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公开(公告)号：PL180652B1
公开(公告)日：2001-03-30
申请号：PL32115995
申请日：1995-04-26
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MUELLER STEFAN , DE POTZOLLI BERND , RITTER KURT , THYES MARCO , ZIERKE THOMAS
Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.
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公开(公告)号：HRP950271B1
公开(公告)日：2000-08-31
申请号：HRP950271
申请日：1995-05-04
Applicant: BASF AG
Inventor： AMBERG WILHELM , HARALD BERNARD , BUSCHMANN ERNST , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MULLER STEFAN , POTZOLLI BERND DE , RITTER KURT , THYES MARCO , ZIERKE THOMAS
Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.
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公开(公告)号：ES2136856T3
公开(公告)日：1999-12-01
申请号：ES95920008
申请日：1995-05-09
Applicant: BASF AG
Inventor： KARL ULRICH , MULLER STEFAN , DE POTZOLLI BERND
IPC: C07B61/00 , C07C227/18 , C07C229/12 , C07C269/06 , C07C271/22 , C07C323/59
Abstract: A process for preparing N-protected N-alkylated amino acids of the formula I:in which the substituents have the meanings stated in the description, comprises mixing a compound of the formula IIwith a solution of potassium tert-butanolate in a non-protic organic solvent, and subsequently adding a C1-2-alkyl halide.
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公开(公告)号：AT183994T
公开(公告)日：1999-09-15
申请号：AT95920008
申请日：1995-05-09
Applicant: BASF AG
Inventor： KARL ULRICH , MUELLER STEFAN , DE POTZOLLI BERND
IPC: C07B61/00 , C07C227/18 , C07C229/12 , C07C269/06 , C07C271/22 , C07C323/59
Abstract: A process for preparing N-protected N-alkylated amino acids of the formula I:in which the substituents have the meanings stated in the description, comprises mixing a compound of the formula IIwith a solution of potassium tert-butanolate in a non-protic organic solvent, and subsequently adding a C1-2-alkyl halide.
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公开(公告)号：DE59404049D1
公开(公告)日：1997-10-16
申请号：DE59404049
申请日：1994-10-22
Applicant: BASF AG
Inventor： KNUEHL KLAUS , KARL ULRICH , MUELLER STEFAN , DE POTZOLLI BERND
IPC: C07C269/06 , C07C271/22 , C07C323/52
Abstract: PCT No. PCT/EP94/03480 Sec. 371 Date Sep. 6, 1995 Sec. 102(e) Date Sep. 6, 1995 PCT Filed Oct. 22, 1994 PCT Pub. No. WO95/12574 PCT Pub. Date May 11, 1995A process for preparing N-protected N-alkylated amino acids of the formula where Rs and R1-R3 have the meanings indicated in the description comprises adding a compound of the abovementioned formula where R3 is hydrogen to a solution of a base in a non-protic solvent and subsequently adding an alkylating agent.
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Patent Agency Ranking
公开(公告)号：AT157964T
公开(公告)日：1997-09-15
申请号：AT94930209
申请日：1994-10-22
Applicant: BASF AG
Inventor： KNUEHL KLAUS , KARL ULRICH , MUELLER STEFAN , DE POTZOLLI BERND
IPC: C07C269/06 , C07C271/22 , C07C323/52
Abstract: PCT No. PCT/EP94/03480 Sec. 371 Date Sep. 6, 1995 Sec. 102(e) Date Sep. 6, 1995 PCT Filed Oct. 22, 1994 PCT Pub. No. WO95/12574 PCT Pub. Date May 11, 1995A process for preparing N-protected N-alkylated amino acids of the formula where Rs and R1-R3 have the meanings indicated in the description comprises adding a compound of the abovementioned formula where R3 is hydrogen to a solution of a base in a non-protic solvent and subsequently adding an alkylating agent.
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公开(公告)号：HUT75709A
公开(公告)日：1997-05-28
申请号：HU9603068
申请日：1995-04-26
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , DE POTZOLLI BERND , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MUELLER STEFAN , RITTER KURT , THYES MARCO , ZIERKE THOMAS
Abstract: Compounds of the formulawhere R1, R2, R3 and R4 have the meaning stated in the description, and a process for preparing them are described. The compounds are suitable as starting material for synthesizing substances which are active against tumors.
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公开(公告)号：FI964607A
公开(公告)日：1997-01-16
申请号：FI964607
申请日：1996-11-18
Applicant: BASF AG
Inventor： KARL ULRICH , MUELLER STEFAN , DE POTZOLLI BERND
IPC: C07B61/00 , C07C227/18 , C07C229/12 , C07C269/06 , C07C271/22 , C07C323/59 , C07C
Abstract: A process for preparing N-protected N-alkylated amino acids of the formula I:in which the substituents have the meanings stated in the description, comprises mixing a compound of the formula IIwith a solution of potassium tert-butanolate in a non-protic organic solvent, and subsequently adding a C1-2-alkyl halide.
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公开(公告)号：NO964688A
公开(公告)日：1997-01-02
申请号：NO964688
申请日：1996-11-05
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MULLER STEFAN , POTZOLLI BERND DE , RITTER KURT , THYES MARCO , ZIERKE THOMAS
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公开(公告)号：FI964607A0
公开(公告)日：1996-11-18
申请号：FI964607
申请日：1996-11-18
Applicant: BASF AG
Inventor： KARL ULRICH , MUELLER STEFAN , DE POTZOLLI BERND
IPC: C07B61/00 , C07C227/18 , C07C229/12 , C07C269/06 , C07C271/22 , C07C323/59 , C07C
Abstract: A process for preparing N-protected N-alkylated amino acids of the formula I:in which the substituents have the meanings stated in the description, comprises mixing a compound of the formula IIwith a solution of potassium tert-butanolate in a non-protic organic solvent, and subsequently adding a C1-2-alkyl halide.
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