公开(公告)号：HK1050357A1

公开(公告)日：2003-06-20

申请号：HK03101863

申请日：2003-03-14

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  PORTEVIN BERNARD ,  BENOIST ALAIN ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE

IPC: C07D295/18 ,  A61K31/40 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/5377 ,  A61K38/00 ,  A61P1/00 ,  A61P1/02 ,  A61P3/04 ,  A61P3/10 ,  A61P31/18 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07B57/00 ,  C07D207/16 ,  C07D231/04 ,  C07D233/06 ,  C07D233/48 ,  C07D277/04 ,  C07D277/06 ,  C07D277/10 ,  C07D295/22 ,  C07D403/12 ,  C07K5/062 ,  C07K5/078 ,  C07K5/087 ,  C07K5/097 ,  C07D ,  A61P ,  A61K

Abstract: Sulfonated amino acid derivatives (I), their optical isomers and acid addition salts, are new. Sulfonated amino acid derivatives (I), their optical isomers and acid addition salts, are new. ring A = a 5 membered nitrogen heterocycle that may be substituted by cyano; R1 = H, 1-6C alkyl or acyl, prolyl, alanyl, histidylprolyl, or phenylalanylprolyl; Ak = 1-6C alkylene or heteroalkylene; X = a bond or phenylene optionally substituted by one or more groups selected from halogens, 1-6C alkyl, alkoxy or polyhaloalkyl, or OH; R2 = 1-6C alkyl (optionally substituted by one or more groups selected from aryl, 1-6C alkylsulfonyl, 3-7C cycloalkylsulfonyl, 3-7C cycloalkyl, and halogen), 3-10C cycloalkyl, or a group -NR2aR2b; R2a and R2b = H, 1-6C alkyl, or together with the N atom they form a nitrogen heterocycle; Y = -NR3, -NH-CH=N-, -C(=NH)-NH-, or -NR4-C(=NR5)-NR6-; R3 = H, 1-6C alkyl, 3-7C cycloalkyl, or aryl; R4, R5, R6 = H, 1-6C alkyl; or R4 and R6 together, or R5 and R6 together = imidazolidine or dihydrobenzimidazole in which the term nitrogen heterocycle encompasses a monocyclic saturated ring of 5 - 7 members having 1 - 3 heteroatoms at least one of which is N and others may be N, O or S, and the term 1-6c alkylene encompasses a group that may be straight or branched and one methylene group may be replaced by an atom or O or S.

公开(公告)号：CY2223B1

公开(公告)日：2003-04-18

申请号：CY0100009

申请日：2001-05-17

Applicant: SERVIER LAB

Inventor： NANTEUIL DE GUILLAUME ,  GLOANEC PHILIPPE ,  LILA CHRISTINE ,  PORTEVIN BERNARD ,  VERBEUREN TONY ,  RUPIN ALAIN ,  SIMONET SERGE

IPC: A61K31/69 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07F5/02

Abstract: Boronic acid derivatives of formula (I), their isomers and their acid and base addition salts are new. R1, R2 = H or 1-6C alkyl; or CR1R2 = 3-8C cycloalkyl; R3 = H, 1-6C alkyl or phenyl or benzyl (both optionally substituted); R4 = heterocyclyl, amino, amidino, guanidino isothioureido iminomethylamino or mercapto (all optionally substituted); R5, R6 = H or 1-6C alkyl; or B(OR5)(OR6) = boronic ester of pinanediol; m = 0-6; n = 1-6; A1 = -CO-, -CS- or -SO2-; A = 5-10C bicycloalkyl-phenyl (optionally substituted) or -A2-N(R7)(R8), provided that m is not 0; A2 = -CO- or -CS-; R7, R8 = H, 1-6C alkyl (optionally substituted), 1-6C alkylsulphonyl, arylsulphonyl, aryl, heterocyclyl or 5-10C bicycloalkyl-phenyl (optionally substituted), indanyl or a group of formula (i) or (ii); Ra = 1-6C alkyl or phenyl (optionally substituted); Rb, Rc = H, halo, 1-6C alkyl, 1-6C alkoxy, hydroxy, optionally substituted amino or trihalomethyl.

公开(公告)号：HU0201646A2

公开(公告)日：2003-02-28

申请号：HU0201646

申请日：2002-05-14

Applicant: SERVIER LAB

Inventor： BENOIST ALAIN ,  BOULANGER MICHELLE ,  HUSSON-ROBERT BERNADETTE ,  LEVENS NIGEL ,  DE NANTEUIL GUILLAUME ,  NOSJEAN OLIVIER ,  PORTEVIN BERNARD

IPC: A61K31/40 ,  C07D295/10 ,  A61K31/426 ,  A61P3/04 ,  A61P3/08 ,  A61P3/10 ,  C07D207/16 ,  C07D277/04 ,  C07D277/06 ,  C07D295/185 ,  C07K5/02

Abstract: Alpha amino acid derivatives (I), their optical isomers and addition salts, are new. Alpha amino acid derivatives of formula (I), their optical isomers and addition salts, are new: A = five-membered heterocycle, optionally substituted by a cyano group; Ak = 1-6C alkylene; X = single bond or phenylene; R1, R2, R4 = H or 1-6C alkyl; Y = NR4 or CH-NO2; R3 = NO2 or CN; and provided that: (i) when Y is CH-NO2, then R3 may further be 1-6C alkyl; and (ii) when A is unsubstituted, then Ak is propylene, X is a bond, Y is NH and R3 is NO2, are excluded.

公开(公告)号：ZA200202525B

公开(公告)日：2002-10-24

申请号：ZA200202525

申请日：2002-03-28

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  PORTEVIN BERNARD ,  BENOIST ALAIN ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE

IPC: C07D295/18 ,  A61K31/40 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/5377 ,  A61K38/00 ,  A61P1/00 ,  A61P1/02 ,  A61P3/04 ,  A61P3/10 ,  A61P31/18 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07B57/00 ,  C07D207/16 ,  C07D231/04 ,  C07D233/06 ,  C07D233/48 ,  C07D277/04 ,  C07D277/06 ,  C07D277/10 ,  C07D295/22 ,  C07D403/12 ,  C07K5/062 ,  C07K5/078 ,  C07K5/087 ,  C07K5/097 ,  C07D ,  A61K ,  A61P

Abstract: Sulfonated amino acid derivatives (I), their optical isomers and acid addition salts, are new. Sulfonated amino acid derivatives (I), their optical isomers and acid addition salts, are new. ring A = a 5 membered nitrogen heterocycle that may be substituted by cyano; R1 = H, 1-6C alkyl or acyl, prolyl, alanyl, histidylprolyl, or phenylalanylprolyl; Ak = 1-6C alkylene or heteroalkylene; X = a bond or phenylene optionally substituted by one or more groups selected from halogens, 1-6C alkyl, alkoxy or polyhaloalkyl, or OH; R2 = 1-6C alkyl (optionally substituted by one or more groups selected from aryl, 1-6C alkylsulfonyl, 3-7C cycloalkylsulfonyl, 3-7C cycloalkyl, and halogen), 3-10C cycloalkyl, or a group -NR2aR2b; R2a and R2b = H, 1-6C alkyl, or together with the N atom they form a nitrogen heterocycle; Y = -NR3, -NH-CH=N-, -C(=NH)-NH-, or -NR4-C(=NR5)-NR6-; R3 = H, 1-6C alkyl, 3-7C cycloalkyl, or aryl; R4, R5, R6 = H, 1-6C alkyl; or R4 and R6 together, or R5 and R6 together = imidazolidine or dihydrobenzimidazole in which the term nitrogen heterocycle encompasses a monocyclic saturated ring of 5 - 7 members having 1 - 3 heteroatoms at least one of which is N and others may be N, O or S, and the term 1-6c alkylene encompasses a group that may be straight or branched and one methylene group may be replaced by an atom or O or S.

公开(公告)号：AU9416598A

公开(公告)日：1999-06-17

申请号：AU9416598

申请日：1998-11-26

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  TORDJMAN CHARLES ,  BONNET JACQUELINE ,  PORTEVIN BERNARD

IPC: A61K31/00 ,  A61K31/40 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/407 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61P19/00 ,  A61P19/02 ,  A61P29/00 ,  A61P43/00 ,  C07D209/44 ,  C07D209/52 ,  C07D209/72 ,  C07D401/04 ,  C07D401/14 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D487/04 ,  C07D491/16

Abstract: Compounds of formula (I): wherein: R represents hydrogen, alkyl, optionally-substituted amino, or linear or branched (C1-C6)-acyl, R1 and R2, which may be identical or different, each represents independently of the other aryl, heteroaryl, or (C5-C7)-cycloalkyl, or one of those groups optionally substituted, A, together with the atoms in common with the pyrrole, represents saturated or unsaturated, monocyclic or bicyclic (C3-C12)-cycloalkyl, or a saturated heterocycle having 5 to 7 ring members and containing one or two nitrogen, or 7-oxabicyclo[2.2.1]heptane, or one of those groups optionally substituted, their isomers, and also addition salts thereof with a pharmaceutically-acceptable acid or base, pharmaceutical compositions thereof, and use thereof as medicaments.

公开(公告)号：AU7860898A

公开(公告)日：1999-02-11

申请号：AU7860898

申请日：1998-07-30

Applicant: SERVIER LAB

Inventor： NATEUIL GUILLAUME DE ,  PORTEVIN BERNARD ,  BONNET JACQUELINE ,  FRADIN ARMEL

IPC: C07D235/06 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/4427 ,  A61P29/00 ,  A61P43/00 ,  C07D235/12 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D521/00 ,  C07D403/10 ,  C07D417/10

公开(公告)号：AU3437695A

公开(公告)日：1996-05-02

申请号：AU3437695

申请日：1995-10-19

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  REMOND GEORGES ,  PORTEVIN BERNARD ,  BONNET JACQUELINE ,  CANET EMMANUEL ,  BIRRELL GRAHAM

IPC: A61K31/4427 ,  A61K31/445 ,  A61P1/00 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D401/06 ,  C07D471/04 ,  C07D401/14 ,  C07D409/14

公开(公告)号：AU5795694A

公开(公告)日：1994-09-29

申请号：AU5795694

申请日：1994-03-22

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  PORTEVIN BERNARD ,  REMOND GEORGES ,  LEPAGNOL JEAN ,  HEIDET VERONIQUE

IPC: A61K31/40 ,  A61K31/401 ,  A61K31/42 ,  A61K31/425 ,  A61K31/435 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/47 ,  A61P9/00 ,  A61P25/00 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  A61P43/00 ,  C07D209/42 ,  C07D401/06 ,  C07D403/06 ,  C07D409/08 ,  C07D413/06 ,  C07D417/06 ,  C07D453/02 ,  C07D453/06

Abstract: The invention relates to the compounds of formula (I): in which: A represents, with the carbon and nitrogen atoms to which it is attached, a heterocycle, B represents, with the nitrogen atom to which it is attached, a heterocycle, n is equal to 1, 2, 3 or 4, R represents a phenyl group substituted by at least one halogen atom or one alkyl, hydroxyl, alkoxy, trifluoromethyl, nitro, amino, cyano, carboxyl or alkoxycarbonyl group, a benzyl group, a thienyl group or a pyridyl group. Medicaments.

公开(公告)号：FR2921365B1

公开(公告)日：2012-10-12

申请号：FR0706629

申请日：2007-09-21

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  PORTEVIN BERNARD ,  GLOANEC PHILIPPE ,  PARMENTIER JEAN GILLES ,  BENOIST ALAIN ,  VERBEUREN TONY ,  RUPIN ALAIN ,  COURCHAY CHRISTINE ,  SIMONET SERGE

IPC: C07D207/08 ,  A61K31/34 ,  A61K31/40 ,  A61K31/404 ,  A61K31/407 ,  A61K31/421 ,  A61K31/472 ,  A61P9/00 ,  C07D207/12 ,  C07D209/08 ,  C07D215/48 ,  C07D271/04 ,  C07D339/06 ,  C07D495/10 ,  C07F9/38

公开(公告)号：AU2008217013A8

公开(公告)日：2012-10-04

申请号：AU2008217013

申请日：2008-09-15

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  PORTEVIN BERNARD ,  GLOANEC PHILIPPE ,  PARMENTIER JEAN-GILLES ,  BENOIST ALAIN ,  VERBEUREN TONY ,  RUPIN ALAIN ,  COURCHAY CHRISTINE ,  SIMONET SERGE

IPC: C07D271/08 ,  A61K31/34 ,  A61K31/40 ,  A61K31/403 ,  A61K31/4164 ,  A61K31/4245 ,  A61K31/435 ,  A61K31/5383 ,  A61K31/662 ,  A61P9/10 ,  A61P9/12 ,  A61P29/00 ,  A61P39/00 ,  C07D207/16 ,  C07D209/42 ,  C07D209/52 ,  C07D217/26 ,  C07D233/32 ,  C07D307/93 ,  C07D495/10 ,  C07F9/38

Abstract: -69 New addition salts of angiotensin-converting enzyme inhibitors with NO donor acids, a process for their preparation and pharmaceutical compositions containing them Compounds of formula (I) : 5 (A)m . (B). (I) wherein A represents an angiotensin-converting enzyme inhibitor compound containing at least one salt-forming basic function, B represents a compound containing at least one salt forming acid function and at least one NO donor group, m represents the number of acid functions of B that have been converted to a salt and n represents the number of basic 10 functions of A that have been converted to a salt, the bond or bonds between A and B being of the ionic type. Medicaments.