公开(公告)号：DE602004031037D1

公开(公告)日：2011-02-24

申请号：DE602004031037

申请日：2004-11-18

Applicant: ARRAY BIOPHARMA INC

Inventor： MARLOW ALLISON L ,  WALLACE ELI ,  SEO JEONGBEOB ,  LYSSIKATOS JOSEPH P ,  YANG HONG WOON ,  BLAKE JIM

IPC: A61K31/44 ,  A01N33/02 ,  A01N43/42 ,  A01N43/54 ,  A01N43/58 ,  A01N43/60 ,  A01N43/64 ,  A01N43/90 ,  A61K20060101 ,  A61K31/40 ,  A61K31/415 ,  A61K31/416 ,  A61K31/4353 ,  A61K31/4439 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/50 ,  A61K31/501 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K31/655 ,  C07D20060101 ,  C07D209/44 ,  C07D209/46 ,  C07D213/80 ,  C07D213/82 ,  C07D215/48 ,  C07D221/04 ,  C07D231/56 ,  C07D237/24 ,  C07D237/26 ,  C07D237/28 ,  C07D237/32 ,  C07D239/74 ,  C07D401/04 ,  C07D401/06 ,  C07D403/02 ,  C07D413/02 ,  C07D413/04 ,  C07D413/14 ,  C07D417/02 ,  C07D417/04 ,  C07D471/02 ,  C07D471/04 ,  C07D487/02 ,  C07D491/02 ,  C07D498/02

公开(公告)号：NZ563707A

公开(公告)日：2011-01-28

申请号：NZ56370706

申请日：2006-05-17

Applicant: ARRAY BIOPHARMA INC ,  ASTRAZENECA AB

Inventor： MARLOW ALLISON L ,  WALLACE ELI M ,  SEO JEONGBEOB ,  LYSSIKATOS JOSEPH P ,  YANG HONG WOON ,  BLAKE JIM ,  STOREY RICHARD ANTHONY ,  BOOTH REBECCA JANE ,  PITTMAN JOHN DAVID ,  LEONARD JOHN ,  FIELDING MARK RICHARD

IPC: C07D213/63 ,  A61K31/4412 ,  A61K31/50 ,  C07D211/74 ,  C07D211/86 ,  C07D213/70 ,  C07D237/12 ,  C07D237/14

Abstract: Disclosed herein are compounds of forumula IV and VI along with a crystalline form of a compound of formula XI, wherein substituents and characterizing peaks for the crystalline forms are as defined within the specification. Such compounds are MEK inhibitors which are useful in the treatment of hyperproliferative diseases such as cancer and inflammation in mammals and inflammatory conditions. Also discloses are methods of using such compounds in the treatment of hyperproliferative diseases in mammals, pharmaceutical compositions containing such compounds and methods for preparing compounds of formula IV, VI and XI.

公开(公告)号：HK1141976A1

公开(公告)日：2010-11-26

申请号：HK10105717

申请日：2010-06-09

Applicant: ARRAY BIOPHARMA INC

Inventor： WALLACE ELI M ,  LYSSIKATOS JOSEPH P ,  HURLEY BRIAN T ,  MARLOW ALLISON L

IPC: C07D235/08 ,  A61K20060101 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61P20060101 ,  A61P1/00 ,  A61P1/18 ,  A61P3/10 ,  A61P9/08 ,  A61P9/10 ,  A61P13/08 ,  A61P13/12 ,  A61P17/00 ,  A61P17/04 ,  A61P17/06 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D20060101 ,  C07D235/04 ,  C07D235/06 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D413/04 ,  C07D413/06 ,  C07D417/06 ,  C07D417/12

Abstract: Pharmaceutical compositions comprising a compound of the formula I selected from 6-(4-bromo-2-fluoro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide and pharmaceutically acceptable salts thereof, for use in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals.

公开(公告)号：BRPI0610139A2

公开(公告)日：2010-06-01

申请号：BRPI0610139

申请日：2006-05-17

Applicant: ARRAY BIOPHARMA INC ,  ASTRAZENECA AB ,  WALLACE ELI ,  SEO JEONGBEOB ,  LYSSIKATOS JOSEPH P ,  YANG HONG WOON

Inventor： MARLOW ALLISON L ,  BLAKE JIM ,  STOREY RICHARD ANTHONY ,  BOOTH REBECCA JANE ,  PITTAM JOHN DAVID ,  LEONARD JOHN ,  FIELDING MARK RICHARD ,  WALLACE ELI ,  SEO JEONGBEOB ,  LYSSIKATOS JOSEPH P ,  YANG HONG WOON

IPC: C07D213/84 ,  A61K31/44 ,  C07D213/63

Abstract: This invention relates to a series of novel heterocyclic compounds that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

公开(公告)号：PT1971601E

公开(公告)日：2010-01-26

申请号：PT06837728

申请日：2006-11-15

Applicant: ARRAY BIOPHARMA INC

Inventor： LYSSIKATOS JOSEPH P ,  MARMSATER FREDRIK P ,  ZHAO QIAN ,  GRESCHUK JULIE MARIE

IPC: C07D413/14 ,  A61K31/517 ,  A61P35/00 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

公开(公告)号：ZA200710969B

公开(公告)日：2009-03-25

申请号：ZA200710969

申请日：2007-12-18

Applicant: ARRAY BIOPHARMA INC

Inventor： ELLEN LAIRD ,  LYSSIKATOS JOSEPH P ,  JONAS GRINA ,  BRAD NEWHOUSE ,  GEORGE TOPALOV ,  MIKE WELCH ,  JOSH HANSEN

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

Abstract: Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：CA2478374C

公开(公告)日：2009-01-06

申请号：CA2478374

申请日：2003-03-13

Applicant: ARRAY BIOPHARMA INC

Inventor： MARLOW ALLISON L ,  HURLEY T BRIAN ,  WALLACE ELI M ,  LYSSIKATOS JOSEPH P

IPC: C07D235/06 ,  C07D235/08 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61P1/00 ,  A61P1/18 ,  A61P3/10 ,  A61P9/08 ,  A61P9/10 ,  A61P13/08 ,  A61P13/12 ,  A61P17/00 ,  A61P17/04 ,  A61P17/06 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D235/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D413/04 ,  C07D413/06 ,  C07D417/06 ,  C07D417/12

Abstract: Disclosed are compounds of the formula I, and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1 , R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful i n the treatment of hyperproliferative diseases, such as cancer and inflammatio n, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.

公开(公告)号：HK1115376A1

公开(公告)日：2008-11-28

申请号：HK08105389

申请日：2008-05-15

Applicant: ARRAY BIOPHARMA INC

Inventor： HANS JEREMY ,  WALLACE ELI M ,  ZHAO QIAN ,  ALLEN SHELLEY ,  LAIRD ELLEN ,  LYSSIKATOS JOSEPH P ,  ROBINSON JOHN E ,  CORRETTE CHRISTOPHER P ,  DELISLE ROBERT KIRK ,  VOEGTLI WALTER CHARLES

IPC: C07D20060101

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

公开(公告)号：BRPI0518228A

公开(公告)日：2008-11-04

申请号：BRPI0518228

申请日：2005-10-18

Applicant: ARRAY BIOPHARMA INC

Inventor： HANS JEREMY ,  WALLACE ELI M ,  ZHAO QIAN ,  LYSSIKATOS JOSEPH P ,  AICHER TOM ,  LAIRD ELLEN ,  ROBINSON JOHN ,  ALLEN SHELLEY

IPC: A61K31/4245 ,  C07D413/00 ,  C07D417/00

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

公开(公告)号：CA2682231A1

公开(公告)日：2008-10-09

申请号：CA2682231

申请日：2008-03-27

Applicant: ARRAY BIOPHARMA INC

Inventor： MARMSAETER FREDRIK P ,  RIZZI JAMES P ,  ROBINSON JOHN E ,  LYSSIKATOS JOSEPH P ,  MUNSON MARK C ,  ZHAO QIAN ,  TOPALOV GEORGE T ,  SCHLACHTER STEPHEN T

IPC: C07D471/04 ,  A61K31/4709 ,  A61P35/00

Abstract: Compounds of Formula (I): are receptor tyrosine inhibitors useful in the treatment of diseases mediated by class (3) and class (5) receptor tyrosine kinases. Particular compounds of this invention have also been found to be i nhibitors of Pim-1.