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    COMPACT LIQUID CHROMATOGRAPHY SYSTEM PROVIDING THERMAL MANAGEMENT AND DETECTION
    82.
    发明申请
    COMPACT LIQUID CHROMATOGRAPHY SYSTEM PROVIDING THERMAL MANAGEMENT AND DETECTION 审中-公开

    公开(公告)号：WO2022235752A1

    公开(公告)日：2022-11-10

    申请号：PCT/US2022/027610

    申请日：2022-05-04

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： FOGWILL, Michael O. ,  GRITTI, Fabrice

    IPC: G01N30/20 ,  G01N30/30

    Abstract: The exemplary embodiments may provide liquid chromatography systems that are smaller in size and with reduced extra-column volume than conventional liquid chromatography systems. The exemplary embodiments may reduce the size of the liquid chromatography systems enough that the liquid chromatography systems of the exemplary embodiments may be deployed adjacent to automated sample preparation robotics, adjacent to a process stream, or adjacent to the inlet of a mass spectrometer. In addition, the exemplary embodiments may reduce the extra-column volume of the liquid chromatography system by eliminating many of the connection tubes found in conventional liquid chromatography systems and by situating components of the liquid chromatography system in closer proximity.

    COMPOSITIONS, KITS AND METHODS USEFUL FOR ANALYZING ANTIBODY-CONTAINING SAMPLES
    83.
    发明申请
    COMPOSITIONS, KITS AND METHODS USEFUL FOR ANALYZING ANTIBODY-CONTAINING SAMPLES 审中-公开

    公开(公告)号：WO2022182493A1

    公开(公告)日：2022-09-01

    申请号：PCT/US2022/015112

    申请日：2022-02-03

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： LAUBER, Matthew A. ,  LIU, Xiaoxiao

    IPC: C07K16/00 ,  C07K1/22 ,  G01N33/58 ,  G01N33/68

    Abstract: In some aspects, the present disclosure pertains to sample treatment methods that comprise: contacting an acidic elution solution that is free of primary amine, secondary amine and thiol groups with a sorbent having bound target antibody and separating the elution solution from the sorbent, thereby releasing bound target antibody from the sorbent and forming a first collection fraction that comprises the elution solution and released target antibody; contacting the sorbent with a neutralization buffer solution that is free of primary amine, secondary amine and thiol groups and separating the neutralization buffer solution from the sorbent, thereby forming a second collection fraction that comprises the neutralization buffer solution; and forming a neutralized solution that comprises the first collection fraction and the second collection fraction. In other aspects, the present disclosure pertains to kits for performing such sample treatment methods.

    MIXER FOR LIQUID CHROMATOGRAPHY
    86.
    发明申请
    MIXER FOR LIQUID CHROMATOGRAPHY 审中-公开

    公开(公告)号：WO2022010665A1

    公开(公告)日：2022-01-13

    申请号：PCT/US2021/039058

    申请日：2021-06-25

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： GRITTI, Fabrice

    IPC: G01N30/34

    Abstract: Described is a mixer 50 for a liquid chromatography system. The mixer includes a flow distributor 52, a mixing disk 54 and a flow collector 56. The mixer includes an inlet face, an outlet face and a plurality of channels each having an inlet end at the inlet face and an outlet end at the outlet face. The channels have a flow direction anisotropy between the inlet and outlet faces. A compositional solvent stream received at the flow distributor 52 is distributed across the inlet face of the mixing disk 54 and the flow collector 56 collects the distributed solvent composition stream after passing through the mixing disk 54. The mixing disk 54 may include a dispersive medium having a random porous structure. A retention time distribution of the mixer may depend on the structure of the channels between the inlet and outlet faces of the mixing disk.

    METHODS TO INCREASE SENSITIVITY LC/MS ANALYSIS
    89.
    发明申请
    METHODS TO INCREASE SENSITIVITY LC/MS ANALYSIS 审中-公开

    公开(公告)号：WO2021144761A1

    公开(公告)日：2021-07-22

    申请号：PCT/IB2021/050312

    申请日：2021-01-15

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： RAINVILLE, Paul ,  SMITH, Kerri

    IPC: G01N30/56 ,  G01N30/88 ,  G01N1/405 ,  G01N2030/027 ,  G01N2030/567 ,  G01N2030/8813 ,  G01N30/7233 ,  G01N30/8631

    Abstract: The present disclosure discusses a method of separating a sample (e.g., pharmaceutical drug, genotoxic impurity, biomarker, and/or biological metabolite) including coating a metallic flow path of a chromatographic system; injecting the sample into the chromatographic system; flowing the sample through the chromatographic system; separating the sample; and analyzing the separated sample using mass spectroscopy. In some examples, the coating applied to the surfaces defining the flow path is non-binding with respect to the sample – and the separated sample. Consequently, the sample does not bind to the low-binding surface of the coating of the flow path. The applied coating can increase the chromatographic peak area for the sample of the chromatographic system.

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