公开(公告)号：US20180141976A1

公开(公告)日：2018-05-24

申请号：US15575138

申请日：2016-05-20

Applicant: KAGOSHIMA UNIVERSITY

Inventor： Yuji ITO

IPC: C07K7/08 ,  A61K47/64 ,  C07K16/00

CPC classification number: C07K7/08 ,  A61K38/00 ,  A61K39/395 ,  A61K47/64 ,  C07K16/00 ,  C07K19/00

Abstract: This invention relates to an IgG-binding peptide, an IgG-binding peptide modified with a cross-linking agent, a conjugate of the IgG-binding peptide modified with a cross-linking agent and IgG, and a method for producing the conjugate, etc.

公开(公告)号：US09745275B2

公开(公告)日：2017-08-29

申请号：US15105985

申请日：2014-12-18

Applicant: KYOTO UNIVERSITY ,  KAGOSHIMA UNIVERSITY

Inventor： Masatoshi Hagiwara ,  Masayasu Toyomoto ,  Takamitsu Hosoya ,  Suguru Yoshida ,  Takashi Kurihara

IPC: A61K31/428 ,  C07D277/64

CPC classification number: C07D277/64

Abstract: Provided is a pain-related compound, a pain-related pharmaceutical composition, and use of the same. Provided in one or more embodiments is a compound represented by Formula (I), a prodrug of the same, or a pharmaceutically permissible salt of any of the same.

公开(公告)号：US20170224773A1

公开(公告)日：2017-08-10

申请号：US15503078

申请日：2015-08-06

Applicant: KAGOSHIMA UNIVERSITY

Inventor： Akio IDO ,  Hirohito TSUBOUCHI ,  Yuga KOMAKI

IPC: A61K38/18 ,  A61L31/16

Abstract: According to this invention, the following are provided: a pharmaceutical composition for treating and/or preventing esophageal stenosis, comprising an HGF protein as an active ingredient (wherein the HGF protein may be a polypeptide that is any one of the following: (a) a polypeptide comprising the amino acid sequence shown in SEQ ID NO: 2; (b) a polypeptide comprising an amino acid sequence shown in SEQ ID NO: 2 in which one to several amino acids are deleted, substituted, or added; or (c) a polypeptide comprising an amino acid sequence having at least 90% identity with the amino acid sequence shown in SEQ ID NO: 2; and a stent comprising the pharmaceutical composition.

公开(公告)号：US09633439B2

公开(公告)日：2017-04-25

申请号：US14418663

申请日：2013-06-28

Applicant: National Institute of Advanced Industrial Science and Technology ,  Kagoshima University ,  Hiroshima City University

Inventor： Ryusuke Sagawa ,  Hiroshi Kawasaki ,  Ryo Furukawa

IPC: G06T7/00 ,  G01B11/25 ,  G06T1/00

CPC classification number: G06T7/73 ,  G01B11/2513 ,  G01B11/2545 ,  G06T1/0007 ,  G06T7/521 ,  G06T2207/10012

Abstract: A high-density shape reconstruction is conducted in measuring animal bodies as well. An image processing system has a projection device, an imaging device, and an image processing apparatus connected to the projection device and the imaging device, wherein the projection device projects a projected pattern to an observation target, the imaging device captures the projected pattern, and the image processing apparatus performs shape reconstruction based on an input image including the projected pattern. The image processing apparatus includes a unit for fetching the input image captured by the imaging device and performing line detection for the projected pattern projected by the projection device, wherein the projected pattern is a grid pattern formed of wave lines; and a unit for performing shape reconstruction by associating intersection points of vertical and horizontal lines extracted by the line detection with the projected pattern.

公开(公告)号：US20160000782A1

公开(公告)日：2016-01-07

申请号：US14769220

申请日：2014-02-14

Applicant: KAGOSHIMA UNIVERSITY

Inventor： Hiroshi TAKASHIMA ,  Shuji IZUMO

IPC: A61K31/505 ,  A61K31/42

CPC classification number: A61K31/505 ,  A61K31/42 ,  A61K31/63 ,  A61K31/635 ,  A61K45/06 ,  A61K2300/00

Abstract: [Problem] The purpose of the present invention is to provide a pharmaceutical composition containing an antibacterial agent, which is effective in elucidating one cause of dementia, and in treatment thereof.[Solution] The present invention provides a pharmaceutical composition for treatment of dementia, containing an antibacterial agent. The present invention moreover provides a pharmaceutical composition for treatment of extreme halophile infections, containing a folic acid synthesis inhibitor.

Abstract translation: 本发明的目的是提供一种含有抗菌剂的药物组合物，其有效地阐明一种痴呆原因及其治疗方法。 [解决方案]本发明提供含有抗菌剂的治疗痴呆症的药物组合物。 本发明还提供了用于治疗极度嗜酸性细菌感染的药物组合物，其含有叶酸合成抑制剂。

公开(公告)号：US09118337B2

公开(公告)日：2015-08-25

申请号：US14405760

申请日：2013-06-05

Applicant: KAGOSHIMA UNIVERSITY

Inventor： Kenichi Ohhata

IPC: H03M1/12 ,  H03M1/00 ,  H03M1/36 ,  H03M1/08 ,  G02F7/00 ,  H03M7/16

CPC classification number: H03M1/002 ,  G02F7/00 ,  H03M1/00 ,  H03M1/0607 ,  H03M1/0612 ,  H03M1/0845 ,  H03M1/12 ,  H03M1/1225 ,  H03M1/145 ,  H03M1/361 ,  H03M1/365 ,  H03M7/165

Abstract: A parallel-type AD converter includes: a plurality of comparators that receive comparison reference potentials different from one another and compare the comparison reference potentials and received analog input signals; an encoder that encodes outputs of the plurality of comparators to output digital signals; and a resistor ladder circuit that resistance-divides a reference voltage to generate the comparison reference potentials and supplies the comparison reference potentials to the comparators through output nodes each positioned between resistors, and is designed to supply a correction current corresponding to noise currents that the comparators generate to the output nodes of the comparison reference potentials in the resistor ladder circuit, and thereby the noise currents that the comparators generate are offset by the correction current, a bias current in the resistor ladder circuit can be decreased, and accuracy deterioration in AD conversion can be suppressed.

Abstract translation: 并行型AD转换器包括：多个比较器，其接收彼此不同的比较参考电位，并比较比较参考电位和接收的模拟输入信号; 编码器，其对所述多个比较器的输出进行编码以输出数字信号; 以及电阻分压基准电压以产生比较参考电位的电阻梯形电路，并且通过每个位于电阻器之间的输出节点将比较参考电位提供给比较器，并且被设计为提供对应于噪声电流的校正电流，比较器 生成电阻梯形电路中比较参考电位的输出节点，从而比较器产生的噪声电流被校正电流偏移，电阻梯形电路中的偏置电流可能会降低，AD转换精度下降 可以抑制。

公开(公告)号：US20140295566A1

公开(公告)日：2014-10-02

申请号：US14274521

申请日：2014-05-09

Applicant: Japan Science and Technology Agency ,  National University Corporation Kagoshima University

Inventor： Yasuo SUDA

IPC: G01N33/52 ,  C07H15/04

CPC classification number: G01N33/52 ,  C07H15/04 ,  G01N33/531 ,  G01N2400/00

Abstract: A novel ligand conjugate which is effectively utilizable for analyzing a function of a protein; a ligand-supporting object; and a method of analyzing a protein. The ligand conjugate has a structure which comprises: a linker compound having a structure represented by the following General Formula (1): (wherein n and p each is an integer of 0 to 6) in which X is a structure comprising one, two, or three hydrocarbon derivative chains which have an aromatic amino group at the end and may have a carbon-nitrogen bond in the main chain, Y is a hydro-carbon structure containing one or more sulfur atoms, and Z is a straight-chain structure comprising a carbon-carbon bond or carbon-oxygen bond; and a sugar which has a reducing end and is bonded to the linker compound through the aromatic amino group.

Abstract translation: 一种新颖的配体结合物，可有效用于分析蛋白质的功能; 配体支持物; 和分析蛋白质的方法。 配体缀合物具有以下结构：包含具有以下通式（1）表示的结构的连接体化合物：（其中n和p各自为0〜6的整数），其中，X为包含1〜 或在末端具有芳香族氨基并且在主链中可具有碳 - 氮键的三个烃衍生物链，Y是含有一个或多个硫原子的氢碳结构，Z是直链结构，包括 碳 - 碳键或碳 - 氧键; 和具有还原性末端并通过芳香族氨基与连接体化合物键合的糖。

公开(公告)号：US20140273049A1

公开(公告)日：2014-09-18

申请号：US14349855

申请日：2012-10-05

Applicant: Kagoshima University ,  SUMITOMO BAKELITE COMPANY LIMITED

Inventor： Shoji Natsugoe ,  Yasuto Uchikado ,  Teruto Hashiguchi ,  Hiroyuki Shinchi ,  Kosei Maemura ,  Yuko Mataki ,  Norichika Moriwaki ,  Masaru Sekijima ,  Hideyuki Shimaoka ,  Midori Sakaguchi ,  Masao Fukushima ,  Kota Igarashi ,  Hiroki Abe ,  Taichi Aihara

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N33/57446 ,  G01N33/57469

Abstract: A diagnostic marker for digestive organ cancer according to the present invention is used for determining whether or not to have a digestive organ cancer. The diagnostic marker for digestive organ cancer contains at least one of N-binding type sugar chains released from a glycoprotein contained in blood and represented by the following formulas (1) to (6). This makes it possible to provide a diagnostic marker for digestive organ cancer capable of being used for an inspection method of easily determining whether or not to have a digestive organ cancer at an early stage, and an inspection method for digestive organ cancer of easily determining whether or not to have a digestive organ cancer at an early stage.

Abstract translation: 根据本发明的用于消化器官癌的诊断标记用于确定是否具有消化器官癌。 消化器官癌的诊断标记物含有从血液中含有的糖蛋白释放的N-结合型糖链中的至少一种，由下述式（1）〜（6）表示。 这使得可以提供能够用于容易地确定早期是否具有消化器官癌的检查方法的消化器官癌的诊断标记和消化器官癌的检查方法，以容易地确定是否 或者早期没有消化器官癌。

公开(公告)号：US20250161529A1

公开(公告)日：2025-05-22

申请号：US18843155

申请日：2023-02-27

Applicant: Kagoshima University

Inventor： Takayuki TAKEI ,  Masahiro YOSHIDA ,  Yusuke YAMASHITA

IPC: A61L26/00

Abstract: Provided is a method of preparing a medical hydrogel derived from a chitosan derivative containing aldonic acid bound by dehydration condensation to an amino group of a glucosamine unit of chitosan, the method including placing an aqueous solution containing the chitosan derivative in a mold having a predetermined shape, and then subjecting the aqueous solution to high-pressure steam sterilization, to obtain a sterile medical hydrogel having the predetermined shape. The resulting medical hydrogel can be used as a wound dressing for use in the treatment of wound surfaces of cut wounds, lacerated wounds, contused wounds, burns, bedsores, and the like.

公开(公告)号：US12037417B2

公开(公告)日：2024-07-16

申请号：US16309272

申请日：2017-06-12

Applicant: Kagoshima University

Inventor： Yuji Ito ,  Yoshinari Shoyama ,  Akio Hayashi ,  Norihito Nakata

IPC: C07K7/08 ,  C07K7/64 ,  G01N33/534 ,  G01N33/574

CPC classification number: C07K7/08 ,  C07K7/64 ,  G01N33/534 ,  G01N33/574

Abstract: The present invention relates to an IgG-binding peptide comprising a ligand capable of binding to a radioactive metal nuclide, an IgG-binding peptide labeled with a radioactive metal nuclide, a conjugate of the IgG-binding peptide and IgG, and a radionuclide imaging agent or a diagnostic agent for cancer comprising the IgG-binding peptide or the conjugate, etc.