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    Preparation of optically active alkanol compound, useful for the treatment of depression or incontinence, comprises incubating an enzyme with a polypeptide sequence in a medium containing alkanone compound and isolating
    71.
    发明专利
    Preparation of optically active alkanol compound, useful for the treatment of depression or incontinence, comprises incubating an enzyme with a polypeptide sequence in a medium containing alkanone compound and isolating 未知

    公开(公告)号：DE102005062662A1

    公开(公告)日：2007-06-28

    申请号：DE102005062662

    申请日：2005-12-23

    Applicant: BASF AG

    Inventor： STUERMER RAINER ,  KESELER MARIA ,  HAUER BERNHARD ,  FRIEDRICH THOMAS ,  BREUER MICHAEL ,  SCHROEDER HARTWIG

    IPC: C12N9/04 ,  C12P7/02

    Abstract: Preparation of optically active alkanol compound (I) comprises incubating an enzyme with a polypeptide sequence of SEQ ID NO:1 (Not defined) or the SEQ ID NO:1 with up to 25% of amino acids modified by deletion, insertion and/or substitution and at least 50% of which possess enzymatic activity, in a medium containing alkanone compound (II) and isolating the product, where (II) is enzymatically reduced to (I). Preparation of optically active alkanol compound of formula (I) comprises incubating an enzyme with a polypeptide sequence of SEQ ID NO:1 (Not defined) or the SEQ ID NO:1 with up to 25% of amino acids modified by deletion, insertion and/or substitution and at least 50% of which possess enzymatic activity, in a medium containing alkanone compound of formula Cyc-(C=O)-(CH 2) n-CH 2-R 1>(II) and isolating the product, where (II) is enzymatically reduced to (I). n : 0-5; Cyc : optionally substituted, mono- or polynuclear, (un)saturated, carbocylic or heterocyclic ring; R 1>halo, SH, OH, NO 2, NR 2>R 3> or NR 2>R 3>R 4+>X ->; R 2>-R 4>H, lower alkyl or lower alkoxy; and X ->counter ion. An independent claim is also included for the enzyme with dehydrogenase activity. [Image] ACTIVITY : Antidepressant; Uropathic. No biological data given. MECHANISM OF ACTION : None given.

    72.
    发明专利
    未知

    公开(公告)号：DK1123386T3

    公开(公告)日：2007-05-07

    申请号：DK99952558

    申请日：1999-10-13

    Applicant: BASF AG

    Inventor： MATTES RALF ,  HAUER BERNHARD ,  RESS-LOESCHKE MARION ,  FRIEDRICH THOMAS ,  ENGELS DIRK

    IPC: C12N9/78 ,  C12N15/09 ,  C07H21/00 ,  C12N1/21 ,  C12N15/55 ,  C12N15/63 ,  C12P7/40 ,  C12P7/42 ,  C12P41/00 ,  C12R1/05

    Abstract: The invention relates to nucleic acid sequences which code for a polypeptide having nitrilase activity, to nucleic acid constructs comprising the nucleic acid sequences, and to vectors comprising the nucleic acid sequences or the nucleic acid constructs. The invention further relates to amino acid sequences which are encoded by the nucleic acid sequences, and to microorganisms comprising the nucleic acid sequences, the nucleic acid constructs or vectors comprising the nucleic acid sequences or the nucleic acid constructs.The invention additionally relates to a process for preparing chiral carboxylic acids from the racemic nitriles.

    POLYCONDENSATION OF ORGANIC SILICON COMPOUNDS
    73.
    发明专利
    POLYCONDENSATION OF ORGANIC SILICON COMPOUNDS 未知

    公开(公告)号：CA2422600C

    公开(公告)日：2007-04-24

    申请号：CA2422600

    申请日：2001-09-17

    Applicant: BASF AG

    Inventor： FRIEDRICH THOMAS

    IPC: C12P9/00

    Abstract: The invention relates to a method for the polycondensation of organic silico n compounds at pH values between 6 and 8 in the presence of a lipase, said lipase being optionally immobilised on a carrier consisting of polymer materials. Suitable polycondensable organic silicon compounds are (RO)(R1O)(R2O)(R3O)Si, (RO)(R1O)(R2O)(R3O)SiR3, (RO)(R1O)Si(R2)(R3) and (RO)SiR1R2R3 with R, R1, R2 and R3 independently representing C1- to C10- alkyl, C3- to C10-cycloalkyl, C4- to C20-alkylcycloalkyl, aryl, C6- to C16- alkylaryl, the alkyl groups being linear or branched. It is advantageous tha t the lipase can be obtained relatively easily by means of large-scale fermentation processes. Lipases from Pseudomona species are preferable.

    MUTANTE DE PIRUVATODESCARBOXILASA, SU OBTENCION Y EMPLEO.
    76.
    发明专利
    MUTANTE DE PIRUVATODESCARBOXILASA, SU OBTENCION Y EMPLEO. 未知

    公开(公告)号：ES2253556T3

    公开(公告)日：2006-06-01

    申请号：ES02767395

    申请日：2002-08-16

    Applicant: BASF AG

    Inventor： BREUER MICHAEL ,  HAUER BERNHARD ,  FRIEDRICH THOMAS

    IPC: C12N9/88 ,  C12P7/26 ,  C12P41/00

    Abstract: Microcápsulas con diámetros medios comprendidos en el intervalo de 0, 1 a 5 mm que se pueden obtener (a) procesando preparados acuosos de ingredientes activos con cuerpos oleaginosos en presencia de emulsionantes para producir emulsiones aceite en agua, (b) tratando las emulsiones resultantes con soluciones acuosas de polímeros aniónicos, (c) poniendo en contacto la matriz resultante con soluciones acuosas de quitosano y (d) separando los productos de encapsulado resultantes de la fase acuosa.

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