公开(公告)号：AU749575B2

公开(公告)日：2002-06-27

申请号：AU9342698

申请日：1998-08-14

Applicant: BASF AG

Inventor： BLANK STEFAN ,  STARCK DOROTHEA ,  TREIBER HANS-JORG ,  KOSER STEFAN ,  SCHAFER BERND ,  THYES MARCO ,  HOGER THOMAS

IPC: C07D239/56 ,  A61K20060101 ,  A61K31/395 ,  A61K31/497 ,  A61K31/505 ,  A61K31/506 ,  A61P1/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P43/00 ,  C07D20060101 ,  C07D239/42 ,  C07D239/46 ,  C07D295/125 ,  C07D403/00 ,  C07D403/12 ,  C07D403/14

Abstract: The fumaric acid salt (A) of 2-{3-[4-(2-tert. butyl-6-trifluoromethyl- pyrimidin-4-yl)piperazin-1- yl]propylmercapto}pyrimidin-4-ol (I) is new. The fumarate salt (A) of the pyrimidin-4-ol derivative of formula (I) is new. The tautomers, solvates and hydrates of (A) are also new. ACTIVITY : Neuroleptic; antidepressant; antiemetic; antihistamine. MECHANISM OF ACTION : Dopamine D 3 receptor ligand. (A) has a selectivity Ki D 2/Ki D 3 of 120.

公开(公告)号：AU6691600A

公开(公告)日：2001-02-13

申请号：AU6691600

申请日：2000-07-11

Applicant: BASF AG

Inventor： KNOPP MONIKA ,  KOSER STEFAN ,  SCHAFER BERND

IPC: C07D277/20 ,  C07D277/56

Abstract: The invention relates to processes for preparing 2-aminomethyl-4-cyanothiazole and its salts of the formulae Ia and Ibin whichn=1 or 2 andfor n=1, X is chloride, bromide, triflate and hydrogen sulfate andfor n=2, X is sulfate, which comprises the process step where the aminonitrile of the formula IIis stirred with a cysteine ester of the formula III,in which R is branched or linear C1-10-alkyl orwhere n=0, 1 or 2 and R is branched or linear C1-C10C10-alkyl or C1-C4-alkoxy or C1-C4-dialkylamino in an inert solvent in the presence of a base at from 0° C. to 80° C. until the reaction has essentially proceeded to completion, and to the compounds of the formulae Ia and Ib.

公开(公告)号：CA2375262A1

公开(公告)日：2000-12-28

申请号：CA2375262

申请日：2000-06-21

Applicant: BASF AG

Inventor： DOCKNER TONI ,  KINGMA AREND JOUKE ,  KASEL WOLFGANG ,  MUNDINGER KLAUS ,  KOSER STEFAN

IPC: B01J31/24 ,  C07B61/00 ,  C07C41/03 ,  C07C43/23

Abstract: The invention relates to a method for producing bisphenol alcoxylates, where by at least one bisphenol is reacted with alkylene oxide in the presence of a phosphine catalyst that contains essentially no alkali hydroxide.

公开(公告)号：TR200000406T2

公开(公告)日：2000-05-22

申请号：TR200000406

申请日：1998-08-14

Applicant: BASF AG

Inventor： BLANK STEFAN ,  STARCK DOROTHEA ,  TREIBER HANS-JORG ,  KOSER STEFAN ,  SCHAFER BERND ,  THYES MARCO ,  HOEGER THOMAS

IPC: A61K20060101 ,  C07D239/56 ,  A61K31/395 ,  A61K31/497 ,  A61K31/505 ,  A61K31/506 ,  A61P1/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P43/00 ,  C07D20060101 ,  C07D239/42 ,  C07D239/46 ,  C07D295/125 ,  C07D403/00 ,  C07D403/12 ,  C07D403/14

Abstract: The fumaric acid salt (A) of 2-{3-[4-(2-tert. butyl-6-trifluoromethyl- pyrimidin-4-yl)piperazin-1- yl]propylmercapto}pyrimidin-4-ol (I) is new. The fumarate salt (A) of the pyrimidin-4-ol derivative of formula (I) is new. The tautomers, solvates and hydrates of (A) are also new. ACTIVITY : Neuroleptic; antidepressant; antiemetic; antihistamine. MECHANISM OF ACTION : Dopamine D 3 receptor ligand. (A) has a selectivity Ki D 2/Ki D 3 of 120.

公开(公告)号：ES2143666T3

公开(公告)日：2000-05-16

申请号：ES95941015

申请日：1995-11-25

Applicant: BASF AG

Inventor： BOHM HANS JOACHIM ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  HOFFKEN HANS WOLFGANG

IPC: A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61P7/02 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/072 ,  C07K5/087

公开(公告)号：NO20000665D0

公开(公告)日：2000-02-10

申请号：NO20000665

申请日：2000-02-10

Applicant: BASF AG

Inventor： BLANK STEFAN ,  STARCK DOROTHEA ,  TREIBER HANS-JOERG ,  KOSER STEFAN ,  SCHOFER BERND ,  THYES MARCO ,  HOEGER THOMAS

IPC: A61K20060101 ,  C07D239/56 ,  A61K31/395 ,  A61K31/497 ,  A61K31/505 ,  A61K31/506 ,  A61P1/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P43/00 ,  C07D20060101 ,  C07D239/42 ,  C07D239/46 ,  C07D295/125 ,  C07D403/00 ,  C07D403/12 ,  C07D403/14 ,  C07D

Abstract: The fumaric acid salt (A) of 2-{3-[4-(2-tert. butyl-6-trifluoromethyl- pyrimidin-4-yl)piperazin-1- yl]propylmercapto}pyrimidin-4-ol (I) is new. The fumarate salt (A) of the pyrimidin-4-ol derivative of formula (I) is new. The tautomers, solvates and hydrates of (A) are also new. ACTIVITY : Neuroleptic; antidepressant; antiemetic; antihistamine. MECHANISM OF ACTION : Dopamine D 3 receptor ligand. (A) has a selectivity Ki D 2/Ki D 3 of 120.

公开(公告)号：NO20000665A

公开(公告)日：2000-02-10

申请号：NO20000665

申请日：2000-02-10

Applicant: BASF AG

Inventor： BLANK STEFAN ,  STARCK DOROTHEA ,  TREIBER HANS-JOERG ,  KOSER STEFAN ,  SCHOFER BERND ,  THYES MARCO ,  HOEGER THOMAS

IPC: C07D239/56 ,  A61K20060101 ,  A61K31/395 ,  A61K31/497 ,  A61K31/505 ,  A61K31/506 ,  A61P1/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P43/00 ,  C07D20060101 ,  C07D239/42 ,  C07D239/46 ,  C07D295/125 ,  C07D403/00 ,  C07D403/12 ,  C07D403/14

CPC classification number: C07D239/56

公开(公告)号：NZ302649A

公开(公告)日：2000-01-28

申请号：NZ30264996

申请日：1996-02-12

Applicant: BASF AG

Inventor： BOHM HANS-JOACHIM ,  HOFFKEN HAN WOLFGANG ,  HORNBERGER WILFRIED ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/55 ,  A61P7/02 ,  C07D205/04 ,  C07D207/16 ,  C07D213/53 ,  C07D213/63 ,  C07D213/72 ,  C07D213/78 ,  C07D213/79 ,  C07D239/28 ,  C07D241/14 ,  C07D241/24 ,  C07D401/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/078 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495

Abstract: he present invention relates to carbo- and heterocyclic amidines, the preparation thereof and the use as thrombin inhibitors of the formula 1 Where D is formula 1a R2 is H, C1-4 alkyl, phenyl and phenyl C1-4 alkyl, R18O-CH2, R18CO- R18-O-CH2-CO-, R18O-CO-CO-, R18-NH-CO-CO, where R18 is H or C1-4-alkyl, CF3-CO- or C2F5-Co- A is formula IIa, IIb or Iic B is selected from IIIa-IIIg The other substituents are defined in the specification.

公开(公告)号：AU708001B2

公开(公告)日：1999-07-29

申请号：AU4875196

申请日：1996-02-12

Applicant: BASF AG

Inventor： BOHM HANS-JOACHIM ,  HOFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/55 ,  A61P7/02 ,  C07D205/04 ,  C07D207/16 ,  C07D213/53 ,  C07D213/63 ,  C07D213/72 ,  C07D213/78 ,  C07D213/79 ,  C07D239/28 ,  C07D241/14 ,  C07D241/24 ,  C07D401/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/078 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495

Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R 1 , R 2 , A, B, C and D have the meanings described in the specification.

公开(公告)号：HU9800634A2

公开(公告)日：1999-06-28

申请号：HU9800634

申请日：1996-02-06

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  HORNBERGER WILFRIED ,  HOEFFKEN HANS WOLFGANG ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/087

Abstract: PCT No. PCT/EP96/00472 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 6, 1996 PCT Pub. No. WO96/24609 PCT Pub. Date Aug. 15, 1996Thrombin inhibitors of the formula where R1, A, B and D have the meaning indicated in the description, and intermediates for the preparation thereof are described. The compounds I are suitable for controlling diseases.