公开(公告)号：AU707707B2

公开(公告)日：1999-07-15

申请号：AU7562496

申请日：1996-11-04

Applicant: HOECHST AG

Inventor： THORWART WERNER ,  SCHWAB WILFRIED ,  SCHUDOK MANFRED ,  HAASE BURKHARD ,  BARTNIK ECKART ,  WEITHMANN KLAUS-ULRICH

IPC: A61K31/00 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/4725 ,  A61P43/00 ,  C07D209/42 ,  C07D217/26 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/056 ,  C07D221/16 ,  A61K31/40

Abstract: Cyclic and heterocyclic N-substituted alpha-iminohydroxamic and -carboxylic acidsCompounds of the formula Iare suitable for preparing pharmaceuticals for the treatment of disorders in the course of which is involved an increased activity of matrix-degrading metalloproteinases.

公开(公告)号：MX9800757A

公开(公告)日：1998-10-31

申请号：MX9800757

申请日：1998-01-27

Applicant: HOECHST AG

Inventor： MULLNER STEFAN ,  KIRSCHBAUM BERND ,  SCHWAB WILFRIED

IPC: B01J20/281 ,  A61K31/167 ,  A61K31/275 ,  A61K31/42 ,  A61K39/385 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07C233/58 ,  C07C235/28 ,  C07C235/74 ,  C07C237/04 ,  C07C255/23 ,  C07C255/30 ,  C07D261/08 ,  C07D261/18 ,  G01N30/88 ,  G01N33/53 ,  G01N33/543 ,  G01N33/558 ,  G01N33/68 ,  G01N33/94 ,  C07D261/14

Abstract: Un compuesto de la formula I (Ver Formula), representando R1 el radical de la formula II o III, (Ver formula); es apropiado para la preparacion de un medicamento para el tratamiento de inflamaciones, enfermedades cancerosas o enfermedades autoinmunes. Un compuesto de la formula IV (Ver Formula) es apropiado para la preparacion de anticuerpos específicos contra un compuesto de la formula I y para descubrir proteínas que se fijen específicamente a partir de extractos celulares, suero, sangre o líquidos sinoviales, para purificar proteínas, para modificar placas de microtitulacion o para preparar un material para cromatografía, especialmente un material para cromatografía de afinidad, y para su empleo en agentes de diagnostico.

公开(公告)号：TR199800117A2

公开(公告)日：1998-08-21

申请号：TR9800117

申请日：1998-01-26

Applicant: HOECHST AG

Inventor： MUELLNER STEFAN ,  KIRSCHBAUM BERND ,  SCHWAB WILFRIED

IPC: B01J20/281 ,  A61K31/167 ,  A61K31/275 ,  A61K31/42 ,  A61K39/385 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07C233/58 ,  C07C235/28 ,  C07C235/74 ,  C07C237/04 ,  C07C255/23 ,  C07C255/30 ,  C07D261/08 ,  C07D261/18 ,  G01N30/88 ,  G01N33/53 ,  G01N33/543 ,  G01N33/558 ,  G01N33/68 ,  G01N33/94 ,  C07C ,  A61K

公开(公告)号：MX9706931A

公开(公告)日：1998-03-31

申请号：MX9706931

申请日：1997-09-11

Applicant: HOECHST AG

Inventor： SCHWAB WILFRIED ,  RAISS RUTH

IPC: A61K31/275 ,  A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/52 ,  A61K31/522 ,  A61P1/02 ,  A61P3/00 ,  A61P29/00 ,  C07C7/00 ,  C07C255/20 ,  C07C255/23 ,  C07C255/41 ,  C07C255/57 ,  C07C255/59 ,  C07C323/41 ,  C07D213/56 ,  C07D213/57 ,  C07D307/42 ,  C07D307/54 ,  C07D317/60 ,  C07D333/24 ,  C07D333/26 ,  C07D473/04 ,  C07D473/06 ,  C07C233/00

Abstract: Derivados de amida de ácido 2-ciano-3,5-dihidroxi-hex-2-eno-carboxílico son adecuados para la preparacion de medicamentos para la profilaxis y terapia de enfermedades o trastornos en cuyo curso está involucrada una intensa degradacion del tejido conjuntivo o del cartílago.

公开(公告)号：HRP940734A2

公开(公告)日：1997-06-30

申请号：HRP940734

申请日：1994-10-24

Applicant: HOECHST AG ,  RUHRCHEMIE AG

Inventor： KIRRSTEITER REINER ,  DUERCKHEIMER WALTER ,  LATTRELL RUDOLF ,  SCHWAB WILFRIED

IPC: C07D501/46

公开(公告)号：CA2237590A1

公开(公告)日：1997-05-22

申请号：CA2237590

申请日：1996-11-04

Applicant: HOECHST AG

Inventor： SCHUDOK MANFRED ,  BARTNIK ECKART ,  WEITHMANN KLAUS-ULRICH ,  SCHWAB WILFRIED ,  HAASE BURKHARD ,  THORWART WERNER

IPC: A61K31/00 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/4725 ,  A61P43/00 ,  C07D209/42 ,  C07D217/26 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/056 ,  C07D487/04 ,  C07D495/04 ,  C07D409/12 ,  C07D221/16 ,  A61K31/40 ,  A61K31/495 ,  A61K31/535

Abstract: Compounds of formula (I) are suitable for use in the production of medicaments used for treating disorders associated with increased activity of matrixdegrading metalloproteinases.

公开(公告)号：CA2188228A1

公开(公告)日：1997-04-26

申请号：CA2188228

申请日：1996-10-18

Applicant: HOECHST AG

Inventor： SCHWAB WILFRIED ,  CZECH JOERG ,  BOSLETT KLAUS

IPC: C07D213/75 ,  A61K31/275 ,  A61K31/42 ,  A61K31/422 ,  A61K31/44 ,  A61K31/4418 ,  A61P35/00 ,  A61P35/02 ,  C07D261/18 ,  C07D413/12 ,  C07D213/06 ,  A61K31/198 ,  C07C255/22

Abstract: The use of isoxazole and crotonamide derivatives for the treatment of carcinomatous disorders The compound of the formula ? or ?? (?) (??) is suitable for the production of a pharmaceutical for the treatment of carcinomatous disorders, where R1 is (C3-C5)-cycloalkyl, (C2-C6)-alkenyl or (C2-C6)-alkynyl, R~ is CF3, OCF3, SCF3, OH, N?, halogen, benzyl, phenyl, CN or O-phenyl, R3 is (C1-C4)-alkyl, halogen or a hydrogen atom and X is a -CH group or a nitrogen atom.

公开(公告)号：NO963560L

公开(公告)日：1996-08-26

申请号：NO963560

申请日：1996-08-26

Applicant: HOECHST AG

Inventor： SCHWAB WILFRIED ,  ANAGNOSTOPULOS HIRISTO ,  BARTLETT ROBERT RYDER ,  SCHLEYERBACH RUDOLF ,  WEITHMANN KLAUS ULRICH

IPC: A61K31/41 ,  A61K31/42 ,  A61K31/423 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5377 ,  A61P11/00 ,  A61P29/00 ,  A61P37/00 ,  C07C205/51 ,  C07D261/04 ,  C07D261/08 ,  C07D261/18 ,  C07D261/20 ,  C07D263/30 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07F9/653 ,  C07D

Abstract: PCT No. PCT/EP95/00784 Sec. 371 Date Nov. 19, 1996 Sec. 102(e) Date Nov. 19, 1996 PCT Filed Mar. 3, 1995 PCT Pub. No. WO95/24397 PCT Pub. Date Sep. 14, 1995A compound having the formula (I), a physiologically tolerable salt of the compound having the formula (I) and/or a steroisomeric form of the compound having the formula (I), in which one residue R1 or R2 stands for the formula (II), are suitable for preparing medicaments for the therapy of inflammations, asthma, rheumatoid diseases and auto-immune diseases.

公开(公告)号：DE4408084A1

公开(公告)日：1995-09-14

申请号：DE4408084

申请日：1994-03-10

Applicant: HOECHST AG

Inventor： SCHWAB WILFRIED ,  ANAGNOSTOPULOS HIRISTO ,  BARTLETT ROBERT RYDER ,  SCHLEYERBACH RUDOLF ,  WEITHMANN KLAUS ULRICH

IPC: A61K31/41 ,  A61K31/42 ,  A61K31/423 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5377 ,  A61P11/00 ,  A61P29/00 ,  A61P37/00 ,  C07C205/51 ,  C07D261/04 ,  C07D261/08 ,  C07D261/18 ,  C07D261/20 ,  C07D263/30 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07F9/653 ,  A61K31/425 ,  A61K31/44

Abstract: A compound having the formula (I), a physiologically tolerable salt of the compound having the formula (I) and/or a stereoisomeric form of the compound having the formula (I), in which one residue R or R stands for the formula (II), are suitable for preparing medicaments for the therapy of inflammations, asthma, rheumatoid diseases and auto-immune diseases.

公开(公告)号：NZ236199A

公开(公告)日：1994-03-25

申请号：NZ23619990

申请日：1990-11-23

Applicant: HOECHST AG

Inventor： LOHER HEINZ JOSEF ,  SCHWAB WILFRIED ,  BAUER KLAUS ,  BIERINGER HERMANN

IPC: A01N25/32 ,  A01N55/10 ,  C07D261/04 ,  C07D413/06 ,  C07F7/10