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    성게 유래 칼시토닌 유사 펩타이드를 유효성분으로 포함하는 골 질환 예방 또는 치료용 조성물
    2.
    发明公开
    성게 유래 칼시토닌 유사 펩타이드를 유효성분으로 포함하는 골 질환 예방 또는 치료용 조성물 审中-实审
    用于预防或治疗骨疾病的组合物，其包含作为活性成分的来自海胆的钙调磷酸酶样肽

    公开(公告)号：KR1020170138666A

    公开(公告)日：2017-12-18

    申请号：KR1020160070735

    申请日：2016-06-08

    Applicant: 부경대학교 산학협력단

    Inventor： 정원교 ,  박남규 ,  응구앤반띤 ,  고석천 ,  허성영

    IPC: C07K14/46 ,  A61K38/17 ,  A23L1/305

    Abstract: 본발명은성게유래칼시토닌유사펩타이드를유효성분으로포함하는골질환예방또는치료용조성물에관한것이다. 본발명은성게유래칼시토닌유사펩타이드를유효성분으로포함하는골질환예방또는치료용조성물에관한것이다. 본발명에따른펩타이드는 ALP(Alkaline phosphatase) 활성을증가시키고, 골미네랄화를촉진시키는활성이우수하여골 질환치료용조성물로유용하게사용할수 있다. 또한, 세포독성이일어나지않으며, 약물에대한독성및 부작용도없어장기간복용시에도안심하고사용할수 있으며, 체내에서도안정한효과가있다.

    Abstract translation: 本发明涉及用于预防或治疗骨疾病的组合物，其包含海胆来源的降钙素样肽作为有效成分。 本发明涉及用于预防或治疗骨疾病的组合物，其包含海胆来源的降钙素样肽作为有效成分。 根据本发明的肽可以通过增加ALP（碱性磷酸酶）活性和促进骨矿化而有用地用作治疗骨疾病的组合物。 此外，无细胞毒性发生，以及药物的没有毒副作用，即使在长期使用中安全地使用，有在体内稳定的作用。

    에드워드병의 원인세균에 대한 아피대신의 항균작용
    5.
    发明公开
    에드워드병의 원인세균에 대한 아피대신의 항균작용 无效
    APIDAECINE对EDWARDSIELLISIS的致病菌的抗微生物活性

    公开(公告)号：KR1020130077920A

    公开(公告)日：2013-07-09

    申请号：KR1020110144400

    申请日：2011-12-28

    Applicant: 부경대학교 산학협력단

    Inventor： 박남규 ,  서정길 ,  고혜진 ,  김혜림 ,  우경은 ,  이민정 ,  박태현

    IPC: A61K38/10 ,  A61K38/17 ,  C07K7/08 ,  A61P33/00

    CPC classification number: A61K38/10 ,  A23K20/147 ,  A23K50/80 ,  C07K7/08

    Abstract: PURPOSE: A composition containing apidaecin as an active ingredient for preventing and treating Edwardsiellosis in fish is provided to ensure specific and efficient antibacterial activities through a bacteriostatic mechanism without membrane selectivity. CONSTITUTION: A composition for preventing and treating Edwardsiellosis in fish contains apidaecin as an active ingredient. The apidaecin is an apidaecin Ib with an amino acid sequence of the number 2. The composition is provided in the form of a feed additive. A method for preventing and treating Edwardsiellosis in fish comprises a step of administering apidaecin to the fish.

    Abstract translation: 目的：提供含有apidaecin作为预防和治疗鱼类Edwardsiellosis活性成分的组合物，以通过抑菌机制确保特异性和有效的抗菌活性，而无需膜选择性。 构成：用于预防和治疗鱼类爱德华病的组合物含有apidaecin作为活性成分。 apidaecin是具有2号氨基酸序列的apidaecin Ib。该组合物以饲料添加剂的形式提供。 用于预防和治疗鱼类爱德华病的方法包括向鱼中施用apidaecin的步骤。

    평활근 이완활성을 지닌 칼시토닌 관련 펩타이드
    6.
    发明公开
    평활근 이완활성을 지닌 칼시토닌 관련 펩타이드 有权
    具有平滑肌肉松弛活性的钙依素类肽

    公开(公告)号：KR1020110009451A

    公开(公告)日：2011-01-28

    申请号：KR1020090066854

    申请日：2009-07-22

    Applicant: 부경대학교 산학협력단

    Inventor： 박남규 ,  고혜진 ,  김은정

    IPC: C07K14/435 ,  C07K14/585 ,  A61K38/23 ,  A61P21/02

    Abstract: PURPOSE: A novel calcitonin-relating peptide(SF-calcitonin) with relaxation activity is provided to ensure relaxation activity to DRM(dorsal retractor muscle). CONSTITUTION: A novel calcitonin-relating peptide(SF-CT) with relaxation activity of smooth muscle has an amino acid sequence of sequence number 1. SF-CT is isolated from Asterina pectinifera. SF-CT is obtained by preparing methanol-acid extract from Asterina pectinifera, purifying by CM52 anion exchange resin column chromatography, and isolating through HPLC system. SF-CT has homology with calcitonin.

    Abstract translation: 目的：提供具有松弛活性的新型降钙素相关肽（SF降钙素），以确保对DRM（背侧牵开肌）的松弛活性。 构成：具有平滑肌松弛活性的新型降钙素相关肽（SF-CT）具有序列号1的氨基酸序列。从Asterina pectinifera分离SF-CT。 SF-CT是通过从Asterina pectinifera制备甲醇酸提取物，通过CM52阴离子交换树脂柱色谱法纯化，并通过HPLC系统分离获得的。 SF-CT与降钙素具有同源性。

    먹장어 체조직으로부터 디형 아미노산을 지닌 신경성펩타이드 버그키닌 아이
    7.
    发明授权
    먹장어 체조직으로부터 디형 아미노산을 지닌 신경성펩타이드 버그키닌 아이 失效
    神经元与D-氨基酸，BURGERKININ I（（B）），从HAGFISH，EPTATRETUS BURGERI的身体组织中纯化

    公开(公告)号：KR100819780B1

    公开(公告)日：2008-04-07

    申请号：KR1020060103295

    申请日：2006-10-24

    Applicant: 부경대학교 산학협력단

    Inventor： 박남규 ,  김찬희 ,  고혜진

    IPC: C07K7/06

    Abstract: A neuropeptide is provided to be isolated from a body tissue of Eptatretus burgeri and have the contraction activity on smooth muscle of the Eptatretus burgeri, thereby being useful as a candidate material for developing a new drug. A neuropeptide with smooth muscle contraction activity has a primary structure including a D-amino acid extracted and purified from a body tissue of Eptatretus burgeri and is characterized in that the amino acid sequence is represented by Val-Gly-Gly-D-Phe-Gly-Ser-Ser-D-Ala-His-Trp-NH2.

    Abstract translation: 提供了一种神经肽，可以分离出来自汉普通白藜芦醇的身体组织，并且具有对白藜芦醇平滑肌的收缩活性，因此可用作开发新药的候选材料。 具有平滑肌收缩活性的神经肽具有包含从埃克斯顿克鲁维酵母的身体组织提取和纯化的D-氨基酸的一级结构，其特征在于氨基酸序列由Val-Gly-Gly-D-Phe-Gly -Ser-SER-D-ALA-的His-TRP-NH 2。

    평활근 이완활성을 지닌 신경성 펩타이드
    8.
    发明公开
    평활근 이완활성을 지닌 신경성 펩타이드 失效
    具有平滑肌肉松弛活性的神经细胞

    公开(公告)号：KR1020060115052A

    公开(公告)日：2006-11-08

    申请号：KR1020050037342

    申请日：2005-05-04

    Applicant: 부경대학교 산학협력단

    Inventor： 박남규 ,  김은정 ,  김찬희 ,  고혜진 ,  김인혜 ,  홍용기 ,  윤호동 ,  박희연 ,  장영채

    IPC: C07K7/08 ,  C07K7/06

    CPC classification number: C07K7/06 ,  A61K38/08 ,  C12N15/81 ,  C12N2510/02

    Abstract: A neuropeptide having relaxing activity of smooth muscle is provided to improve smooth muscle-relaxing activity, and reduce the number of amino acids, so that the neuropeptide is mass produced. The neuropeptide having relaxing activity of smooth muscle has the amino acid sequence of SEQ ID NO:2, wherein the C-terminal is carboxylated or amidated and the amine group of N-terminal is substituted by alkyl or acetyl group; the amino acid sequence is L-type and/or D-type. A nucleic acid containing DNA or RNA encodes the neuropeptide of SEQ ID NO:2. A recombinant vector contains the nucleic acid. The neuropeptide having relaxing activity of smooth muscle is produced by transforming bacterium, yeast or fungus with the recombinant vector, and culturing the transformed microorganism. A composition is used for improving at least one symptom selected from bronchial asthma, hypertension, diuresis and impotence.

    Abstract translation: 提供具有平滑肌松弛活性的神经肽，以提高平滑肌松弛活性，减少氨基酸数量，从而大量生产神经肽。 具有平滑肌松弛活性的神经肽具有SEQ ID NO：2的氨基酸序列，其中C末端被羧基化或酰胺化，并且N-末端的胺基被烷基或乙酰基取代; 氨基酸序列是L型和/或D型。 含有DNA或RNA的核酸编码SEQ ID NO：2的神经肽。 重组载体含有核酸。 具有平滑肌松弛活性的神经肽通过用重组载体转化细菌，酵母或真菌产生，并培养转化的微生物。 一种组合物用于改善选自支气管哮喘，高血压，利尿和阳at的至少一种症状。

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