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    신규 히드록사믹산 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 비정상 세포 성장 질환의 예방 또는 치료용 약학적 조성물
    74.
    发明公开
    신규 히드록사믹산 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 비정상 세포 성장 질환의 예방 또는 치료용 약학적 조성물 有权
    新型羟基酸衍生物或其药学上可接受的盐，其制备方法和药物组合物，用于预防或治疗含有其作为活性成分的增殖性疾病

    公开(公告)号：KR1020120038677A

    公开(公告)日：2012-04-24

    申请号：KR1020100100249

    申请日：2010-10-14

    Applicant: 한국화학연구원

    Inventor： 이정옥 ,  김형래 ,  류재욱 ,  하재두 ,  조성윤 ,  정희정 ,  이종국

    IPC: C07C259/04 ,  C07D213/56 ,  A61K31/16 ,  A61P35/00

    Abstract: PURPOSE: A hydroxamic acid derivative is provided to have excellent restraining effect against various protein kinase useful for treating abnormal cell growth disease, for example b-raf, Fak, Fms, etc. CONSTITUTION: A hydroxamic acid derivative is in chemical formula 1. A manufacturing method of the hydroxamic derivatives comprises: a step of manufacturing a compound in chemical formula 3 by hydryolysis of a compound in chemical formula 2 which is starting material; a step of manufacturing a compound in chemical formula 5 through a condensation reaction of the compound in chemical formula 3 with a compound in chemical formula 4, and a step of manufacturing a compound in chemical formula 1a through an addition reaction of the chemical formula 5 with a compound in chemical formula 6.

    Abstract translation: 目的：提供异羟肟酸衍生物对于治疗异常细胞生长疾病的各种蛋白激酶具有优异的抑制作用，例如b-raf，Fak，Fms等。构成：异羟肟酸衍生物在化学式1中。 异羟肟基衍生物的制造方法包括：通过化学式2中作为起始原料的化合物的水解来制备化学式3中的化合物的步骤; 通过化学式3中的化合物与化学式4的化合物的缩合反应制备化学式5中的化合物的步骤，以及通过化学式5与化学式5的化合物的加成反应制备化学式1a的化合物的步骤 化学式6中的化合物。

    신규 피라졸로[4,3-ｂ]피리딘 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물
    77.
    发明公开
    신규 피라졸로[4,3-ｂ]피리딘 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물 失效
    新型吡咯并[4,3-B]吡啶衍生物或其药学上可接受的盐，其制备方法和含有其作为活性成分的药物组合物

    公开(公告)号：KR1020100057433A

    公开(公告)日：2010-05-31

    申请号：KR1020080116472

    申请日：2008-11-21

    Applicant: 한국화학연구원

    Inventor： 하재두 ,  이정옥 ,  류재욱 ,  조성윤 ,  정희정 ,  이종국 ,  한선영

    IPC: C07D471/04 ,  C07D487/04

    Abstract: PURPOSE: A pharmaceutical composition for preventing or treating melanoma containing a novel pyrazolo[4,3-b]pyridine derivative is provided to ensure suppression activity to tyrosine kinase. CONSTITUTION: A pyrazolo[4,3-b]pyridine derivative is denoted by chemical formula 1. A method for manufacturing the pyrazolo[4,3-b]pyridine derivative comprises: a step of reacting Boc-protected hydrazine to a compound of chemical formula 2 to obtain a compound of chemical formula 3; a step of adding acid to the compound of chemical formula 3 to obtain a compound of chemical formula 4; and a step of reacting benzylhalide or arylmethylene halide under the presence of inorganic base to obtain a compound of chemical formula 5.

    Abstract translation: 目的：提供一种用于预防或治疗含有新型吡唑并[4,3-b]吡啶衍生物的黑色素瘤的药物组合物，以确保对酪氨酸激酶的抑制活性。 构成：吡唑并[4,3-b]吡啶衍生物由化学式1表示。吡唑并[4,3-b]吡啶衍生物的制造方法包括：使Boc-保护的肼与化学式 式2得到化学式3的化合物; 向化学式3的化合物中加入酸以获得化学式4的化合物的步骤; 和在无机碱存在下使苄基卤或芳基亚甲基卤反应得到化学式5的化合物的步骤。

    새로운 불소함유 페닐포름아미딘 유도체 및 살충제로서 이의 용도
    78.
    发明公开
    새로운 불소함유 페닐포름아미딘 유도체 및 살충제로서 이의 용도 失效
    新型氟虫腈的合成及其生物活性

    公开(公告)号：KR1020090024394A

    公开(公告)日：2009-03-09

    申请号：KR1020070089389

    申请日：2007-09-04

    Applicant: 한국화학연구원

    Inventor： 정근회 ,  고영관 ,  류재욱 ,  우재춘 ,  구동완 ,  김대황 ,  이동국 ,  박노중 ,  최용호 ,  정봉진 ,  김태준 ,  홍미숙 ,  조창섭

    IPC: A01N37/34 ,  A01N37/44 ,  A01P7/04

    CPC classification number: A01N37/52 ,  A01N41/12 ,  C07C257/12 ,  C07C381/06

    Abstract: A derivative from fluorine-containing phenyl formamidine is provided to secure excellent insecticidal activity for prevention the breeding and extermination of harmful insects while maintaining useful plants. A derivative from fluorine-containing phenyl formamidine is represented by the formula I. In the formula 1, F is fluorine; X indicates a hydrogen atom, cyano, amino, carbo C1-C2 alkoxy, C1-C2 alkylcarbamoyl, C1-C4 alkyl or an alkoxy group; R1 shows a hydrogen atom or a C1-C4 alkyl group; Y is a C1-C8 alkyl or a dialkyl aminosulphenyl group; and n is 1,2,3 or 4. If the Y is the dialkyl aminosulphenyl group, the derivative from fluorine-containing phenyl formamidine is represented by the formula II.

    Abstract translation: 提供含氟苯基甲脒的衍生物，以确保优异的杀虫活性，以防止有害昆虫的繁殖和灭绝，同时保持有用的植物。 含氟苯甲酰胺的衍生物由式I表示。在式1中，F为氟; X表示氢原子，氰基，氨基，碳C1-C2烷氧基，C1-C2烷基氨基甲酰基，C1-C4烷基或烷氧基; R1表示氢原子或C1-C4烷基; Y是C1-C8烷基或二烷基氨基磺酰基; 并且n为1,2,3或4.如果Y为二烷基氨基磺苯基，则含氟苯基甲脒的衍生物由式II表示。

    제초활성을 가지는테트라하이드로티아디아졸로피리다지논계 화합물
    79.
    发明授权
    제초활성을 가지는테트라하이드로티아디아졸로피리다지논계 화합물 失效
    제초활성을가지는테트라하이드로티아디아졸로피리다지논계화

    公开(公告)号：KR100750288B1

    公开(公告)日：2007-08-20

    申请号：KR1020060030662

    申请日：2006-04-04

    Applicant: 한국화학연구원 ,  주식회사 디비하이텍

    Inventor： 김대황 ,  고영관 ,  정근회 ,  류재욱 ,  우재춘 ,  구동완 ,  최정섭 ,  정봉진 ,  김태준 ,  권오연

    IPC: A01N43/82 ,  A01P13/00

    Abstract: Tetrahydro thiadiazolo pyridazinone derivatives having herbicidal activity are provided to control gramineous weeds and broad-leaved weeds without harmful effects on useful crops such as corn and wheat, so that the compounds are useful as nonselective herbicide used in an orchard. The Tetrahydro thiadiazolo pyridazinone derivatives represented by the formula(1) are provided, wherein X is halogen atom or cyano group; Y is oxygen or sulfur; R is hydrogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C2-C6 alkoxyalkyl group, C1-C6 hydroxyalkyl group, C2-C6 alkenyl group or C2-C6 alkynyl group; R1 is C1-C6 alkyl group, C1-C6 haloalkyl group, C2-C6 alkenyl group, C2-C6 alkynyl group, phenyl group or benzyl group; and the benzene ring of the phenyl group or benzyl group is optionally substituted by hydrogen atom, C1-C6 alkyl group, C1-C6 alkoxy group, C1-C6 haloalkyl group, C2-C4 alkenyl group or C2-C4 alkynyl group.

    Abstract translation: 提供具有除草活性的四氢噻二唑并哒嗪酮衍生物以控制禾本科杂草和阔叶杂草，而对有用作物如玉米和小麦没有有害作用，从而使得该化合物可用作果园中使用的非选择性除草剂。 提供由式（1）表示的四氢噻二唑并哒嗪酮衍生物，其中X是卤素原子或氰基; Y是氧或硫; R为氢原子，C1-C6烷基，C1-C6卤代烷基，C2-C6烷氧基烷基，C1-C6羟烷基，C2-C6烯基或C2-C6炔基; R 1为C 1 -C 6烷基，C 1 -C 6卤代烷基，C 2 -C 6烯基，C 2 -C 6炔基，苯基或苄基; 并且苯基或苄基的苯环任选被氢原子，C1-C6烷基，C1-C6烷氧基，C1-C6卤代烷基，C2-C4链烯基或C2-C4炔基取代。

    제초활성을 가지는 하이단토인계 화합물
    80.
    发明授权
    제초활성을 가지는 하이단토인계 화합물 失效
    제초활성을가지는하이단토인계화합물

    公开(公告)号：KR100685473B1

    公开(公告)日：2007-02-26

    申请号：KR1020050118376

    申请日：2005-12-06

    Applicant: 한국화학연구원 ,  주식회사 디비하이텍

    Inventor： 김대황 ,  고영관 ,  정근회 ,  류재욱 ,  우재춘 ,  구동완 ,  최정섭 ,  정봉진 ,  김태준 ,  권오연

    IPC: A01N43/60 ,  A01P13/00

    Abstract: Hydantoin-based derivatives having herbicidal activity are provided to selectively control weeds without harmful effects to useful crops such as corn, and prevent environmental pollution by reducing the use amount of herbicides. The hydantoin-based derivatives having herbicidal activity, represented by the formula(1) are provided, wherein n is an integer from 0 to 3; R1 is hydrogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C2-C6 alkoxyalkyl group, C1-C6 hydroxyalkyl group, C2-C6 alkenyl group or C2-C6 alkynyl group; R2 is hydrogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C2-C6 alkenyl group or C2-C6 alkynyl group; and X is hydrogen atom, halogen atom, cyano group, hydroxyl group, C1-C4 alkyl group, C1-C4 alkoxy group, C2-C4 alkenyl group, C2-C4 alkynyl group, C2-C4 alkoxyalkyl group or C1-C4 hydroxyalkyl group. The hydantoin-based derivatives having herbicidal activity, represented by the formula(1) are prepared by halogenization of hydantoin carboxylic acid represented by the formula(2) to prepare compounds represented by the formula(4), and reacting the compounds represented by the formula(4) with compounds represented by the formula(3). A herbicidal composition comprises the hydantoin-based derivatives having herbicidal activity, represented by the formula(1).

    Abstract translation: 提供具有除草活性的乙内酰脲类衍生物以选择性地控制杂草，而不会对有用作物例如玉米产生有害影响，并且通过减少除草剂的使用量来防止环境污染。 提供了由式（1）表示的具有除草活性的乙内酰脲类衍生物，其中n是0-3的整数; R1为氢原子，C1-C6烷基，C1-C6卤代烷基，C2-C6烷氧基烷基，C1-C6羟烷基，C2-C6烯基或C2-C6炔基; R 2为氢原子，C 1 -C 6烷基，C 1 -C 6卤代烷基，C 2 -C 6烯基或C 2 -C 6炔基; X为氢原子，卤原子，氰基，羟基，C1-C4烷基，C1-C4烷氧基，C2-C4烯基，C2-C4炔基，C2-C4烷氧基烷基或C1-C4羟烷基 。 由式（1）表示的具有除草活性的乙内酰脲类衍生物是通过将式（2）表示的乙内酰脲羧酸卤化以制备式（4）表示的化合物，然后使式 （4）所示的化合物与式（3）所示的化合物反应。 除草组合物包含由式（1）表示的具有除草活性的乙内酰脲衍生物。

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