Patent search ap:("ABBOTT LAB") AND inv:"THOMAS SHEELA A" Page 1

1.

发明申请
N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS 审中-公开
Title translation: N-氨基磺酰胺疫苗促进剂

公开(公告)号：WO0224636A3

公开(公告)日：2002-09-26

申请号：PCT/US0129432

申请日：2001-09-20

Applicant: ABBOTT LAB

Inventor： MCCLELLAN WILLIAM , OOST THORSTEN , BRUNCKO MILAN , WANG XILU , AUGERI DAVID J , BAUMEISTER STEVEN A , DICKMAN DANIEL A , DING HONG , DINGES JURGEN , FESIK STEPHEN W , HAJDUK PHILIP J , KUNZER AARON R , NETTESHEIM DAVID G , PETROS ANDREW M , ROSENBERG SAUL H , SHEN WANG , THOMAS SHEELA A , WENDT MICHAEL D

IPC: A61K31/18 , A61K31/428 , A61K31/63 , A61K31/635 , A61P9/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , C07C311/46 , C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/43 , C07C323/44 , C07C323/48 , C07C323/58 , C07C323/60 , C07D203/10 , C07D205/04 , C07D205/12 , C07D207/09 , C07D207/24 , C07D207/40 , C07D207/404 , C07D209/08 , C07D209/52 , C07D209/54 , C07D209/96 , C07D211/14 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D233/60 , C07D235/08 , C07D235/26 , C07D241/08 , C07D241/16 , C07D249/04 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/155 , C07D295/16 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D333/70 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D417/12 , C07D451/02 , C07D491/107 , C07D295/14 , C07D317/58

CPC classification number: C07D207/404 , C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/58 , C07C323/60 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/28 , C07C2602/42 , C07C2602/44 , C07C2603/74 , C07D203/10 , C07D205/12 , C07D207/24 , C07D209/08 , C07D209/96 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/61 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/227 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D235/08 , C07D235/26 , C07D241/16 , C07D249/04 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/155 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D401/06 , C07D401/12 , C07D405/04 , C07D417/12 , C07D451/02

Abstract: N-Benzoyl arylsulfonamides having the formula (I) are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.

Abstract translation: 具有式（I）的N-苯甲酰基芳基磺酰胺是BCL-X1抑制剂，可用于促进细胞凋亡。还公开了BCL-X1抑制组合物和促进哺乳动物细胞凋亡的方法。

2.

发明申请
PYRAZOLOQUINAZOLINONES AS PARP INHIBITORS 审中-公开
Title translation: PYRAZOLOQUINAZOLINONES作为PARP抑制剂

公开(公告)号：WO2007149907A3

公开(公告)日：2008-02-07

申请号：PCT/US2007071649

申请日：2007-06-20

Applicant: ABBOTT LAB , PENNING THOMAS D , THOMAS SHEELA A , HAJDUK PHILIP J , SAUER DARYL R , SARRIS KATHY , GIRANDA VINCENT L

Inventor： PENNING THOMAS D , THOMAS SHEELA A , HAJDUK PHILIP J , SAUER DARYL R , SARRIS KATHY , GIRANDA VINCENT L

IPC: C07D487/04 , A61K31/519

CPC classification number: C07D487/04

Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.

Abstract translation: 本发明涉及式（I）的1H-苯并咪唑-4-甲酰胺，其制备及其作为制备药物的聚（ADP-核糖）聚合酶的抑制剂的用途。

3.

发明申请
APOPTOSIS PROMOTERS 审中-公开
Title translation: APOPTOSIS促销者

公开(公告)号：WO2007008627A2

公开(公告)日：2007-01-18

申请号：PCT/US2006026424

申请日：2006-07-07

Applicant: ABBOTT LAB , WENDT MICHAEL D , SHEN WANG , DICKMAN DANIEL A , DING HONG , THOMAS SHEELA A , AUGERI DAVID , ELMORE STEVEN W

Inventor： WENDT MICHAEL D , SHEN WANG , DICKMAN DANIEL A , DING HONG , THOMAS SHEELA A , AUGERI DAVID , ELMORE STEVEN W

IPC: A61K31/192 , A61P35/00 , C07C15/12

CPC classification number: C07C311/41 , C07C63/48 , C07C63/49 , C07C65/26 , C07C65/28 , C07C205/58 , C07C229/52 , C07C229/56 , C07C233/81 , C07C311/13 , C07C311/18 , C07C311/21 , C07C311/37 , C07C311/44 , C07C323/20 , C07C323/25 , C07C323/62 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/18 , C07C2603/74 , C07D207/30 , C07D213/53 , C07D215/12 , C07D215/48 , C07D333/34

Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl-1 protein are disclosed.

Abstract translation: 公开了抑制抗细胞凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物和治疗疾病的方法，其表达为Mcl-1蛋白。

4.

发明申请
SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS 审中-公开
Title translation: 取代的1H-苯并咪唑-4-羧酰胺是残留的PARP抑制剂

公开(公告)号：WO2007131016A3

公开(公告)日：2008-12-18

申请号：PCT/US2007067991

申请日：2007-05-02

Applicant: ABBOTT LAB , GIRANDA VINCENT L , PENNING THOMAS D , GANDHI VIRAJKUMAR B , THOMAS SHEELA A , ZHU GUI-DONG , GONG JIANCHUN

Inventor： GIRANDA VINCENT L , PENNING THOMAS D , GANDHI VIRAJKUMAR B , THOMAS SHEELA A , ZHU GUI-DONG , GONG JIANCHUN

IPC: C07D403/10

CPC classification number: C07D403/10 , C07D235/18 , C07D409/04

Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.

Abstract translation: 本发明涉及式（I）的1H-苯并咪唑-4-甲酰胺，其制备及其作为制备药物的聚（ADP-核糖）聚合酶的抑制剂的用途。

5.

发明申请
SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS 审中-公开
Title translation: 取代的1H-苯并咪唑-4-羧酰胺是残留的PARP抑制剂

公开(公告)号：WO2007059230A2

公开(公告)日：2007-05-24

申请号：PCT/US2006044379

申请日：2006-11-15

Applicant: ABBOTT LAB , PENNING THOMAS D , THOMAS SHEELA A , ZHU GUI-DONG , GONG JIANCHUN , GIRANDA VINCENT L , GANDHI VIRAJ B

Inventor： PENNING THOMAS D , THOMAS SHEELA A , ZHU GUI-DONG , GONG JIANCHUN , GIRANDA VINCENT L , GANDHI VIRAJ B

CPC classification number: C07D235/18 , C07D409/04 , C07D413/04 , C07D417/04

Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).

Abstract translation: 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。

6.

发明公开
SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS 有权
Title translation: 取代的1H-苯并咪唑-4-甲酰胺作为泛醇 - 甲酰胺

公开(公告)号：EP2012780A4

公开(公告)日：2009-06-24

申请号：EP07761722

申请日：2007-05-02

Applicant: ABBOTT LAB

Inventor： GIRANDA VINCENT L , PENNING THOMAS D , GANDHI VIRAJKUMAR B , THOMAS SHEELA A , ZHU GUI-DONG , GONG JIANCHUN

IPC: C07D403/10 , A61K31/4184 , A61P29/00 , A61P37/00 , C07D235/18 , C07D409/04

CPC classification number: C07D403/10 , C07D235/18 , C07D409/04

7.

发明专利
Las 1H-bencimidazol-4-carboxamidas substituidas son potentes inhibidores de la PARP 未知

公开(公告)号：ES2385849T3

公开(公告)日：2012-08-01

申请号：ES07761722

申请日：2007-05-02

Applicant: ABBOTT LAB

Inventor： GIRANDA VINCENT L , PENNING THOMAS D , GANDHI VIRAJKUMAR B , THOMAS SHEELA A , ZHU GUI-DONG , GONG JIANCHUN

IPC: C07D403/10 , A61K31/4184 , A61P29/00 , A61P37/00 , C07D235/18 , C07D409/04

Abstract: Un compuesto de Formula (I)**Fórmula**o una sal terapeuticamente aceptable del mismo, dondeR1, R2 y R3 son independientemente seleccionados entre el grupo consistente en hidrogeno y halogeno;Ar1 es arilo, donde Ar1 esta eventualmente substituido con halogeno;X1 es alquilenilo;Z es heterociclo, donde Z esta sustituido con 1, 2, 3 o 4 substituyentes seleccionados entre el grupo consistente enalcoxialquilo, haloalquilo, hidroxialquilo, NRCRD y NRCRDalquilo; yRC y RD son independientemente seleccionados entre el grupo consistente en hidrogeno, alquilo, cicloalquilo ycicloalquilalquilo,a condicion de que, cuando Z sea un anillo no aromatico de 5 o 6 miembros que contiene 1 o 2 atomos de nitrogenoy eventualmente un atomo de azufre u oxigeno, entonces Z no este unido a X1 a traves de un atomo de carbono.