丙基丙烯酰胺）的藻酸盐颗粒以在聚（N-异丙基丙烯酰胺）Tg以下发射相对少量的捕获目标材料，并在聚（N-异丙基丙烯酰胺）的Tg以上发射相对大量的捕获目标材料， 异丙基丙烯酰胺）。 制备具有捕获目标材料的藻酸盐颗粒的方法包括以下步骤：将捕获目标材料熔融或分散在含有聚（N-异丙基丙烯酰胺）和藻酸盐的共聚物的液体或胶态悬浮液中; 并将液体或胶体悬浮液滴入或喷雾于含Ca（2+），Mg（2+），Al（3+），Cr（3+）的溶液中。 通过使NH 2基团与聚（N-异丙基丙烯酰胺）反应，然后使聚（N-异丙基丙烯酰胺）与藻酸盐的羧基缩合反应来制备聚（N-异丙基丙烯酰胺）和藻酸盐的共聚物。
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Patent Agency Ranking
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公开(公告)号：KR1020180121103A
公开(公告)日：2018-11-07
申请号：KR1020170055390
申请日：2017-04-28
Applicant: 강원대학교산학협력단
Abstract: 본발명은포도당응답성모노올레인큐빅상및 이의제조방법에관한것이다. 보다상세하게는, 큐빅상의수상채널에폴리비닐알콜을고정화시키고동시에붕산염을포함시킴으로써제조되는것으로, 포도당의농도에감응하여큐빅상내 함유하고있는유효성분의방출제어를용이하게할 수있는포도당응답성모노올레인큐빅상및 이의제조방법에관한것이다.
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