公开(公告)号：WO2015177784A3

公开(公告)日：2015-11-26

申请号：PCT/IL2015/050511

申请日：2015-05-14

Applicant: ADOM, ADVANCED OPTICAL TECHNOLOGIES LTD.

Inventor： ARIELI, Yoel ,  COHEN, Yoel

IPC: G01B11/25

Abstract: A system (10) for analyzing an object (11) includes a light source (12) producing multiple light components, each of different wavelength and a respective amplitude, phase and polarization. An optical element (13) directs the light components on to the object to create known 2D patterns at different image planes displaced from the optical element by distances that are known functions of the wavelength of the light component. A 2D imager (20) images the 2D patterns and produces a plurality of full view 2D wavelength dependent patterns each corresponding to a known distance from the optical element and each having variable image contrast dependent on displacement of a surface of the object from the image plane, maximal image contrast being achieved when the surface of the object and image plane are coincident. A processing unit (25) determines the object surface based on the variable image contrast of each image.

公开(公告)号：WO2015132788A3

公开(公告)日：2015-12-17

申请号：PCT/IL2015050232

申请日：2015-03-04

Applicant: ADOM ADVANCED OPTICAL TECHNOLOGIES LTD

Inventor： ARIELI YOEL ,  COHEN YOEL ,  EPSTEIN SHLOMI ,  ARBEL DROR

IPC: A61B3/10

CPC classification number: A61B3/101 ,  A61B3/0025 ,  A61B3/1005 ,  A61B3/152 ,  G01B9/02021 ,  G01B9/02025 ,  G01B9/02027 ,  G01B9/02044 ,  G01B9/02087 ,  G01B9/0209 ,  G01B11/06 ,  G01B11/0625 ,  G01B11/0675 ,  G01B2290/45 ,  G01N21/274 ,  G01N2201/066 ,  G01N2201/127 ,  G02B3/08

Abstract: In a system and method for performing tear film structure measurement and evaporation rate measurements a broadband light source illuminates the tear film and a spectrometer measures respective spectra of reflected light from at least one point of the tear film. A color camera obtains a large field of view image of the tear film so as to obtain color information for all points of the tear film imaged by the color camera and an autofocusing mechanism focusses the color camera and the spectrometer. A processing unit coupled to the camera and to the spectrometer calibrates the camera so that the color obtained by the camera at the at least one point measured by the spectrometer matches the color of the spectrometer at the same point, and determines from the color of each point of the calibrated camera the thickness of the lipids at the respective point.

Abstract translation: 在用于执行泪膜结构测量和蒸发速率测量的系统和方法中，宽带光源照射泪膜，光谱仪测量来自泪膜的至少一个点的反射光的各个光谱。 彩色照相机获得泪膜的大视场图像，以获得由彩色照相机成像的泪膜的所有点的颜色信息，并且自动聚焦机构聚焦彩色照相机和光谱仪。 耦合到相机和光谱仪的处理单元校准相机，使得在由光谱仪测量的至少一个点处由相机获得的颜色在同一点匹配分光计的颜色，并且根据每个 点的校准相机的脂质在相应点的厚度。

公开(公告)号：WO2015166495A2

公开(公告)日：2015-11-05

申请号：PCT/IL2015/050445

申请日：2015-04-29

Applicant: ADOM, ADVANCED OPTICAL TECHNOLOGIES LTD.

Inventor： ARIELI, Yoel ,  COHEN, Yoel

IPC: G01B9/02

CPC classification number: G01B9/02047 ,  G01B9/0209 ,  G01B9/02091

Abstract: A method for high dynamic range and high accuracy interferometry measurements is described. The method uses a broadband light source for generating light, an interferometer, a phase shifting device, an imaging optical system and a detector array for collecting and measuring the reflected light from an object. The detected light is processed by a processor unit to obtain the object's surface.

Abstract translation: 描述了用于高动态范围和高精度干涉测量的方法。 该方法使用用于产生光的宽带光源，干涉仪，相移装置，成像光学系统和用于收集和测量来自物体的反射光的检测器阵列。 检测到的光被处理器单元处理以获得物体的表面。

公开(公告)号：WO2020053847A1

公开(公告)日：2020-03-19

申请号：PCT/IL2019/050749

申请日：2019-07-04

Applicant: ADOM, ADVANCED OPTICAL TECHNOLOGIES LTD.

Inventor： COHEN, Yoel ,  GEFEN, Ra'anan ,  EPSTEIN, Shlomi ,  ARIELI, Yoel

IPC: A61B3/107 ,  A61B3/10

Abstract: Apparatus and methods are described for calibrating an optical system that is used for measuring optical properties of a portion of a subject's body. During a calibration stage, a front surface of a calibration object (300) is illuminated, light reflected from a plurality of points on the calibration object (300) is detected, and intensities of the light reflected from the plurality of points on the calibration object (300) are measured. During a measurement stage, the portion of the subject's body is illuminated, and light reflected from the portion of the subject's body is detected. Measurements performed upon the light that was reflected from the portion of the subject's body are calibrated, using the measured intensities of the light reflected from the plurality of points on the calibration object (300). Other applications are also described.

公开(公告)号：WO2018025265A2

公开(公告)日：2018-02-08

申请号：PCT/IL2017/050853

申请日：2017-08-02

Applicant: ADOM, ADVANCED OPTICAL TECHNOLOGIES LTD.

Inventor： ARIELI, Yoel ,  COHEN, Yoel ,  EPSTEIN, Shlomi ,  ARBEL, Dror ,  GEFEN, Ra'anan

IPC: A61B3/10

Abstract: Apparatus and methods are described for performing tear film structure measurement on a tear film of an eye of a subject. A broadband light source (100) is configured to generate broadband light. A spectrometer (250) is configured to measure a spectrum of light of the broadband light that is reflected from at least one spot on the tear film, the spot having a diameter of between 100 microns and 240 microns. A computer processor (28) is coupled to the spectrometer and configured to determine a characteristic of the tear film based upon the spectrum of light measured by the spectrometer. Other applications are also described.

Abstract translation: 描述了用于在受试者的眼睛的泪膜上执行泪膜结构测量的设备和方法。 宽带光源（100）被配置为产生宽带光。 分光计（250）被配置为测量从泪膜上的至少一个点反射的宽带光的光谱，该点具有在100微米与240微米之间的直径。 计算机处理器（28）耦合到光谱仪并且被配置为基于由光谱仪测量的光谱来确定泪膜的特性。 还介绍了其他应用程序。

公开(公告)号：WO2016024270A2

公开(公告)日：2016-02-18

申请号：PCT/IL2015/050808

申请日：2015-08-07

Applicant: ADOM, ADVANCED OPTICAL TECHNOLOGIES LTD.

Inventor： ARIELI, Yoel ,  COHEN, Yoel

IPC: G01B9/02

CPC classification number: G01B9/02091 ,  G01B9/02019 ,  G01J3/0208 ,  G01J3/0224 ,  G01J3/447 ,  G01J3/453 ,  G01N21/31 ,  G01N2201/0636 ,  G01N2201/0683

Abstract: In a system for analyzing optical properties of an object (350) a point source of light (100) composed of multiple spectral bands each having a respective amplitude, phase and polarization is converted by first optics (120, 150) into a line light source to illuminate an object line on the object. A beam splitter (200) splits the light exiting the first optics and directs a first portion of light on to the object (350) as an illuminated line and a second portion of the light on to a reference mirror (450). Second optics (500) collects respective first and second lines of light reflected by the object and mirror of and collinearly images the reflected lines of light as an image line on to an imaging spectrometer (550) wherein mutual interference allows determination of the optical properties of the object at each point along the object line.

Abstract translation: 在用于分析物体（350）的光学特性的系统中，由具有相应振幅，相位和极化的多个光谱带组成的光源（100）由第一光学器件（120,150）转换成线光源 以照亮物体上的物体线。 分束器（200）将离开第一光学器件的光分开，并将光的第一部分作为照明线引导到物体（350），并将光的第二部分引导到参考反射镜（450）上。 第二光学器件（500）收集由物体和反射镜反射的相应的第一和第二光线，并将反射的光线作为图像线映射到成像光谱仪（550），其中相互干涉允许确定光学特性 物体沿着物体线的每个点。

公开(公告)号：WO2015177784A2

公开(公告)日：2015-11-26

申请号：PCT/IL2015050511

申请日：2015-05-14

Applicant: ADOM ADVANCED OPTICAL TECHNOLOGIES LTD

Inventor： ARIELI YOEL ,  COHEN YOEL

IPC: G01B11/25

CPC classification number: G01B11/25 ,  G01B2210/50 ,  G01N21/39 ,  G01N21/4795 ,  G01N2021/1787 ,  H04N5/2254 ,  H04N5/2256

Abstract: A system (10) for analyzing an object (11) includes a light source (12) producing multiple light components, each of different wavelength and a respective amplitude, phase and polarization. An optical element (13) directs the light components on to the object to create known 2D patterns at different image planes displaced from the optical element by distances that are known functions of the wavelength of the light component. A 2D imager (20) images the 2D patterns and produces a plurality of full view 2D wavelength dependent patterns each corresponding to a known distance from the optical element and each having variable image contrast dependent on displacement of a surface of the object from the image plane, maximal image contrast being achieved when the surface of the object and image plane are coincident. A processing unit (25) determines the object surface based on the variable image contrast of each image.

Abstract translation: 用于分析物体（11）的系统（10）包括产生多个光分量的光源（12），每个光分量具有不同的波长和相应的振幅，相位和极化。 光学元件（13）将光分量引导到物体上，以在与光学元件偏移的不同图像平面上产生已知的2D图案，该距离是光分量的波长的已知功能。 2D成像器（20）对2D图案进行成像，并且产生多个全视图2D波长相关图案，每个图案对应于从光学元件的已知距离，并且每个具有可变图像对比度，取决于物体表面与图像平面的位移 当物体和图像平面的表面一致时，实现最大的图像对比度。 处理单元（25）基于每个图像的可变图像对比度确定对象表面。

公开(公告)号：WO2021220266A1

公开(公告)日：2021-11-04

申请号：PCT/IL2021/050472

申请日：2021-04-25

Applicant: ADOM, ADVANCED OPTICAL TECHNOLOGIES LTD.

Inventor： COHEN, Yoel ,  GEFEN, Ra'anan ,  BARNEA NEHOSHTAN, Lee ,  DERI, Naor ,  ARIELI, Yoel

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/15

Abstract: Systems and methods for detecting physical characteristics of a multilayered tissue of a subject, such as a tear film including analyzing received detector-output indicative of optical properties of light reflected or deflected from the respective multilayered tissue, to determine spectral properties of the multilayered tissue; and determining physical characteristics of the multilayered tissue by using multiple spectral models of the of the multilayered tissue, each model being associated with spectral properties indicative of different tissue characteristics, wherein physical characteristics of the multilayered tissue are determined by hierarchal determination of a best-fit model from the multiple spectral models.

公开(公告)号：WO2016024270A3

公开(公告)日：2016-06-23

申请号：PCT/IL2015050808

申请日：2015-08-07

Applicant: ADOM ADVANCED OPTICAL TECHNOLOGIES LTD

Inventor： ARIELI YOEL ,  COHEN YOEL

IPC: G01B9/02 ,  G01J3/02 ,  G01J3/453

CPC classification number: G01B9/02091 ,  G01B9/02019 ,  G01J3/0208 ,  G01J3/0224 ,  G01J3/447 ,  G01J3/453 ,  G01N21/31 ,  G01N2201/0636 ,  G01N2201/0683

Abstract: In a system for analyzing optical properties of an object (350) a point source of light (100) composed of multiple spectral bands each having a respective amplitude, phase and polarization is converted by first optics (120, 150) into a line light source to illuminate an object line on the object. A beam splitter (200) splits the light exiting the first optics and directs a first portion of light on to the object (350) as an illuminated line and a second portion of the light on to a reference mirror (450). Second optics (500) collects respective first and second lines of light reflected by the object and mirror of and collinearly images the reflected lines of light as an image line on to an imaging spectrometer (550) wherein mutual interference allows determination of the optical properties of the object at each point along the object line.

Abstract translation: 在用于分析物体（350）的光学性质的系统中，由多个光谱带组成的点光源（100）分别由第一光学器件（120,150）转换为线光源 照亮物体上的物体线。 分束器（200）分离出射第一光学器件的光并且将第一部分光引导到物体（350）上作为照明线并且将光的第二部分引导到参考镜（450）上。 第二光学装置（500）收集由物体反射的各自的第一和第二线，以及将反射的线作为图像线共线地成像到成像光谱仪（550）上，其中相互干涉允许确定 沿着对象线的每个点处的对象。

公开(公告)号：WO2014020597A1

公开(公告)日：2014-02-06

申请号：PCT/IL2013/050641

申请日：2013-07-28

Applicant: ADOM, ADVANCED OPTICAL TECHNOLOGIES LTD.

Inventor： ARIELI, Yoel ,  WEITZMAN, Yosef

IPC: G01B9/02 ,  G02B27/10 ,  A61B6/00

CPC classification number: G01B9/0203 ,  A61B3/102 ,  G01B9/02032 ,  G01B9/02036 ,  G01B9/02043 ,  G01B9/02044 ,  G01B9/02057 ,  G01B9/02065 ,  G01B9/02091 ,  G01B2290/60

Abstract: A system (10) for measuring a physical characteristic of an object (1 1) using dual path, two-dimensional Optical Coherence Tomography (OCT) includes an extended broadband light source (13) producing an incident light beam (14) and an interferometer (15) having a beam splitter (16) that splits the incident beam into first and second component (17, 18) beams and directs the second component beam (18) on to a moveable mirror (19) for creating an optical path difference between the first component beam (17) and a reflection (20) of the second component beam. A focusing lens (21) having a focal plane (22) focuses the first component beam and the reflection of the second component beam to form a fringe pattern (23) on the focal plane, and a configurable imaging system (25) images the fringe pattern on to a plane (12) of the object to allow two-dimensional measurement of the object without spatial scanning.

Abstract translation: 使用双路径二维光学相干断层摄影（OCT）测量物体（11）的物理特性的系统（10）包括产生入射光束（14）的扩展宽带光源（13）和干涉仪 （15），其具有将入射光束分成第一和第二分量（17,18）的分束器（16），并将第二分量光束（18）引导到可移动反射镜（19）上，以产生第二分量光束 第一分量光束（17）和第二分量光束的反射（20）。 具有焦平面（22）的聚焦透镜（21）将第一分量光束和第二分量光束的反射聚焦以在焦平面上形成条纹图案（23），并且可配置成像系统（25）对边缘进行成像 图案对象的平面（12），以允许物体的二维测量而不进行空间扫描。