公开(公告)号：FI115769B

公开(公告)日：2005-07-15

申请号：FI955024

申请日：1995-10-20

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  REMOND GEORGES ,  PORTEVIN BERNARD ,  BONNET JACQUELINE ,  CANET EMMANUEL ,  BIRRELL GRAHAM

IPC: A61K31/4427 ,  A61K31/445 ,  A61P1/00 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D401/06 ,  C07D471/04

公开(公告)号：NO313997B1

公开(公告)日：2003-01-13

申请号：NO974253

申请日：1997-09-15

Applicant: SERVIER LAB

Inventor： DHAINAUT ALAIN ,  TIZOT ANDRE ,  CANET EMMANUEL ,  LONCHAMPT MICHEL

IPC: A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/47 ,  A61K31/495 ,  A61K31/505 ,  A61P11/00 ,  A61P11/08 ,  A61P29/00 ,  A61P43/00 ,  C07D211/22 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  C07D401/14

公开(公告)号：CY2173B1

公开(公告)日：2002-08-23

申请号：CY0000020

申请日：2000-05-30

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  VERBEUREN TONY ,  VALLEZ MARIE-ODILE ,  CANET EMMANUEL ,  YVES ROLLAND

IPC: A61K31/35 ,  A61K31/352 ,  A61P9/00 ,  A61P9/14 ,  A61P29/00 ,  C07D311/30 ,  C07D407/12 ,  C07D407/14 ,  C07H15/26

Abstract: Diosmetin derivs. of formula (I) and their diastereomers and/or enantiomers are new. R1 = H, propyl, allyl or 1,2-dideuteroallyl; R2 = H, propyl, allyl, propargyl, 2,3-dihydroxypropyl, (2,2-dimethyl- 1,3-dioxol-4-yl) methyl or 3-acetyloxy-2-hydroxypropyl; R3 = H, propyl, allyl or 1,2-dideuteroallyl; R4 = H, Me, propyl, allyl, propargyl, 2,3-dihydroxypropyl, (2,2-dimethyl- 1,3-dioxol-4-yl)methyl or COR4'; R5 = H, propyl, allyl or 1,2-dideuteroallyl; and R6 = H, Me, propyl, allyl, propargyl, 2,3-dihydroxypropyl, (2,2-dimethyl- 1,3-dioxol-4-yl)methyl, COR6' or a gp. of formula (i); R4', R6' = 1-5C alkyl or Ph; provided that at least one of R1-R6 is other than H; and if R1- R3 = H, then R4 = H.

公开(公告)号：AU3836297A

公开(公告)日：1998-03-26

申请号：AU3836297

申请日：1997-09-19

Applicant: SERVIER LAB

Inventor： DHAINAUT ALAIN ,  TIZOT ANDRE ,  CANET EMMANUEL ,  LONCHAMPT MICHEL

IPC: A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/47 ,  A61K31/495 ,  A61K31/505 ,  A61P11/00 ,  A61P11/08 ,  A61P29/00 ,  A61P43/00 ,  C07D211/22 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  C07D401/10 ,  C07D413/10 ,  C07D473/00

公开(公告)号：AU3437695A

公开(公告)日：1996-05-02

申请号：AU3437695

申请日：1995-10-19

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  REMOND GEORGES ,  PORTEVIN BERNARD ,  BONNET JACQUELINE ,  CANET EMMANUEL ,  BIRRELL GRAHAM

IPC: A61K31/4427 ,  A61K31/445 ,  A61P1/00 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D401/06 ,  C07D471/04 ,  C07D401/14 ,  C07D409/14

公开(公告)号：DE69717044T2

公开(公告)日：2003-07-24

申请号：DE69717044

申请日：1997-09-23

Applicant: SERVIER LAB

Inventor： DHAINAUT ALAIN ,  LEWIN GUY ,  CANET EMMANUEL ,  LONCHAMPT MICHEL ,  ROLLAND YVES

IPC: A61K31/35 ,  A61K31/352 ,  A61P11/00 ,  A61P29/00 ,  A61P43/00 ,  C07D311/30 ,  C07D405/12

Abstract: Flavone derivatives of formula (I), their optical and geometric isomers, mixtures and salts are new. R1 = alkyl; R2 = 3-9C cyclic hydrocarbon (optionally containing at least one intracyclic double bond and optionally substituted), 6-15C polycyclic hydrocarbon (optionally containing at least one double bond and optionally substituted) or 1-13C hydrocarbon (optionally containing one or more double and/or triple bond and optionally substituted); R3 = H or OH; Alk = e.g. 1-6C alkylene; X = O, -CR'= or -CHR'-; R' = H or alkyl; Y = e.g. -C IDENTICAL N, -C(=Z2)(R4), C(=Z1)(-O-R4), -C(=Z1)(N(R4)(R4')), N(R4)(R4'), - N(R5)(R5')(R5'') Hal , -C(=Z1)(N(R4)(-OR4') or C(=N-R4'')(NR4R4'); Z1 = O or S; Z2 = O, S, =N-OR4 or =N(O)R5; R4, R4', R4" = H, optionally substituted alkyl, aryl, heteroaryl or cycloalkyl; R5, R5' , R5" = optionally substituted alkyl, aryl, heteroaryl or cycloalkyl; provided that: (i) the alkyl and alkoxy groups contain 1-6C and are optionally substituted by halog en and OH, the alkyl groups being optionally further be substituted by alkoxy; (ii) aryl is phenyl or naphthyl (optionally substituted by halogen, alkyl, OH and/or alkoxy; (iii) heteroaryl denotes furyl, thienyl, thiazolyl, isothiazolyl, oxazolyl, pyrrolyl, imidazolyl, pyrazolyl, pyridyl, pyrazinyl, pyrimidyl, pyridazinyl, indolyl, quinolyl, isoquinolyl or quinazolinyl (optionally substituted by one or more halogens, alkyl, OH and/or alkoxy).

公开(公告)号：PT832886E

公开(公告)日：2003-03-31

申请号：PT97402202

申请日：1997-09-23

Applicant: SERVIER LAB

Inventor： DHAINAUT ALAIN ,  LONCHAMPT MICHEL ,  ROLLAND YVES ,  LEWIN GUY ,  CANET EMMANUEL

IPC: A61K31/35 ,  A61K31/352 ,  A61P11/00 ,  A61P29/00 ,  A61P43/00 ,  C07D311/30 ,  C07D405/12

Abstract: Flavone derivatives of formula (I), their optical and geometric isomers, mixtures and salts are new. R1 = alkyl; R2 = 3-9C cyclic hydrocarbon (optionally containing at least one intracyclic double bond and optionally substituted), 6-15C polycyclic hydrocarbon (optionally containing at least one double bond and optionally substituted) or 1-13C hydrocarbon (optionally containing one or more double and/or triple bond and optionally substituted); R3 = H or OH; Alk = e.g. 1-6C alkylene; X = O, -CR'= or -CHR'-; R' = H or alkyl; Y = e.g. -C IDENTICAL N, -C(=Z2)(R4), C(=Z1)(-O-R4), -C(=Z1)(N(R4)(R4')), N(R4)(R4'), - N(R5)(R5')(R5'') Hal , -C(=Z1)(N(R4)(-OR4') or C(=N-R4'')(NR4R4'); Z1 = O or S; Z2 = O, S, =N-OR4 or =N(O)R5; R4, R4', R4" = H, optionally substituted alkyl, aryl, heteroaryl or cycloalkyl; R5, R5' , R5" = optionally substituted alkyl, aryl, heteroaryl or cycloalkyl; provided that: (i) the alkyl and alkoxy groups contain 1-6C and are optionally substituted by halog en and OH, the alkyl groups being optionally further be substituted by alkoxy; (ii) aryl is phenyl or naphthyl (optionally substituted by halogen, alkyl, OH and/or alkoxy; (iii) heteroaryl denotes furyl, thienyl, thiazolyl, isothiazolyl, oxazolyl, pyrrolyl, imidazolyl, pyrazolyl, pyridyl, pyrazinyl, pyrimidyl, pyridazinyl, indolyl, quinolyl, isoquinolyl or quinazolinyl (optionally substituted by one or more halogens, alkyl, OH and/or alkoxy).

公开(公告)号：DK0832886T3

公开(公告)日：2003-03-10

申请号：DK97402202

申请日：1997-09-23

Applicant: SERVIER LAB

Inventor： DHAINAUT ALAIN ,  LEWIN GUY ,  CANET EMMANUEL ,  LONCHAMPT MICHEL ,  ROLLAND YVES

IPC: A61K31/35 ,  A61K31/352 ,  A61P11/00 ,  A61P29/00 ,  A61P43/00 ,  C07D311/30 ,  C07D405/12

Abstract: Flavone derivatives of formula (I), their optical and geometric isomers, mixtures and salts are new. R1 = alkyl; R2 = 3-9C cyclic hydrocarbon (optionally containing at least one intracyclic double bond and optionally substituted), 6-15C polycyclic hydrocarbon (optionally containing at least one double bond and optionally substituted) or 1-13C hydrocarbon (optionally containing one or more double and/or triple bond and optionally substituted); R3 = H or OH; Alk = e.g. 1-6C alkylene; X = O, -CR'= or -CHR'-; R' = H or alkyl; Y = e.g. -C IDENTICAL N, -C(=Z2)(R4), C(=Z1)(-O-R4), -C(=Z1)(N(R4)(R4')), N(R4)(R4'), - N(R5)(R5')(R5'') Hal , -C(=Z1)(N(R4)(-OR4') or C(=N-R4'')(NR4R4'); Z1 = O or S; Z2 = O, S, =N-OR4 or =N(O)R5; R4, R4', R4" = H, optionally substituted alkyl, aryl, heteroaryl or cycloalkyl; R5, R5' , R5" = optionally substituted alkyl, aryl, heteroaryl or cycloalkyl; provided that: (i) the alkyl and alkoxy groups contain 1-6C and are optionally substituted by halog en and OH, the alkyl groups being optionally further be substituted by alkoxy; (ii) aryl is phenyl or naphthyl (optionally substituted by halogen, alkyl, OH and/or alkoxy; (iii) heteroaryl denotes furyl, thienyl, thiazolyl, isothiazolyl, oxazolyl, pyrrolyl, imidazolyl, pyrazolyl, pyridyl, pyrazinyl, pyrimidyl, pyridazinyl, indolyl, quinolyl, isoquinolyl or quinazolinyl (optionally substituted by one or more halogens, alkyl, OH and/or alkoxy).

公开(公告)号：DE69717044D1

公开(公告)日：2002-12-19

申请号：DE69717044

申请日：1997-09-23

Applicant: SERVIER LAB

Inventor： DHAINAUT ALAIN ,  LEWIN GUY ,  CANET EMMANUEL ,  LONCHAMPT MICHEL ,  ROLLAND YVES

IPC: A61K31/35 ,  A61K31/352 ,  A61P11/00 ,  A61P29/00 ,  A61P43/00 ,  C07D311/30 ,  C07D405/12

Abstract: Flavone derivatives of formula (I), their optical and geometric isomers, mixtures and salts are new. R1 = alkyl; R2 = 3-9C cyclic hydrocarbon (optionally containing at least one intracyclic double bond and optionally substituted), 6-15C polycyclic hydrocarbon (optionally containing at least one double bond and optionally substituted) or 1-13C hydrocarbon (optionally containing one or more double and/or triple bond and optionally substituted); R3 = H or OH; Alk = e.g. 1-6C alkylene; X = O, -CR'= or -CHR'-; R' = H or alkyl; Y = e.g. -C IDENTICAL N, -C(=Z2)(R4), C(=Z1)(-O-R4), -C(=Z1)(N(R4)(R4')), N(R4)(R4'), - N(R5)(R5')(R5'') Hal , -C(=Z1)(N(R4)(-OR4') or C(=N-R4'')(NR4R4'); Z1 = O or S; Z2 = O, S, =N-OR4 or =N(O)R5; R4, R4', R4" = H, optionally substituted alkyl, aryl, heteroaryl or cycloalkyl; R5, R5' , R5" = optionally substituted alkyl, aryl, heteroaryl or cycloalkyl; provided that: (i) the alkyl and alkoxy groups contain 1-6C and are optionally substituted by halog en and OH, the alkyl groups being optionally further be substituted by alkoxy; (ii) aryl is phenyl or naphthyl (optionally substituted by halogen, alkyl, OH and/or alkoxy; (iii) heteroaryl denotes furyl, thienyl, thiazolyl, isothiazolyl, oxazolyl, pyrrolyl, imidazolyl, pyrazolyl, pyridyl, pyrazinyl, pyrimidyl, pyridazinyl, indolyl, quinolyl, isoquinolyl or quinazolinyl (optionally substituted by one or more halogens, alkyl, OH and/or alkoxy).

公开(公告)号：PT834508E

公开(公告)日：2001-11-30

申请号：PT97402321

申请日：1997-10-03

Applicant: SERVIER LAB

Inventor： DHAINAUT ALAIN ,  LONCHAMPT MICHEL ,  CANET EMMANUEL ,  POISSONNET GUILLAUME

IPC: C07D233/64 ,  A61K31/05 ,  A61K31/11 ,  A61K31/135 ,  A61K31/15 ,  A61K31/165 ,  A61K31/275 ,  A61K31/34 ,  A61K31/343 ,  A61K31/38 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/415 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/47 ,  A61K31/495 ,  A61P11/00 ,  A61P11/08 ,  A61P25/00 ,  A61P27/16 ,  A61P29/00 ,  A61P37/00 ,  A61P37/08 ,  A61P43/00 ,  C07C43/20 ,  C07C45/71 ,  C07C47/546 ,  C07C47/57 ,  C07C47/575 ,  C07C49/798 ,  C07C49/84 ,  C07C49/86 ,  C07C65/21 ,  C07C67/14 ,  C07C69/157 ,  C07C69/24 ,  C07C69/28 ,  C07C69/75 ,  C07C201/12 ,  C07C205/20 ,  C07C205/44 ,  C07C205/60 ,  C07C217/82 ,  C07C235/44 ,  C07C235/60 ,  C07C251/48 ,  C07C251/54 ,  C07C251/86 ,  C07C255/53 ,  C07C255/54 ,  C07C255/58 ,  C07C257/18 ,  C07C259/10 ,  C07C323/31 ,  C07D209/08 ,  C07D213/06 ,  C07D213/50 ,  C07D215/12 ,  C07D231/12 ,  C07D307/79 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D213/61 ,  C07C223/06 ,  C07C291/02

Abstract: Substituted biphenyl and phenyl pyridyl derivatives of formula (I), their isomers and their salts are new. R1 = 3-7C cycloalkyl, phenyl, naphthyl, optionally unsaturated mono- or bicyclic heterocycle having 1-3 O, S or N, 1-6C alkyl or 1-6C alkenyl (sic) (all optionally substituted); A = a bond (provided that R1 is other than C1 or C2 alkyl) or O, S, -CO-, -C(=N-ORc)- or -CH(ORc)-; Rc = H, 1-6C alkyl or 3-7C cycloalkyl; R2 = 1-6C alkyl, 1-6C alkenyl (sic), 1-6C alkynyl (sic) or 3-7C cycloalkyl (all optionally substituted) halo, formyl, carboxy, 1-6C alkylcarbonyl, 3-7C cycloalkylcarbonyl, 1-6C alkoxycarbonyl, 3-7C cycloalkoxycarbonyl, carbamoyl (optionally substituted), amino (optionally substituted by one or two 1-6C alkyl, 1-6C acyl, 3-7C cycloalkyl or forming with the N atom which bears them a 5-7 membered heterocycle containing 1-3 O, N or S (sic)), formamido, CN, amidino (optionally substituted), hydroxyaminomethyl (optionally substituted), amide-oxime (optionally substituted), hydrazono (optionally substituted), -C(R21)=N-O-R22 or -C(R21)=N(O)-R23; R21 = H, 1-6C alkyl or 3-7C cycloalkyl; R22 = H, 1-6C alkyl, 3-7C cycloalkyl or 1-6C acyl; R23 = 1-6C alkyl or 3-7C cycloalkyl; R3 = H, 1-6C alkyl, 3-7C cycloalkyl or 1-6C acyl or =C(R2)-C(X-R3)= forms an unsaturated 5-membered heterocyclic ring of formula (i); X = O, S or NR"; R" = H, 1-6C alkyl, 3-7C cycloalkyl or 1-6C acyl; ring B is phenyl or pyridyl; Ra, Rb = H, halo, 1-6C alkyl, OH, 1-6C alkoxy, carboxy, 1-6C polyhaloalkyl, CN, NO2, 1-6C alkoxycarbonyl, 3-7C cycloalkoxy carbonyl, amino (optionally substituted), carbamoyl (optionally substituted); provided that when A is a bond or O, B is phenyl, R1 is 3-7C cycloalkyl, phenyl or naphthyl (all optionally substituted), X is O, NH or amino(1-6C alkyl) and R3 is H or 1-6C alkyl, then R2 is not carboxy.