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公开(公告)号：KR1020100077770A
公开(公告)日：2010-07-08
申请号：KR1020080135808
申请日：2008-12-29
Applicant: 한국과학기술연구원
CPC classification number: A61L31/16 , A61L31/10 , A61L31/14 , A61L31/148 , A61L2300/61 , A61L2400/12 , A61L2400/18 , A61F2/82 , A61L27/34 , A61L27/54 , C08L67/04
Abstract: PURPOSE: A method of manufacturing a medical stent for releasing medical drugs and a medical stent for releasing medical drugs using the same method are provided, which have the nano-structured pattern using the plasma-assisted chemical vapor deposition. CONSTITUTION: A method of manufacturing medical stent for releasing medical drug having the nano-structured pattern includes: a step of coating the surface of stent with the biodegradable polymer; a step of forming the nano-structured pattern on the surface of the stent coated with the biodegradable polymer through the ion beam or the plasma process using the method of plasma-assisted chemical vapor deposition; and a step of dipping the medical drugs within the biodegradable polymer in which the nano-structured pattern is formed. The biodegradable polymer is the biodegradable polymer in which the medical drugs are dipped.
Abstract translation: 目的：提供一种使用等离子体辅助化学气相沉积制造具有纳米结构图案的用于使用相同方法制造用于释放药物的医用支架和用于释放药物的药物支架的方法。 构成：制造具有纳米结构图案的医药用医用支架的方法，其特征在于，包括以下步骤：用生物降解性聚合物涂布支架表面; 使用等离子体辅助化学气相沉积的方法通过离子束或等离子体处理在涂覆有可生物降解的聚合物的支架的表面上形成纳米结构图案的步骤; 以及将药物浸渍在其中形成纳米结构图案的生物可降解聚合物中的步骤。 可生物降解的聚合物是医用药物浸渍的可生物降解的聚合物。
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公开(公告)号：KR100794174B1
公开(公告)日：2008-01-14
申请号：KR1020060113227
申请日：2006-11-16
Applicant: 한국과학기술연구원
Abstract: A method for preparing a biodegradable porous polymer scaffold having hydroxyapatite on the surface is provided to produce the biodegradable porous polymer scaffolds having improved cell affinity and osteoconductivity in a simple and effective manner. A method for preparing a biodegradable porous polymer scaffold having hydroxyapatite on the surface includes the steps of: (1) graft-polymerizing a functional group-containing hydrophilic monomer on the surface of a biodegradable porous polymer scaffold; and (2) immersing the obtained functional group-containing polymer scaffold in a simulated body fluid solution to form hydroxyapatite on the surface of the scaffold. The functional group-containing hydrophilic monomer is selected from the group consisting of organic acids having carboxylic acids at the terminals, monomers having phosphoric acids at the terminals, and mixtures thereof.
Abstract translation: 提供了一种在表面上制备具有羟基磷灰石的可生物降解的多孔聚合物支架的方法，以简单且有效的方式制备具有改善的细胞亲和力和骨传导性的可生物降解的多孔聚合物支架。 一种在表面上制备具有羟基磷灰石的可生物降解的多孔聚合物支架的方法包括以下步骤：（1）在可生物降解的多孔聚合物支架的表面上接枝聚合含官能团的亲水单体; 和（2）将获得的含官能团的聚合物支架浸入模拟的体液溶液中以在支架的表面上形成羟基磷灰石。 含官能团的亲水性单体选自末端具有羧酸的有机酸，末端具有磷酸的单体及其混合物。
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公开(公告)号：KR100752100B1
公开(公告)日：2007-08-27
申请号：KR1020060104844
申请日：2006-10-27
Applicant: 한국과학기술연구원
Abstract: A cardiovascular system transplanting metallic material is provided to improve blood compatibility by modifying the surface of the metallic material with a sulfobetaine poly(ethylene glycol) derivative having anions. A metallic material has improved blood compatibility by modifying a surface of the metallic material with a sulfobetaine poly(ethylene glycol) derivative of the formula 1, X-R1-PEG-R1-Y, where R1 is one or more functional groups connected by urethane, urea, amide, ester, ether or anhydride comprising 0 to 20 alkyl groups or aryl groups; X is -NCO or -CHO; and Y is sulfobetaine(-N^+ -R2 -SO3^-) as a zwitterionic derivative, wherein R2 is an alkyl group or an aryl group. A manufacturing method of a metallic material of which surface is modified with a sulfobetaine poly(ethylene glycol) derivative comprises the steps of: oxidizing the surface of the metallic material to introduce a hydroxyl group(-OH) into the surface thereof; and chemically bonding the sulfobetaine poly(ethylene glycol) derivative to the hydroxyl group of the metallic material surface.
Abstract translation: 提供心血管系统移植金属材料以通过用具有阴离子的磺基甜菜碱聚（乙二醇）衍生物修饰金属材料的表面来改善血液相容性。 金属材料通过用式1的磺基甜菜碱聚（乙二醇）衍生物X-R1-PEG-R1-Y对金属材料的表面进行改性来改善血液相容性，其中R1是通过氨基甲酸酯连接的一个或多个官能团 ，包含0至20个烷基或芳基的脲，酰胺，酯，醚或酸酐; X是-NCO或-CHO; 并且Y是磺基甜菜碱（-N ^ + -R 2 -SO 3 - ） - 作为两性离子衍生物，其中R 2是烷基或芳基。 其表面用磺基甜菜碱聚（乙二醇）衍生物改性的金属材料的制造方法包括以下步骤：氧化金属材料的表面以将羟基（-OH）引入其表面; 并将磺基甜菜碱聚（乙二醇）衍生物化学结合到金属材料表面的羟基上。
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公开(公告)号：KR100518998B1
公开(公告)日：2005-10-06
申请号：KR1020030060180
申请日：2003-08-29
IPC: A61K6/08
Abstract: 본 발명은 물리적, 기계적 특성 및 생체 적합성이 개선된 치과용 자가중합형 레진시멘트 조성물에 관한 것으로, 보다 구체적으로는 2,2-비스[4-(2-히드록시-3-메타크릴옥시프로폭시)페닐]프로판 (이하 "Bis-GMA로 칭함)과 Bis-GMA에 존재하는 히드록시기 (-OH)가 메타크릴레이트기로 치환된 멀티메타크릴레이트기 함유 다관능성 프리폴리머를 혼합한 프리폴리머 혼합물, 희석제, 접착 단량체, 중합개시제, 중합금지제, 광안정제, 산화방지제, 무기 안료 및 무기 충전재가 혼합된 페이스트(paste) A 조성물과, 상기 페이스트 A 조성물의 프리폴리머 혼합물과 동일한 프리폴리머 혼합물, 희석제, 접착 단량체, 환원제, 중합금지제, 광안정제, 산화방지제, 무기 안료 및 무기 충전재가 혼합된 페이스트 B 조성물로 구성된 치과용 자가중합형 레진시멘트 조성물에 관한 것이 다.
발명의 치과용 자가중합형 레진시멘트는 종래의 자가중합형 레진시멘트보다 우수한 물리적, 기계적 특성 및 생체 적합성을 나타내며, 연고-연고형 시스템으로서 사용이 간편하다.-
公开(公告)号：KR1020050023109A
公开(公告)日：2005-03-09
申请号：KR1020030060180
申请日：2003-08-29
IPC: A61K6/08
Abstract: PURPOSE: A composition of dental self-curing resin cements is provided, which composition is ointment-ointment system of which usage is convenient, and has improved fluidity, low polymerization contraction rate, low water absorption, low water solubility and low viscosity, so that the amount of an added diluting agent can be reduced and a large amount of inorganic filler can be mixed. CONSTITUTION: The composition of dental self-curing resin cements comprises a paste composition A comprising 1 to 25 wt.% of prepolymer mixture, 1 to 20 wt.% of diluting agent, 0.1 to 15 wt.% of adhesive monomer, 0.1 to 3 wt.% of polymerization initiator, 0.1 to 3 wt.% of polymerization inhibitor, 0.1 to 2 wt.% of photo-stabilizing agent, 0.1 to 2 wt.% of oxidation inhibitor, 0.005 to 1 wt.% of inorganic dye, and inorganic filler; and a paste composition B comprising 1 to 25 wt.% of prepolymer, 1 to 20 wt.% of diluting agent, 0.1 to 15 wt.% of adhesive monomer, 0.1 to 3 wt.% of reducing agent, 0.1 to 3 wt.% of polymerization inhibitor, 0.1 to 2 wt.% of photo-stabilizing agent, 0.1 to 2 wt.% of oxidation inhibitor, 0.005 to 1 wt.% of inorganic dye and inorganic filler, wherein the prepolymer is selected from 2,2-bis£4-(2-hydroxy-3-methacryloxypropoxy)phenyl|propane (Bis-GMA) of formula (1), Tri-GMA of formula (2), a mixture of Bis-GMA and Tetra-GMA of formula (3), and a mixture of Bis-GMA, Tri-GMA and Tetra-GMA.
Abstract translation: 目的：提供牙科自固化树脂水泥的组合物，其组成为使用方便的软膏系统，流动性好，聚合收缩率低，吸水率低，水溶性低，粘度低，因此 可以减少添加的稀释剂的量，并且可以混合大量的无机填料。 构成：牙科自固化树脂水泥的组成包括糊组合物A，其包含1至25重量％的预聚物混合物，1至20重量％的稀释剂，0.1至15重量％的粘合剂单体，0.1至3 聚合引发剂的重量百分数，聚合抑制剂的0.1〜3重量％，光稳定剂0.1〜2重量％，氧化抑制剂0.1〜2重量％，无机染料0.005〜1重量％ 无机填料; 和含有1〜25重量％预聚物，1〜20重量％稀释剂，0.1〜15重量％粘合剂单体，0.1〜3重量％还原剂，0.1〜3重量％ ％的阻聚剂，0.1〜2重量％的光稳定剂，0.1〜2重量％的氧化抑制剂，0.005〜1重量％的无机染料和无机填料，其中预聚物选自2,2-二 式（1）的双4-（2-羟基-3-甲基丙烯酰氧基丙氧基）苯基|丙烷（Bis-GMA），式（2）的三-GMA，式（3）的Bis-GMA和四-GMA的混合物 ）和Bis-GMA，Tri-GMA和Tetra-GMA的混合物。
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Patent Agency Ranking
公开(公告)号：KR1020030018325A
公开(公告)日：2003-03-06
申请号：KR1020010051994
申请日：2001-08-28
Applicant: 한국과학기술연구원 , 주식회사 티씨 싸이언스
IPC: C08J7/18
Abstract: PURPOSE: A method for preparing a soft lens is provided to obtain an unharmful soft lens for inhibiting the adsorption of proteins, thereby improving the wearing feeling and the lifetime of the lens. CONSTITUTION: The method comprises the steps of treating the surface of a contact lens with plasma to activate the surface; and grafting the protein adsorption inhibiting material represented by the formula 1 onto the surface, wherein R1 is H or methyl group; and R2 is polyethylene glycol, polypropylene glycol, polyethylene glycol-polypropylene glycol copolymer, polyethylene glycol-polypropylene glycol-polyethylene glycol copolymer, poly(vinyl pyrrolidone), their copolymers or their mixtures. The protein adsorption inhibiting material has a molecular weight of 100-10,000. Preferably the plasma treatment is carried out by using the plasma of 1 W to 1 kW; and the grafting is carried out at a temperature of 10-100 deg.C and in the presence of sodium hydrogensulfite as an oxidizing agent.
Abstract translation: 目的：提供一种制备软透镜的方法，以获得抑制蛋白质吸附的不好的软透镜，从而提高透镜的穿戴感和使用寿命。 构成：该方法包括用等离子体处理隐形眼镜表面以激活表面的步骤; 并将由式1表示的蛋白质吸附抑制物质接枝到表面上，其中R1是H或甲基; R2是聚乙二醇，聚丙二醇，聚乙二醇 - 聚丙二醇共聚物，聚乙二醇 - 聚丙二醇 - 聚乙二醇共聚物，聚（乙烯基吡咯烷酮），它们的共聚物或它们的混合物。 蛋白质吸附抑制物质的分子量为100〜10000。 优选地，通过使用1W至1kW的等离子体来进行等离子体处理; 接枝在10-100℃的温度下进行，在亚硫酸氢钠存在下作为氧化剂进行。
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公开(公告)号：KR100367042B1
公开(公告)日：2003-01-15
申请号：KR1019990046512
申请日：1999-10-26
Applicant: 한국과학기술연구원
IPC: C07C50/18
CPC classification number: Y02P20/55
Abstract: PURPOSE: A method for forming a fine fluorescent image by using protected hydroxy group-containing anthraquinone derivatives or naphthacenequinone derivatives is provided. Thereby the obtained protected hydroxy group-containing compound can be applied to recording material and censor material because it can easily form a fine fluorescent image of micrometer units under the condition of a chemically amplified fine image forming process. CONSTITUTION: This method comprises the steps of: preparing a transparent solution by dissolving protected hydroxy group-containing anthraquinone derivatives of formula 1 or naphthacenequinone derivatives of formula 2 and a soluble polymer in an organic solvent; forming a thin film by coating the solution on a substrate; prebaking the thin film coated substrate; and removing a hydroxy protecting group of the anthraquinone derivatives or naphthacenequinone derivatives by treating under the condition of a chemically amplified fine image forming process.
Abstract translation: 目的：提供一种通过使用被保护的含羟基蒽醌衍生物或并四苯醌衍生物来形成精细荧光图像的方法。 因此，所获得的被保护的含羟基化合物可以应用于记录材料和传感材料，因为它可以在化学放大的精细图像形成过程的条件下容易地形成微米单位的精细荧光图像。 构成：该方法包括以下步骤：通过将式1的受保护的含羟基蒽醌衍生物或式2的萘并萘醌衍生物和可溶性聚合物溶解在有机溶剂中制备透明溶液; 通过将溶液涂覆在基底上形成薄膜; 预烘烤薄膜涂覆的基材; 并通过在化学放大的精细图像形成过程的条件下处理除去蒽醌衍生物或萘并萘醌衍生物的羟基保护基。
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公开(公告)号：KR100351074B1
公开(公告)日：2002-09-05
申请号：KR1020000038132
申请日：2000-07-05
IPC: A61K6/00
Abstract: 본 발명은 종래 치과수복용 프리폴리머로 사용되고 있는 2,2-비스-(4-(2-히드록시-3-메타크릴로일옥시프로폭시)페닐)프로판 [이하, "Bis-GMA"라 명명함]에, 이 Bis-GMA 분자 중의 히드록시기의 수소 원자를 메타크릴레이트기로 치환한 멀티메타크릴레이트기 함유 다관능성 프리폴리머를 혼합한 프리폴리머 혼합물을 기재로 하고, 희석제, 무기 충전제, 광개시계 및 기타 첨가제를 포함하는 치과수복용 광중합성 복합레진 조성물에 관한 것이다. 다관능성 프리폴리머 혼합물을 기재로 하는 본 발명의 치과수복용 광중합성 복합레진 조성물은 기재로서 Bis-GMA 자체만을 포함하는 종래의 것보다 우수한 물리적, 기계적 특성과 생체 적합성을 나타낸다.
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公开(公告)号：KR100341426B1
公开(公告)日：2002-06-21
申请号：KR1019990046511
申请日：1999-10-26
Applicant: 한국과학기술연구원
IPC: C07C50/16
CPC classification number: Y02P20/55
Abstract: 본발명은미세형광화상형성용재료의전구물질로서유용한히드록시보호된 1,4-디히드록시안트라퀴논유도체및 그의공중합체와, 이공중합체를이용한미세형광화상형성방법에관한것이다. 본발명의히드록시보호된 1,4-디히드록시안트라퀴논공중합체는히드록시기의분자내수소결합을한시적으로차단한다음, 산, 열또는광 등에의해탈보호되어색 및형광의변화를일으키기때문에, 화학증폭성미세화상형성공정조건에서쉽게미크론미터단위의미세형광화상을형성할수 있어서, 색화상및 형광화상물질과같은기록용재료, 그리고센서재료로응용될수 있다.
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公开(公告)号：KR100324644B1
公开(公告)日：2002-02-27
申请号：KR1019990046513
申请日：1999-10-26
Applicant: 한국과학기술연구원
IPC: C07C15/28
Abstract: 본발명은미세형광화상형성용재료의전구물질로서유용한, α-아미노안트라센유도체및 그의공중합체와, 이공중합체를이용한미세형광화상형성방법에관한것이다. 본발명의α-아미노안트라센함유공중합체는유기산또는무기산에의해형광이변하고, 광산발생제와혼합하여박막상태에서노광할경우쉽게미크론미터단위의미세형광화상을형성할수 있으며, 용액, 필름및 입자상태에서센서기능이우수하여기록용재료및 센서재료로응용될수 있다.
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