公开(公告)号：WO2018158730A1

公开(公告)日：2018-09-07

申请号：PCT/IB2018/051324

申请日：2018-03-01

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： FOGWILL, Michael O. ,  JARRELL, Joseph A. ,  MICHIENZI, Joseph D. ,  MCDONALD, Thomas S.

IPC: B01D15/40 ,  G01N30/32 ,  G01N30/34 ,  G01N30/62

CPC classification number: G01N30/32 ,  B01D15/163 ,  B01D15/40 ,  G01N30/34 ,  G01N30/36 ,  G01N30/62 ,  G01N30/7233 ,  G01N2030/326 ,  G01N2030/347 ,  G01N2030/623

Abstract: The present disclosure relates to methodologies, systems and apparatus for controlling pressure in a CO 2 -based chromatography system. A first CO 2 pump operates in constant flow mode and delivers CO 2 to a chromatography column, and liquid modifier is introduced to the chromatography column according to a gradient. A second CO 2 pump is disposed downstream of the column and operates in constant pressure mode to introduce CO 2 into a flow stream at an output of the column. Liquid modifier is also introduced into the flow stream at the output of the column according to a reverse gradient compared to the gradient entering the chromatography column.

公开(公告)号：WO2018160405A1

公开(公告)日：2018-09-07

申请号：PCT/US2018/018947

申请日：2018-02-21

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： JARRELL, Joseph A.

IPC: B01L3/00 ,  G01N33/50

Abstract: A method and apparatus for analyzing a response of a cellular entity to a component of interest are described. The cellular entity may be a cell or an organoid. The method includes processing a heterogeneous population of cellular entities that are combined with the component of interest. An entity flow containing the cellular entities is generated. A morphological image of a portion of the entity flow having a cellular entity is acquired and the cellular entity is identified as belonging to an entity class. The entity flow is provided to a mass spectrometer system that performs an analysis of the cellular entity. The mass spectrometer analysis of the cellular entity can be correlated with the identified entity class. Alternatively, portions of the entity flow are deposited as samples on a sample plate and the mass spectrometer analysis is performed offline, for example, using an ionization process with each sample.

公开(公告)号：WO2021207494A1

公开(公告)日：2021-10-14

申请号：PCT/US2021/026383

申请日：2021-04-08

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： JARRELL, Joseph A. ,  GILAR, Martin

IPC: H01J49/02 ,  G01N27/62 ,  G01N33/48

Abstract: An ion detector comprises a surface configured to receive one or more ions and a detector configured to detect one or more ions by detecting electromagnetic radiation scattered by one or more ions at the surface.

公开(公告)号：WO2020264270A1

公开(公告)日：2020-12-30

申请号：PCT/US2020/039788

申请日：2020-06-26

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： JARRELL, Joseph A. ,  MARTIN, LeRoy B.

IPC: H01J49/04 ,  B01L3/00

Abstract: A method of mass spectrometry is disclosed comprising focusing electromagnetic radiation into a region of a liquid sample (3) below a surface of the liquid sample so as to generate one or more bubbles (4). The one or more bubbles (4) rise to the surface of the liquid whereupon one or more droplets of liquid (6) are emitted from the surface of the liquid sample. The method further comprises directing the one or more emitted droplets (6) towards an inlet of a mass spectrometer (8).

公开(公告)号：WO2018134736A1

公开(公告)日：2018-07-26

申请号：PCT/IB2018/050274

申请日：2018-01-17

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： JUNG, Moon Chul ,  BELANGER, Jonathan L. ,  SONG, Xiangjin ,  TARAFDER, Abhijit ,  JARRELL, Joseph A. ,  LEVEILLE, SR., Wade P.

IPC: G01M3/20 ,  G01M3/26 ,  G01N30/02

CPC classification number: G01N30/88 ,  G01M3/202 ,  G01M3/26 ,  G01N30/02 ,  G01N30/04 ,  G01N30/26 ,  G01N30/6052 ,  G01N30/8675 ,  G01N2030/889

Abstract: Systems, methods, and devices for detecting leaks in chromatography systems are disclosed. The leak detection system includes a sealable compartment disposed to surround at least one component of a chromatography system. The detector is in communication, e.g., fluid communication, with an interior of the sealable compartment and configured to detect the leak by various mean including the presence of liquid or the presence of vapor, or both within the sealable compartment.

公开(公告)号：WO2013134223A1

公开(公告)日：2013-09-12

申请号：PCT/US2013/029049

申请日：2013-03-05

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： JACKSON, Michael ,  USOWICZ, James E. ,  TIZIANI, Lucas ,  JARRELL, Joseph A. ,  WITTMER, Douglas P.

IPC: F04B49/03

CPC classification number: F04B53/10 ,  B01D15/40 ,  G01N30/38 ,  G01N30/72 ,  G01N2030/8813 ,  H01J49/04

Abstract: A method includes passing a mobile phase fluid flow comprising liquefied CO2 through a separation column; then introducing a makeup fluid flow into the mobile phase fluid flow to form a mixed fluid flow; and then splitting the mixed fluid flow.

Abstract translation: 一种方法包括使包含液化CO 2的流动相流体流通过分离塔; 然后将补充流体流引入流动相流体流中以形成混合流体流; 然后分离混合流体流。