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公开(公告)号：HRP20201011T1
公开(公告)日：2020-10-16
申请号：HRP20201011
申请日：2020-06-26
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME WIREDU , O'NEIL SIMON ADAM , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA
IPC: C07D401/14 , A61K31/506 , A61P35/00
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公开(公告)号：DK3424920T3
公开(公告)日：2020-06-08
申请号：DK18188034
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME WIREDU , O'NEIL SIMON ADAM , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA
IPC: C07D401/14 , A61K31/506 , A61P35/00
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公开(公告)号：DK3057953T3
公开(公告)日：2018-11-19
申请号：DK14799578
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME WIREDU , O'NEIL SIMON ADAM , ZHANG YUEGANG , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA , MUDUNURI PRAVEEN
IPC: C07D401/14 , A61K31/506 , A61P35/00
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公开(公告)号：CL2016000916A1
公开(公告)日：2016-11-11
申请号：CL2016000916
申请日：2016-04-15
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME WIREDU , O'NEIL SIMON ADAM , ZHANG YUEGANG , WALDO MICHAEL , MUDUNURI PRAVEEN , SONG BIN , VAN ALSTEN JOHN GREGG , STROHMEIER MARK , STAVROPOULOS KATHY , KADIYALA IRINA NIKOLAEVNA , NAVAMAL METTACHIT
IPC: C07D401/14 , A61K31/506 , A61P35/00
Abstract: Co-cristales que comprenden un compuesto derivado de quinolina-2carboxamida de fórmula (I) y un formador de cristales; composiciones que los comprenden; método de preparación de los co-cristales y uso de estos en la preparación de un medicamento útil para el tratamiento de cáncer
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Patent Agency Ranking
公开(公告)号：AU2015202975B2
公开(公告)日：2016-05-12
申请号：AU2015202975
申请日：2015-06-03
Applicant: VERTEX PHARMA
IPC: A61K9/20 , A61K31/404
Abstract: PHARMACEUTICAL COMPOSITION OF (R)-1-(2,2 DIFLUOROBENZO[D][1,3]DIOXOL-5-YL)-N-(1 -(2,3-DIHYDROXY PROPYL)-6-FLUORO-2-(1 -HYDROXY-2-METHYLPROPAN-2-YL)-1 H INDOL-5-YL) CYCLOPROPANECARBOXAMIDE AND ADMINISTRATION THEREOF A pharmaceutical composition comprising Compound , (R)-1-(2,2-difluorobenzo[d][1,3]dioxol 5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-IH-indol-5 yl)cyclopropanecarboxamide, and at least one excipient selected from: a filler, a diluent, a disintegrant, a surfactant, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering the pharmaceutical composition of Compound I are also disclosed.
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公开(公告)号：CY1111439T1
公开(公告)日：2015-08-05
申请号：CY101101151
申请日：2010-12-13
Applicant: VERTEX PHARMA
Inventor： KADIYALA IRINA NIKOLAEVNA , LIN WU , HURTER PATRICIA
IPC: A61K9/16 , A61K9/20 , A61K31/401
Abstract: Ηεφεύρεσησχετίζεταιμεμιασύνθεσηελεγχόμενηςαπελευθέρωσηςγιαένανδιαστόματοςχορηγηθέντααναστολέακυτοκίνηςτουενζύμουμετατροπήςτηςιντερλευκίνης-1 βήτα.
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78.发明专利
公开(公告)号：MX2014005565A
公开(公告)日：2014-05-30
申请号：MX2014005565
申请日：2012-11-06
Applicant: VERTEX PHARMA
Inventor： KADIYALA IRINA NIKOLAEVNA , JAMZAD SHAHLA , HOOCK THOMAS CARL , TAYLOR LORI KELL , SEWELL KATHRYN LEA
IPC: A61K45/06 , A61K31/506 , A61P29/00
Abstract: La presente invención proporciona un método para tratar o disminuir la severidad de una enfermedad seleccionada de espondiloartropatía, lupus eritematoso sistémico, artritis reumatoide, o cualquier combinación de los mismos que comprende administración de un compuesto de la Fórmula I y una co-terapia opcional (por ejemplo, agente de quimioterapia, DMARD, o cualquier combinación de estos). La presente invención también proporciona una composición farmacéutica que comprende un compuesto de la Fórmula I, un método para elaborar una composición farmacéutica que comprende un compuesto de la Fórmula I, y un método para administrar una composición farmacéutica que comprende una forma sólida de un compuesto de la Fórmula I.
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79.发明专利
公开(公告)号：AU2012336019A1
公开(公告)日：2014-05-29
申请号：AU2012336019
申请日：2012-11-06
Applicant: VERTEX PHARMA
Inventor： KADIYALA IRINA NIKOLAEVNA , JAMZAD SHAHLA , HOOCK THOMAS CARL , TAYLOR LORI KELL , SEWELL KATHRYN LEA
IPC: A61K31/506 , A61K45/06 , A61P29/00
Abstract: The present invention provides method of treating or lessening the severity of a disease selected from spondyloarthropathy, systemic lupus erythematosus, rheumatoid arthritis, or any combination thereof comprising the administration of a compound of Formula I and an optional co-therapy (e.g., chemotherapy agent, DMARD, or any combination thereof). The present invention also provides a pharmaceutical composition comprising a compound of Formula I, a method of manufacturing a pharmaceutical composition comprising a compound of Formula I, and a method of administering a pharmaceutical composition comprising a solid form of a compound of Formula I.
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公开(公告)号：AU2011293658A1
公开(公告)日：2013-04-04
申请号：AU2011293658
申请日：2011-08-22
Applicant: VERTEX PHARMA
IPC: A61K9/20 , A61K31/404
Abstract: A pharmaceutical composition comprising Compound 1, (R)-l-(2,2-difluorobenzo[d][l,3]dioxol-5-yl)-N-(l-(2,3-dihydroxypropyl)-6-fluoro-2-(l-hydroxy-2- methylpropan-2-yl)-lH-indol-5-yl)cyclopropanecarboxamide, and at least one excipient selected from: a filler, a diluent, a disintegrant, a surfactant, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering the pharmaceutical composition of Compound 1 are also disclosed.
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