公开(公告)号：DE69431753D1

公开(公告)日：2003-01-02

申请号：DE69431753

申请日：1994-05-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K48/00 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01J13/02

Abstract: Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.

公开(公告)号：GR3036289T3

公开(公告)日：2001-10-31

申请号：GR20010401139

申请日：2001-07-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61B6/03 ,  A61K9/10 ,  A61K9/14 ,  A61K49/04 ,  A61K51/06 ,  A61K101/02 ,  A61P9/00 ,  C08K5/02 ,  C08L101/00 ,  G01N33/60 ,  A61K49/00

公开(公告)号：AU6188501A

公开(公告)日：2001-10-18

申请号：AU6188501

申请日：2001-08-17

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  FRITZ THOMAS A ,  RAMASWAMI VARADA RAJAN

IPC: A61B8/13

公开(公告)号：AU733492B2

公开(公告)日：2001-05-17

申请号：AU3313197

申请日：1997-06-16

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  FRITZ THOMAS A ,  RAMASWAMI VARADA RAJAN

IPC: A61M5/00 ,  A61B8/00 ,  A61K49/00 ,  A61K49/22 ,  A61K51/02 ,  A61B5/055

Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

公开(公告)号：DE69131721T2

公开(公告)日：2000-03-02

申请号：DE69131721

申请日：1991-04-09

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61B5/055 ,  A61K49/00 ,  A61K49/18 ,  G01R33/28

公开(公告)号：AU713127B2

公开(公告)日：1999-11-25

申请号：AU5627198

申请日：1998-02-24

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61K9/127 ,  A61K49/00 ,  A61K51/12

公开(公告)号：GR3030481T3

公开(公告)日：1999-10-29

申请号：GR990401555

申请日：1999-06-10

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61B8/00 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  B01J13/02 ,  B01J13/12 ,  A61B8/14

Abstract: The present invention relates to a method for synthesizing a liposome having encapsulated therein a gas comprising contacting the liposomes in the liquid medium with gas under elevated pressure. The liposomes so produced and are useful in ultrasonic imaging techniques.

公开(公告)号：DE69229342T2

公开(公告)日：1999-10-14

申请号：DE69229342

申请日：1992-03-18

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61B6/03 ,  A61K9/10 ,  A61K9/14 ,  A61K49/04 ,  A61K51/06 ,  A61K101/02 ,  A61P9/00 ,  C08K5/02 ,  C08L101/00 ,  G01N33/60 ,  C08F20/06 ,  A61K49/00 ,  A61K51/00 ,  C08F122/38 ,  C08F126/10 ,  C08J9/30 ,  G01R33/28

公开(公告)号：AU708341B2

公开(公告)日：1999-08-05

申请号：AU3146595

申请日：1995-07-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY ,  YELLOWHAIR DAVID

IPC: G01R33/28 ,  A61B5/055 ,  A61J1/00 ,  A61K8/04 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K9/133 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B65D81/20

Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.

公开(公告)号：DK0660687T3

公开(公告)日：1999-07-12

申请号：DK92912455

申请日：1992-03-31

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61F7/00 ,  A61B17/00 ,  A61B17/22 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/22 ,  A61N7/00 ,  A61N7/02 ,  A61Q19/00 ,  B01J13/02 ,  A61B8/14

Abstract: Gas filled liposomes prepared by a vacuum drying gas instillation method and/or gas filled liposomes substantially devoid of liquid in the interior thereof, are presented as novel potentiators for ultrasonic hyperthermia. The liposomes of the present invention, which may be administered into the vasculature, interstitially or into any body cavity are designed to accumulate in cancerous and diseased tissues. When therapeutic ultrasonic energy is applied to the diseased region heating is increased because of the greater effectiveness of sound energy absorption caused by these agents.