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公开(公告)号：KR1020140109631A
公开(公告)日：2014-09-16
申请号：KR1020130023817
申请日：2013-03-06
Applicant: 대한민국(농촌진흥청장)
CPC classification number: A61K36/53 , A23V2200/02 , A23V2200/302 , A61K8/97 , A61K2236/331 , A61K2236/333 , A61Q19/08
Abstract: Provided is an extract of Isodon japonicas having antioxidant activity. The extract of Isodon japonicas and a fraction have a marvelous antioxidant effect and can be used as a medicine, a cosmetic, and a functional food composition related to antioxidation, thereby having a wide range of applications.
Abstract translation: 提供具有抗氧化活性的Isodon japonicas提取物。 Isodon japonicas的提取物和一部分具有奇妙的抗氧化作用，可用作与抗氧化相关的药物，化妆品和功能性食品组合物，因此具有广泛的应用。
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公开(公告)号：KR101258695B1
公开(公告)日：2013-04-29
申请号：KR1020100119377
申请日：2010-11-29
Applicant: 대한민국(농촌진흥청장)
Abstract: 본 발명은 마늘로부터 5-하이드록시메틸-2-푸랄데하이드를 생산하는 방법에 관한 것으로, 보다 구체적으로는 (S1) 마늘을 고온숙성시키는 단계; (S2) 숙성된 마늘을 열수추출하는 단계; (S3) 열수추출물을 여과 및 농축하는 단계; (S4) 에틸아세테이트 또는 부탄올로 분획하는 단계; 및 (S5) 분획물을 분리 정제하는 단계;를 포함하는 5-하이드록시메틸-2-푸랄데하이드의 생산 방법에 대한 것이다. 본 발명에 따르면 마늘을 이용하여 순도 높은 HMF를 보다 경제적이고 용이하게 고수율로 생산할 수 있다.
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公开(公告)号：KR1020120057848A
公开(公告)日：2012-06-07
申请号：KR1020100119377
申请日：2010-11-29
Applicant: 대한민국(농촌진흥청장)
CPC classification number: A23L27/105 , A23V2002/00 , A23V2300/14 , A23V2300/50
Abstract: PURPOSE: A producing method of 5-hydroxymethyl-2-furaldehyde using garlic is provided to enable users to easily obtain the high purity 5-hydroxymethyl-2-furaldehyde with the high yield. CONSTITUTION: A producing method of 5-hydroxymethyl-2-furaldehyde using garlic comprises the following steps: high-temperature aging the garlic at 70-90 deg C for 15-40 days by sealing the garlic with a polyethylene film; hot-water extracting the aged garlic; filtering and concentrating the garlic hot-water extract; fractionating the concentrated garlic hot-water extract using ethyl acetate or butanol; separating and purifying the obtained fractions; and freeze-drying the fractions. The concentration of the garlic hot-water extract is processed by using a rotational vacuum concentrator. The fractionating process of the concentrated garlic hot-water extract is performed by using the high-performance liquid chromatography of the reverse-phase column chromatography method.
Abstract translation: 目的：提供使用大蒜的5-羟甲基-2-糠醛的制备方法，使用户能够以高产率容易地获得高纯度的5-羟甲基-2-糠醛。 构成：使用大蒜制备5-羟甲基-2-糠醛的方法包括以下步骤：通过用聚乙烯膜密封大蒜，使大蒜在70-90℃下高温老化15-40天; 热水提取老化大蒜; 过滤浓缩大蒜热水提取物; 使用乙酸乙酯或丁醇对浓缩的大蒜热水提取物进行分馏; 分离和纯化得到的级分; 并冷冻干燥该级分。 通过使用旋转式真空浓缩器处理大蒜热水提取物的浓度。 浓缩大蒜热水提取物的分馏过程通过使用反相柱色谱法的高效液相色谱法进行。
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4.发明公开5-하이드록시메틸-2-푸랄데하이드(5-ｈｙｄｒｏｘｙｍｅｔｈｙｌ-2-ｆｕｒａｌｄｅｈｙｄｅ) 저함유 숙성마늘 추출물 및 이의 제조방법 有权低5-羟基甲基-2-呋喃二恶烷黑加味提取物及其生产方法
公开(公告)号：KR1020120040543A
公开(公告)日：2012-04-27
申请号：KR1020100102018
申请日：2010-10-19
Applicant: 대한민국(농촌진흥청장)
CPC classification number: A23L2/04 , A23L2/08 , A23P10/20 , A23V2002/00 , A23V2300/14 , A23V2300/50
Abstract: PURPOSE: An aged garlic extract with the low content of 5-hydroxymethyl-2-furaldehyde, and a producing method thereof are provided to reduce the content of the 5-hydroxymethyl-2-furaldehyde by aging the garlic in the proper temperature and humidity. CONSTITUTION: A producing method of an garlic extract with the low content of 5-hydroxymethyl-2-furaldehyde comprises the following steps: aging garlic at 50-60 deg C for 15-35 days in the humidity of 70-90%; mixing the aged garlic with water in a water ratio of 1:3-5 before crushing; and refluxing and cooling the crushed mixture before extracting and filtering to obtain the extract. The aged garlic contains less than 1mg/g of 5-hydroxymethyl-2-furaldehyde, and more than 35%/g.DW of fructose.
Abstract translation: 目的：提供5-羟甲基-2-糠醛含量低的老化大蒜提取物及其制备方法，通过在适当的温度和湿度下老化大蒜来降低5-羟甲基-2-糠醛的含量。 构成：5-羟甲基-2-糠醛含量低的大蒜提取物的生产方法包括以下步骤：在70-60％的湿度下将大蒜在50-60℃老化15-35天; 将老化大蒜与水比例为1：3-5混合，然后粉碎; 回流并冷却粉碎的混合物，然后提取和过滤，得到提取物。 老化大蒜含有少于1mg / g的5-羟甲基-2-糠醛，超过35％/ g.DW的果糖。
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5.发明公开신규한 페디오코커스 펜토사세우스 EP106 균주 및 이를 이용한 칡 또는 대두배아 발효물의 제조 방법 无效新颖的PEDIOCOCCUS PENTOSACEUS SP。 EP106及其生产使用该方法的灭活多肽RADIX或SOY HYPOCOTYL
公开(公告)号：KR1020150055792A
公开(公告)日：2015-05-22
申请号：KR1020130138194
申请日：2013-11-14
Applicant: 대한민국(농촌진흥청장) , 가천대학교 산학협력단
IPC: C12N1/20 , A23L33/00 , A61K36/488 , A23L11/20
Abstract: 본발명은다이드제인또는제니스테인을각각다이하이드로다이드제인(dihydrodaidzein, DHD) 또는디하이드로제니스테인(dihydrogenistein, DHG)으로전환할수 있는페디오코커스펜토사세우스 () EP106 (수탁번호: KACC91829P) 균주및 이를이용한칡 또는대두배아발효물을제조하는방법에관한것이다.
Abstract translation: 本发明涉及能够将黄豆苷原或染料木素分别转化为二氢黄豆苷元（DHD）或二氢黄曲霉素（DHG）的黄芩（Pseudopcoccuspentosaceus）EP106菌株（登录号：KACC91829P）。 本发明还涉及通过使用该方法制备发酵大豆胚（Glycine max）或箭根（Pueraria thunbergiana）的方法。
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Patent Agency Ranking6.发明公开
公开(公告)号：KR1020150053095A
公开(公告)日：2015-05-15
申请号：KR1020130134870
申请日：2013-11-07
Applicant: 대한민국(농촌진흥청장) , 가천대학교 산학협력단
Abstract: 본발명은제니스테인을디하이드로제니스테인(dihydrogenistein, DHG)로전환할수 있는라울텔라플렌티콜라() KACC91828P 균주및 이를이용하여디하이드로제니스테인함유대두배아발효물을제조하는방법에관한것이다.
Abstract translation: 本发明涉及能够将染料木黄酮转化为二氢青霉素（DHG）的种子蓖麻（Kelcella）KACC91828P菌株，以及含有DHG的发酵大豆胚乳的制造方法。 包含DHG的发酵大豆胚乳的制造方法包括以下步骤：（a）用乙醇搅拌和提取粉碎的大豆; 和（b）将Raoultella planticola EF404菌株注入获得的提取物中，并通过搅拌结果获得培养基。
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公开(公告)号：KR1020140064496A
公开(公告)日：2014-05-28
申请号：KR1020120131896
申请日：2012-11-20
Applicant: 대한민국(농촌진흥청장)
CPC classification number: A61K38/30 , A61K35/20 , B01D15/34 , B01D15/363 , Y10S514/909
Abstract: A method for separating insulin-like growth factor 1 (IGF-1) from mammalian milk of the present invention comprises the steps of: a) separating the mammalian milk into whey and casein; b) recovering fractions containing a large amount of IGF-1; c) separating the fractions containing a large amount of materials corresponding to a molecular weight of the IGF-1 by using ion exchange chromatography; d) separating the fractions containing a large amount of IGF-1 by using gel filtration chromatography; and e) recovering the fractions with 7000-13000 Da or less by passing the fractions containing a large amount of the IGF-1 through a membrane with 7000-13000 Da, and then recovering the IGF-1 by concentrating using a membrane with 700-1300 Da.
Abstract translation: 从本发明的哺乳动物乳中分离胰岛素样生长因子1（IGF-1）的方法包括以下步骤：a）将哺乳动物乳分离成乳清和酪蛋白; b）回收含有大量IGF-1的级分; c）使用离子交换色谱法分离含有大量相应于IGF-1分子量的材料; d）使用凝胶过滤层析分离含有大量IGF-1的级分; 和e）通过使含有大量IGF-1的级分通过具有7000-13000Da的膜的7000-13000Da或更低的级分回收级分，然后通过使用具有700-1000Da的膜浓缩来回收IGF-1， 1300 Da
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公开(公告)号：KR1020150057053A
公开(公告)日：2015-05-28
申请号：KR1020130139869
申请日：2013-11-18
Applicant: 대한민국(농촌진흥청장)
Abstract: 본발명은마늘을열처리한후 동결건조하는단계를포함하는마늘조성물제조방법에관한것이다. 본발명의마늘조성물에따르면단순히열처리하여가공하는기존의마늘조성물에비하여알리인성분이안정적으로유지되어마늘의유효한성분을보다효율적으로섭취할수 있는건강기능식품을제조할수 있다.
Abstract translation: 本发明涉及一种大蒜组合物制备方法，其包括用热处理大蒜然后冷冻干燥大蒜的步骤。 与仅通过简单的热处理制备的常规大蒜组合物相比，本发明的大蒜组合物可以稳定地维持大蒜的蒜素含量，以制备膳食补充剂，使消费者能够摄取血液的活性成分。
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9.发明公开마늘종 추출물을 유효성분으로 포함하는 비만, 이상지방혈증, 지방간 또는 인슐린 저항성 증후군의 예방 또는 치료용 조성물 无效用于预防或治疗肥胖，血糖，脂肪肝或胰岛素抵抗综合征的组合物，包括作为主动成分的GARLIC STEM EXTRACT
公开(公告)号：KR1020140065716A
公开(公告)日：2014-05-30
申请号：KR1020120131893
申请日：2012-11-20
Applicant: 대한민국(농촌진흥청장)
IPC: A61K36/8962 , A61P3/04 , A61P3/10 , A61P3/06
Abstract: The present invention provides a composition for preventing or treating metabolic diseases selected from the group consisting of obesity, dyslipidemia, fatty liver, and insulin resistance syndrome, comprising an Allium sativum L. stem extract as an active ingredient. The composition of the present invention induces the inhibition of adipocyte differentiation, reduction in body fat, reduction in visceral fat, reduction of total cholesterol, and reductions in serum triglycerides and hepatic triglyceride, thereby ultimately exhibiting activity to prevent or treat obesity, hyperlipidemia, or fatty liver. Further, the composition of the present invention causes significant reductions in fasting blood level and serum insulin concentration, thereby exhibiting an effect of improving insulin resistance and an efficacy of ameliorating metabolic diseases closely associated therewith.
Abstract translation: 本发明提供了一种预防或治疗选自肥胖症，血脂异常，脂肪肝和胰岛素抵抗综合征的代谢疾病的组合物，其包含芜菁L.提取物作为活性成分。 本发明的组合物诱导脂肪细胞分化的抑制，体内脂肪的减少，内脏脂肪的减少，总胆固醇的降低以及血清甘油三酯和肝脏甘油三酯的降低，从而最终表现出预防或治疗肥胖症，高脂血症或 脂肪肝。 此外，本发明的组合物导致空腹血液水平和血清胰岛素浓度的显着降低，从而表现出改善胰岛素抵抗的作用和改善与其密切相关的代谢性疾病的功效。
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10.发明授权
公开(公告)号：KR101229395B1
公开(公告)日：2013-02-05
申请号：KR1020100102018
申请日：2010-10-19
Applicant: 대한민국(농촌진흥청장)
Abstract: 본 발명은 마늘을 적절한 온도와 습도 조건하에서 숙성함으로써 5-하이드록시메틸-2-푸랄데하이드(5-hydroxymethyl-2- furaldehyde, HMF) 함량이 낮은 숙성마늘 추출물 또는 건조분말을 제조하는 방법에 관한 것이다. 본 발명에 따른 숙성마늘 추출물은, 과당과 에스알릴시스테인 함량이 높아 기능성이 우수할 뿐 아니라, HMF 함량이 낮은 특징을 가지고 있어서 여러 가지 식품원료로 사용될 때 식품유해성 논란에서 자유로울 수 있다는 장점이 있다. 따라서, 본 발명에 따라 제조된 숙성마늘 추출물은 마늘쨈, 천연감미료, 양갱 등의 식품제조용 조성물, 염증질환 개선 및 치료용 조성물, 혈중 콜레스테롤 개선 건강기능성 식품, 의약, 및 화장품 등의 원료물질로 폭넓게 사용이 가능하다.
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