公开(公告)号：NZ625114A

公开(公告)日：2016-02-26

申请号：NZ62511412

申请日：2012-11-23

Applicant: PORTOLA PHARM INC

Inventor： PANDEY ANJALI ,  SONG YONGHONG ,  XU QING ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  BAUER SHAWN M

IPC: A61K31/4965 ,  C07D241/20 ,  C07D241/28

Abstract: Provided are pyrazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

公开(公告)号：HK1201460A1

公开(公告)日：2015-09-04

申请号：HK15102026

申请日：2015-02-28

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: A61K20060101

公开(公告)号：CL2014001346A1

公开(公告)日：2015-03-13

申请号：CL2014001346

申请日：2014-05-22

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: C07D403/12 ,  A61K31/4965 ,  A61P9/00 ,  A61P35/00

Abstract: COMPUESTOS DERIVADOS DE 3-AMINO-5-[(2-AMINO-2-OXOETIL)AMINO]PIRAZINA-2-CARBOXAMIDA, INHIBIDORES DE PIRAZINA QUINASA; COMPOSICIÓN Y MÉTODO PARA TRATAR UNA AFECCIÓN COMO ENFERMEDAD CARDIOVASCULAR, TRASTORNO DE PROLIFERACIÓN, ENTRE OTROS

公开(公告)号：MX2014006242A

公开(公告)日：2014-10-06

申请号：MX2014006242

申请日：2012-11-23

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  SONG YONGHONG ,  XU QING ,  PANDEY ANJALI ,  KANE BRIAN ,  JIA ZHAOZHONG J

IPC: A61K31/4965

Abstract: En la presente se proporcionan compuestos de pirazina para inhibir cinasa Syk, los intermedios utilizados para realizar dichos compuestos, métodos para su preparación, composiciones farmacéuticas de estos, métodos para inhibir la actividad de cinasa Syk, y métodos para tratar afecciones mediadas al menos en parte por la actividad cinasa Syk.

公开(公告)号：CA3094793A1

公开(公告)日：2013-05-30

申请号：CA3094793

申请日：2012-11-23

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: C07D403/12 ,  A61K31/395 ,  A61K31/495 ,  A61K31/497 ,  C07D241/30 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

公开(公告)号：AU2011323484A1

公开(公告)日：2013-05-09

申请号：AU2011323484

申请日：2011-11-01

Applicant: PORTOLA PHARM INC

Inventor： JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  KANE BRIAN ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: C07D213/82 ,  A61K31/455 ,  A61P35/00 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D495/04

Abstract: The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma.

公开(公告)号：NZ589315A

公开(公告)日：2012-11-30

申请号：NZ58931509

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： JIA ZHAOZHONG J ,  VENKATARAMANI CHANDRASEKAR ,  HUANG WOLIN ,  MEHROTRA MUKUND ,  SONG YONGHONG ,  XU QING ,  BAUER SHAWN M ,  PANDEY ANJALI ,  KANE BRIAN ,  ROSE JACK W

IPC: A61P35/00 ,  A61K31/506 ,  A61P9/00 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present disclosure is directed to 2,6-diamino-pyrimidin-5-yl-carboxamide derivatives of formula (I) and tautomers thereof or pharmaceutically acceptable salts thereof which are inhibitors of Spleen tryosine kinase (syk) or Janus kinase (JAK). The disclosure is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions such as undesired thrombosis and Non Hodgkin's Lymphoma which are mediated at least in part by syk kinase or JAK kinase activity. These compounds are used in the preparation of a medicament for inhibiting syk or JAK kinase or a signal transduction pathway mediated at least in part by syk kinase activity, wherein the medicament is suitable for treating a condition or disorder selected from the group consisting of cardiovascular disease, inflammatory disease and autoimmune disease and cell proliferative disorder.

公开(公告)号：HK1158179A1

公开(公告)日：2012-07-13

申请号：HK11112350

申请日：2011-11-16

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101

公开(公告)号：MA32442B1

公开(公告)日：2011-07-03

申请号：MA33302

申请日：2010-11-01

Applicant: PORTOLA PHARM INC

Inventor： JIA ZHAOZHONG J ,  VENKATARAMANI CHANDRASEKAR ,  HUANG WOLIN ,  MEHROTRA MUKUND ,  SONG YONGHONG ,  XU QING ,  BAUER SHAWN M ,  PANDEY ANJALI ,  KANE BRIAN ,  ROSE JACK W

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: L'invention concerne des composés représentés par les formules i-v et des tautomères de ceux-ci, ou des sels pharmaceutiquement acceptables, des esters et des promédicaments de ceux-ci qui constituent des inhibiteurs de la syk kinase. L'invention concerne aussi des produits intermédiaires utilisés dans la fabrication de tels composés, la préparation d'un tel composé, des compositions pharmaceutiques contenant un tel composé, des procédés d'inhibition de l'activité de la syk kinase, des procédés d'inhibition de l'agrégation plaquettaire et des procédés destinés à prévenir ou à traiter des états pathologiques dus au moins en partie à l'activité de la syk kinase, tels qu'une thrombose indésirable et un lymphome malin non hodgkinien.

公开(公告)号：TN2009000091A1

公开(公告)日：2010-08-19

申请号：TN2009000091

申请日：2009-03-19

Applicant: PORTOLA PHARM INC

Inventor： SCARBOROUGH ROBERT M ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: A61K31/381 ,  A61K31/517 ,  A61K31/536 ,  A61P7/02 ,  C07D239/96 ,  C07D265/22 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14