公开(公告)号：CA1264752A

公开(公告)日：1990-01-23

申请号：CA494392

申请日：1985-11-01

Applicant: BASF AG

Inventor： HIMMELE WALTER ,  WIERSDORFF WALTER-WIELANT ,  THYES MARCO

IPC: C07D211/12 ,  C07D211/14 ,  C07D211/16 ,  C07D295/023 ,  C07D211/10 ,  C07D217/02

Abstract: Piperidines substituted in the 3- and/or 4-position are prepared by reacting a glutardialdehyde substituted in the 2- and/or 3-position with ammonia or a primary amine and hydrogen at elevated temperature and under superatmospheric pressure in the presence of a hydrogenation catalyst.

公开(公告)号：NO160258B

公开(公告)日：1988-12-19

申请号：NO823682

申请日：1982-11-05

Applicant: BASF AG

Inventor： KROPP RUDOLF ,  THYES MARCO ,  SCHLECKER RAINER ,  FRANKE ALBRECHT ,  REICHENEDER FRANZ ,  AMANN AUGUST ,  TESCHENDORF HANS-JUERGEN ,  KRETZSCHMAR ROLF ,  TRAUT MARTIN ,  GRIES JOSEF

IPC: A61K31/50 ,  A61P9/02 ,  A61P25/00 ,  A61P25/24 ,  A61P25/26 ,  C07D237/20 ,  C07D237/22

公开(公告)号：ZA865148B

公开(公告)日：1987-03-25

申请号：ZA865148

申请日：1986-07-10

Applicant: BASF AG

Inventor： STEINER GERD ,  THYES MARCO

IPC: C07D333/00 ,  C07D409/14 ,  C07D495/14 ,  C07D

公开(公告)号：DK149590C

公开(公告)日：1987-02-09

申请号：DK532679

申请日：1979-12-14

Applicant: BASF AG

Inventor： THYES MARCO ,  GRIES JOSEF ,  LEHMANN HANS DIETER ,  KUNZE JOHANNES ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/395 ,  A61K31/502 ,  A61P7/02 ,  A61P9/12 ,  C07C62/38 ,  C07C205/56 ,  C07D231/54 ,  C07D237/26 ,  C07D403/10

Abstract: 2-Aryl-3,4-diaza-bicyclo-[4.1.0]hept-2-en-5-ones, substituted in the phenyl ring, of the general formula their preparation, and therapeutic agents, containing these compounds, which may be used for the treatment of hypertension or of thrombo-embolic disorders.

公开(公告)号：ZA8507272B

公开(公告)日：1986-05-28

申请号：ZA8507272

申请日：1985-09-23

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER ,  NUERRENBACH AXEL ,  THYES MARCO

IPC: A61K31/41 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  C07D20060101 ,  C07D257/04 ,  C07D ,  A61K

CPC classification number: C07D257/04

公开(公告)号：DK527885A

公开(公告)日：1986-05-17

申请号：DK527885

申请日：1985-11-15

Applicant: BASF AG

Inventor： HIMMELE WALTER ,  WIERSDORFF WALTER-WIELANT ,  THYES MARCO

IPC: C07D211/12 ,  C07D211/14 ,  C07D211/16 ,  C07D295/023 ,  C07D

Abstract: Piperidines substituted in the 3- and/or 4-position are prepared by reacting a glutardialdehyde substituted in the 2- and/or 3-position with ammonia or a primary amine and hydrogen at elevated temperature and under superatmospheric pressure in the presence of a hydrogenation catalyst.

公开(公告)号：CA1194024A

公开(公告)日：1985-09-24

申请号：CA423169

申请日：1983-03-09

Applicant: BASF AG

Inventor： ROSSY PHILLIP A ,  THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  GRIES JOSEF ,  LEHMANN HANS D ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/502 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/26

Abstract: 6-aryl-4,5-dihydro-3(2H)-pyridazinones of the formula (I), where R is hydrogen, R1 is hydrogen or C1-C3-alkyl, or R and R1 together are methylene, R2 and R3 are identical or different and are each hydrogen or C1-C6-alkyl, and A is hydroxyl, C1-C6-alkoxy, C2-C7-acyloxy, a C2-C7-carbamic acid ester group, C1-C6-alkylsul-fonyloxy, C1-C6-alkylmercapto, carboxyl, C2-C7-alkoxy-carbonyl or nitrile, and their preparation are described. The substances are suitable for the treatment of high blood pressure or thrombo-embolic disorders.

公开(公告)号：NO840213L

公开(公告)日：1984-07-23

申请号：NO840213

申请日：1984-01-20

Applicant: BASF AG

Inventor： ROSSY PHILLIP A ,  THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  LEHMANN HANS DIETER ,  GRIES JOSEF ,  FRIEDRICH LUDWIG ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/502 ,  A61K31/535 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/14 ,  C07D237/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/14 ,  C07D521/00 ,  C07D

Abstract: Novel 6-(acylaminaryl)-3(2H)-pyridazinones of the formula (I) where R1, R2, R3, R4, A and B have the meanings given in the description, and their preparation are described. The compounds have thrombocyte aggregation-inhibiting activity.

公开(公告)号：HU182454B

公开(公告)日：1984-01-30

申请号：HUBA003905

申请日：1979-12-14

Applicant: BASF AG

Inventor： THYES MARCO ,  GRIES JOSEF ,  LEHMANN HANS D ,  LENKE DIETER ,  KUNZE JOHANNES

IPC: A61K31/395 ,  A61K31/502 ,  A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07C62/38 ,  C07C205/56 ,  C07D231/54 ,  C07D237/26 ,  C07D403/10

Abstract: 2-Aryl-3,4-diaza-bicyclo-[4.1.0]hept-2-en-5-ones, substituted in the phenyl ring, of the general formula their preparation, and therapeutic agents, containing these compounds, which may be used for the treatment of hypertension or of thrombo-embolic disorders.

公开(公告)号：NO823682A

公开(公告)日：1983-05-09

申请号：NO823682

申请日：1982-11-05

Applicant: BASF AG

Inventor： KROPP RUDOLF ,  THYES MARCO ,  SCHLECKER RAINER ,  FRANKE ALBRECHT ,  REICHENEDER FRANZ ,  AMANN AUGUST ,  TESCHENDORF HANS-JUERGEN ,  KRETZSCHMAR ROLF ,  TRAUT MARTIN ,  GRIES JOSEF

IPC: A61K31/50 ,  A61P9/02 ,  A61P25/00 ,  A61P25/24 ,  A61P25/26 ,  C07D237/20 ,  C07D237/22 ,  C07D

CPC classification number: C07D237/22 ,  C07D237/20