公开(公告)号：JP2007169651A

公开(公告)日：2007-07-05

申请号：JP2006345255

申请日：2006-12-22

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft

Inventor： DOBRAWA RAINER ,  WIDMAIER RALF ,  EBERHARD SCHUPP ,  KLAUS SCHNELL ,  KARL-HERMANN STRUBE ,  NIEBERLE JUERGEN ,  POTZOLLI BERND DE ,  ANDREAS GRUBER ,  DIEING REINHOLD DR

IPC: C08F2/00 ,  C08F226/06

CPC classification number: C08F226/10 ,  C08F216/10

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a water-soluble copolymer of at least one kind of water-soluble N-vinyl lactam and at least one kind of hydrophobic comonomer by the radical polymerization of the monomers in an organic solvent. SOLUTION: A vinyl lactam copolymer is produced by the radical polymerization of at least one kind of water-soluble N-vinyl lactam and at least one kind of hydrophobic comonomer in an organic solvent in the presence of an initiator under refluxing condition. In the above method, at least 10 mol% of the N-vinyl lactam is added to the polymerization mixture when at least 90 mol% of the hydrophobic monomer is completely reacted. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 待解决的问题：提供通过单体在有机物中的自由基聚合制备至少一种水溶性N-乙烯基内酰胺和至少一种疏水性共聚单体的水溶性共聚物的方法 溶剂。 解决方案：在回流条件下，在引发剂存在下，通过至少一种水溶性N-乙烯基内酰胺和至少一种疏水性共聚单体在有机溶剂中的自由基聚合制备乙烯基内酰胺共聚物。 在上述方法中，当至少90mol％的疏水性单体完全反应时，向聚合混合物中加入至少10mol％的N-乙烯基内酰胺。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：HRP950271B1

公开(公告)日：2000-08-31

申请号：HRP950271

申请日：1995-05-04

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  HARALD BERNARD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANITSCHKE LOTHAR ,  JANSSEN BERND ,  KARL ULRICH ,  KLING ANDREAS ,  MULLER STEFAN ,  POTZOLLI BERND DE ,  RITTER KURT ,  THYES MARCO ,  ZIERKE THOMAS

IPC: A61K38/08 ,  A61K38/00 ,  A61P35/00 ,  C07K1/08 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  C07K14/52

Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.

公开(公告)号：NO964688A

公开(公告)日：1997-01-02

申请号：NO964688

申请日：1996-11-05

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANITSCHKE LOTHAR ,  JANSSEN BERND ,  KARL ULRICH ,  KLING ANDREAS ,  MULLER STEFAN ,  POTZOLLI BERND DE ,  RITTER KURT ,  THYES MARCO ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/08 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  C07K14/52

CPC classification number: C07K7/06 ,  A61K38/00 ,  C07K5/101 ,  Y02P20/55

公开(公告)号：AU688037B2

公开(公告)日：1998-03-05

申请号：AU2408395

申请日：1995-04-26

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANITSCHKE LOTHAR ,  JANSSEN BERND ,  KARL ULRICH ,  KLING ANDREAS ,  MULLER STEFAN ,  POTZOLLI BERND DE ,  RITTER KURT ,  THYES MARCO ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/08 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  C07K14/52

Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.

公开(公告)号：ZA9503584B

公开(公告)日：1996-11-04

申请号：ZA9503584

申请日：1995-05-04

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANITSCHKE LOTHAR ,  JANSSEN BERND ,  KARL ULRICH ,  KLING ANDREAS ,  MUELLER STEFAN ,  POTZOLLI BERND DE ,  RITTER KURT ,  THYES MARCO ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/08 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  C07K14/52 ,  C07K ,  A61K

CPC classification number: C07K7/06 ,  A61K38/00 ,  C07K5/101 ,  Y02P20/55

公开(公告)号：DE102006056206A1

公开(公告)日：2007-06-28

申请号：DE102006056206

申请日：2006-11-29

Applicant: BASF AG

Inventor： DOBRAWA RAINER ,  WIDMAIER RALF ,  SCHUPP EBERHARD ,  SCHNELL KLAUS ,  STRUBE KARL-HERMANN ,  NIEBERLE JUERGEN ,  POTZOLLI BERND DE ,  GRUBER ANDREAS ,  DIEING REINHOLD

IPC: C08F226/06 ,  C08F2/06 ,  C08F218/04 ,  C08F220/00

Abstract: Free-radical polymerization of at least one of water-soluble N-vinyl lactam and at least one of hydrophobic comonomer, is carried out in an organic solvent, in presence of initiator under reflux conditions, such that at least 10 mol% of N-vinyl lactam is added to polymerization mixture after at least 90 mol% of hydrophobic monomer is completely reacted. Thus, a vinyl lactam copolymer is produced.

公开(公告)号：NO964688D0

公开(公告)日：1996-11-05

申请号：NO964688

申请日：1996-11-05

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANITSCHKE LOTHAR ,  JANSSEN BERND ,  KARL ULRICH ,  KLING ANDREAS ,  MULLER STEFAN ,  POTZOLLI BERND DE ,  RITTER KURT ,  THYES MARCO ,  ZIERKE THOMAS

IPC: A61K38/08 ,  A61K38/00 ,  A61P35/00 ,  C07K1/08 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  C07K14/52 ,  C07K

Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.

公开(公告)号：AU2562695A

公开(公告)日：1995-12-18

申请号：AU2562695

申请日：1995-05-09

Applicant: BASF AG

Inventor： KARL ULRICH ,  MULLER STEFAN ,  POTZOLLI BERND DE

IPC: C07B61/00 ,  C07C227/18 ,  C07C229/12 ,  C07C269/06 ,  C07C271/22 ,  C07C323/59

Abstract: A process for preparing N-protected N-alkylated amino acids of the formula I:in which the substituents have the meanings stated in the description, comprises mixing a compound of the formula IIwith a solution of potassium tert-butanolate in a non-protic organic solvent, and subsequently adding a C1-2-alkyl halide.

公开(公告)号：AU2408295A

公开(公告)日：1995-11-29

申请号：AU2408295

申请日：1995-04-26

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANITSCHKE LOTHAR ,  JANSSEN BERND ,  KARL ULRICH ,  KLING ANDREAS ,  MULLER STEFAN ,  POTZOLLI BERND DE ,  RITTER KURT ,  THYES MARCO ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61P35/00 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06

Abstract: Compounds of the formulawhere R1, R2, R3 and R4 have the meaning stated in the description, and a process for preparing them are described. The compounds are suitable as starting material for synthesizing substances which are active against tumors.

公开(公告)号：DE10150282A1

公开(公告)日：2003-04-30

申请号：DE10150282

申请日：2001-10-12

Applicant: BASF AG

Inventor： DAUSCH WILMA M ,  POTZOLLI BERND DE ,  ICHIHARA HIDEYUKI

IPC: A61K8/81 ,  A61K8/87 ,  A61K8/88 ,  A61Q5/06 ,  A61K7/11

Abstract: A hair-fixing agent containing a homopolymer of N-vinyl-caprolactame or an anionic or non-ionic copolymer consisting of at least 70 wt. % B-vinyl-caprolactame (polymer A) and Polymer B, chosen from the group consisting of polyamides, polyurethanes, homocopolymers and copolymers of monoolefinically unsaturated monomers and panthenol at an amount which ranges from 0.01 0.75 wt. %.