公开(公告)号：EP2903573A4

公开(公告)日：2016-06-01

申请号：EP13843989

申请日：2013-10-07

Applicant: UNIV SOUTHERN CALIFORNIA ,  DOHENY EYE INST ,  CALIFORNIA INST OF TECHN

Inventor： HUMAYUN MARK S ,  MURALI KARTHIK ,  RIBEIRO RAMIRO MAGALHAES ,  TAI YU-CHONG ,  SCIANMARELLO NICHOLAS

IPC: A61F9/00

CPC classification number: A61M37/00 ,  A61F9/0017 ,  A61M5/14276 ,  A61M2005/14204 ,  A61M2205/3334 ,  A61M2210/0612 ,  C25B1/02 ,  C25B9/08

Abstract: An implantable oxygenator may have a configuration that is suitable for implantation within a human body be implanted within a human body, such as within a human eye. The implantable oxygenator may include an electrolyte reservoir having a configuration suitable for storing electrolyte and an electrolysis system having a configuration that performs electrolysis on a portion of the electrolyte, thereby producing oxygen in the region of the electrolysis system.

公开(公告)号：EP2238232A4

公开(公告)日：2013-11-27

申请号：EP09706188

申请日：2009-01-26

Applicant: CALIFORNIA INST OF TECHN ,  UNIV SOUTHERN CALIFORNIA

Inventor： ZHENG SIYANG ,  COTE RICHARD ,  LIN HENRY ,  LU BO ,  TAI YU-CHONG

IPC: C12M1/12 ,  B01D61/18 ,  B01D63/08 ,  B01D67/00 ,  B01D69/12 ,  B01D71/28 ,  C12M3/06 ,  G01N33/48

CPC classification number: B01D69/12 ,  B01D61/18 ,  B01D63/082 ,  B01D67/0034 ,  B01D71/28 ,  B01D2325/021

Abstract: A microfiltration apparatus and method for separating cells, such as circulating tumor cells, from a sample using a microfiltration device having a top porous membrane and a bottom porous membrane. The porous membranes are formed from parylene and assembled using microfabrication techniques. The porous membranes are arranged so that the pores in the top membrane are offset from the pores in the bottom membrane.

公开(公告)号：EP2389101A4

公开(公告)日：2013-06-19

申请号：EP10738838

申请日：2010-01-21

Applicant: CALIFORNIA INST OF TECHN

Inventor： TAI YU-CHONG ,  HUANG RAY KUI-JUI

IPC: A61B5/024 ,  A61B5/0255 ,  A61M1/10

CPC classification number: A61B5/0031 ,  A61B5/04001 ,  A61B5/0478 ,  A61B5/6846 ,  A61B2562/0209 ,  A61B2562/028 ,  A61B2562/046 ,  A61N1/36003 ,  A61N1/36036 ,  A61N1/36046 ,  A61N1/375 ,  Y10T29/49117

Abstract: Systems and methods for providing biologically compatible pockets or envelopes that can contain chips and other circuit elements and can make electrical connection between those elements and living organisms. The assembled biologically compatible pockets and circuit components can have biomedical applications, such as bioimplantable devices such as retinal, cochlear and cortical prosthesis implants, muscular stimulators, and other uses. In various embodiments, the described technology explains how to make and use pocket systems for dealing with chips having connectors on one or two surfaces, and with other circuit components such as resistors, capacitors, inductors and transistors. Operation of chips encapsulated according to the described technology is demonstrated. Accelerated life testing suggests that the pocket systems described will survive for years at 37 degrees C.

Abstract translation: 用于提供可包含芯片和其它电路元件并且可以在这些元件和活生物体之间进行电连接的生物相容的袋或包络的系统和方法。 组装的生物相容的袋和电路组件可以具有生物医学应用，例如生物可植入装置，例如视网膜，人工耳蜗和皮质假体植入物，肌肉刺激器和其它用途。 在各种实施例中，所描述的技术解释了如何制造和使用用于处理在一个或两个表面上具有连接器的芯片以及其它电路部件如电阻器，电容器，电感器和晶体管的芯片的口袋系统。 证明了根据所述技术封装的芯片的操作。 加速寿命测试表明，描述的口袋系统将在37摄氏度下存活多年。

公开(公告)号：EP2056708A4

公开(公告)日：2013-04-03

申请号：EP07814555

申请日：2007-08-29

Applicant: CALIFORNIA INST OF TECHN

Inventor： TAI YU-CHONG ,  CHEN PO-JUI ,  RODGER DAMIEN C ,  HUMAYUN MARK S

IPC: A61B3/16 ,  A61B5/0215 ,  A61B5/03 ,  A61B13/00 ,  G01L9/00

CPC classification number: A61B3/16 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/03 ,  G01L9/0072

公开(公告)号：EP2049283A4

公开(公告)日：2013-02-20

申请号：EP07800089

申请日：2007-08-10

Applicant: CALIFORNIA INST OF TECHN

Inventor： TAI YU-CHONG ,  CHEN PO-JUI ,  RODGER DAMIEN C ,  HUMAYUN MARK S

IPC: F16K15/02 ,  F16K99/00

CPC classification number: F16K99/0005 ,  F16K99/0015 ,  F16K99/0057 ,  Y10T29/49409 ,  Y10T137/0497 ,  Y10T137/7866 ,  Y10T137/7895 ,  Y10T137/7904 ,  Y10T137/7914

公开(公告)号：EP1572576A4

公开(公告)日：2009-11-25

申请号：EP03739310

申请日：2003-06-25

Applicant: CALIFORNIA INST OF TECHN

Inventor： TAI YU-CHONG ,  XIE JUN ,  HE QING ,  LEE TERRY DWIGHT

IPC: G01N27/27 ,  B01L3/00 ,  B01L3/02 ,  B81B3/00 ,  F04B17/00 ,  F04B19/00 ,  G01N30/28 ,  G01N30/32 ,  G01N30/60 ,  G01N30/72 ,  H01J49/04

CPC classification number: G01N30/6095 ,  B01L3/0268 ,  B01L3/50273 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2400/046 ,  F04B17/00 ,  F04B19/006 ,  G01N30/32 ,  G01N30/7266 ,  G01N2030/285 ,  G01N2030/326 ,  H01J49/04

公开(公告)号：EP1186002A4

公开(公告)日：2009-01-14

申请号：EP00913858

申请日：2000-03-10

Applicant: CALIFORNIA INST OF TECHN

Inventor： JIANG FUKANG ,  HAN ZHIGANG ,  WANG XUAN-QI ,  TAI YU-CHONG

IPC: B81C1/00 ,  B81B3/00 ,  B81B7/02 ,  H01L21/00 ,  H01L21/302 ,  H01L21/3065 ,  H01L29/84

CPC classification number: B81C1/00246 ,  B81B2203/0127 ,  B81C2203/0735

Abstract: A combined IC/Mems process forms the IC parts first, and then forms the MEMS parts (110). One option forms a parylene overlayer, then forms a cavity under the parylene overlayer.

公开(公告)号：EP1715932A4

公开(公告)日：2007-10-17

申请号：EP05723290

申请日：2005-02-17

Applicant: CALIFORNIA INST OF TECHN

Inventor： TAI YU-CHONG ,  XIE JUN ,  SHIH CHI-YUAN ,  HE QING

IPC: B01D15/08 ,  G01N1/00 ,  G01N30/30 ,  G01N30/54 ,  G01N30/60 ,  G01N35/00

CPC classification number: G01N30/54 ,  G01N30/30 ,  G01N30/6095 ,  G01N2030/3007 ,  G01N2030/3015 ,  G01N2030/303 ,  G01N2030/3053 ,  G01N2035/00108

Abstract: An apparatus for liquid chromatography comprises a liquid chromatography separation column on a substrate, wherein the separation column is coupled to a heater on the substrate. A chip-based temperature controlled liquid chromatography device comprises a substrate, a thermal isolation zone, and a separation column thermally isolated from the substrate by the thermal isolation zone. An apparatus for chip-based liquid chromatography comprising a cooling device is provided. A temperature gradient liquid chromatography system comprises a chip-based temperature controlled liquid chromatography device, a fluidic coupling, and an electrical interface. Methods of making and methods of using of chip-based temperature gradient liquid chromatography devices are also provided.

公开(公告)号：EP1590588A4

公开(公告)日：2006-11-22

申请号：EP04702242

申请日：2004-01-14

Applicant: CALIFORNIA INST OF TECHN

Inventor： XIE JUN ,  SHIH JASON ,  TAI YU-CHONG

IPC: B81B3/00 ,  F16K31/00 ,  F16K99/00 ,  G01F1/684 ,  G01F15/00 ,  G05D7/06 ,  F27D11/00

CPC classification number: F16K99/0001 ,  F16K99/0015 ,  F16K99/0044 ,  F16K99/0051 ,  F16K99/0061 ,  F16K2099/0074 ,  F16K2099/008 ,  G01F1/6845 ,  G01F15/005 ,  G05D7/0694 ,  Y10T29/49412 ,  Y10T137/0391

Abstract: A surface-micromachined mass flow controller (MFC) comprises an electrostatically actuated microvalve integrated with a thermal flow sensor. The microvalve comprises a normally-open diaphragm defining an aperture allowing fluid communication between first and second flow channels. The diaphragm includes a second electrode actuable toward a valve seat including a first electrode. Fabricated utilizing a multilayer Parylene process, the active microvalve and the flow sensor are integrated onto a single chip to perform closed-loop flow control. For flow control, both Pulse Width Modulation (PWM) and actuation voltage adjustment are demonstrated.

公开(公告)号：EP0958593A4

公开(公告)日：2006-08-30

申请号：EP98906009

申请日：1998-01-27

Applicant: CALIFORNIA INST OF TECHN

Inventor： TAI YU-CHONG ,  DESAI AMISH ,  LEE TERRY ,  DAVIS MIKE

IPC: H01J49/04 ,  H01J49/10

CPC classification number: H01J49/167 ,  H01J49/0018 ,  H01J49/04

Abstract: A MEMS electrospray nozzle (320) for mass spectroscopy is disclosed. The nozzle has: a channel field (380) having an inner diameter between 0.3-3 νm; a nozzle tip (390); and a filter structure (370) positioned on the channel field. A method of fabricating the nozzle is also disclosed.

Abstract translation: 公开了用于质谱的MEMS电喷嘴（320）。 该喷嘴具有：内径在0.3-3νm之间的通道区域（380） 一个喷嘴尖端（390）; 和位于通道场上的滤波器结构（370）。 还公开了制造喷嘴的方法。