公开(公告)号：US20070205379A1

公开(公告)日：2007-09-06

申请号：US11712917

申请日：2007-03-02

Applicant: Matthew P. Nelson ,  Patrick J. Treado

Inventor： Matthew P. Nelson ,  Patrick J. Treado

IPC: G01J1/58 ,  G02B6/06 ,  G01B9/10 ,  G01N21/64 ,  F21V9/16

CPC classification number: G01J3/2803 ,  G01J3/0221 ,  G01J3/44 ,  G01N21/474 ,  G01N21/55 ,  G01N21/645 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/6423 ,  G01N2021/6484 ,  G01N2201/0833 ,  G01N2201/0846 ,  G02B6/06

Abstract: The disclosure relates generally to methods and apparatus for using a fiber array spectral translator-based (“FAST”) spectroscopic system for improved imaging, spectral analysis, and interactive probing of a sample. In an embodiment, the confocality of a fiber array spectral translator-based spectroscopic system is improved through the use of structured illumination and/or structured collection of photons. User input may be received and acted upon to allow a user to interactively in real time and/or near real time view and analyze specific regions of the sample.

Abstract translation: 本公开一般涉及使用用于改进样品的成像，光谱分析和交互式探测的光纤阵列基于光谱转换器的（“FAST”）光谱系统的方法和装置。 在一个实施例中，通过使用结构化照明和/或光子的结构化收集来提高基于光纤阵列光谱转换器的光谱系统的共焦度。 可以接收用户输入并执行操作以允许用户以实时和/或接近实时的方式进行交互式查看和分析样本的特定区域。

公开(公告)号：US20070081156A1

公开(公告)日：2007-04-12

申请号：US11544648

申请日：2006-10-10

Applicant: Patrick Treado ,  Thomas Voigt ,  Wesley Hutchison

Inventor： Patrick Treado ,  Thomas Voigt ,  Wesley Hutchison

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/0227 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/0286 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/26 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/44 ,  G01J3/4406 ,  G01J3/447 ,  G01N2021/656 ,  G01N2201/0846

Abstract: The disclosure relates to a portable and/or handheld bioagent detector and methodology described herein that is based in part on advanced Raman Chemical Imaging (“RCI”) technology. According to one embodiment of the present disclosure, the detection system may include a fiber array spectral translator (“FAST”) and may also include a probe which may include a complementary metal oxide semiconductor (CMOS) camera. The probe alleviates the need to place the main instrument close to an unconfined release of a potentially hazardous material and facilitates analysis of a sample that is situated in a hard-to-reach location while minimizing contamination of the detector and operator.

Abstract translation: 本公开涉及部分基于先进的拉曼化学成像（“RCI”）技术的本文描述的便携式和/或手持式生物代谢检测器和方法。 根据本公开的一个实施例，检测系统可以包括光纤阵列光谱转换器（“FAST”），并且还可以包括可以包括互补金属氧化物半导体（CMOS）照相机的探针。 探头减轻了将主仪器置于非限制性释放潜在危险物质的需要，并有助于分析位于难以到达的位置的样品，同时最大限度地减少检测器和操作者的污染。

公开(公告)号：US07190457B2

公开(公告)日：2007-03-13

申请号：US10758318

申请日：2004-01-13

Applicant: Mary Elizabeth Tabacco ,  Marc W Mittelman ,  J. Anthony Schanzie

Inventor： Mary Elizabeth Tabacco ,  Marc W Mittelman ,  J. Anthony Schanzie

IPC: G01N21/25

CPC classification number: G01N21/8422 ,  G01N17/008 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/763 ,  G01N21/8507 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2021/8411 ,  G01N2021/8528 ,  G01N2201/0846 ,  G01N2201/1296

Abstract: Real time biofilm monitoring systems are provided. Said systems comprise single or multiple fiber-optic probes detecting wavelength-specific fluorescence from biomarkers of fouling organisms; a compact optoelectronic interface and data acquisition system interfaced with said probes, wherein said probe or probes are bifurcated and contain at least one excitation and at least one emission filter permitting the simultaneous resolution of multiple biomarkers.

Abstract translation: 提供实时生物膜监测系统。 所述系统包括检测来自污染生物体的生物标志物的波长特异性荧光的单个或多个光纤探针; 与所述探针接口的紧凑型光电接口和数据采集系统，其中所述探针或探针分叉并且包含至少一个激发和至少一个允许同时分辨多个生物标志物的发射过滤器。

公开(公告)号：US07158230B2

公开(公告)日：2007-01-02

申请号：US11404158

申请日：2006-04-13

Applicant: Brian T. Cunningham ,  Peter Y. Li ,  Frank DiFilippi

Inventor： Brian T. Cunningham ,  Peter Y. Li ,  Frank DiFilippi

IPC: G01J3/28

CPC classification number: G01N21/253 ,  B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/54373 ,  G01N2201/0635 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/0846 ,  G01N2201/1248 ,  G02B5/1809 ,  G02B5/1814 ,  G02B21/06

Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.

Abstract translation: 用于检测生物分子相互作用的方法和装置。 不需要使用标签，并且可以以高通量的方式执行方法。 用于检测在生物传感器的表面上发生的生物化学相互作用的装置包括光源。 第一光纤耦合到光源并照亮生物传感器。 第二光纤检测从生物传感器反射的波长。 光谱仪确定来自生物传感器的反射信号的光谱。

公开(公告)号：US20050196317A1

公开(公告)日：2005-09-08

申请号：US11040504

申请日：2005-01-21

Applicant: David Walt ,  Todd Dickinson

Inventor： David Walt ,  Todd Dickinson

IPC: C12M1/34 ,  C40B60/14 ,  G01N21/64 ,  G01N21/77 ,  G01N33/00 ,  G01N33/543 ,  G01N21/00

CPC classification number: C12Q1/682 ,  B01J2219/00317 ,  B01J2219/0045 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00585 ,  B01J2219/00648 ,  B01J2219/00659 ,  C12Q1/6834 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/7703 ,  G01N33/0031 ,  G01N33/54313 ,  G01N2201/0846 ,  Y10T436/101666 ,  Y10T436/109163

Abstract: A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

Abstract translation: 公开了一种基于微球的分析化学系统，其中具有针对特定目标分析物的不同特征光学响应特征的自编码微球可以混合在一起，同时保留能力以识别大尺度随机色散中的每个传感器的传感器类型和位置 使用光学可询问编码方案的传感器阵列中的这种传感器的数量。 还公开了一种光纤束传感器，其中单个微球传感器设置在纤维束的远端处的微孔中，并且光束耦合到束内的离散纤维或纤维组。 阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编​​码，同时用激发光能照射阵列。 单个传感器阵列可携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。

公开(公告)号：US20020169379A1

公开(公告)日：2002-11-14

申请号：US10142003

申请日：2002-05-09

Applicant: HOSPITAL FOR SPECIAL SURGERY

Inventor： Nancy P. Camacho ,  Mathias P.G. Bostrom ,  Steve L. Bertha

IPC: A61B005/00 ,  A61B017/22

CPC classification number: G01N21/552 ,  A61B5/0059 ,  A61B5/4504 ,  G01N21/35 ,  G01N21/359 ,  G01N2021/559 ,  G01N2201/0846

Abstract: A method of evaluating the surface of a material that has a distinguishable infrared spectrum comprising (a) positioning an infrared fiber optic probe to be in contact with a surface of the sample or material at a region of interest for detecting attenuated total reflectance or within a sufficient distance from the surface of the region for detecting reflection, (b) detecting mid- or near-infrared radiation attenuated total reflectance or reflection off of the surface of the sample or the material, (c) analyzing the infrared radiation from step (b) for at least one of peak height, peak area, frequency and chemometric parameters, and (d) actuating the removal device when a signal from the infrared fiber optic probe is between pre-selected values for at least one of peak height, peak area, frequency and chemometric parameters for the sample of the material.

Abstract translation: 一种评估具有可区别的红外光谱的材料的表面的方法，包括（a）将红外光纤探针定位成与感兴趣区域的样品或材料的表面接触以检测衰减的全反射率，或者在 距离用于检测反射的区域的表面足够的距离，（b）检测中间或近红外辐射减弱了样品或材料表面的全反射或反射，（c）分析来自步骤（b）的红外辐射 ），用于峰高，峰面积，频率和化学计量参数中的至少一个，以及（d）当来自红外光纤探针的信号处于峰值高度，峰值面积之中的至少一个的预选值之间时，启动去除装置 ，样品的频率和化学计量参数。

公开(公告)号：US20010029049A1

公开(公告)日：2001-10-11

申请号：US09287573

申请日：1999-04-06

Inventor： DAVID R. WALT ,  TODD A. DICKINSON

IPC: G01N033/543

CPC classification number: C12Q1/682 ,  B01J2219/00317 ,  B01J2219/0045 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00585 ,  B01J2219/00648 ,  B01J2219/00659 ,  C12Q1/6834 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/7703 ,  G01N33/0031 ,  G01N33/54313 ,  G01N2201/0846 ,  Y10T436/101666 ,  Y10T436/109163

Abstract: A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

Abstract translation: 公开了一种基于微球的分析化学系统，其中具有针对特定目标分析物的不同特征光学响应特征的自编码微球可以混合在一起，同时保留能力以识别大尺度随机色散中的每个传感器的传感器类型和位置 使用光学可询问编码方案的传感器阵列中的这种传感器的数量。 还公开了一种光纤束传感器，其中单个微球传感器设置在纤维束的远端处的微孔中，并且光束耦合到束内的离散纤维或纤维组。 阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编​​码，同时用激发光能照射阵列。 单个传感器阵列可携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。

公开(公告)号：US5835649A

公开(公告)日：1998-11-10

申请号：US867621

申请日：1997-06-02

Applicant: Robin Fredrick Bruce Turner ,  Michael Walter Blades ,  Lloyd Shane Greek ,  Hans Georg Schulze

Inventor： Robin Fredrick Bruce Turner ,  Michael Walter Blades ,  Lloyd Shane Greek ,  Hans Georg Schulze

IPC: G01N21/64 ,  G01N21/65 ,  G02B6/24 ,  G02B6/26

CPC classification number: G01N21/8507 ,  G01N21/645 ,  G02B6/241 ,  G01N2021/6484 ,  G01N21/65 ,  G01N2201/0846

Abstract: A fiber-optic probe is formed by a pair of optical fibers one of which delivers light to a target zone and the other collects light from a field of view in the target zone. One of these fibers is provided with a window that opens substantially perpendicular to the longitudinal axis of the fiber and with a transverse surface oriented at an angle to the longitudinal axis of the fiber to reflect light through the window or from the window longitudinally of the axis of this fiber. Two fibers are physically interconnected to position the window on one side of and immediately adjacent to the target zone and the axial end of other fiber to deliver or receive light from another side of the target zone preferably substantially perpendicular to the one side.

Abstract translation: 光纤探针由一对光纤形成，其中一个光纤将光传送到目标区域，另一个光纤从目标区域的视场中收集光。 这些光纤中的一个设置有基本上垂直于光纤的纵向轴线的窗口，并且横向表面定向成与光纤的纵向轴线成一定角度，以反射光线穿过窗口或从窗口纵向轴线反射 的纤维。 两个纤维物理互连，以将窗口定位在目标区域的一侧并且紧邻其它光纤的轴向端，以将目标区域另一侧的光优选地基本垂直于该一侧。

公开(公告)号：KR1020170026196A

公开(公告)日：2017-03-08

申请号：KR1020160107484

申请日：2016-08-24

Applicant: 오츠카덴시가부시끼가이샤

Inventor： 시라이와히사시

IPC: G01N21/64 ,  G01N33/02 ,  G02B21/00

CPC classification number: G01J3/28 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/18 ,  G01J3/2803 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/6452 ,  G01N21/6458 ,  G01N21/65 ,  G01N2021/6484 ,  G01N2201/0833 ,  G01N2201/0846 ,  G02B21/0032 ,  G02B21/004 ,  G02B21/0064

Abstract: 보다우수한현미분광장치를제공한다. 현미분광장치는, 광원과, 상기광원으로부터의광을받는복수의투광파이버와, 분광기와, 받은광을상기분광기로유도하기위한복수의수광파이버와, 상기복수의투광파이버로부터의복수의광속을각각집광하여시료에조사하고, 상기시료에있어서의복수의집광점으로부터의복수의광속을상기복수의수광파이버에각각결상하기위한공초점광학계를구비한다.

Abstract translation: 显微光谱仪（101）包括：光源（11,17）; 多个从所述光源（11,17）接收光的投光光纤（12）; 分光仪（1）; 多个光接收光纤（22），用于将接收到的光引导到所述分光器（1）; 以及共焦光学系统（5），用于使来自所述多个投光光纤（12）的多个光束中的每一个被聚集并照射到样本上，并且从多个聚光点形成多个光束的图像 分别在多个受光光纤（22）上。

公开(公告)号：KR1020140103304A

公开(公告)日：2014-08-26

申请号：KR1020147018275

申请日：2012-11-08

Applicant: 바이오크롬 리미티드

Inventor： 기포드,그라함에릭

IPC: G01N21/03 ,  G01N21/17 ,  G01N21/31 ,  G01N21/64 ,  G01J3/02 ,  G01J3/28

CPC classification number: G01N21/0303 ,  G01J3/02 ,  G01J3/0218 ,  G01N21/01 ,  G01N2021/035 ,  G01N2201/0846

Abstract: 개선점들은 액체 샘플들을 수용하기 위한 장치들에 관한 것이다. 액체 샘플을 수용하기 위한 장치는 분광광도계와 같은 기구를 위한 마이크로 샘플링 헤드의 일부를 형성할 수 있다. 상기 장치는 샘플을 통해 전자기 방사선을 통과시키는 것을 포함하는 공정에 의해 분석될 액체 샘플을 수용하며, 전자기 방사선을 샘플의 내측으로 지향시키기 위한 광 입구 가이드(20), 및 상기 가이드와 대향 관계로 위치되며 사용시, 샘플로 충전되는 일정한 경로 길이의 갭(21)을 형성하도록 일정한 거리만큼 가이드로부터 이격되는 광 수용 요소(23)를 포함한다. 사용시, 방사선은 광 입구 가이드로부터 광 수용 요소(23)로 통과하며, 샘플을 통한 방사선의 경로 길이는 상기 갭(23)에 의해 형성된다. 상기 장치는 샘플의 액적이 갭 내에 직접적으로 놓이게 허용하도록 개방 또는 개방될 수 있다.