公开(公告)号：AT461923T

公开(公告)日：2010-04-15

申请号：AT06837694

申请日：2006-11-15

Applicant: ABBOTT LAB

Inventor： PENNING THOMAS D ,  THOMAS SHEELA A ,  ZHU GUI-DONG ,  GONG JIANCHUN ,  GIRANDA VINCENT L ,  GANDHI VIRAJ B

IPC: C07D235/18

Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).

公开(公告)号：MX2009007051A

公开(公告)日：2009-07-10

申请号：MX2009007051

申请日：2007-12-20

Applicant: ABBOTT LAB

Inventor： GONG JIANCHUN ,  GIRANDA VINCENT L ,  ZHU GUI-DONG ,  GHANDI VIRAJ B ,  PENNING THOMAS D

IPC: A01N43/58 ,  A61K31/495 ,  A61K31/50

Abstract: Se describen inhibidores de poli(ADP-ribosa)polimerasa, maneras de obtenerlos y métodos de tratamiento de pacientes usando los mismos.

公开(公告)号：NO20083923L

公开(公告)日：2008-11-04

申请号：NO20083923

申请日：2008-09-15

Applicant: ABBOTT LAB

Inventor： PENNING THOMAS D ,  ZHU GUI-DONG ,  GANDHI VIRAJKUMAR B ,  GONG JIANCHUN ,  GIRANDA VINCENT L

IPC: C07D471/04 ,  C07D491/04 ,  C07D495/04

Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).

公开(公告)号：CR10277A

公开(公告)日：2008-10-13

申请号：CR10277

申请日：2008-09-09

Applicant: ABBOTT LAB

Inventor： PENNING THOMAS D ,  ZHU GUI-DONG ,  GANDHI VIRAJKUMAR B ,  GONG JIANCHUN ,  GIRANDA VINCENT L

IPC: A61K31/438 ,  A61P35/00 ,  C07D471/04 ,  C07D495/04

Abstract: Compuestos de la formula (I) que inhiben la enzima PARP y son de utilidad para el tratamiento de una enfermedad o un trastorno asociado con PARP. Tambien se divulgan composiciones farmaceuticas que comprenden a los compuestos de la formula (I), metodos de tratamiento que comprenden a los compuestos de la formula (I) y metodos para inhibir la enzima PARP que comprende a los compuestos de la formula (I).

公开(公告)号：MX2007012593A

公开(公告)日：2007-11-16

申请号：MX2007012593

申请日：2006-04-11

Applicant: ABBOTT LAB

Inventor： ZHU GUIDONG ,  GONG JIANCHUN ,  GANDHI VIRAJKUMAR B ,  PENNING THOMAS D ,  GIRANDA VINCENT

IPC: C07D401/04 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/55 ,  A61P9/10 ,  C07D403/04

Abstract: Los compuestos de Formula (I) inhiben la enzima PARP y son utiles para tratar una enfermedad o un desorden asociado con PARP. Tambien se describen composiciones farmaceuticas comprendiendo compuestos de Formula (I), metodos de tratamiento comprendiendo compuestos de Formula (I) y metodos para inhibir la enzima PARP comprendiendo compuestos de Formula (I) (ver Formula (I)).

公开(公告)号：CA2647373A1

公开(公告)日：2007-11-15

申请号：CA2647373

申请日：2007-05-02

Applicant: ABBOTT LAB

Inventor： ZHU GUI-DONG ,  THOMAS SHEELA A ,  GONG JIANCHUN ,  GANDHI VIRAJKUMAR B ,  GIRANDA VINCENT L ,  PENNING THOMAS D

IPC: C07D403/10

Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.

公开(公告)号：CA2635691A1

公开(公告)日：2007-07-26

申请号：CA2635691

申请日：2007-01-17

Applicant: ABBOTT LAB

Inventor： WERNET WOLFGANG ,  GIRANDA VINCENT L ,  PENNING THOMAS D

IPC: A61K31/41 ,  A61K31/4164 ,  A61K49/00 ,  C07D401/02 ,  C07D471/00

公开(公告)号：AU2006235492A1

公开(公告)日：2006-10-19

申请号：AU2006235492

申请日：2006-04-11

Applicant: ABBOTT LAB

Inventor： GANDHI VIRAJKUMAR B ,  ZHU GUIDONG ,  PENNING THOMAS D ,  GIRANDA VINCENT ,  GONG JIANCHUN

IPC: A61K31/4184 ,  A61K31/454 ,  A61K31/55 ,  A61P9/10 ,  C07D401/04 ,  C07D403/04

Abstract: Compounds of Formula (I) (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).