公开(公告)号：HUT66820A

公开(公告)日：1995-01-30

申请号：HU9401226

申请日：1994-04-28

Applicant: HOECHST AG

Inventor： SCHOELKENS BERNWARD ,  HENKE STEPHAN ,  KNOLLE JOCHEN ,  LINZ WOLFGANG ,  WIRTH KLAUS ,  BREIPOHL GERHARD

IPC: A61K38/00 ,  A61K38/04 ,  A61P9/10

公开(公告)号：AU6073794A

公开(公告)日：1994-11-03

申请号：AU6073794

申请日：1994-04-27

Applicant: HOECHST AG

Inventor： LINZ WOLFGANG ,  WIRTH KLAUS ,  SCHOLKENS BERNWARD ,  BREIPOHL GERHARD ,  HENKE STEPHAN ,  KNOLLE JOCHEN

IPC: A61K38/00 ,  A61K38/04 ,  A61P9/10 ,  A61K37/02

公开(公告)号：FI940810A0

公开(公告)日：1994-02-21

申请号：FI940810

申请日：1994-02-21

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH ,  MANIA DIETER ,  HARTUNG JENS ,  GOEGELEIN HEINZ ,  KAISER JOACHIM ,  LINZ WOLFGANG ,  WETTLAUFER DAVID

IPC: A61K31/18 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  C07C303/40 ,  C07C311/46 ,  C07C311/58 ,  C07C323/67 ,  C07C335/42 ,  C07C

Abstract: There are described benzenesulphonylureas and -thioureas of the formula I where R(1) is H, (fluoro)methyl, R(2) is H, Hal, (fluoro)(mercapto) alkyl(oxy), E is O, S; Y is -[CR(3)2]n- where R(3) = H or alkyl and n = 1 - 4, X is H, Hal, alkyl, Z is Hal, NO2, alkyl(oxy). The compounds (I) are used for the treatment of cardiac arrhythmias and for the prevention of sudden heart death due to arrhythmias and can therefore be used as antiarrhythmics. They are particularly suitable for those cases in which arrhythmias are the result of constriction of a coronary vessel, such as in angina pectoris or in acute cardiac infarct.

公开(公告)号：NO932391L

公开(公告)日：1994-01-03

申请号：NO932391

申请日：1993-06-30

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  LINZ WOLFGANG ,  WAGNER ADALBERT ,  KLEEMANN HEINZ-WERNER

IPC: A61K31/00 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/435 ,  A61K31/44 ,  A61K31/495 ,  A61K31/505 ,  A61K31/53 ,  A61K45/00 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/04 ,  C07D249/06 ,  C07D249/08 ,  C07D249/10 ,  C07D249/12 ,  C07D249/14 ,  C07D257/02 ,  C07D257/04 ,  C07D403/10 ,  C07D471/04 ,  C07D487/04 ,  A61K31/33

Abstract: Antagonists of angiotensin II receptors of the AT1 subtype can be used to control cardiac arrhythmias, employing, for example, azole derivatives of the formula (I)

公开(公告)号：NO930512A

公开(公告)日：1993-08-16

申请号：NO930512

申请日：1993-02-12

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH ,  MANIA DIETER ,  LANG HANS-JOCHEN ,  SCHOLZ WOLFGANG ,  LINZ WOLFGANG ,  ALBUS UDO

IPC: A61K31/155 ,  A61K31/165 ,  A61K31/445 ,  A61P1/16 ,  A61P3/08 ,  A61P3/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  C07C279/22 ,  C07D213/65 ,  C07D295/14 ,  C07D295/155 ,  A61K31/40 ,  C07C279/20

CPC classification number: C07D295/155 ,  C07C279/22 ,  C07D213/65

公开(公告)号：CA2089442A1

公开(公告)日：1993-08-16

申请号：CA2089442

申请日：1993-02-12

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH ,  MANIA DIETER ,  LANG HANS-JOCHEN ,  SCHOLZ WOLFGANG ,  LINZ WOLFGANG ,  ALBUS UDO

IPC: A61K31/155 ,  A61K31/165 ,  A61K31/445 ,  A61P1/16 ,  A61P3/08 ,  A61P3/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  C07C279/22 ,  C07D213/65 ,  C07D295/14 ,  C07D295/155 ,  C07D401/12 ,  A61K31/40

Abstract: HOE 92/F 036 Amino-substituted benzoylguanidines, process for their preparation, their use as a medicament and medicament containing them Benzoylguanidines of the formula I (I) are described in which R(1) or R(2) is an amino group -NR(3)R(4), where R(3) and R(4) are H or (cyclo)alkyl or R(3) is phenyl-(CH2)p- where p = 0, 1, 2, 3 or 4, or phenyl, or R(3) and R(4) can also together be a methylene chain, and in which the other substituent R(1) or R(2) in each case is H, F, Cl, alkyl, alkoxy, CF3, CmF2m+1-CH2-, benzyl or phenoxy, and their pharmaceutically tolerable salts. The compounds according to the invention have very good antiarrhythmic properties, as occur, for example, in the case of oxygen deficiency symptoms. The compounds are used as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment as well as for the treatment of angina pectoris, where they also preventively inhibit or greatly decrease the pathophysiological processes in the formation of ischemically induced damage, in particular in the production of ischemically induced cardiac arrhythmias.

公开(公告)号：ZA9204522B

公开(公告)日：1993-02-24

申请号：ZA9204522

申请日：1992-06-19

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HOLGER HEITSCH ,  URBACH HANSJOERG ,  HANSJOERG URBACH ,  LINZ WOLFGANG ,  WOLFGANG LINZ ,  HENNING RAINER ,  RAINER HENNING ,  RUPPERT DIETER ,  DIETER RUPPERT

IPC: A61K31/33 ,  A61K31/415 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P9/00 ,  A61P9/12 ,  A61P31/12 ,  A61P43/00 ,  C07D213/30 ,  C07D213/40 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D ,  A61K

CPC classification number: C07D213/30 ,  C07D401/12 ,  C07D401/14 ,  C07D417/14

公开(公告)号：IE921996A1

公开(公告)日：1992-12-30

申请号：IE921996

申请日：1992-07-01

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HENNING RAINER ,  URBACH HANSJORG ,  RUPPERT DIETER ,  LINZ WOLFGANG

IPC: A61K31/495 ,  A61P9/12 ,  A61P43/00 ,  C07D241/10 ,  C07D249/08 ,  C07D401/04 ,  C07D487/04 ,  C07D519/00

Abstract: Heterocyclic compounds of the formula (I) in which the radicals have the following meanings: R is, for example, propyl or isobutyl, R is, for example, phenyl or pyridyl, R is, for example, hydrogen, R is, for example, cyclohexylmethyl, R is, for example, hydrogen or hydroxyl, R is, for example, a radical of the formula (II> (CH2)5-CHR -Z (II> where R is, for example, hydrogen, Z represents a 5- to 7-membered heterocyclic ring and s denotes 0, 1, 2, 3 or 4; are potent renin-inhibiting compounds.

公开(公告)号：HU206704B

公开(公告)日：1992-12-28

申请号：HU585990

申请日：1990-09-11

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HENNING RAINER ,  LINZ WOLFGANG ,  NICKEL WOLF-ULRICH ,  RUPPERT DIETER ,  URBACH HANSJOERG

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61P9/12 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07K5/02

Abstract: The invention relates to renin-inhibiting amino-acid derivatives of the formula in which R is a radical of a substituted nitrogen-containing heterocycle such as piperidine, X is CO, CS, SO2 or SO, Y is CH2, O or S, B is the residue of an amino acid of the formula H-B-OH, and R , R and R are as defined in the description, process for their preparation, agents containing them and their use.

公开(公告)号：NO922426A

公开(公告)日：1992-12-22

申请号：NO922426

申请日：1992-06-19

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HENNING RAINER ,  URBACH HANSJOERG ,  RUPPERT DIETER ,  LINZ WOLFGANG

IPC: A61K31/33 ,  A61K31/415 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P9/00 ,  A61P9/12 ,  A61P31/12 ,  A61P43/00 ,  C07D213/30 ,  C07D213/40 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  A61K31/44

CPC classification number: C07D213/30 ,  C07D401/12 ,  C07D401/14 ,  C07D417/14